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Items: 39

1.

Using Flow Cytometry to Detect and Measure Intracellular Thiol Redox Status in Viable T Cells from Heterogeneous Populations.

Wadley AJ, Morgan RG, Darley RL, Hole PS, Coles SJ.

Methods Mol Biol. 2019;1990:53-70. doi: 10.1007/978-1-4939-9463-2_5.

PMID:
31148062
2.

LEF-1 drives aberrant β-catenin nuclear localization in myeloid leukemia cells.

Morgan RG, Ridsdale J, Payne M, Heesom KJ, Wilson MC, Davidson A, Greenhough A, Davies S, Williams AC, Blair A, Waterman ML, Tonks A, Darley RL.

Haematologica. 2019 Jul;104(7):1365-1377. doi: 10.3324/haematol.2018.202846. Epub 2019 Jan 10.

3.

Cord Blood-Derived Quiescent CD34+ Cells Are More Transcriptionally Matched to AML Blasts Than Cytokine-Induced Normal Human Hematopoietic CD34+ Cells.

Munje C, Hills RK, Whetton A, Burnett AK, Darley RL, Tonks A.

Gene Expr. 2015;16(4):169-175. doi: 10.3727/105221615X14399878166159.

4.

Targeting the Ataxia Telangiectasia Mutated-null phenotype in chronic lymphocytic leukemia with pro-oxidants.

Agathanggelou A, Weston VJ, Perry T, Davies NJ, Skowronska A, Payne DT, Fossey JS, Oldreive CE, Wei W, Pratt G, Parry H, Oscier D, Coles SJ, Hole PS, Darley RL, McMahon M, Hayes JD, Moss P, Stewart GS, Taylor AM, Stankovic T.

Haematologica. 2015 Aug;100(8):1076-85. doi: 10.3324/haematol.2014.115170. Epub 2015 Apr 3.

5.

The immunosuppressive ligands PD-L1 and CD200 are linked in AML T-cell immunosuppression: identification of a new immunotherapeutic synapse.

Coles SJ, Gilmour MN, Reid R, Knapper S, Burnett AK, Man S, Tonks A, Darley RL.

Leukemia. 2015 Sep;29(9):1952-4. doi: 10.1038/leu.2015.62. Epub 2015 Mar 9. No abstract available.

PMID:
25748687
6.

Factors affecting the nuclear localization of β-catenin in normal and malignant tissue.

Morgan RG, Ridsdale J, Tonks A, Darley RL.

J Cell Biochem. 2014 Aug;115(8):1351-61. doi: 10.1002/jcb.24803. Review.

PMID:
24610469
7.

The PDK1 master kinase is over-expressed in acute myeloid leukemia and promotes PKC-mediated survival of leukemic blasts.

Zabkiewicz J, Pearn L, Hills RK, Morgan RG, Tonks A, Burnett AK, Darley RL.

Haematologica. 2014 May;99(5):858-64. doi: 10.3324/haematol.2013.096487. Epub 2013 Dec 13.

8.

Overproduction of NOX-derived ROS in AML promotes proliferation and is associated with defective oxidative stress signaling.

Hole PS, Zabkiewicz J, Munje C, Newton Z, Pearn L, White P, Marquez N, Hills RK, Burnett AK, Tonks A, Darley RL.

Blood. 2013 Nov 7;122(19):3322-30. doi: 10.1182/blood-2013-04-491944. Epub 2013 Oct 2.

9.

γ-Catenin is expressed throughout normal human hematopoietic development and is required for normal PU.1-dependent monocyte differentiation.

Morgan RG, Liddiard K, Pearn L, Pumford SL, Burnett AK, Darley RL, Tonks A.

Leukemia. 2013 Oct;27(10):2096-100. doi: 10.1038/leu.2013.96. Epub 2013 Apr 2. No abstract available.

PMID:
23545990
10.

γ-Catenin is overexpressed in acute myeloid leukemia and promotes the stabilization and nuclear localization of β-catenin.

Morgan RG, Pearn L, Liddiard K, Pumford SL, Burnett AK, Tonks A, Darley RL.

Leukemia. 2013 Feb;27(2):336-43. doi: 10.1038/leu.2012.221. Epub 2012 Aug 3.

11.

Increased CD200 expression in acute myeloid leukemia is linked with an increased frequency of FoxP3+ regulatory T cells.

Coles SJ, Hills RK, Wang EC, Burnett AK, Man S, Darley RL, Tonks A.

Leukemia. 2012 Sep;26(9):2146-8. doi: 10.1038/leu.2012.75. Epub 2012 Mar 20. No abstract available.

12.

Expression of CD200 on AML blasts directly suppresses memory T-cell function.

Coles SJ, Hills RK, Wang EC, Burnett AK, Man S, Darley RL, Tonks A.

Leukemia. 2012 Sep;26(9):2148-51. doi: 10.1038/leu.2012.77. Epub 2012 Mar 20. No abstract available.

13.

RUNX1-ETO deregulates the proliferation and growth factor responsiveness of human hematopoietic progenitor cells downstream of the myeloid transcription factor, MYCT1.

Liddiard K, Burnett AK, Darley RL, Tonks A.

Leukemia. 2012 Jan;26(1):177-9. doi: 10.1038/leu.2011.188. Epub 2011 Jul 29. No abstract available.

14.

Do reactive oxygen species play a role in myeloid leukemias?

Hole PS, Darley RL, Tonks A.

Blood. 2011 Jun 2;117(22):5816-26. doi: 10.1182/blood-2011-01-326025. Epub 2011 Mar 11. Review. Erratum in: Blood. 2014 Jan 30;123(5):798.

15.

CD200 expression suppresses natural killer cell function and directly inhibits patient anti-tumor response in acute myeloid leukemia.

Coles SJ, Wang EC, Man S, Hills RK, Burnett AK, Tonks A, Darley RL.

Leukemia. 2011 May;25(5):792-9. doi: 10.1038/leu.2011.1. Epub 2011 Jan 28.

16.

Low connexin channel-dependent intercellular communication in human adult hematopoietic progenitor/stem cells: probing mechanisms of autologous stem cell therapy.

Yang J, Darley RL, Hallett M, Evans WH.

Cell Commun Adhes. 2009 Dec;16(5-6):138-45. doi: 10.3109/15419061003653763.

17.

OGG1 is a novel prognostic indicator in acute myeloid leukaemia.

Liddiard K, Hills R, Burnett AK, Darley RL, Tonks A.

Oncogene. 2010 Apr 1;29(13):2005-12. doi: 10.1038/onc.2009.462. Epub 2009 Dec 21.

PMID:
20023702
18.

Ras-induced reactive oxygen species promote growth factor-independent proliferation in human CD34+ hematopoietic progenitor cells.

Hole PS, Pearn L, Tonks AJ, James PE, Burnett AK, Darley RL, Tonks A.

Blood. 2010 Feb 11;115(6):1238-46. doi: 10.1182/blood-2009-06-222869. Epub 2009 Dec 10.

19.

Translocation or just location? Pseudopodia affect fluorescent signals.

Dewitt S, Darley RL, Hallett MB.

J Cell Biol. 2009 Jan 26;184(2):197-203. doi: 10.1083/jcb.200806047.

20.

Transcriptional dysregulation mediated by RUNX1-RUNX1T1 in normal human progenitor cells and in acute myeloid leukaemia.

Tonks A, Pearn L, Musson M, Gilkes A, Mills KI, Burnett AK, Darley RL.

Leukemia. 2007 Dec;21(12):2495-505. Epub 2007 Sep 27.

PMID:
17898786
21.

FUS expression alters the differentiation response to all-trans retinoic acid in NB4 and NB4R2 cells.

Walsby EJ, Gilkes AF, Tonks A, Darley RL, Mills KI.

Br J Haematol. 2007 Oct;139(1):94-7.

PMID:
17854312
22.

The role of PKC and PDK1 in monocyte lineage specification by Ras.

Pearn L, Fisher J, Burnett AK, Darley RL.

Blood. 2007 May 15;109(10):4461-9. Epub 2007 Jan 25.

23.

CD200 as a prognostic factor in acute myeloid leukaemia.

Tonks A, Hills R, White P, Rosie B, Mills KI, Burnett AK, Darley RL.

Leukemia. 2007 Mar;21(3):566-8. Epub 2007 Jan 25. No abstract available.

PMID:
17252007
24.

The sensitivity of human cells expressing RUNX1-RUNX1T1 to chemotherapeutic agents.

Tonks A, Pearn L, Mills KI, Burnett AK, Darley RL.

Leukemia. 2006 Oct;20(10):1883-5. Epub 2006 Aug 17. No abstract available.

PMID:
16932340
25.

Ral is both necessary and sufficient for the inhibition of myeloid differentiation mediated by Ras.

Omidvar N, Pearn L, Burnett AK, Darley RL.

Mol Cell Biol. 2006 May;26(10):3966-75.

26.

Optimized retroviral transduction protocol which preserves the primitive subpopulation of human hematopoietic cells.

Tonks A, Tonks AJ, Pearn L, Mohamad Z, Burnett AK, Darley RL.

Biotechnol Prog. 2005 May-Jun;21(3):953-8.

PMID:
15932279
27.

Expression of AML1-ETO in human myelomonocytic cells selectively inhibits granulocytic differentiation and promotes their self-renewal.

Tonks A, Tonks AJ, Pearn L, Pearce L, Hoy T, Couzens S, Fisher J, Burnett AK, Darley RL.

Leukemia. 2004 Jul;18(7):1238-45.

PMID:
15152269
28.

The AML1-ETO fusion gene promotes extensive self-renewal of human primary erythroid cells.

Tonks A, Pearn L, Tonks AJ, Pearce L, Hoy T, Phillips S, Fisher J, Downing JR, Burnett AK, Darley RL.

Blood. 2003 Jan 15;101(2):624-32. Epub 2002 Aug 22.

29.

Protein kinase C mediates mutant N-Ras-induced developmental abnormalities in normal human erythroid cells.

Darley RL, Pearn L, Omidvar N, Sweeney M, Fisher J, Phillips S, Hoy T, Burnett AK.

Blood. 2002 Dec 1;100(12):4185-92. Epub 2002 Jul 18.

30.

Alternative effects of RAS and RAF oncogenes on the proliferation and apoptosis of factor-dependent FDC-P1 cells.

McGlynn AP, Padua RA, Burnett AK, Darley RL.

Leuk Res. 2000 Jan;24(1):47-54.

PMID:
10634645
31.
32.
33.

Oncogenic RAS genes impair erythroid differentiation of erythroleukaemia cells.

Zaker F, Darley RL, al Sabah A, Burnett AK.

Leuk Res. 1997 Jul;21(7):635-40.

PMID:
9301684
34.

Mutant N-RAS induces erythroid lineage dysplasia in human CD34+ cells.

Darley RL, Hoy TG, Baines P, Padua RA, Burnett AK.

J Exp Med. 1997 Apr 7;185(7):1337-47.

35.

The molecular basis of myelodysplastic syndromes.

Gallagher A, Darley RL, Padua R.

Haematologica. 1997 Mar-Apr;82(2):191-204. Review.

36.

Aberrant expression of p21RAS but not p120GAP is a common feature of myelodysplasia.

Gallagher A, Padua RA, al-Sabah A, Hoy T, Burnett AK, Darley RL.

Leukemia. 1995 Nov;9(11):1833-40.

PMID:
7475271
37.

Upregulation of p21 RAS levels in HL-60 cells during differentiation induction with DMSO, all-trans-retinoic acid and TPA.

Kuliczkowski K, Darley RL, Jacobs A, Padua RA, Hoy TG.

Leuk Res. 1995 Apr;19(4):291-6.

PMID:
7752674
38.

Sequential changes in MHC antigen expression induced by the v-Ki-ras oncogene.

Darley RL, Morris AG.

Cancer Immunol Immunother. 1993 Nov;37(6):361-6.

PMID:
8242660

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