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Items: 1 to 50 of 60

1.

Hypoxia-induced SUMOylation of E3 ligase HAF determines specific activation of HIF2 in clear-cell renal cell carcinoma.

Koh MY, Nguyen V, Lemos R Jr, Darnay BG, Kiriakova G, Abdelmelek M, Ho TH, Karam J, Monzon FA, Jonasch E, Powis G.

Cancer Res. 2015 Jan 15;75(2):316-29. doi: 10.1158/0008-5472.CAN-13-2190. Epub 2014 Nov 24.

2.

A TRAF2 binding independent region of TNFR2 is responsible for TRAF2 depletion and enhancement of cytotoxicity driven by TNFR1.

Cabal-Hierro L, Artime N, Iglesias J, Prado MA, Ugarte-Gil L, Casado P, Fernández-García B, Darnay BG, Lazo PS.

Oncotarget. 2014 Jan 15;5(1):224-36.

3.

Ubiquitin-specific protease 25 regulates TLR4-dependent innate immune responses through deubiquitination of the adaptor protein TRAF3.

Zhong B, Liu X, Wang X, Liu X, Li H, Darnay BG, Lin X, Sun SC, Dong C.

Sci Signal. 2013 May 14;6(275):ra35. doi: 10.1126/scisignal.2003708.

4.

BSTA promotes mTORC2-mediated phosphorylation of Akt1 to suppress expression of FoxC2 and stimulate adipocyte differentiation.

Yao Y, Suraokar M, Darnay BG, Hollier BG, Shaiken TE, Asano T, Chen CH, Chang BH, Lu Y, Mills GB, Sarbassov D, Mani SA, Abbruzzese JL, Reddy SA.

Sci Signal. 2013 Jan 8;6(257):ra2. doi: 10.1126/scisignal.2003295.

5.

Deletion of TAK1 in the myeloid lineage results in the spontaneous development of myelomonocytic leukemia in mice.

Lamothe B, Lai Y, Hur L, Orozco NM, Wang J, Campos AD, Xie M, Schneider MD, Lockworth CR, Jakacky J, Tran D, Ho M, Dawud S, Dong C, Lin HK, Hu P, Estrov Z, Bueso-Ramos CE, Darnay BG.

PLoS One. 2012;7(12):e51228. doi: 10.1371/journal.pone.0051228. Epub 2012 Dec 10.

6.

TAK1 is essential for osteoclast differentiation and is an important modulator of cell death by apoptosis and necroptosis.

Lamothe B, Lai Y, Xie M, Schneider MD, Darnay BG.

Mol Cell Biol. 2013 Feb;33(3):582-95. doi: 10.1128/MCB.01225-12. Epub 2012 Nov 19.

7.
8.

The E3 ubiquitin ligase TRAF6 intercedes in starvation-induced skeletal muscle atrophy through multiple mechanisms.

Paul PK, Bhatnagar S, Mishra V, Srivastava S, Darnay BG, Choi Y, Kumar A.

Mol Cell Biol. 2012 Apr;32(7):1248-59. doi: 10.1128/MCB.06351-11. Epub 2012 Jan 30.

9.

Critical role of monoubiquitination of histone H2AX protein in histone H2AX phosphorylation and DNA damage response.

Wu CY, Kang HY, Yang WL, Wu J, Jeong YS, Wang J, Chan CH, Lee SW, Zhang X, Lamothe B, Campos AD, Darnay BG, Lin HK.

J Biol Chem. 2011 Sep 2;286(35):30806-15. doi: 10.1074/jbc.M111.257469. Epub 2011 Jun 20.

10.

NF-kappaB signal triggering and termination by tumor necrosis factor receptor 2.

Rodríguez M, Cabal-Hierro L, Carcedo MT, Iglesias JM, Artime N, Darnay BG, Lazo PS.

J Biol Chem. 2011 Jul 1;286(26):22814-24. doi: 10.1074/jbc.M111.225631. Epub 2011 May 10.

11.

Targeted ablation of TRAF6 inhibits skeletal muscle wasting in mice.

Paul PK, Gupta SK, Bhatnagar S, Panguluri SK, Darnay BG, Choi Y, Kumar A.

J Cell Biol. 2010 Dec 27;191(7):1395-411. doi: 10.1083/jcb.201006098.

12.

Multiple functions of Osterix are required for bone growth and homeostasis in postnatal mice.

Zhou X, Zhang Z, Feng JQ, Dusevich VM, Sinha K, Zhang H, Darnay BG, de Crombrugghe B.

Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):12919-24. doi: 10.1073/pnas.0912855107. Epub 2010 Jul 6.

13.

Dasatinib inhibits both osteoclast activation and prostate cancer PC-3-cell-induced osteoclast formation.

Araujo JC, Poblenz A, Corn P, Parikh NU, Starbuck MW, Thompson JT, Lee F, Logothetis CJ, Darnay BG.

Cancer Biol Ther. 2009 Nov;8(22):2153-9. Epub 2009 Nov 8.

14.

Structural basis for the lack of E2 interaction in the RING domain of TRAF2.

Yin Q, Lamothe B, Darnay BG, Wu H.

Biochemistry. 2009 Nov 10;48(44):10558-67. doi: 10.1021/bi901462e.

15.

The E3 ligase TRAF6 regulates Akt ubiquitination and activation.

Yang WL, Wang J, Chan CH, Lee SW, Campos AD, Lamothe B, Hur L, Grabiner BC, Lin X, Darnay BG, Lin HK.

Science. 2009 Aug 28;325(5944):1134-8. doi: 10.1126/science.1175065.

16.

A20 negatively regulates T cell receptor signaling to NF-kappaB by cleaving Malt1 ubiquitin chains.

Düwel M, Welteke V, Oeckinghaus A, Baens M, Kloo B, Ferch U, Darnay BG, Ruland J, Marynen P, Krappmann D.

J Immunol. 2009 Jun 15;182(12):7718-28. doi: 10.4049/jimmunol.0803313.

17.

E2 interaction and dimerization in the crystal structure of TRAF6.

Yin Q, Lin SC, Lamothe B, Lu M, Lo YC, Hura G, Zheng L, Rich RL, Campos AD, Myszka DG, Lenardo MJ, Darnay BG, Wu H.

Nat Struct Mol Biol. 2009 Jun;16(6):658-66. doi: 10.1038/nsmb.1605. Epub 2009 May 24.

18.
19.

Cthrc1 is a positive regulator of osteoblastic bone formation.

Kimura H, Kwan KM, Zhang Z, Deng JM, Darnay BG, Behringer RR, Nakamura T, de Crombrugghe B, Akiyama H.

PLoS One. 2008 Sep 9;3(9):e3174. doi: 10.1371/journal.pone.0003174.

20.

TRAF6 and the three C-terminal lysine sites on IRF7 are required for its ubiquitination-mediated activation by the tumor necrosis factor receptor family member latent membrane protein 1.

Ning S, Campos AD, Darnay BG, Bentz GL, Pagano JS.

Mol Cell Biol. 2008 Oct;28(20):6536-46. doi: 10.1128/MCB.00785-08. Epub 2008 Aug 18.

21.

The RING domain and first zinc finger of TRAF6 coordinate signaling by interleukin-1, lipopolysaccharide, and RANKL.

Lamothe B, Campos AD, Webster WK, Gopinathan A, Hur L, Darnay BG.

J Biol Chem. 2008 Sep 5;283(36):24871-80. doi: 10.1074/jbc.M802749200. Epub 2008 Jul 10.

22.

Association between imatinib-resistant BCR-ABL mutation-negative leukemia and persistent activation of LYN kinase.

Wu J, Meng F, Kong LY, Peng Z, Ying Y, Bornmann WG, Darnay BG, Lamothe B, Sun H, Talpaz M, Donato NJ.

J Natl Cancer Inst. 2008 Jul 2;100(13):926-39. doi: 10.1093/jnci/djn188. Epub 2008 Jun 24.

23.

Molecular basis for the unique deubiquitinating activity of the NF-kappaB inhibitor A20.

Lin SC, Chung JY, Lamothe B, Rajashankar K, Lu M, Lo YC, Lam AY, Darnay BG, Wu H.

J Mol Biol. 2008 Feb 15;376(2):526-40. doi: 10.1016/j.jmb.2007.11.092. Epub 2007 Dec 4.

24.

Nuclear tumor necrosis factor receptor-associated factor 6 in lymphoid cells negatively regulates c-Myb-mediated transactivation through small ubiquitin-related modifier-1 modification.

Pham LV, Zhou HJ, Lin-Lee YC, Tamayo AT, Yoshimura LC, Fu L, Darnay BG, Ford RJ.

J Biol Chem. 2008 Feb 22;283(8):5081-9. Epub 2007 Dec 19.

25.

A novel high-throughput screening system identifies a small molecule repressive for matrix metalloproteinase-9 expression.

Nair RR, Avila H, Ma X, Wang Z, Lennartz M, Darnay BG, Boyd DD, Yan C.

Mol Pharmacol. 2008 Mar;73(3):919-29. Epub 2007 Dec 7.

PMID:
18065684
27.

TRAFs in RANK signaling.

Darnay BG, Besse A, Poblenz AT, Lamothe B, Jacoby JJ.

Adv Exp Med Biol. 2007;597:152-9. Review.

PMID:
17633024
28.

TRAF6 ubiquitin ligase is essential for RANKL signaling and osteoclast differentiation.

Lamothe B, Webster WK, Gopinathan A, Besse A, Campos AD, Darnay BG.

Biochem Biophys Res Commun. 2007 Aug 10;359(4):1044-9. Epub 2007 Jun 11.

29.

TRAF-interacting protein (TRIP) is a RING-dependent ubiquitin ligase.

Besse A, Campos AD, Webster WK, Darnay BG.

Biochem Biophys Res Commun. 2007 Aug 3;359(3):660-4. Epub 2007 May 30.

PMID:
17544371
30.

Inhibition of RANKL-mediated osteoclast differentiation by selective TRAF6 decoy peptides.

Poblenz AT, Jacoby JJ, Singh S, Darnay BG.

Biochem Biophys Res Commun. 2007 Aug 3;359(3):510-5. Epub 2007 May 30.

PMID:
17544369
31.

CARMA3 deficiency abrogates G protein-coupled receptor-induced NF-{kappa}B activation.

Grabiner BC, Blonska M, Lin PC, You Y, Wang D, Sun J, Darnay BG, Dong C, Lin X.

Genes Dev. 2007 Apr 15;21(8):984-96.

32.

Phosphorylation and ubiquitination of the IkappaB kinase complex by two distinct signaling pathways.

Shambharkar PB, Blonska M, Pappu BP, Li H, You Y, Sakurai H, Darnay BG, Hara H, Penninger J, Lin X.

EMBO J. 2007 Apr 4;26(7):1794-805. Epub 2007 Mar 15.

33.

TAK1-dependent signaling requires functional interaction with TAB2/TAB3.

Besse A, Lamothe B, Campos AD, Webster WK, Maddineni U, Lin SC, Wu H, Darnay BG.

J Biol Chem. 2007 Feb 9;282(6):3918-28. Epub 2006 Dec 8.

34.

Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation.

Lamothe B, Besse A, Campos AD, Webster WK, Wu H, Darnay BG.

J Biol Chem. 2007 Feb 9;282(6):4102-12. Epub 2006 Nov 29.

35.

Inhibition of prostate tumor growth and bone remodeling by the vascular targeting agent VEGF121/rGel.

Mohamedali KA, Poblenz AT, Sikes CR, Navone NM, Thorpe PE, Darnay BG, Rosenblum MG.

Cancer Res. 2006 Nov 15;66(22):10919-28.

36.

Evidence that TNF-TNFR1-TRADD-TRAF2-RIP-TAK1-IKK pathway mediates constitutive NF-kappaB activation and proliferation in human head and neck squamous cell carcinoma.

Jackson-Bernitsas DG, Ichikawa H, Takada Y, Myers JN, Lin XL, Darnay BG, Chaturvedi MM, Aggarwal BB.

Oncogene. 2007 Mar 1;26(10):1385-97. Epub 2006 Sep 4.

PMID:
16953224
37.

TWEAK mediates signal transduction and differentiation of RAW264.7 cells in the absence of Fn14/TweakR. Evidence for a second TWEAK receptor.

Polek TC, Talpaz M, Darnay BG, Spivak-Kroizman T.

J Biol Chem. 2003 Aug 22;278(34):32317-23. Epub 2003 Jun 6.

38.

Distinct molecular mechanism for initiating TRAF6 signalling.

Ye H, Arron JR, Lamothe B, Cirilli M, Kobayashi T, Shevde NK, Segal D, Dzivenu OK, Vologodskaia M, Yim M, Du K, Singh S, Pike JW, Darnay BG, Choi Y, Wu H.

Nature. 2002 Jul 25;418(6896):443-7.

PMID:
12140561
39.

3-Hydroxy-3-methylglutaryl-CoA reductase.

Rodwell VW, Beach MJ, Bischoff KM, Bochar DA, Darnay BG, Friesen JA, Gill JF, Hedl M, Jordan-Starck T, Kennelly PJ, Kim DY, Wang Y.

Methods Enzymol. 2000;324:259-80. No abstract available.

PMID:
10989436
40.

Signal transduction by tumour necrosis factor and tumour necrosis factor related ligands and their receptors.

Darnay BG, Aggarwal BB.

Ann Rheum Dis. 1999 Nov;58 Suppl 1:I2-I13. Review. No abstract available.

43.
44.

Sanguinarine (pseudochelerythrine) is a potent inhibitor of NF-kappaB activation, IkappaBalpha phosphorylation, and degradation.

Chaturvedi MM, Kumar A, Darnay BG, Chainy GB, Agarwal S, Aggarwal BB.

J Biol Chem. 1997 Nov 28;272(48):30129-34.

46.

Early events in TNF signaling: a story of associations and dissociations.

Darnay BG, Aggarwal BB.

J Leukoc Biol. 1997 May;61(5):559-66. Review.

PMID:
9129204
48.
50.

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