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Pre-mRNA processing includes N6 methylation of adenosine residues that are retained in mRNA exons and the fallacy of "RNA epigenetics".

Darnell RB, Ke S, Darnell JE Jr.

RNA. 2018 Mar;24(3):262-267. doi: 10.1261/rna.065219.117. Epub 2017 Dec 8.


m6A mRNA modifications are deposited in nascent pre-mRNA and are not required for splicing but do specify cytoplasmic turnover.

Ke S, Pandya-Jones A, Saito Y, Fak JJ, Vågbø CB, Geula S, Hanna JH, Black DL, Darnell JE Jr, Darnell RB.

Genes Dev. 2017 May 15;31(10):990-1006. doi: 10.1101/gad.301036.117.


Mutations in the linker domain affect phospho-STAT3 function and suggest targets for interrupting STAT3 activity.

Mertens C, Haripal B, Klinge S, Darnell JE.

Proc Natl Acad Sci U S A. 2015 Dec 1;112(48):14811-6. doi: 10.1073/pnas.1515876112. Epub 2015 Nov 9. Erratum in: Proc Natl Acad Sci U S A. 2015 Dec 29;112(52):E7303.


A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation.

Ke S, Alemu EA, Mertens C, Gantman EC, Fak JJ, Mele A, Haripal B, Zucker-Scharff I, Moore MJ, Park CY, Vågbø CB, Kusśnierczyk A, Klungland A, Darnell JE Jr, Darnell RB.

Genes Dev. 2015 Oct 1;29(19):2037-53. doi: 10.1101/gad.269415.115. Epub 2015 Sep 24.


Joys and surprises of a career studying eukaryotic gene expression.

Darnell JE Jr.

J Biol Chem. 2013 May 3;288(18):12957-66. doi: 10.1074/jbc.X113.471722. Epub 2013 Mar 22.


Reflections on the history of pre-mRNA processing and highlights of current knowledge: a unified picture.

Darnell JE Jr.

RNA. 2013 Apr;19(4):443-60. doi: 10.1261/rna.038596.113. Epub 2013 Feb 25. Review.


The JAK-STAT pathway at twenty.

Stark GR, Darnell JE Jr.

Immunity. 2012 Apr 20;36(4):503-14. doi: 10.1016/j.immuni.2012.03.013. Review.


The JAK-STAT pathway at 20.

Darnell JE Jr.

JAKSTAT. 2012 Jan 1;1(1):2. doi: 10.4161/jkst.18726. No abstract available.


Pillars article: Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor. Science. 1992. 257: 809-813.

Schindler C, Shuai K, Prezioso VR, Darnell JE Jr.

J Immunol. 2011 Dec 1;187(11):5489-94. No abstract available.


STAT3, HIF-1, glucose addiction and Warburg effect.

Darnell JE Jr.

Aging (Albany NY). 2010 Dec;2(12):890-1. No abstract available.


Obituary: Hidesaburo Hanafusa (1929-2009).

Foster DA, Darnell JE Jr.

Nature. 2009 Apr 9;458(7239):718. doi: 10.1038/458718a. No abstract available.


Serpin B3/B4, activated by STAT3, promote survival of squamous carcinoma cells.

Ahmed ST, Darnell JE Jr.

Biochem Biophys Res Commun. 2009 Jan 23;378(4):821-5. doi: 10.1016/j.bbrc.2008.11.147. Epub 2008 Dec 12.


STAT92E is a positive regulator of Drosophila inhibitor of apoptosis 1 (DIAP/1) and protects against radiation-induced apoptosis.

Betz A, Ryoo HD, Steller H, Darnell JE Jr.

Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):13805-10. doi: 10.1073/pnas.0806291105. Epub 2008 Sep 8.


SnapShot: JAK-STAT signaling.

Mertens C, Darnell JE Jr.

Cell. 2007 Nov 2;131(3):612. No abstract available.


Interferon research: impact on understanding transcriptional control.

Darnell JE Jr.

Curr Top Microbiol Immunol. 2007;316:155-63. Review.


Amino acid residues required for physical and cooperative transcriptional interaction of STAT3 and AP-1 proteins c-Jun and c-Fos.

Ginsberg M, Czeko E, Müller P, Ren Z, Chen X, Darnell JE Jr.

Mol Cell Biol. 2007 Sep;27(18):6300-8. Epub 2007 Jul 16.


A Hopscotch-chromatin connection.

Betz A, Darnell JE Jr.

Nat Genet. 2006 Sep;38(9):977-9. No abstract available.


Cyclin D1 is transcriptionally regulated by and required for transformation by activated signal transducer and activator of transcription 3.

Leslie K, Lang C, Devgan G, Azare J, Berishaj M, Gerald W, Kim YB, Paz K, Darnell JE, Albanese C, Sakamaki T, Pestell R, Bromberg J.

Cancer Res. 2006 Mar 1;66(5):2544-52.


Validating Stat3 in cancer therapy.

Darnell JE.

Nat Med. 2005 Jun;11(6):595-6. No abstract available.


Reduced STAT3 activity in mice mimics clinical disease syndromes.

Shen Y, La Perle KM, Levy DE, Darnell JE Jr.

Biochem Biophys Res Commun. 2005 Apr 29;330(1):305-9.


Structural bases of unphosphorylated STAT1 association and receptor binding.

Mao X, Ren Z, Parker GN, Sondermann H, Pastorello MA, Wang W, McMurray JS, Demeler B, Darnell JE Jr, Chen X.

Mol Cell. 2005 Mar 18;17(6):761-71.


Implications of an antiparallel dimeric structure of nonphosphorylated STAT1 for the activation-inactivation cycle.

Zhong M, Henriksen MA, Takeuchi K, Schaefer O, Liu B, ten Hoeve J, Ren Z, Mao X, Chen X, Shuai K, Darnell JE Jr.

Proc Natl Acad Sci U S A. 2005 Mar 15;102(11):3966-71. Epub 2005 Mar 7.


Transformation fingerprint: induced STAT3-C, v-Src and Ha-Ras cause small initial changes but similar established profiles in mRNA.

Paz K, Socci ND, van Nimwegen E, Viale A, Darnell JE.

Oncogene. 2004 Nov 4;23(52):8455-63.


Essential role of STAT3 in postnatal survival and growth revealed by mice lacking STAT3 serine 727 phosphorylation.

Shen Y, Schlessinger K, Zhu X, Meffre E, Quimby F, Levy DE, Darnell JE Jr.

Mol Cell Biol. 2004 Jan;24(1):407-19.


STAT3-dependent enhanceosome assembly and disassembly: synergy with GR for full transcriptional increase of the alpha 2-macroglobulin gene.

Lerner L, Henriksen MA, Zhang X, Darnell JE Jr.

Genes Dev. 2003 Oct 15;17(20):2564-77. Epub 2003 Oct 1.


Distinct transcriptional activation functions of STAT1alpha and STAT1beta on DNA and chromatin templates.

Zakharova N, Lymar ES, Yang E, Malik S, Zhang JJ, Roeder RG, Darnell JE Jr.

J Biol Chem. 2003 Oct 31;278(44):43067-73. Epub 2003 Aug 25.


Decay rates of human mRNAs: correlation with functional characteristics and sequence attributes.

Yang E, van Nimwegen E, Zavolan M, Rajewsky N, Schroeder M, Magnasco M, Darnell JE Jr.

Genome Res. 2003 Aug;13(8):1863-72.


Independent and cooperative activation of chromosomal c-fos promoter by STAT3.

Yang E, Lerner L, Besser D, Darnell JE Jr.

J Biol Chem. 2003 May 2;278(18):15794-9. Epub 2003 Feb 24.


A reinterpretation of the dimerization interface of the N-terminal domains of STATs.

Chen X, Bhandari R, Vinkemeier U, Van Den Akker F, Darnell JE Jr, Kuriyan J.

Protein Sci. 2003 Feb;12(2):361-5.


Transcription factors as targets for cancer therapy.

Darnell JE Jr.

Nat Rev Cancer. 2002 Oct;2(10):740-9. Review.


Special Achienvement in Medical Science Award. The surprises of mammalian molecular cell biology.

Darnell JE.

Nat Med. 2002 Oct;8(10):1068-71. No abstract available.


Negative regulation of STAT92E by an N-terminally truncated STAT protein derived from an alternative promoter site.

Henriksen MA, Betz A, Fuccillo MV, Darnell JE Jr.

Genes Dev. 2002 Sep 15;16(18):2379-89. Erratum in: Genes Dev 2002 Oct 15;16(20):2729.


Stats: transcriptional control and biological impact.

Levy DE, Darnell JE Jr.

Nat Rev Mol Cell Biol. 2002 Sep;3(9):651-62. Review.


Requirement of Ca2+ and CaMKII for Stat1 Ser-727 phosphorylation in response to IFN-gamma.

Nair JS, DaFonseca CJ, Tjernberg A, Sun W, Darnell JE Jr, Chait BT, Zhang JJ.

Proc Natl Acad Sci U S A. 2002 Apr 30;99(9):5971-6. Epub 2002 Apr 23.


Dissociation time from DNA determines transcriptional function in a STAT1 linker mutant.

Yang E, Henriksen MA, Schaefer O, Zakharova N, Darnell JE Jr.

J Biol Chem. 2002 Apr 19;277(16):13455-62. Epub 2002 Feb 7.


Signal transduction and the control of gene expression.

Brivanlou AH, Darnell JE Jr.

Science. 2002 Feb 1;295(5556):813-8. Review.


A Drosophila PIAS homologue negatively regulates stat92E.

Betz A, Lampen N, Martinek S, Young MW, Darnell JE Jr.

Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9563-8. Erratum in: Proc Natl Acad Sci U S A 2001 Nov 20;98(24):14186.


Functional importance of Stat3 tetramerization in activation of the alpha 2-macroglobulin gene.

Zhang X, Darnell JE Jr.

J Biol Chem. 2001 Sep 7;276(36):33576-81. Epub 2001 Jul 3.


Potential roles of Stat1 and Stat3 in cellular transformation.

Bromberg JF, Darnell JE Jr.

Cold Spring Harb Symp Quant Biol. 1999;64:425-8. Review. No abstract available.


Constitutively activated Stat3 protects fibroblasts from serum withdrawal and UV-induced apoptosis and antagonizes the proapoptotic effects of activated Stat1.

Shen Y, Devgan G, Darnell JE Jr, Bromberg JF.

Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1543-8. Epub 2001 Feb 6.


The role of STATs in transcriptional control and their impact on cellular function.

Bromberg J, Darnell JE Jr.

Oncogene. 2000 May 15;19(21):2468-73. Review.


Interacting regions in Stat3 and c-Jun that participate in cooperative transcriptional activation.

Zhang X, Wrzeszczynska MH, Horvath CM, Darnell JE Jr.

Mol Cell Biol. 1999 Oct;19(10):7138-46.


A nuclear protein tyrosine phosphatase is required for the inactivation of Stat1.

Haspel RL, Darnell JE Jr.

Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10188-93.


Stat3 as an oncogene.

Bromberg JF, Wrzeszczynska MH, Devgan G, Zhao Y, Pestell RG, Albanese C, Darnell JE Jr.

Cell. 1999 Aug 6;98(3):295-303. Erratum in: Cell 1999 Oct 15;99(2):239.


The linker domain of Stat1 is required for gamma interferon-driven transcription.

Yang E, Wen Z, Haspel RL, Zhang JJ, Darnell JE Jr.

Mol Cell Biol. 1999 Jul;19(7):5106-12.


E.B. Wilson Lecture, 1998. Eukaryotic RNAs: once more from the beginning.

Darnell JE Jr.

Mol Biol Cell. 1999 Jun;10(6):1685-92. No abstract available.


An SH2 domain in disguise.

Kuriyan J, Darnell JE Jr.

Nature. 1999 Mar 4;398(6722):22-3, 25. No abstract available.


The significance of tetramerization in promoter recruitment by Stat5.

John S, Vinkemeier U, Soldaini E, Darnell JE Jr, Leonard WJ.

Mol Cell Biol. 1999 Mar;19(3):1910-8.

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