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Items: 1 to 50 of 123

1.

A Transcriptomic Signature of Mouse Liver Progenitor Cells.

Passman AM, Low J, London R, Tirnitz-Parker JE, Miyajima A, Tanaka M, Strick-Marchand H, Darlington GJ, Finch-Edmondson M, Ochsner S, Zhu C, Whelan J, Callus BA, Yeoh GC.

Stem Cells Int. 2016;2016:5702873. Epub 2016 Oct 3.

2.

Long non-coding RNAs control hematopoietic stem cell function.

Luo M, Jeong M, Sun D, Park HJ, Rodriguez BA, Xia Z, Yang L, Zhang X, Sheng K, Darlington GJ, Li W, Goodell MA.

Cell Stem Cell. 2015 Apr 2;16(4):426-38. doi: 10.1016/j.stem.2015.02.002. Epub 2015 Mar 12.

3.

Dnmt3a and Dnmt3b have overlapping and distinct functions in hematopoietic stem cells.

Challen GA, Sun D, Mayle A, Jeong M, Luo M, Rodriguez B, Mallaney C, Celik H, Yang L, Xia Z, Cullen S, Berg J, Zheng Y, Darlington GJ, Li W, Goodell MA.

Cell Stem Cell. 2014 Sep 4;15(3):350-364. doi: 10.1016/j.stem.2014.06.018. Epub 2014 Aug 14.

4.

Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal.

Sun D, Luo M, Jeong M, Rodriguez B, Xia Z, Hannah R, Wang H, Le T, Faull KF, Chen R, Gu H, Bock C, Meissner A, Göttgens B, Darlington GJ, Li W, Goodell MA.

Cell Stem Cell. 2014 May 1;14(5):673-88. doi: 10.1016/j.stem.2014.03.002.

5.

Ocular surface disease and dacryoadenitis in aging C57BL/6 mice.

McClellan AJ, Volpe EA, Zhang X, Darlington GJ, Li DQ, Pflugfelder SC, de Paiva CS.

Am J Pathol. 2014 Mar;184(3):631-43. doi: 10.1016/j.ajpath.2013.11.019. Epub 2014 Jan 3.

6.

Large conserved domains of low DNA methylation maintained by Dnmt3a.

Jeong M, Sun D, Luo M, Huang Y, Challen GA, Rodriguez B, Zhang X, Chavez L, Wang H, Hannah R, Kim SB, Yang L, Ko M, Chen R, Göttgens B, Lee JS, Gunaratne P, Godley LA, Darlington GJ, Rao A, Li W, Goodell MA.

Nat Genet. 2014 Jan;46(1):17-23. doi: 10.1038/ng.2836. Epub 2013 Nov 24.

7.

Farnesoid X receptor directly regulates xenobiotic detoxification genes in the long-lived Little mice.

Jiang Y, Jin J, Iakova P, Hernandez JC, Jawanmardi N, Sullivan E, Guo GL, Timchenko NA, Darlington GJ.

Mech Ageing Dev. 2013 Sep;134(9):407-15. doi: 10.1016/j.mad.2013.08.003. Epub 2013 Sep 2.

8.

Meta-analysis of gene expression in the mouse liver reveals biomarkers associated with inflammation increased early during aging.

Lee JS, Ward WO, Ren H, Vallanat B, Darlington GJ, Han ES, Laguna JC, DeFord JH, Papaconstantinou J, Selman C, Corton JC.

Mech Ageing Dev. 2012 Jul;133(7):467-78. doi: 10.1016/j.mad.2012.05.006. Epub 2012 Jun 13.

PMID:
22704917
9.

Dnmt3a is essential for hematopoietic stem cell differentiation.

Challen GA, Sun D, Jeong M, Luo M, Jelinek J, Berg JS, Bock C, Vasanthakumar A, Gu H, Xi Y, Liang S, Lu Y, Darlington GJ, Meissner A, Issa JP, Godley LA, Li W, Goodell MA.

Nat Genet. 2011 Dec 4;44(1):23-31. doi: 10.1038/ng.1009.

10.

Elevated interferon gamma signaling contributes to impaired regeneration in the aged liver.

Singh P, Goode T, Dean A, Awad SS, Darlington GJ.

J Gerontol A Biol Sci Med Sci. 2011 Sep;66(9):944-56. doi: 10.1093/gerona/glr094. Epub 2011 Jun 30.

11.

CD24-positive cells from normal adult mouse liver are hepatocyte progenitor cells.

Qiu Q, Hernandez JC, Dean AM, Rao PH, Darlington GJ.

Stem Cells Dev. 2011 Dec;20(12):2177-88. doi: 10.1089/scd.2010.0352. Epub 2011 Oct 21.

12.

Direct activation of forkhead box O3 by tumor suppressors p53 and p73 is disrupted during liver regeneration in mice.

Kurinna S, Stratton SA, Tsai WW, Akdemir KC, Gu W, Singh P, Goode T, Darlington GJ, Barton MC.

Hepatology. 2010 Sep;52(3):1023-32. doi: 10.1002/hep.23746.

13.

The age-associated decline of glycogen synthase kinase 3beta plays a critical role in the inhibition of liver regeneration.

Jin J, Wang GL, Shi X, Darlington GJ, Timchenko NA.

Mol Cell Biol. 2009 Jul;29(14):3867-80. doi: 10.1128/MCB.00456-09. Epub 2009 Apr 27.

14.

Cardiac function in young and old Little mice.

Reddy AK, Amador-Noguez D, Darlington GJ, Scholz BA, Michael LH, Hartley CJ, Entman ML, Taffet GE.

J Gerontol A Biol Sci Med Sci. 2007 Dec;62(12):1319-25.

15.

Inoculation and passaging of Mammalian monolayer cell cultures.

Darlington GJ.

CSH Protoc. 2008 Aug 1;2008:pdb.prot4347. doi: 10.1101/pdb.prot4347.

PMID:
21356879
16.

Transcriptional profiling of bipotential embryonic liver cells to identify liver progenitor cell surface markers.

Ochsner SA, Strick-Marchand H, Qiu Q, Venable S, Dean A, Wilde M, Weiss MC, Darlington GJ.

Stem Cells. 2007 Oct;25(10):2476-87. Epub 2007 Jul 19.

17.

Viability staining of Mammalian cell cultures.

Darlington GJ.

CSH Protoc. 2007 Jun 1;2007:pdb.prot4769. doi: 10.1101/pdb.prot4769.

PMID:
21357107
18.

Inoculation and passaging of Mammalian cell suspension cultures.

Darlington GJ.

CSH Protoc. 2007 Jun 1;2007:pdb.prot4346. doi: 10.1101/pdb.prot4346.

PMID:
21357091
19.

C/EBPalpha and HNF6 protein complex formation stimulates HNF6-dependent transcription by CBP coactivator recruitment in HepG2 cells.

Yoshida Y, Hughes DE, Rausa FM 3rd, Kim IM, Tan Y, Darlington GJ, Costa RH.

Hepatology. 2006 Feb;43(2):276-86.

20.

Epstein-barr virus transformation of lymphoblasts.

Darlington GJ.

CSH Protoc. 2006 Jul 1;2006(2). pii: pdb.prot4481. doi: 10.1101/pdb.prot4481. No abstract available.

PMID:
22485828
21.

Lymphocyte isolation and culture.

Darlington GJ.

CSH Protoc. 2006 Jul 1;2006(2). pii: pdb.prot4480. doi: 10.1101/pdb.prot4480. No abstract available.

PMID:
22485827
22.

Detection of Mycoplasma in Mammalian cell cultures using fluorescence microscopy.

Darlington GJ.

CSH Protoc. 2006 Jun 1;2006(1). pii: pdb.prot4351. doi: 10.1101/pdb.prot4351. No abstract available.

PMID:
22485725
23.

Cryopreservation of Mammalian culture cells: preparation and recovery of samples.

Darlington GJ.

CSH Protoc. 2006 Jun 1;2006(1). pii: pdb.prot4350. doi: 10.1101/pdb.prot4350. No abstract available.

PMID:
22485724
24.

Trypsinization of cells grown in monolayer.

Darlington GJ.

CSH Protoc. 2006 Jun 1;2006(1). pii: pdb.prot4349. doi: 10.1101/pdb.prot4349. No abstract available.

PMID:
22485723
25.

Serum testing for Mammalian cell culture.

Darlington GJ.

CSH Protoc. 2006 Jun 1;2006(1). pii: pdb.prot4348. doi: 10.1101/pdb.prot4348. No abstract available.

PMID:
22485722
26.

Metabolic response of mice to a postnatal ablation of CCAAT/enhancer-binding protein alpha.

Yang J, Croniger CM, Lekstrom-Himes J, Zhang P, Fenyus M, Tenen DG, Darlington GJ, Hanson RW.

J Biol Chem. 2005 Nov 18;280(46):38689-99. Epub 2005 Sep 15.

27.

CCAAT enhancer-binding protein alpha is required for interleukin-6 receptor alpha signaling in newborn hepatocytes.

Mackey SL, Darlington GJ.

J Biol Chem. 2004 Apr 16;279(16):16206-13. Epub 2004 Feb 11.

28.

Making the liver young again.

Mackey S, Singh P, Darlington GJ.

Hepatology. 2003 Dec;38(6):1349-52. No abstract available.

PMID:
14647042
29.

Expression and regulation of the gene for arginase I in mouse salivary glands: requirement of CCAAT/enhancer-binding protein alpha for the expression in the parotid gland.

Akiba T, Kuroiwa N, Shimizu-Yabe A, Iwase K, Hiwasa T, Yokoe H, Kubosawa H, Kageyama R, Darlington GJ, Mori M, Tanzawa H, Takiguchi M.

J Biochem. 2002 Oct;132(4):621-7. Erratum in: J Biochem (Tokyo). 2002 Nov;132(5):829. Dahrington GJ [corrected to Darlington GJ].

30.

C/EBPalpha is required for proteolytic cleavage of cyclin A by calpain 3 in myeloid precursor cells.

Welm AL, Timchenko NA, Ono Y, Sorimachi H, Radomska HS, Tenen DG, Lekstrom-Himes J, Darlington GJ.

J Biol Chem. 2002 Sep 13;277(37):33848-56. Epub 2002 Jul 8.

31.

Mitochondrial biogenesis and thyroid status maturation in brown fat require CCAAT/enhancer-binding protein alpha.

Carmona MC, Iglesias R, Obregón MJ, Darlington GJ, Villarroya F, Giralt M.

J Biol Chem. 2002 Jun 14;277(24):21489-98. Epub 2002 Apr 8.

32.

Mice lacking CCAAt/enhancer-binding protein-alpha show hyperproliferation of alveolar type II cells and increased surfactant protein mRNAs.

Sugahara K, Iyama KI, Kimura T, Sano K, Darlington GJ, Akiba T, Takiguchi M.

Cell Tissue Res. 2001 Oct;306(1):57-63.

PMID:
11683182
33.

C/EBPalpha is required for differentiation of white, but not brown, adipose tissue.

Linhart HG, Ishimura-Oka K, DeMayo F, Kibe T, Repka D, Poindexter B, Bick RJ, Darlington GJ.

Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12532-7. Epub 2001 Oct 16.

34.

Cultures of human liver cells in simulated microgravity environment.

Yoffe B, Darlington GJ, Soriano HE, Krishnan B, Risin D, Pellis NR, Khaoustov VI.

Adv Space Res. 1999;24(6):829-36.

PMID:
11542629
35.

CCAAT/enhancer-binding protein-alpha cooperates with p21 to inhibit cyclin-dependent kinase-2 activity and induces growth arrest independent of DNA binding.

Harris TE, Albrecht JH, Nakanishi M, Darlington GJ.

J Biol Chem. 2001 Aug 3;276(31):29200-9. Epub 2001 May 21.

36.

C/EBP regulates hepatic transcription of 11beta -hydroxysteroid dehydrogenase type 1. A novel mechanism for cross-talk between the C/EBP and glucocorticoid signaling pathways.

Williams LJ, Lyons V, MacLeod I, Rajan V, Darlington GJ, Poli V, Seckl JR, Chapman KE.

J Biol Chem. 2000 Sep 29;275(39):30232-9.

37.
38.

Molecular mechanisms of liver development and differentiation.

Darlington GJ.

Curr Opin Cell Biol. 1999 Dec;11(6):678-82. Review.

PMID:
10600708
39.

Induction of three-dimensional assembly of human liver cells by simulated microgravity.

Khaoustov VI, Darlington GJ, Soriano HE, Krishnan B, Risin D, Pellis NR, Yoffe B.

In Vitro Cell Dev Biol Anim. 1999 Oct;35(9):501-9.

PMID:
10548431
40.

E2F/p107 and E2F/p130 complexes are regulated by C/EBPalpha in 3T3-L1 adipocytes.

Timchenko NA, Wilde M, Iakova P, Albrecht JH, Darlington GJ.

Nucleic Acids Res. 1999 Sep 1;27(17):3621-30.

41.

C/EBPalpha regulates formation of S-phase-specific E2F-p107 complexes in livers of newborn mice.

Timchenko NA, Wilde M, Darlington GJ.

Mol Cell Biol. 1999 Apr;19(4):2936-45.

42.

Cross-regulation of C/EBP alpha and PPAR gamma controls the transcriptional pathway of adipogenesis and insulin sensitivity.

Wu Z, Rosen ED, Brun R, Hauser S, Adelmant G, Troy AE, McKeon C, Darlington GJ, Spiegelman BM.

Mol Cell. 1999 Feb;3(2):151-8.

43.

C/EBPalpha regulates generation of C/EBPbeta isoforms through activation of specific proteolytic cleavage.

Welm AL, Timchenko NA, Darlington GJ.

Mol Cell Biol. 1999 Mar;19(3):1695-704.

44.

CCAAT/enhancer binding protein alpha (C/EBPalpha) is an important mediator of mouse C/EBPbeta protein isoform production.

Burgess-Beusse BL, Timchenko NA, Darlington GJ.

Hepatology. 1999 Feb;29(2):597-601.

PMID:
9918941
45.

C/EBPalpha is critical for the neonatal acute-phase response to inflammation.

Burgess-Beusse BL, Darlington GJ.

Mol Cell Biol. 1998 Dec;18(12):7269-77.

46.

The role of C/EBP genes in adipocyte differentiation.

Darlington GJ, Ross SE, MacDougald OA.

J Biol Chem. 1998 Nov 13;273(46):30057-60. Review. No abstract available.

47.

Glucocorticoid receptor, C/EBP, HNF3, and protein kinase A coordinately activate the glucocorticoid response unit of the carbamoylphosphate synthetase I gene.

Christoffels VM, Grange T, Kaestner KH, Cole TJ, Darlington GJ, Croniger CM, Lamers WH.

Mol Cell Biol. 1998 Nov;18(11):6305-15.

48.

Hypoglycemia-associated hyperammonemia caused by impaired expression of ornithine cycle enzyme genes in C/EBPalpha knockout mice.

Kimura T, Christoffels VM, Chowdhury S, Iwase K, Matsuzaki H, Mori M, Lamers WH, Darlington GJ, Takiguchi M.

J Biol Chem. 1998 Oct 16;273(42):27505-10.

50.

Retrovirus-mediated in vivo gene transfer in the replicating liver using recombinant hepatocyte growth factor without liver injury or partial hepatectomy.

Kosai KI, Finegold MJ, Thi-Huynh BT, Tewson M, Ou CN, Bowles N, Woo SL, Schwall RH, Darlington GJ.

Hum Gene Ther. 1998 Jun 10;9(9):1293-301.

PMID:
9650614

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