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Items: 1 to 50 of 94

1.

The pivotal role of glycogen synthase kinase 3 (GSK-3) in vomiting evoked by specific emetogens in the least shrew (Cryptotis parva).

Zhong W, Darmani NA.

Neurochem Int. 2020 Jan;132:104603. doi: 10.1016/j.neuint.2019.104603. Epub 2019 Nov 15.

2.

Δ9-THC and related cannabinoids suppress substance P- induced neurokinin NK1-receptor-mediated vomiting via activation of cannabinoid CB1 receptor.

Darmani NA, Belkacemi L, Zhong W.

Eur J Pharmacol. 2019 Dec 15;865:172806. doi: 10.1016/j.ejphar.2019.172806. Epub 2019 Nov 15.

PMID:
31738934
3.

Ultra-low doses of the transient receptor potential vanilloid 1 agonist, resiniferatoxin, prevents vomiting evoked by diverse emetogens in the least shrew (Cryptotis parva).

Darmani NA, Henry DA, Zhong W, Chebolu S.

Behav Pharmacol. 2020 Feb;31(1):3-14. doi: 10.1097/FBP.0000000000000499.

PMID:
31503071
4.

Intracellular emetic signaling cascades by which the selective neurokinin type 1 receptor (NK1R) agonist GR73632 evokes vomiting in the least shrew (Cryptotis parva).

Zhong W, Chebolu S, Darmani NA.

Neurochem Int. 2019 Jan;122:106-119. doi: 10.1016/j.neuint.2018.11.012. Epub 2018 Nov 16.

5.

Intracellular emetic signaling evoked by the L-type Ca2+ channel agonist FPL64176 in the least shrew (Cryptotis parva).

Zhong W, Chebolu S, Darmani NA.

Eur J Pharmacol. 2018 Sep 5;834:157-168. doi: 10.1016/j.ejphar.2018.06.035. Epub 2018 Jun 30.

6.

The anti-asthmatic drug pranlukast suppresses the delayed-phase vomiting and reverses intracellular indices of emesis evoked by cisplatin in the least shrew (Cryptotis parva).

Darmani NA, Chebolu S, Zhong W, Kim WD, Narlesky M, Adams J, Dong F.

Eur J Pharmacol. 2017 Aug 15;809:20-31. doi: 10.1016/j.ejphar.2017.05.014. Epub 2017 May 10.

PMID:
28501575
8.

Ca2+ signaling and emesis: Recent progress and new perspectives.

Zhong W, Picca AJ, Lee AS, Darmani NA.

Auton Neurosci. 2017 Jan;202:18-27. doi: 10.1016/j.autneu.2016.07.006. Epub 2016 Jul 26. Review.

PMID:
27473611
9.

Thapsigargin-induced activation of Ca(2+)-CaMKII-ERK in brainstem contributes to substance P release and induction of emesis in the least shrew.

Zhong W, Chebolu S, Darmani NA.

Neuropharmacology. 2016 Apr;103:195-210. doi: 10.1016/j.neuropharm.2015.11.023. Epub 2015 Nov 26.

PMID:
26631534
10.

L-type calcium channels contribute to 5-HT3-receptor-evoked CaMKIIα and ERK activation and induction of emesis in the least shrew (Cryptotis parva).

Hutchinson TE, Zhong W, Chebolu S, Wilson SM, Darmani NA.

Eur J Pharmacol. 2015 May 15;755:110-8. doi: 10.1016/j.ejphar.2015.02.042. Epub 2015 Mar 5.

PMID:
25748600
11.

Differential and additive suppressive effects of 5-HT3 (palonosetron)- and NK1 (netupitant)-receptor antagonists on cisplatin-induced vomiting and ERK1/2, PKA and PKC activation.

Darmani NA, Zhong W, Chebolu S, Mercadante F.

Pharmacol Biochem Behav. 2015 Apr;131:104-11. doi: 10.1016/j.pbb.2015.02.010. Epub 2015 Feb 14.

PMID:
25687374
12.

Serotonin 5-HT3 receptor-mediated vomiting occurs via the activation of Ca2+/CaMKII-dependent ERK1/2 signaling in the least shrew (Cryptotis parva).

Zhong W, Hutchinson TE, Chebolu S, Darmani NA.

PLoS One. 2014 Aug 14;9(8):e104718. doi: 10.1371/journal.pone.0104718. eCollection 2014.

13.

Histomorphology and immunohistochemistry of the lower esophageal sphincter of the least shrew (Cryptotis parva).

Al-Tikriti MS, Khamas W, Chebolu S, Darmani NA.

Cells Tissues Organs. 2013;198(5):390-7. doi: 10.1159/000359999. Epub 2014 Mar 21.

PMID:
24662490
14.

Broad-spectrum antiemetic efficacy of the L-type calcium channel blocker amlodipine in the least shrew (Cryptotis parva).

Zhong W, Chebolu S, Darmani NA.

Pharmacol Biochem Behav. 2014 May;120:124-32. doi: 10.1016/j.pbb.2014.03.005. Epub 2014 Mar 12.

PMID:
24631485
16.
17.

Preface. New vistas in the pharmacology and neurochemistry of diverse causes of nausea and vomiting.

Darmani NA.

Eur J Pharmacol. 2014 Jan 5;722:1. doi: 10.1016/j.ejphar.2013.12.012. No abstract available.

PMID:
24384393
18.

Regulation of nausea and vomiting by cannabinoids and the endocannabinoid system.

Sharkey KA, Darmani NA, Parker LA.

Eur J Pharmacol. 2014 Jan 5;722:134-46. doi: 10.1016/j.ejphar.2013.09.068. Epub 2013 Nov 1.

19.

Additive antiemetic efficacy of low-doses of the cannabinoid CB(1/2) receptor agonist Δ(9)-THC with ultralow-doses of the vanilloid TRPV1 receptor agonist resiniferatoxin in the least shrew (Cryptotis parva).

Darmani NA, Chebolu S, Zhong W, Trinh C, McClanahan B, Brar RS.

Eur J Pharmacol. 2014 Jan 5;722:147-55. doi: 10.1016/j.ejphar.2013.08.051. Epub 2013 Oct 22.

PMID:
24157976
20.

Cisplatin causes over-expression of tachykinin NK(1) receptors and increases ERK1/2- and PKA- phosphorylation during peak immediate- and delayed-phase emesis in the least shrew (Cryptotis parva) brainstem.

Darmani NA, Dey D, Chebolu S, Amos B, Kandpal R, Alkam T.

Eur J Pharmacol. 2013 Jan 5;698(1-3):161-9. doi: 10.1016/j.ejphar.2012.09.008. Epub 2012 Sep 19.

PMID:
23001014
21.

Synergistic antiemetic interactions between serotonergic 5-HT3 and tachykininergic NK1-receptor antagonists in the least shrew (Cryptotis parva).

Darmani NA, Chebolu S, Amos B, Alkam T.

Pharmacol Biochem Behav. 2011 Oct;99(4):573-9. doi: 10.1016/j.pbb.2011.05.025. Epub 2011 Jun 13.

PMID:
21683089
22.

Exercise-induced nausea and vomiting: another sign and symptom of pheochromocytoma and paraganglioma.

King KS, Darmani NA, Hughes MS, Adams KT, Pacak K.

Endocrine. 2010 Jun;37(3):403-7. doi: 10.1007/s12020-010-9319-3. Epub 2010 Apr 21.

23.
24.
25.

Zebrafish-encoded 3-O-sulfotransferase-3 isoform mediates herpes simplex virus type 1 entry and spread.

Hubbard S, Darmani NA, Thrush GR, Dey D, Burnham L, Thompson JM, Jones K, Tiwari V.

Zebrafish. 2010 Jun;7(2):181-7. doi: 10.1089/zeb.2009.0621.

PMID:
20441522
26.

In vitro antiviral activity of neem (Azardirachta indica L.) bark extract against herpes simplex virus type-1 infection.

Tiwari V, Darmani NA, Yue BY, Shukla D.

Phytother Res. 2010 Aug;24(8):1132-40. doi: 10.1002/ptr.3085.

27.

Pranlukast prevents cysteinyl leukotriene-induced emesis in the least shrew (Cryptotis parva).

Chebolu S, Wang Y, Ray AP, Darmani NA.

Eur J Pharmacol. 2010 Feb 25;628(1-3):195-201. doi: 10.1016/j.ejphar.2009.11.030. Epub 2009 Nov 24.

28.

Differential temporal changes in brain and gut substance P mRNA expression throughout the time-course of cisplatin-induced vomiting in the least shrew (Cryptotis parva).

Dey D, Abad J, Ray AP, Darmani NA.

Brain Res. 2010 Jan 15;1310:103-12. doi: 10.1016/j.brainres.2009.11.005. Epub 2009 Nov 11.

PMID:
19912998
29.

An unusual dependence of human herpesvirus-8 glycoproteins-induced cell-to-cell fusion on heparan sulfate.

Tiwari V, Darmani NA, Thrush GR, Shukla D.

Biochem Biophys Res Commun. 2009 Dec 18;390(3):382-7. doi: 10.1016/j.bbrc.2009.08.174. Epub 2009 Sep 9.

30.

Receptor-selective agonists induce emesis and Fos expression in the brain and enteric nervous system of the least shrew (Cryptotis parva).

Ray AP, Chebolu S, Darmani NA.

Pharmacol Biochem Behav. 2009 Nov;94(1):211-8. doi: 10.1016/j.pbb.2009.08.010. Epub 2009 Aug 21.

31.

Evidence for a re-evaluation of the neurochemical and anatomical bases of chemotherapy-induced vomiting.

Darmani NA, Ray AP.

Chem Rev. 2009 Jul;109(7):3158-99. doi: 10.1021/cr900117p. Review. No abstract available.

PMID:
19522506
32.

Ablation of least shrew central neurokinin NK1 receptors reduces GR73632-induced vomiting.

Ray AP, Chebolu S, Ramirez J, Darmani NA.

Behav Neurosci. 2009 Jun;123(3):701-6. doi: 10.1037/a0015733.

33.

A re-evaluation of the neurotransmitter basis of chemotherapy-induced immediate and delayed vomiting: evidence from the least shrew.

Darmani NA, Crim JL, Janoyan JJ, Abad J, Ramirez J.

Brain Res. 2009 Jan 12;1248:40-58. doi: 10.1016/j.brainres.2008.10.063. Epub 2008 Nov 6.

PMID:
19022231
34.

The antiemetic interaction of Delta9-tetrahydrocannabinol when combined with tropisetron or dexamethasone in the least shrew.

Wang Y, Ray AP, McClanahan BA, Darmani NA.

Pharmacol Biochem Behav. 2009 Jan;91(3):367-73. doi: 10.1016/j.pbb.2008.08.008. Epub 2008 Aug 9.

35.

Delta 9-tetrahydrocannabinol suppresses vomiting behavior and Fos expression in both acute and delayed phases of cisplatin-induced emesis in the least shrew.

Ray AP, Griggs L, Darmani NA.

Behav Brain Res. 2009 Jan 3;196(1):30-6. doi: 10.1016/j.bbr.2008.07.028. Epub 2008 Jul 31.

36.

Utilization of the least shrew as a rapid and selective screening model for the antiemetic potential and brain penetration of substance P and NK1 receptor antagonists.

Darmani NA, Wang Y, Abad J, Ray AP, Thrush GR, Ramirez J.

Brain Res. 2008 Jun 12;1214:58-72. doi: 10.1016/j.brainres.2008.03.077. Epub 2008 Apr 9.

37.

Role of osteopathic manipulative treatment in altering pain biomarkers: a pilot study.

Degenhardt BF, Darmani NA, Johnson JC, Towns LC, Rhodes DC, Trinh C, McClanahan B, DiMarzo V.

J Am Osteopath Assoc. 2007 Sep;107(9):387-400.

PMID:
17908831
39.

Receptor mechanism and antiemetic activity of structurally-diverse cannabinoids against radiation-induced emesis in the least shrew.

Darmani NA, Janoyan JJ, Crim J, Ramirez J.

Eur J Pharmacol. 2007 Jun 1;563(1-3):187-96. Epub 2007 Feb 16.

40.
41.

1,3-dinitrobenzene toxicity in the least shrew, Cryptotis parva.

Mock OB, Casteel SW, Darmani NA, Shaddy JH, Besch-Williford C, Towns LC.

Environ Toxicol Chem. 2005 Oct;24(10):2519-25.

PMID:
16268153
42.

Cisplatin increases brain 2-arachidonoylglycerol (2-AG) and concomitantly reduces intestinal 2-AG and anandamide levels in the least shrew.

Darmani NA, McClanahan BA, Trinh C, Petrosino S, Valenti M, Di Marzo V.

Neuropharmacology. 2005 Sep;49(4):502-13.

PMID:
15921709
43.

Involvement of the cannabimimetic compound, N-palmitoyl-ethanolamine, in inflammatory and neuropathic conditions: review of the available pre-clinical data, and first human studies.

Darmani NA, Izzo AA, Degenhardt B, Valenti M, Scaglione G, Capasso R, Sorrentini I, Di Marzo V.

Neuropharmacology. 2005 Jun;48(8):1154-63. Review.

PMID:
15910891
46.

Behaviorally active doses of the CB1 receptor antagonist SR 141716A increase brain serotonin and dopamine levels and turnover.

Darmani NA, Janoyan JJ, Kumar N, Crim JL.

Pharmacol Biochem Behav. 2003 Jul;75(4):777-87.

PMID:
12957219
47.

Antiemetic and motor-depressive actions of CP55,940: cannabinoid CB1 receptor characterization, distribution, and G-protein activation.

Darmani NA, Sim-Selley LJ, Martin BR, Janoyan JJ, Crim JL, Parekh B, Breivogel CS.

Eur J Pharmacol. 2003 Jan 10;459(1):83-95.

PMID:
12505537
48.

Anatomic and physiologic reference values in least shrews (Cryptotis parva).

Mock OB, Casteel SW, Darmani NA, Shaddy JH, Besch-Williford C, Towns LC.

Comp Med. 2001 Dec;51(6):534-7.

PMID:
11924816
49.

Reversal of SR 141716A-induced head-twitch and ear-scratch responses in mice by delta 9-THC and other cannabinoids.

Janoyan JJ, Crim JL, Darmani NA.

Pharmacol Biochem Behav. 2002 Jan-Feb;71(1-2):155-62.

PMID:
11812518

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