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Items: 1 to 50 of 322

1.

The Role of Metabolic Plasticity in Blood and Brain Stem Cell Pathophysiology.

Libby CJ, McConathy J, Darley-Usmar V, Hjelmeland AB.

Cancer Res. 2019 Oct 1. pii: canres.1169.2019. doi: 10.1158/0008-5472.CAN-19-1169. [Epub ahead of print]

PMID:
31575548
2.

A precision medicine approach to defining the impact of doxorubicin on the bioenergetic-metabolite interactome in human platelets.

Smith MR, Chacko BK, Johnson MS, Benavides GA, Uppal K, Go YM, Jones DP, Darley-Usmar VM.

Redox Biol. 2019 Sep 7;28:101311. doi: 10.1016/j.redox.2019.101311. [Epub ahead of print]

3.

Targeting Glycolysis through Inhibition of Lactate Dehydrogenase Impairs Tumor Growth in Preclinical Models of Ewing Sarcoma.

Yeung C, Gibson AE, Issaq SH, Oshima N, Baumgart JT, Edessa LD, Rai G, Urban DJ, Johnson MS, Benavides GA, Squadrito GL, Yohe ME, Lei H, Eldridge S, Hamre J 3rd, Dowdy T, Ruiz-Rodado V, Lita A, Mendoza A, Shern JF, Larion M, Helman LJ, Stott GM, Krishna MC, Hall MD, Darley-Usmar V, Neckers LM, Heske CM.

Cancer Res. 2019 Oct 1;79(19):5060-5073. doi: 10.1158/0008-5472.CAN-19-0217. Epub 2019 Aug 20.

PMID:
31431459
4.

Precisely Control Mitochondria with Light to Manipulate Cell Fate Decision.

Ernst P, Xu N, Qu J, Chen H, Goldberg MS, Darley-Usmar V, Zhang JJ, O'Rourke B, Liu X, Zhou L.

Biophys J. 2019 Aug 20;117(4):631-645. doi: 10.1016/j.bpj.2019.06.038. Epub 2019 Jul 26.

PMID:
31400914
5.

SIRT1 regulates metabolism and leukemogenic potential in CML stem cells.

Abraham A, Qiu S, Chacko BK, Li H, Paterson A, He J, Agarwal P, Shah M, Welner R, Darley-Usmar VM, Bhatia R.

J Clin Invest. 2019 Jun 10;129(7):2685-2701. doi: 10.1172/JCI127080. eCollection 2019 Jun 10.

6.

Enhanced Keap1-Nrf2 signaling protects the myocardium from isoproterenol-induced pathological remodeling in mice.

Shanmugam G, Challa AK, Litovsky SH, Devarajan A, Wang D, Jones DP, Darley-Usmar VM, Rajasekaran NS.

Redox Biol. 2019 May 4:101212. doi: 10.1016/j.redox.2019.101212. [Epub ahead of print]

7.

New quantitative approach reveals heterogeneity in mitochondrial structure-function relations in tumor-initiating cells.

Spurlock B, Gupta P, Basu MK, Mukherjee A, Hjelmeland AB, Darley-Usmar V, Parker D, Foxall ME, Mitra K.

J Cell Sci. 2019 May 2;132(9). pii: jcs230755. doi: 10.1242/jcs.230755.

PMID:
30910831
8.

Mitochondria in precision medicine; linking bioenergetics and metabolomics in platelets.

Chacko BK, Smith MR, Johnson MS, Benavides G, Culp ML, Pilli J, Shiva S, Uppal K, Go YM, Jones DP, Darley-Usmar VM.

Redox Biol. 2019 Apr;22:101165. doi: 10.1016/j.redox.2019.101165. Epub 2019 Mar 10.

9.

Acute increases in O-GlcNAc indirectly impair mitochondrial bioenergetics through dysregulation of LonP1-mediated mitochondrial protein complex turnover.

Wright JN, Benavides GA, Johnson MS, Wani W, Ouyang X, Zou L, Collins HE, Zhang J, Darley-Usmar V, Chatham JC.

Am J Physiol Cell Physiol. 2019 Jun 1;316(6):C862-C875. doi: 10.1152/ajpcell.00491.2018. Epub 2019 Mar 13.

PMID:
30865517
10.

Feasibility of cellular bioenergetics as a biomarker in porphyria patients.

Chacko B, Culp ML, Bloomer J, Phillips J, Kuo YF, Darley-Usmar V, Singal AK.

Mol Genet Metab Rep. 2019 Jan 29;19:100451. doi: 10.1016/j.ymgmr.2019.100451. eCollection 2019 Jun.

11.

Mitoquinone ameliorates pressure overload-induced cardiac fibrosis and left ventricular dysfunction in mice.

Goh KY, He L, Song J, Jinno M, Rogers AJ, Sethu P, Halade GV, Rajasekaran NS, Liu X, Prabhu SD, Darley-Usmar V, Wende AR, Zhou L.

Redox Biol. 2019 Feb;21:101100. doi: 10.1016/j.redox.2019.101100. Epub 2019 Jan 8.

12.

SIRT3 diminishes inflammation and mitigates endotoxin-induced acute lung injury.

Kurundkar D, Kurundkar AR, Bone NB, Becker EJ Jr, Liu W, Chacko B, Darley-Usmar V, Zmijewski JW, Thannickal VJ.

JCI Insight. 2019 Jan 10;4(1). pii: 120722. doi: 10.1172/jci.insight.120722. [Epub ahead of print]

13.

Truncating PKHD1 and PKD2 mutations alter energy metabolism.

Chumley P, Zhou J, Mrug S, Chacko B, Parant JM, Challa AK, Wilson LS, Berryhill TF, Barnes S, Kesterson RA, Bell PD, Darley-Usmar VM, Yoder BK, Mrug M.

Am J Physiol Renal Physiol. 2019 Mar 1;316(3):F414-F425. doi: 10.1152/ajprenal.00167.2018. Epub 2018 Dec 19.

PMID:
30566001
14.

N-acetylcysteine targets 5 lipoxygenase-derived, toxic lipids and can synergize with prostaglandin E2 to inhibit ferroptosis and improve outcomes following hemorrhagic stroke in mice.

Karuppagounder SS, Alin L, Chen Y, Brand D, Bourassa MW, Dietrich K, Wilkinson CM, Nadeau CA, Kumar A, Perry S, Pinto JT, Darley-Usmar V, Sanchez S, Milne GL, Pratico D, Holman TR, Carmichael ST, Coppola G, Colbourne F, Ratan RR.

Ann Neurol. 2018 Dec;84(6):854-872. doi: 10.1002/ana.25356. Epub 2018 Nov 29.

15.

Author Correction: Metformin reverses established lung fibrosis in a bleomycin model.

Rangarajan S, Bone NB, Zmijewska AA, Jiang S, Park DW, Bernard K, Locy ML, Ravi S, Deshane J, Mannon RB, Abraham E, Darley-Usmar V, Thannickal VJ, Zmijewski JW.

Nat Med. 2018 Oct;24(10):1627. doi: 10.1038/s41591-018-0170-z.

PMID:
30104770
16.

Reply to Bailey et al.: New perspectives on the novel role of the Poldip2/ACSM1 axis in a functional mammalian lipoylation salvage pathway.

Paredes F, Lassègue B, Williams HC, Faidley EA, Benavides GA, Yeligar SM, Griendling KK, Darley-Usmar V, San Martin A.

Proc Natl Acad Sci U S A. 2018 Aug 7;115(32):E7460-E7461. doi: 10.1073/pnas.1807968115. Epub 2018 Jul 24. No abstract available.

17.

AMPK-ACC signaling modulates platelet phospholipids and potentiates thrombus formation.

Lepropre S, Kautbally S, Octave M, Ginion A, Onselaer MB, Steinberg GR, Kemp BE, Hego A, Wéra O, Brouns S, Swieringa F, Giera M, Darley-Usmar VM, Ambroise J, Guigas B, Heemskerk J, Bertrand L, Oury C, Beauloye C, Horman S.

Blood. 2018 Sep 13;132(11):1180-1192. doi: 10.1182/blood-2018-02-831503. Epub 2018 Jul 17.

18.

Exosomal transfer of mitochondria from airway myeloid-derived regulatory cells to T cells.

Hough KP, Trevor JL, Strenkowski JG, Wang Y, Chacko BK, Tousif S, Chanda D, Steele C, Antony VB, Dokland T, Ouyang X, Zhang J, Duncan SR, Thannickal VJ, Darley-Usmar VM, Deshane JS.

Redox Biol. 2018 Sep;18:54-64. doi: 10.1016/j.redox.2018.06.009. Epub 2018 Jun 25.

19.

Metformin reverses established lung fibrosis in a bleomycin model.

Rangarajan S, Bone NB, Zmijewska AA, Jiang S, Park DW, Bernard K, Locy ML, Ravi S, Deshane J, Mannon RB, Abraham E, Darley-Usmar V, Thannickal VJ, Zmijewski JW.

Nat Med. 2018 Aug;24(8):1121-1127. doi: 10.1038/s41591-018-0087-6. Epub 2018 Jul 2. Erratum in: Nat Med. 2018 Oct;24(10):1627.

20.

Effector CD4 T cells with progenitor potential mediate chronic intestinal inflammation.

Shin B, Kress RL, Kramer PA, Darley-Usmar VM, Bellis SL, Harrington LE.

J Exp Med. 2018 Jul 2;215(7):1803-1812. doi: 10.1084/jem.20172335. Epub 2018 Jun 18.

21.

Rust never sleeps: The continuing story of the Iron Bolt.

van der Vliet A, Dick TP, Aust SD, Koppenol WH, Ursini F, Kettle AJ, Beckman JS, O'Donnell V, Darley-Usmar V, Lancaster J Jr, Hogg N, Davies KJA, Forman HJ, Janssen-Heininger YMW.

Free Radic Biol Med. 2018 Aug 20;124:353-357. doi: 10.1016/j.freeradbiomed.2018.06.017. Epub 2018 Jun 18. Review.

PMID:
29913216
22.

Identification of Compounds That Decrease Glioblastoma Growth and Glucose Uptake in Vitro.

Libby CJ, Zhang S, Benavides GA, Scott SE, Li Y, Redmann M, Tran AN, Otamias A, Darley-Usmar V, Napierala M, Zhang J, Augelli-Szafran CE, Zhang W, Hjelmeland AB.

ACS Chem Biol. 2018 Aug 17;13(8):2048-2057. doi: 10.1021/acschembio.8b00251. Epub 2018 Jun 15.

23.

Integrative metabolomics and transcriptomics signatures of clinical tolerance to Plasmodium vivax reveal activation of innate cell immunity and T cell signaling.

Gardinassi LG, Arévalo-Herrera M, Herrera S, Cordy RJ, Tran V, Smith MR, Johnson MS, Chacko B, Liu KH, Darley-Usmar VM, Go YM; MaHPIC Consortium, Jones DP, Galinski MR, Li S.

Redox Biol. 2018 Jul;17:158-170. doi: 10.1016/j.redox.2018.04.011. Epub 2018 Apr 11.

24.

Methods for assessing mitochondrial quality control mechanisms and cellular consequences in cell culture.

Redmann M, Benavides GA, Wani WY, Berryhill TF, Ouyang X, Johnson MS, Ravi S, Mitra K, Barnes S, Darley-Usmar VM, Zhang J.

Redox Biol. 2018 Jul;17:59-69. doi: 10.1016/j.redox.2018.04.005. Epub 2018 Apr 10.

25.

Poldip2 is an oxygen-sensitive protein that controls PDH and αKGDH lipoylation and activation to support metabolic adaptation in hypoxia and cancer.

Paredes F, Sheldon K, Lassègue B, Williams HC, Faidley EA, Benavides GA, Torres G, Sanhueza-Olivares F, Yeligar SM, Griendling KK, Darley-Usmar V, San Martin A.

Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):1789-1794. doi: 10.1073/pnas.1720693115. Epub 2018 Feb 6.

26.

An overview of the emerging interface between cardiac metabolism, redox biology and the circadian clock.

Peliciari-Garcia RA, Darley-Usmar V, Young ME.

Free Radic Biol Med. 2018 May 1;119:75-84. doi: 10.1016/j.freeradbiomed.2018.02.013. Epub 2018 Feb 10. Review.

27.

Temporal partitioning of adaptive responses of the murine heart to fasting.

Brewer RA, Collins HE, Berry RD, Brahma MK, Tirado BA, Peliciari-Garcia RA, Stanley HL, Wende AR, Taegtmeyer H, Rajasekaran NS, Darley-Usmar V, Zhang J, Frank SJ, Chatham JC, Young ME.

Life Sci. 2018 Mar 15;197:30-39. doi: 10.1016/j.lfs.2018.01.031. Epub 2018 Feb 1.

28.

Mitochondrial function and autophagy: integrating proteotoxic, redox, and metabolic stress in Parkinson's disease.

Zhang J, Culp ML, Craver JG, Darley-Usmar V.

J Neurochem. 2018 Mar;144(6):691-709. doi: 10.1111/jnc.14308. Epub 2018 Feb 14. Review.

29.

Addition of carbonic anhydrase 9 inhibitor SLC-0111 to temozolomide treatment delays glioblastoma growth in vivo.

Boyd NH, Walker K, Fried J, Hackney JR, McDonald PC, Benavides GA, Spina R, Audia A, Scott SE, Libby CJ, Tran AN, Bevensee MO, Griguer C, Nozell S, Gillespie GY, Nabors B, Bhat KP, Bar EE, Darley-Usmar V, Xu B, Gordon E, Cooper SJ, Dedhar S, Hjelmeland AB.

JCI Insight. 2017 Dec 21;2(24). pii: 92928. doi: 10.1172/jci.insight.92928.

30.

Glutaminolysis is required for transforming growth factor-β1-induced myofibroblast differentiation and activation.

Bernard K, Logsdon NJ, Benavides GA, Sanders Y, Zhang J, Darley-Usmar VM, Thannickal VJ.

J Biol Chem. 2018 Jan 26;293(4):1218-1228. doi: 10.1074/jbc.RA117.000444. Epub 2017 Dec 8.

31.

Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH).

Rai G, Brimacombe KR, Mott BT, Urban DJ, Hu X, Yang SM, Lee TD, Cheff DM, Kouznetsova J, Benavides GA, Pohida K, Kuenstner EJ, Luci DK, Lukacs CM, Davies DR, Dranow DM, Zhu H, Sulikowski G, Moore WJ, Stott GM, Flint AJ, Hall MD, Darley-Usmar VM, Neckers LM, Dang CV, Waterson AG, Simeonov A, Jadhav A, Maloney DJ.

J Med Chem. 2017 Nov 22;60(22):9184-9204. doi: 10.1021/acs.jmedchem.7b00941. Epub 2017 Nov 9.

32.

Regulation of autophagy, mitochondrial dynamics, and cellular bioenergetics by 4-hydroxynonenal in primary neurons.

Dodson M, Wani WY, Redmann M, Benavides GA, Johnson MS, Ouyang X, Cofield SS, Mitra K, Darley-Usmar V, Zhang J.

Autophagy. 2017;13(11):1828-1840. doi: 10.1080/15548627.2017.1356948. Epub 2017 Sep 29.

33.

Genetic disruption of the cardiomyocyte circadian clock differentially influences insulin-mediated processes in the heart.

McGinnis GR, Tang Y, Brewer RA, Brahma MK, Stanley HL, Shanmugam G, Rajasekaran NS, Rowe GC, Frank SJ, Wende AR, Abel ED, Taegtmeyer H, Litovsky S, Darley-Usmar V, Zhang J, Chatham JC, Young ME.

J Mol Cell Cardiol. 2017 Sep;110:80-95. doi: 10.1016/j.yjmcc.2017.07.005. Epub 2017 Jul 20.

34.

O-GlcNAc regulation of autophagy and α-synuclein homeostasis; implications for Parkinson's disease.

Wani WY, Ouyang X, Benavides GA, Redmann M, Cofield SS, Shacka JJ, Chatham JC, Darley-Usmar V, Zhang J.

Mol Brain. 2017 Jul 19;10(1):32. doi: 10.1186/s13041-017-0311-1.

35.

Constitutive activation of Nrf2 induces a stable reductive state in the mouse myocardium.

Shanmugam G, Narasimhan M, Tamowski S, Darley-Usmar V, Rajasekaran NS.

Redox Biol. 2017 Aug;12:937-945. doi: 10.1016/j.redox.2017.04.038. Epub 2017 May 3.

36.

Monocyte bioenergetic function is associated with body composition in virologically suppressed HIV-infected women.

Willig AL, Kramer PA, Chacko BK, Darley-Usmar VM, Heath SL, Overton ET.

Redox Biol. 2017 Aug;12:648-656. doi: 10.1016/j.redox.2017.04.005. Epub 2017 Apr 4.

37.

Autophagy and the redox connection: Virtual collection Vol 2.

Zhang J, Darley-Usmar V.

Redox Biol. 2017 Apr;11:620-621. doi: 10.1016/j.redox.2016.10.005. Epub 2016 Oct 13. No abstract available.

38.

Endostatin inhibits androgen-independent prostate cancer growth by suppressing nuclear receptor-mediated oxidative stress.

Lee JH, Kang M, Wang H, Naik G, Mobley JA, Sonpavde G, Garvey WT, Darley-Usmar VM, Ponnazhagan S.

FASEB J. 2017 Apr;31(4):1608-1619. doi: 10.1096/fj.201601178R. Epub 2017 Jan 9.

39.

Trehalose does not improve neuronal survival on exposure to alpha-synuclein pre-formed fibrils.

Redmann M, Wani WY, Volpicelli-Daley L, Darley-Usmar V, Zhang J.

Redox Biol. 2017 Apr;11:429-437. doi: 10.1016/j.redox.2016.12.032. Epub 2017 Jan 3.

40.

NADPH Oxidase 4 (Nox4) Suppresses Mitochondrial Biogenesis and Bioenergetics in Lung Fibroblasts via a Nuclear Factor Erythroid-derived 2-like 2 (Nrf2)-dependent Pathway.

Bernard K, Logsdon NJ, Miguel V, Benavides GA, Zhang J, Carter AB, Darley-Usmar VM, Thannickal VJ.

J Biol Chem. 2017 Feb 17;292(7):3029-3038. doi: 10.1074/jbc.M116.752261. Epub 2017 Jan 3.

41.

Inhibition of autophagy with bafilomycin and chloroquine decreases mitochondrial quality and bioenergetic function in primary neurons.

Redmann M, Benavides GA, Berryhill TF, Wani WY, Ouyang X, Johnson MS, Ravi S, Barnes S, Darley-Usmar VM, Zhang J.

Redox Biol. 2017 Apr;11:73-81. doi: 10.1016/j.redox.2016.11.004. Epub 2016 Nov 18.

42.

A biphasic effect of TNF-α in regulation of the Keap1/Nrf2 pathway in cardiomyocytes.

Shanmugam G, Narasimhan M, Sakthivel R, Kumar R R, Davidson C, Palaniappan S, Claycomb WW, Hoidal JR, Darley-Usmar VM, Rajasekaran NS.

Redox Biol. 2016 Oct;9:77-89. doi: 10.1016/j.redox.2016.06.004. Epub 2016 Jun 27.

43.

Pleiotropic effects of 4-hydroxynonenal on oxidative burst and phagocytosis in neutrophils.

Chacko BK, Wall SB, Kramer PA, Ravi S, Mitchell T, Johnson MS, Wilson L, Barnes S, Landar A, Darley-Usmar VM.

Redox Biol. 2016 Oct;9:57-66. doi: 10.1016/j.redox.2016.06.003. Epub 2016 Jun 23.

44.

O-GlcNAcylation and neurodegeneration.

Wani WY, Chatham JC, Darley-Usmar V, McMahon LL, Zhang J.

Brain Res Bull. 2017 Jul;133:80-87. doi: 10.1016/j.brainresbull.2016.08.002. Epub 2016 Aug 4. Review.

45.

Diagnosis and Treatment of Alcoholic Hepatitis: A Systematic Review.

Singal AK, Kodali S, Vucovich LA, Darley-Usmar V, Schiano TD.

Alcohol Clin Exp Res. 2016 Jul;40(7):1390-402. doi: 10.1111/acer.13108. Epub 2016 Jun 2. Review.

46.

Redox biology and the interface between bioenergetics, autophagy and circadian control of metabolism.

Wende AR, Young ME, Chatham J, Zhang J, Rajasekaran NS, Darley-Usmar VM.

Free Radic Biol Med. 2016 Nov;100:94-107. doi: 10.1016/j.freeradbiomed.2016.05.022. Epub 2016 May 27. Review.

47.

Mapping the Human Platelet Lipidome Reveals Cytosolic Phospholipase A2 as a Regulator of Mitochondrial Bioenergetics during Activation.

Slatter DA, Aldrovandi M, O'Connor A, Allen SM, Brasher CJ, Murphy RC, Mecklemann S, Ravi S, Darley-Usmar V, O'Donnell VB.

Cell Metab. 2016 May 10;23(5):930-44. doi: 10.1016/j.cmet.2016.04.001. Epub 2016 Apr 28.

48.
49.

Abrogation of Nrf2 impairs antioxidant signaling and promotes atrial hypertrophy in response to high-intensity exercise stress.

Kumar RR, Narasimhan M, Shanmugam G, Hong J, Devarajan A, Palaniappan S, Zhang J, Halade GV, Darley-Usmar VM, Hoidal JR, Rajasekaran NS.

J Transl Med. 2016 Apr 5;14:86. doi: 10.1186/s12967-016-0839-3.

50.

Assessing Cardiac Metabolism: A Scientific Statement From the American Heart Association.

Taegtmeyer H, Young ME, Lopaschuk GD, Abel ED, Brunengraber H, Darley-Usmar V, Des Rosiers C, Gerszten R, Glatz JF, Griffin JL, Gropler RJ, Holzhuetter HG, Kizer JR, Lewandowski ED, Malloy CR, Neubauer S, Peterson LR, Portman MA, Recchia FA, Van Eyk JE, Wang TJ; American Heart Association Council on Basic Cardiovascular Sciences.

Circ Res. 2016 May 13;118(10):1659-701. doi: 10.1161/RES.0000000000000097. Epub 2016 Mar 24. Review. Erratum in: Circ Res. 2016 May 13;118(10):e35.

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