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Items: 1 to 50 of 228

1.

Safety and Efficacy of the SNAP 12-hour Acetylcysteine Regimen for the Treatment of Paracetamol Overdose.

Pettie JM, Caparrotta TM, Hunter RW, Morrison EE, Wood DM, Dargan PI, Thanacoody RH, Thomas SHL, Elamin MEMO, Francis B, Webb DJ, Sandilands EA, Eddleston M, Dear JW.

EClinicalMedicine. 2019 May 2;11:11-17. doi: 10.1016/j.eclinm.2019.04.005. eCollection 2019 May-Jun.

2.

Nonmedical use of alprazolam in the UK: Results from a nationally representative survey.

Hockenhull J, Amioka E, Black JC, Haynes CM, Dargan PI, Dart RC, Wood DM.

Br J Clin Pharmacol. 2019 Aug;85(8):1841-1845. doi: 10.1111/bcp.13959. Epub 2019 Jun 5.

PMID:
31165490
3.

Detection of cocaine and its metabolites in whole blood and plasma following a single dose controlled administration of intranasal cocaine.

Menzies EL, Archer JRH, Dargan PI, Parkin MC, Yamamoto T, Wood DM, Braithwaite RA, Elliott SP, Kicman AT.

Drug Test Anal. 2019 May 31. doi: 10.1002/dta.2657. [Epub ahead of print]

PMID:
31150569
4.

Authors' reply to comment on "Epidemiology, clinical features and management of patients presenting to European emergency departments with acute cocaine toxicity: comparison between powder cocaine and crack cocaine cases".

Miró Ò, Dargan PI, Galicia M; Euro-DEN Plus Research Group.

Clin Toxicol (Phila). 2019 May 17:1-3. doi: 10.1080/15563650.2019.1613549. [Epub ahead of print] No abstract available.

PMID:
31096802
5.

Cold water extraction of codeine/paracetamol combination products: a case series and literature review.

Harnett JT, Dines AM, Wood DM, Archer JRH, Dargan PI.

Clin Toxicol (Phila). 2019 May 13:1-5. doi: 10.1080/15563650.2019.1612069. [Epub ahead of print]

PMID:
31081395
6.

Seizures as a complication of recreational drug use: Analysis of the Euro-DEN Plus data-set.

Wolfe CE, Wood DM, Dines A, Whatley BP, Yates C, Heyerdahl F, Hovda KE, Giraudon I, Dargan PI; Euro-DEN Research Group.

Neurotoxicology. 2019 Jul;73:183-187. doi: 10.1016/j.neuro.2019.04.003. Epub 2019 Apr 8.

PMID:
30974132
7.

Epidemiology, toxicokinetics and biomarkers after self-poisoning with Gloriosa superba.

Wijerathna TM, Gawarammana IB, Mohamed F, Dissanayaka DM, Dargan PI, Chathuranga U, Jayathilaka C, Buckley NA.

Clin Toxicol (Phila). 2019 Mar 19:1-7. doi: 10.1080/15563650.2019.1581939. [Epub ahead of print]

PMID:
30888889
8.

Epidemiology, clinical features and management of patients presenting to European emergency departments with acute cocaine toxicity: comparison between powder cocaine and crack cocaine cases.

Miró Ò, Dargan PI, Wood DM, Dines AM, Yates C, Heyerdahl F, Hovda KE, Giraudon I; Euro-DEN Plus Research Group, Galicia M.

Clin Toxicol (Phila). 2019 Aug;57(8):718-726. doi: 10.1080/15563650.2018.1549735. Epub 2019 Jan 30.

PMID:
30696283
9.

Acute toxicity following analytically confirmed use of the novel psychoactive substance (NPS) methiopropamine. A report from the Identification of Novel psychoActive substances (IONA) study.

White JC, Wood DM, Hill SL, Eddleston M, Officer J, Dargan PI, Dunn M, Thomas SHL.

Clin Toxicol (Phila). 2019 Jul;57(7):663-667. doi: 10.1080/15563650.2018.1538519. Epub 2019 Jan 24.

PMID:
30676081
10.

UK survey of non-medical use of prescription drugs (NMURx) as a valuable source of general population illicit drug use data.

Ng FL, Rockhill K, Black J, May KP, Whittington MD, Wood DM, Dargan PI, Green JL.

Postgrad Med J. 2018 Nov;94(1117):627-633. doi: 10.1136/postgradmedj-2018-135798.

PMID:
30635430
11.

Poor Identification of Emergency Department Acute Recreational Drug Toxicity Presentations Using Routine Hospital Coding Systems: the Experience in Denmark, Switzerland and the UK.

Wood DM, De La Rue L, Hosin AA, Jurgens G, Liakoni E, Heyerdahl F, Hovda KE, Dines A, Giraudon I, Liechti ME, Dargan PI.

J Med Toxicol. 2019 Apr;15(2):112-120. doi: 10.1007/s13181-018-0687-z. Epub 2019 Jan 2.

12.

Validation of Activity-Based Screening for Synthetic Cannabinoid Receptor Agonists in a Large Set of Serum Samples.

Cannaert A, Vandeputte M, Hudson S, Wood DM, Dargan PI, Stove CP.

Clin Chem. 2019 Feb;65(2):347-349. doi: 10.1373/clinchem.2018.296905. Epub 2018 Nov 30. No abstract available.

PMID:
30504261
13.

Quantification of cocaine and cocaine metabolites in dried blood spots from a controlled administration study using liquid chromatography-tandem mass spectrometry.

Ambach L, Menzies E, Parkin MC, Kicman A, Archer JRH, Wood DM, Dargan PI, Stove C.

Drug Test Anal. 2019 May;11(5):709-720. doi: 10.1002/dta.2537. Epub 2018 Dec 13.

PMID:
30379417
14.

An evaluation of the role of mixing techniques in the observed variation in acetylcysteine infusion concentrations.

Layne K, Hope L, Rab E, Archer J, Wood DM, Dargan PI.

Br J Clin Pharmacol. 2019 Jan;85(1):252-257. doi: 10.1111/bcp.13800. Epub 2018 Nov 8.

PMID:
30362143
15.

Stability of mephedrone and five of its phase I metabolites in human whole blood.

Czerwinska J, Parkin MC, Dargan PI, George C, Kicman AT, Abbate V.

Drug Test Anal. 2019 Apr;11(4):586-594. doi: 10.1002/dta.2525. Epub 2018 Dec 2.

PMID:
30341975
16.

Presentations to the emergency department with non-medical use of benzodiazepines and Z-drugs: profiling and relation to sales data.

Lyphout C, Yates C, Margolin ZR, Dargan PI, Dines AM, Heyerdahl F, Hovda KE, Giraudon I, Bucher-Bartelson B, Green JL; Euro-DEN Research Group, Wood DM.

Eur J Clin Pharmacol. 2019 Jan;75(1):77-85. doi: 10.1007/s00228-018-2550-1. Epub 2018 Sep 22.

PMID:
30244371
17.

Global Mortality From Firearms, 1990-2016.

Global Burden of Disease 2016 Injury Collaborators, Naghavi M, Marczak LB, Kutz M, Shackelford KA, Arora M, Miller-Petrie M, Aichour MTE, Akseer N, Al-Raddadi RM, Alam K, Alghnam SA, Antonio CAT, Aremu O, Arora A, Asadi-Lari M, Assadi R, Atey TM, Avila-Burgos L, Awasthi A, Ayala Quintanilla BP, Barker-Collo SL, Bärnighausen TW, Bazargan-Hejazi S, Behzadifar M, Behzadifar M, Bennett JR, Bhalla A, Bhutta ZA, Bilal AI, Borges G, Borschmann R, Brazinova A, Campuzano Rincon JC, Carvalho F, Castañeda-Orjuela CA, Dandona L, Dandona R, Dargan PI, De Leo D, Dharmaratne SD, Ding EL, Phuc Do H, Doku DT, Doyle KE, Driscoll TR, Edessa D, El-Khatib Z, Endries AY, Esteghamati A, Faro A, Farzadfar F, Feigin VL, Fischer F, Foreman KJ, Franklin RC, Fullman N, Futran ND, Gebrehiwot TT, Gutiérrez RA, Hafezi-Nejad N, Haghparast Bidgoli H, Hailu GB, Haro JM, Hassen HY, Hawley C, Hendrie D, Híjar M, Hu G, Ilesanmi OS, Jakovljevic M, James SL, Jayaraman S, Jonas JB, Kahsay A, Kasaeian A, Keiyoro PN, Khader Y, Khalil IA, Khang YH, Khubchandani J, Ahmad Kiadaliri A, Kieling C, Kim YJ, Kosen S, Krohn KJ, Kumar GA, Lami FH, Lansingh VC, Larson HJ, Linn S, Lunevicius R, Magdy Abd El Razek H, Magdy Abd El Razek M, Malekzadeh R, Carvalho Malta D, Mason-Jones AJ, Matzopoulos R, Memiah PTN, Mendoza W, Meretoja TJ, Mezgebe HB, Miller TR, Mohammed S, Moradi-Lakeh M, Mori R, Nand D, Tat Nguyen C, Le Nguyen Q, Ningrum DNA, Akpojene Ogbo F, Olagunju AT, Patton GC, Phillips MR, Polinder S, Pourmalek F, Qorbani M, Rahimi-Movaghar A, Rahimi-Movaghar V, Rahman M, Rai RK, Ranabhat CL, Rawaf DL, Rawaf S, Rowhani-Rahbar A, Safdarian M, Safiri S, Sagar R, Salama JS, Sanabria J, Santric Milicevic MM, Sarmiento-Suárez R, Sartorius B, Satpathy M, Schwebel DC, Seedat S, Sepanlou SG, Shaikh MA, Sharew NT, Shiue I, Singh JA, Sisay M, Skirbekk V, Soares Filho AM, Stein DJ, Stokes MA, Sufiyan MB, Swaroop M, Sykes BL, Tabarés-Seisdedos R, Tadese F, Tran BX, Thanh Tran T, Ukwaja KN, Vasankari TJ, Vlassov V, Werdecker A, Ye P, Yip P, Yonemoto N, Younis MZ, Zaidi Z, El Sayed Zaki M, Hay SI, Lim SS, Lopez AD, Mokdad AH, Vos T, Murray CJL.

JAMA. 2018 Aug 28;320(8):792-814. doi: 10.1001/jama.2018.10060. Erratum in: JAMA. 2018 Sep 25;320(12):1288.

18.

Change in the new psychoactive substances associated with Emergency Department acute toxicity presentations associated with the introduction of the UK 2016 Psychoactive Substances Act.

Webb NE, Wood DM, Greene SL, Hunter LJ, Archer JRH, Dines AM, Dargan PI.

Clin Toxicol (Phila). 2019 Jan;57(1):36-41. doi: 10.1080/15563650.2018.1494277. Epub 2018 Aug 1.

PMID:
30067112
19.

Concurrent Use of Benzodiazepine by Heroin Users-What Are the Prevalence and the Risks Associated with This Pattern of Use?

Yamamoto T, Dargan PI, Dines A, Yates C, Heyerdahl F, Hovda KE, Giraudon I, Sedefov R, Wood DM; Euro-DEN Research Group.

J Med Toxicol. 2019 Jan;15(1):4-11. doi: 10.1007/s13181-018-0674-4. Epub 2018 Jul 31.

PMID:
30066312
20.

Gadolinium deposition and the potential for toxicological sequelae - A literature review of issues surrounding gadolinium-based contrast agents.

Layne KA, Dargan PI, Archer JRH, Wood DM.

Br J Clin Pharmacol. 2018 Nov;84(11):2522-2534. doi: 10.1111/bcp.13718. Epub 2018 Aug 17. Review.

PMID:
30032482
21.

Epidemiology of adolescent substance use in Norfolk schools.

Roderick E, Penney J, Murrells T, Dargan PI, Norman IJ.

QJM. 2018 Oct 1;111(10):699-706. doi: 10.1093/qjmed/hcy153.

PMID:
30016528
22.

Pesticide-Poisoned Patients: Can They Be Used as Potential Organ Donors?

Mistry U, Dargan PI, Wood DM.

J Med Toxicol. 2018 Dec;14(4):278-282. doi: 10.1007/s13181-018-0673-5. Epub 2018 Jul 9.

PMID:
29987646
23.

Patterns of Acute Toxicity Associated with New Psychoactive Substances.

Hill SL, Dargan PI.

Handb Exp Pharmacol. 2018;252:475-494. doi: 10.1007/164_2018_135.

PMID:
29896654
24.

Assessment of the Availability, Cost, and Motivations for Use over Time of the New Psychoactive Substances-Benzodiazepines Diclazepam, Flubromazepam, and Pyrazolam-in the UK.

Abouchedid R, Gilks T, Dargan PI, Archer JRH, Wood DM.

J Med Toxicol. 2018 Jun;14(2):134-143. doi: 10.1007/s13181-018-0659-3. Epub 2018 Apr 18.

25.

Acute recreational drug toxicity: Comparison of self-reports and results of immunoassay and additional analytical methods in a multicenter European case series.

Liakoni E, Yates C, Dines AM, Dargan PI, Heyerdahl F, Hovda KE, Wood DM, Eyer F, Liechti ME; Euro-DEN Plus Research Group.

Medicine (Baltimore). 2018 Feb;97(5):e9784. doi: 10.1097/MD.0000000000009784.

26.

Baclofen in gamma-hydroxybutyrate withdrawal: patterns of use and online availability.

Floyd CN, Wood DM, Dargan PI.

Eur J Clin Pharmacol. 2018 Mar;74(3):349-356. doi: 10.1007/s00228-017-2387-z. Epub 2017 Dec 3. Review.

27.

Risk stratification after paracetamol overdose using mechanistic biomarkers: results from two prospective cohort studies.

Dear JW, Clarke JI, Francis B, Allen L, Wraight J, Shen J, Dargan PI, Wood D, Cooper J, Thomas SHL, Jorgensen AL, Pirmohamed M, Park BK, Antoine DJ.

Lancet Gastroenterol Hepatol. 2018 Feb;3(2):104-113. doi: 10.1016/S2468-1253(17)30266-2. Epub 2017 Nov 14.

28.

Human Toxicity Caused by Indole and Indazole Carboxylate Synthetic Cannabinoid Receptor Agonists: From Horizon Scanning to Notification.

Hill SL, Dunn M, Cano C, Harnor SJ, Hardcastle IR, Grundlingh J, Dargan PI, Wood DM, Tucker S, Bartram T, Thomas SHL.

Clin Chem. 2018 Feb;64(2):346-354. doi: 10.1373/clinchem.2017.275867. Epub 2017 Oct 16.

29.

Metal-on-Metal Hip Joint Prostheses: a Retrospective Case Series Investigating the Association of Systemic Toxicity with Serum Cobalt and Chromium Concentrations.

Ho JH, Leikin JB, Dargan PI, Archer JRH, Wood DM, Brent J.

J Med Toxicol. 2017 Dec;13(4):321-328. doi: 10.1007/s13181-017-0629-1. Epub 2017 Sep 12.

30.

The toxicity of paracetamol-codeine combination in overdose is an unresolved issue.

Floyd CN, Dargan PI.

Br J Clin Pharmacol. 2018 Apr;84(4):806-807. doi: 10.1111/bcp.13362. Epub 2017 Jul 30. No abstract available.

31.

Activated charcoal significantly reduces the amount of colchicine released from Gloriosa superba in simulated gastric and intestinal media.

Zawahir S, Gawarammana I, Dargan PI, Abdulghni M, Dawson AH.

Clin Toxicol (Phila). 2017 Sep;55(8):914-918. doi: 10.1080/15563650.2017.1325897. Epub 2017 May 23.

32.

Analytical confirmation of synthetic cannabinoids in a cohort of 179 presentations with acute recreational drug toxicity to an Emergency Department in London, UK in the first half of 2015.

Abouchedid R, Hudson S, Thurtle N, Yamamoto T, Ho JH, Bailey G, Wood M, Sadones N, Stove CP, Dines A, Archer JRH, Wood DM, Dargan PI.

Clin Toxicol (Phila). 2017 Jun;55(5):338-345. doi: 10.1080/15563650.2017.1287373. Epub 2017 Feb 20.

PMID:
28421836
33.

The impact of the Psychoactive Substances Act 2016 on the online availability of MDMB-CHMICA.

Haden M, Wood DM, Dargan PI.

QJM. 2017 Oct 1;110(10):619-622. doi: 10.1093/qjmed/hcx045.

PMID:
28339898
34.

The dark cloud of recreational drugs and vaping.

Blundell MS, Dargan PI, Wood DM.

QJM. 2018 Mar 1;111(3):145-148. doi: 10.1093/qjmed/hcx049. Review.

PMID:
28339800
35.

Outcomes from massive paracetamol overdose: a retrospective observational study.

Marks DJB, Dargan PI, Archer JRH, Davies CL, Dines AM, Wood DM, Greene SL.

Br J Clin Pharmacol. 2017 Jun;83(6):1263-1272. doi: 10.1111/bcp.13214. Epub 2017 Jan 25.

36.

Erratum to: Psychosis associated with acute recreational drug toxicity: a European case series.

Vallersnes OM, Dines AM, Wood DM, Yates C, Heyerdahl F, Hovda KE, Giraudon I; Euro-DEN Research Group, Dargan PI.

BMC Psychiatry. 2016 Nov 16;16(1):405. No abstract available.

37.

Circulating acetaminophen metabolites are toxicokinetic biomarkers of acute liver injury.

Vliegenthart A, Kimmitt RA, Seymour JH, Homer NZ, Clarke JI, Eddleston M, Gray A, Wood DM, Dargan PI, Cooper JG, Antoine DJ, Webb DJ, Lewis SC, Bateman DN, Dear JW.

Clin Pharmacol Ther. 2017 Apr;101(4):531-540. doi: 10.1002/cpt.541. Epub 2016 Nov 30.

38.

MDMB-CHMICA: Availability, Patterns of Use, and Toxicity Associated With This Novel Psychoactive Substance.

Haden M, Archer JR, Dargan PI, Wood DM.

Subst Use Misuse. 2017 Jan 28;52(2):223-232. Epub 2016 Oct 19. Review.

PMID:
27759479
39.

Management of body stuffers presenting to the emergency department.

Yamamoto T, Malavasi E, Archer JR, Dargan PI, Wood DM.

Eur J Emerg Med. 2016 Dec;23(6):425-429.

PMID:
25969343
40.

Improving GHB withdrawal with baclofen: study protocol for a feasibility study for a randomised controlled trial.

Lingford-Hughes A, Patel Y, Bowden-Jones O, Crawford MJ, Dargan PI, Gordon F, Parrott S, Weaver T, Wood DM.

Trials. 2016 Sep 27;17(1):472.

41.

Prevalence of Use of Electronic Nicotine Delivery Systems (ENDS) to Vape Recreational Drugs by Club Patrons in South London.

Thurtle N, Abouchedid R, Archer JR, Ho J, Yamamoto T, Dargan PI, Wood DM.

J Med Toxicol. 2017 Mar;13(1):61-65. doi: 10.1007/s13181-016-0583-3. Epub 2016 Sep 6.

42.

Microwave-assisted on-spot derivatization for gas chromatography-mass spectrometry based determination of polar low molecular weight compounds in dried blood spots.

Sadones N, Van Bever E, Archer JR, Wood DM, Dargan PI, Van Bortel L, Lambert WE, Stove CP.

J Chromatogr A. 2016 Sep 23;1465:175-83. doi: 10.1016/j.chroma.2016.08.057. Epub 2016 Aug 26.

PMID:
27578413
43.

Urine Toxicology in Adults Evaluated for a Central Hypersomnia and How the Results Modify the Physician's Diagnosis.

Kosky CA, Bonakis A, Yogendran A, Hettiarachchi G, Dargan PI, Williams AJ.

J Clin Sleep Med. 2016 Nov 15;12(11):1499-1505.

44.

An assessment of the variation in the concentration of acetylcysteine in infusions for the treatment of paracetamol overdose.

Bailey GP, Wood DM, Archer JR, Rab E, Flanagan RJ, Dargan PI.

Br J Clin Pharmacol. 2017 Feb;83(2):393-399. doi: 10.1111/bcp.13099. Epub 2016 Sep 29.

45.

Psychosis associated with acute recreational drug toxicity: a European case series.

Vallersnes OM, Dines AM, Wood DM, Yates C, Heyerdahl F, Hovda KE, Giraudon I; Euro-DEN Research Group, Dargan PI.

BMC Psychiatry. 2016 Aug 18;16:293. doi: 10.1186/s12888-016-1002-7. Erratum in: BMC Psychiatry. 2016 Nov 16;16(1):405.

46.

Polonium-210 poisoning: a first-hand account.

Nathwani AC, Down JF, Goldstone J, Yassin J, Dargan PI, Virchis A, Gent N, Lloyd D, Harrison JD.

Lancet. 2016 Sep 10;388(10049):1075-1080. doi: 10.1016/S0140-6736(16)00144-6. Epub 2016 Jul 23.

PMID:
27461439
47.

Acute Toxicity Associated with Use of 5F-Derivations of Synthetic Cannabinoid Receptor Agonists with Analytical Confirmation.

Abouchedid R, Ho JH, Hudson S, Dines A, Archer JR, Wood DM, Dargan PI.

J Med Toxicol. 2016 Dec;12(4):396-401. Epub 2016 Jul 25.

48.

Delays during the administration of acetylcysteine for the treatment of paracetamol overdose.

Bailey GP, Najafi J, Elamin ME, Waring WS, Thomas SH, Archer JR, Wood DM, Dargan PI.

Br J Clin Pharmacol. 2016 Nov;82(5):1358-1363. doi: 10.1111/bcp.13063. Epub 2016 Aug 10.

49.

Taking stock: UK national antidote availability increasing, but further improvements are required.

Bailey GP, Rehman B, Wind K, Wood DM, Thanacoody R, Nash S, Archer J, Eddleston M, Thompson JP, Vale JA, Thomas S, Dargan PI.

Eur J Hosp Pharm Sci Pract. 2016 May;23(3):145-150. doi: 10.1136/ejhpharm-2015-000802. Epub 2015 Nov 18.

50.

Phenibut (4-amino-3-phenyl-butyric acid): Availability, prevalence of use, desired effects and acute toxicity.

Owen DR, Wood DM, Archer JR, Dargan PI.

Drug Alcohol Rev. 2016 Sep;35(5):591-6. doi: 10.1111/dar.12356. Epub 2015 Dec 23.

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