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Prion protein PrP nucleic acid binding and mobilization implicates retroelements as the replicative component of transmissible spongiform encephalopathy.

Lathe R, Darlix JL.

Arch Virol. 2020 Mar;165(3):535-556. doi: 10.1007/s00705-020-04529-2. Epub 2020 Feb 5. Review.


Prion Protein PRNP: A New Player in Innate Immunity? The Aβ Connection.

Lathe R, Darlix JL.

J Alzheimers Dis Rep. 2017 Dec 16;1(1):263-275. doi: 10.3233/ADR-170037.


Rationally Designed Peptides as Efficient Inhibitors of Nucleic Acid Chaperone Activity of HIV-1 Nucleocapsid Protein.

Shvadchak V, Zgheib S, Basta B, Humbert N, Langedijk J, Morris MC, Ciaco S, Maskri O, Darlix JL, Mauffret O, Fossé P, Réal E, Mély Y.

Biochemistry. 2018 Jul 31;57(30):4562-4573. doi: 10.1021/acs.biochem.8b00527. Epub 2018 Jul 18.


The multiple roles of the nucleocapsid in retroviral RNA conversion into proviral DNA by reverse transcriptase.

Darlix JL, de Rocquigny H, Mély Y.

Biochem Soc Trans. 2016 Oct 15;44(5):1427-1440. Review.


Characterization of the interaction between the HIV-1 Gag structural polyprotein and the cellular ribosomal protein L7 and its implication in viral nucleic acid remodeling.

Mekdad HE, Boutant E, Karnib H, Biedma ME, Sharma KK, Malytska I, Laumond G, Roy M, Réal E, Paillart JC, Moog C, Darlix JL, Mély Y, de Rocquigny H.

Retrovirology. 2016 Aug 11;13(1):54. doi: 10.1186/s12977-016-0287-4.


Role of the nucleocapsid domain in HIV-1 Gag oligomerization and trafficking to the plasma membrane: a fluorescence lifetime imaging microscopy investigation.

El Meshri SE, Dujardin D, Godet J, Richert L, Boudier C, Darlix JL, Didier P, Mély Y, de Rocquigny H.

J Mol Biol. 2015 Mar 27;427(6 Pt B):1480-1494. doi: 10.1016/j.jmb.2015.01.015. Epub 2015 Jan 30.


Role of the nucleocapsid region in HIV-1 Gag assembly as investigated by quantitative fluorescence-based microscopy.

de Rocquigny H, El Meshri SE, Richert L, Didier P, Darlix JL, Mély Y.

Virus Res. 2014 Nov 26;193:78-88. doi: 10.1016/j.virusres.2014.06.009. Epub 2014 Jul 9. Review.


Retrospective on the all-in-one retroviral nucleocapsid protein.

Darlix JL, de Rocquigny H, Mauffret O, Mély Y.

Virus Res. 2014 Nov 26;193:2-15. doi: 10.1016/j.virusres.2014.05.011. Epub 2014 Jun 4. Review.


HIV-1 reverse transcription.

Cimarelli A, Darlix JL.

Methods Mol Biol. 2014;1087:55-70. doi: 10.1007/978-1-62703-670-2_6.


The specificity and flexibility of l1 reverse transcription priming at imperfect T-tracts.

Monot C, Kuciak M, Viollet S, Mir AA, Gabus C, Darlix JL, Cristofari G.

PLoS Genet. 2013 May;9(5):e1003499. doi: 10.1371/journal.pgen.1003499. Epub 2013 May 9.


Role of the primer activation signal in tRNA annealing onto the HIV-1 genome studied by single-molecule FRET microscopy.

Beerens N, Jepsen MD, Nechyporuk-Zloy V, Krüger AC, Darlix JL, Kjems J, Birkedal V.

RNA. 2013 Apr;19(4):517-26. doi: 10.1261/rna.035733.112. Epub 2013 Feb 12.


MoMuLV and HIV-1 nucleocapsid proteins have a common role in genomic RNA packaging but different in late reverse transcription.

Chamontin C, Yu B, Racine PJ, Darlix JL, Mougel M.

PLoS One. 2012;7(12):e51534. doi: 10.1371/journal.pone.0051534. Epub 2012 Dec 7.


Foreword to the virus research special issue on "retroviral RNA, protein co-factors and chaperones".

Mirambeau G, Darlix JL, Summers M, Berkhout B.

Virus Res. 2012 Nov;169(2):322-3. doi: 10.1016/j.virusres.2012.09.005. No abstract available.


Reprint of: Core protein-mediated 5'-3' annealing of the West Nile virus genomic RNA in vitro.

Ivanyi-Nagy R, Darlix JL.

Virus Res. 2012 Nov;169(2):448-57. doi: 10.1016/j.virusres.2012.09.009. Epub 2012 Sep 27.


Comparative nucleic acid chaperone properties of the nucleocapsid protein NCp7 and Tat protein of HIV-1.

Godet J, Boudier C, Humbert N, Ivanyi-Nagy R, Darlix JL, Mély Y.

Virus Res. 2012 Nov;169(2):349-60. doi: 10.1016/j.virusres.2012.06.021. Epub 2012 Jun 26. Review.


The role of Vif oligomerization and RNA chaperone activity in HIV-1 replication.

Batisse J, Guerrero S, Bernacchi S, Sleiman D, Gabus C, Darlix JL, Marquet R, Tisné C, Paillart JC.

Virus Res. 2012 Nov;169(2):361-76. doi: 10.1016/j.virusres.2012.06.018. Epub 2012 Jun 21. Review.


Core protein-mediated 5'-3' annealing of the West Nile virus genomic RNA in vitro.

Ivanyi-Nagy R, Darlix JL.

Virus Res. 2012 Aug;167(2):226-35. doi: 10.1016/j.virusres.2012.05.003. Epub 2012 May 28.


Adult-brain-derived neural stem cells grafting into a vein bridge increases postlesional recovery and regeneration in a peripheral nerve of adult pig.

Liard O, Segura S, Sagui E, Nau A, Pascual A, Cambon M, Darlix JL, Fusai T, Moyse E.

Stem Cells Int. 2012;2012:128732. doi: 10.1155/2012/128732. Epub 2012 Feb 2.


Fuzziness in the core of the human pathogenic viruses HCV and HIV.

Ivanyi-Nagy R, Darlix JL.

Adv Exp Med Biol. 2012;725:142-58. doi: 10.1007/978-1-4614-0659-4_9. Review.


The Andes hantavirus NSs protein is expressed from the viral small mRNA by a leaky scanning mechanism.

Vera-Otarola J, Solis L, Soto-Rifo R, Ricci EP, Pino K, Tischler ND, Ohlmann T, Darlix JL, López-Lastra M.

J Virol. 2012 Feb;86(4):2176-87. doi: 10.1128/JVI.06223-11. Epub 2011 Dec 7.


Analysis of the RNA chaperoning activity of the hepatitis C virus core protein on the conserved 3'X region of the viral genome.

Sharma KK, de Rocquigny H, Darlix JL, Lavergne JP, Pénin F, Lessinger JM, Mély Y.

Nucleic Acids Res. 2012 Mar;40(6):2540-53. doi: 10.1093/nar/gkr1140. Epub 2011 Nov 29.


Characterization of the inhibition mechanism of HIV-1 nucleocapsid protein chaperone activities by methylated oligoribonucleotides.

Avilov SV, Boudier C, Gottikh M, Darlix JL, Mély Y.

Antimicrob Agents Chemother. 2012 Feb;56(2):1010-8. doi: 10.1128/AAC.05614-11. Epub 2011 Nov 14.


Functional mechanisms of the cellular prion protein (PrP(C)) associated anti-HIV-1 properties.

Alais S, Soto-Rifo R, Balter V, Gruffat H, Manet E, Schaeffer L, Darlix JL, Cimarelli A, Raposo G, Ohlmann T, Leblanc P.

Cell Mol Life Sci. 2012 Apr;69(8):1331-52. doi: 10.1007/s00018-011-0879-z. Epub 2011 Nov 11.


Packaging of HCV-RNA into lentiviral vector.

Caval V, Piver E, Ivanyi-Nagy R, Darlix JL, Pagès JC.

Biochem Biophys Res Commun. 2011 Nov 4;414(4):808-13. doi: 10.1016/j.bbrc.2011.10.011. Epub 2011 Oct 8.


APOBEC3A is a specific inhibitor of the early phases of HIV-1 infection in myeloid cells.

Berger G, Durand S, Fargier G, Nguyen XN, Cordeil S, Bouaziz S, Muriaux D, Darlix JL, Cimarelli A.

PLoS Pathog. 2011 Sep;7(9):e1002221. doi: 10.1371/journal.ppat.1002221. Epub 2011 Sep 22.


A single zinc finger optimizes the DNA interactions of the nucleocapsid protein of the yeast retrotransposon Ty3.

Chaurasiya KR, Geertsema H, Cristofari G, Darlix JL, Williams MC.

Nucleic Acids Res. 2012 Jan;40(2):751-60. doi: 10.1093/nar/gkr726. Epub 2011 Sep 14.


Flexible nature and specific functions of the HIV-1 nucleocapsid protein.

Darlix JL, Godet J, Ivanyi-Nagy R, Fossé P, Mauffret O, Mély Y.

J Mol Biol. 2011 Jul 22;410(4):565-81. doi: 10.1016/j.jmb.2011.03.037. Review.


Analysis of nucleic acid chaperoning by the prion protein and its inhibition by oligonucleotides.

Guichard C, Ivanyi-Nagy R, Sharma KK, Gabus C, Marc D, Mély Y, Darlix JL.

Nucleic Acids Res. 2011 Oct;39(19):8544-58. doi: 10.1093/nar/gkr554. Epub 2011 Jul 7.


Structural determinants of TAR RNA-DNA annealing in the absence and presence of HIV-1 nucleocapsid protein.

Kanevsky I, Chaminade F, Chen Y, Godet J, René B, Darlix JL, Mély Y, Mauffret O, Fossé P.

Nucleic Acids Res. 2011 Oct;39(18):8148-62. doi: 10.1093/nar/gkr526. Epub 2011 Jun 30.


A simple, versatile and efficient method to genetically modify human monocyte-derived dendritic cells with HIV-1-derived lentiviral vectors.

Berger G, Durand S, Goujon C, Nguyen XN, Cordeil S, Darlix JL, Cimarelli A.

Nat Protoc. 2011 Jun;6(6):806-16. doi: 10.1038/nprot.2011.327. Epub 2011 May 19.


Specific implications of the HIV-1 nucleocapsid zinc fingers in the annealing of the primer binding site complementary sequences during the obligatory plus strand transfer.

Godet J, Ramalanjaona N, Sharma KK, Richert L, de Rocquigny H, Darlix JL, Duportail G, Mély Y.

Nucleic Acids Res. 2011 Aug;39(15):6633-45. doi: 10.1093/nar/gkr274. Epub 2011 May 4.


Identification of a methylated oligoribonucleotide as a potent inhibitor of HIV-1 reverse transcription complex.

Grigorov B, Bocquin A, Gabus C, Avilov S, Mély Y, Agopian A, Divita G, Gottikh M, Witvrouw M, Darlix JL.

Nucleic Acids Res. 2011 Jul;39(13):5586-96. doi: 10.1093/nar/gkr117. Epub 2011 Mar 29.


Properties and functions of the nucleocapsid protein in virus assembly.

Muriaux D, Darlix JL.

RNA Biol. 2010 Nov-Dec;7(6):744-53. Epub 2010 Nov 1. Review.


The 3' untranslated region of the Andes hantavirus small mRNA functionally replaces the poly(A) tail and stimulates cap-dependent translation initiation from the viral mRNA.

Vera-Otarola J, Soto-Rifo R, Ricci EP, Ohlmann T, Darlix JL, López-Lastra M.

J Virol. 2010 Oct;84(19):10420-4. doi: 10.1128/JVI.01270-10. Epub 2010 Jul 21.


Development of a lentiviral vector system to study the role of the Andes virus glycoproteins.

Cifuentes-Muñoz N, Darlix JL, Tischler ND.

Virus Res. 2010 Oct;153(1):29-35. doi: 10.1016/j.virusres.2010.07.001. Epub 2010 Jul 7.


The mechanism of HIV-1 Tat-directed nucleic acid annealing supports its role in reverse transcription.

Boudier C, Storchak R, Sharma KK, Didier P, Follenius-Wund A, Muller S, Darlix JL, Mély Y.

J Mol Biol. 2010 Jul 16;400(3):487-501. doi: 10.1016/j.jmb.2010.05.033. Epub 2010 May 21.


Intrinsic disorder in the core proteins of flaviviruses.

Ivanyi-Nagy R, Darlix JL.

Protein Pept Lett. 2010 Aug;17(8):1019-25. Review.


Implications of the nucleocapsid and the microenvironment in retroviral reverse transcription.

Mougel M, Cimarelli A, Darlix JL.

Viruses. 2010 Apr;2(4):939-60. doi: 10.3390/v2040939. Epub 2010 Apr 2.


Kinetic analysis of the nucleic acid chaperone activity of the hepatitis C virus core protein.

Sharma Kk, Didier P, Darlix JL, de Rocquigny H, Bensikaddour H, Lavergne JP, Pénin F, Lessinger JM, Mély Y.

Nucleic Acids Res. 2010 Jun;38(11):3632-42. doi: 10.1093/nar/gkq094. Epub 2010 Feb 18.


HIV-1 Vpr oligomerization but not that of Gag directs the interaction between Vpr and Gag.

Fritz JV, Dujardin D, Godet J, Didier P, De Mey J, Darlix JL, Mély Y, de Rocquigny H.

J Virol. 2010 Feb;84(3):1585-96. doi: 10.1128/JVI.01691-09. Epub 2009 Nov 18.


Analysis of the viral elements required in the nuclear import of HIV-1 DNA.

Rivière L, Darlix JL, Cimarelli A.

J Virol. 2010 Jan;84(2):729-39. doi: 10.1128/JVI.01952-09. Epub 2009 Nov 4.


Targeting of murine leukemia virus gag to the plasma membrane is mediated by PI(4,5)P2/PS and a polybasic region in the matrix.

Hamard-Peron E, Juillard F, Saad JS, Roy C, Roingeard P, Summers MF, Darlix JL, Picart C, Muriaux D.

J Virol. 2010 Jan;84(1):503-15. doi: 10.1128/JVI.01134-09.


Mechanism of HIV-1 Tat RNA translation and its activation by the Tat protein.

Charnay N, Ivanyi-Nagy R, Soto-Rifo R, Ohlmann T, López-Lastra M, Darlix JL.

Retrovirology. 2009 Aug 11;6:74. doi: 10.1186/1742-4690-6-74.


Characterization of the behavior of functional viral genomes during the early steps of human immunodeficiency virus type 1 infection.

Arfi V, Lienard J, Nguyen XN, Berger G, Rigal D, Darlix JL, Cimarelli A.

J Virol. 2009 Aug;83(15):7524-35. doi: 10.1128/JVI.00429-09. Epub 2009 May 20.


A role for CD81 on the late steps of HIV-1 replication in a chronically infected T cell line.

Grigorov B, Attuil-Audenis V, Perugi F, Nedelec M, Watson S, Pique C, Darlix JL, Conjeaud H, Muriaux D.

Retrovirology. 2009 Mar 11;6:28. doi: 10.1186/1742-4690-6-28.


When is it time for reverse transcription to start and go?

Mougel M, Houzet L, Darlix JL.

Retrovirology. 2009 Mar 4;6:24. doi: 10.1186/1742-4690-6-24. Review.


HIV-1 nucleocapsid traps reverse transcriptase on nucleic acid substrates.

Grohmann D, Godet J, Mély Y, Darlix JL, Restle T.

Biochemistry. 2008 Nov 18;47(46):12230-40. doi: 10.1021/bi801386r. Epub 2008 Oct 24.


Human Discs Large is a new negative regulator of human immunodeficiency virus-1 infectivity.

Perugi F, Muriaux D, Ramirez BC, Chabani S, Decroly E, Darlix JL, Blot V, Pique C.

Mol Biol Cell. 2009 Jan;20(1):498-508. doi: 10.1091/mbc.E08-02-0189. Epub 2008 Oct 22.


Characterization of simian immunodeficiency virus SIVSM/human immunodeficiency virus type 2 Vpx function in human myeloid cells.

Goujon C, Arfi V, Pertel T, Luban J, Lienard J, Rigal D, Darlix JL, Cimarelli A.

J Virol. 2008 Dec;82(24):12335-45. doi: 10.1128/JVI.01181-08. Epub 2008 Oct 1.


Direct Vpr-Vpr interaction in cells monitored by two photon fluorescence correlation spectroscopy and fluorescence lifetime imaging.

Fritz JV, Didier P, Clamme JP, Schaub E, Muriaux D, Cabanne C, Morellet N, Bouaziz S, Darlix JL, Mély Y, de Rocquigny H.

Retrovirology. 2008 Sep 22;5:87. doi: 10.1186/1742-4690-5-87.

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