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Items: 31


Cancer therapies activate RIG-I-like receptor pathway through endogenous non-coding RNAs.

Ranoa DR, Parekh AD, Pitroda SP, Huang X, Darga T, Wong AC, Huang L, Andrade J, Staley JP, Satoh T, Akira S, Weichselbaum RR, Khodarev NN.

Oncotarget. 2016 May 3;7(18):26496-515. doi: 10.18632/oncotarget.8420.


14q32-encoded microRNAs mediate an oligometastatic phenotype.

Uppal A, Wightman SC, Mallon S, Oshima G, Pitroda SP, Zhang Q, Huang X, Darga TE, Huang L, Andrade J, Liu H, Ferguson MK, Greene GL, Posner MC, Hellman S, Khodarev NN, Weichselbaum RR.

Oncotarget. 2015 Feb 28;6(6):3540-52.


STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors.

Deng L, Liang H, Xu M, Yang X, Burnette B, Arina A, Li XD, Mauceri H, Beckett M, Darga T, Huang X, Gajewski TF, Chen ZJ, Fu YX, Weichselbaum RR.

Immunity. 2014 Nov 20;41(5):843-52. doi: 10.1016/j.immuni.2014.10.019. Epub 2014 Nov 6.


DNA repair pathway gene expression score correlates with repair proficiency and tumor sensitivity to chemotherapy.

Pitroda SP, Pashtan IM, Logan HL, Budke B, Darga TE, Weichselbaum RR, Connell PP.

Sci Transl Med. 2014 Mar 26;6(229):229ra42. doi: 10.1126/scitranslmed.3008291.


RIG-I-like receptor LGP2 protects tumor cells from ionizing radiation.

Widau RC, Parekh AD, Ranck MC, Golden DW, Kumar KA, Sood RF, Pitroda SP, Liao Z, Huang X, Darga TE, Xu D, Huang L, Andrade J, Roizman B, Weichselbaum RR, Khodarev NN.

Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):E484-91. doi: 10.1073/pnas.1323253111. Epub 2014 Jan 13.


Irradiation and anti-PD-L1 treatment synergistically promote antitumor immunity in mice.

Deng L, Liang H, Burnette B, Beckett M, Darga T, Weichselbaum RR, Fu YX.

J Clin Invest. 2014 Feb;124(2):687-95. doi: 10.1172/JCI67313. Epub 2014 Jan 2.


Radiation-induced equilibrium is a balance between tumor cell proliferation and T cell-mediated killing.

Liang H, Deng L, Chmura S, Burnette B, Liadis N, Darga T, Beckett MA, Lingen MW, Witt M, Weichselbaum RR, Fu YX.

J Immunol. 2013 Jun 1;190(11):5874-81. doi: 10.4049/jimmunol.1202612. Epub 2013 Apr 29.


Oligo- and polymetastatic progression in lung metastasis(es) patients is associated with specific microRNAs.

Lussier YA, Khodarev NN, Regan K, Corbin K, Li H, Ganai S, Khan SA, Gnerlich JL, Darga TE, Fan H, Karpenko O, Paty PB, Posner MC, Chmura SJ, Hellman S, Ferguson MK, Weichselbaum RR.

PLoS One. 2012;7(12):e50141. doi: 10.1371/journal.pone.0050141. Epub 2012 Dec 10. Erratum in: PLoS One. 2013;8(6). doi: 10.1371/annotation/2489ae5e-3650-4897-8df6-3e974ca585c4. Gnerlich, Jennifer [corrected to Gnerlich, Jennifer L].


A phase I dose escalation study of Ad GV.EGR.TNF.11D (TNFerade™ Biologic) with concurrent chemoradiotherapy in patients with recurrent head and neck cancer undergoing reirradiation.

Seiwert TY, Darga T, Haraf D, Blair EA, Stenson K, Cohen EE, Salama JK, Villaflor V, Witt ME, Lingen MW, Weichselbaum RR, Vokes EE.

Ann Oncol. 2013 Mar;24(3):769-76. doi: 10.1093/annonc/mds523. Epub 2012 Oct 26.


Tumor endothelial inflammation predicts clinical outcome in diverse human cancers.

Pitroda SP, Zhou T, Sweis RF, Filippo M, Labay E, Beckett MA, Mauceri HJ, Liang H, Darga TE, Perakis S, Khan SA, Sutton HG, Zhang W, Khodarev NN, Garcia JG, Weichselbaum RR.

PLoS One. 2012;7(10):e46104. doi: 10.1371/journal.pone.0046104. Epub 2012 Oct 4.


Radiation-inducible immunotherapy for cancer: senescent tumor cells as a cancer vaccine.

Meng Y, Efimova EV, Hamzeh KW, Darga TE, Mauceri HJ, Fu YX, Kron SJ, Weichselbaum RR.

Mol Ther. 2012 May;20(5):1046-55. doi: 10.1038/mt.2012.19. Epub 2012 Feb 14.


Everolimus exhibits efficacy as a radiosensitizer in a model of non-small cell lung cancer.

Mauceri HJ, Sutton HG, Darga TE, Kocherginsky M, Kochanski J, Weichselbaum RR, Vokes EE.

Oncol Rep. 2012 May;27(5):1625-9. doi: 10.3892/or.2012.1666. Epub 2012 Jan 27.


MicroRNA expression characterizes oligometastasis(es).

Lussier YA, Xing HR, Salama JK, Khodarev NN, Huang Y, Zhang Q, Khan SA, Yang X, Hasselle MD, Darga TE, Malik R, Fan H, Perakis S, Filippo M, Corbin K, Lee Y, Posner MC, Chmura SJ, Hellman S, Weichselbaum RR.

PLoS One. 2011;6(12):e28650. doi: 10.1371/journal.pone.0028650. Epub 2011 Dec 13.


p50 (NF-κB1) is an effector protein in the cytotoxic response to DNA methylation damage.

Schmitt AM, Crawley CD, Kang S, Raleigh DR, Yu X, Wahlstrom JS, Voce DJ, Darga TE, Weichselbaum RR, Yamini B.

Mol Cell. 2011 Dec 9;44(5):785-96. doi: 10.1016/j.molcel.2011.09.026.


SOD2-mediated adaptive responses induced by low-dose ionizing radiation via TNF signaling and amifostine.

Murley JS, Baker KL, Miller RC, Darga TE, Weichselbaum RR, Grdina DJ.

Free Radic Biol Med. 2011 Nov 15;51(10):1918-25. doi: 10.1016/j.freeradbiomed.2011.08.032. Epub 2011 Sep 3.


Response of human prostate cancer cells and tumors to combining PARP inhibition with ionizing radiation.

Barreto-Andrade JC, Efimova EV, Mauceri HJ, Beckett MA, Sutton HG, Darga TE, Vokes EE, Posner MC, Kron SJ, Weichselbaum RR.

Mol Cancer Ther. 2011 Jul;10(7):1185-93. doi: 10.1158/1535-7163.MCT-11-0061. Epub 2011 May 13.


Poly(ADP-ribose) polymerase inhibitor induces accelerated senescence in irradiated breast cancer cells and tumors.

Efimova EV, Mauceri HJ, Golden DW, Labay E, Bindokas VP, Darga TE, Chakraborty C, Barreto-Andrade JC, Crawley C, Sutton HG, Kron SJ, Weichselbaum RR.

Cancer Res. 2010 Aug 1;70(15):6277-82. doi: 10.1158/0008-5472.CAN-09-4224. Epub 2010 Jul 7.


Ad.Egr-TNF and local ionizing radiation suppress metastases by interferon-beta-dependent activation of antigen-specific CD8+ T cells.

Meng Y, Mauceri HJ, Khodarev NN, Darga TE, Pitroda SP, Beckett MA, Kufe DW, Weichselbaum RR.

Mol Ther. 2010 May;18(5):912-20. doi: 10.1038/mt.2010.18. Epub 2010 Mar 2.


STAT1 pathway mediates amplification of metastatic potential and resistance to therapy.

Khodarev NN, Roach P, Pitroda SP, Golden DW, Bhayani M, Shao MY, Darga TE, Beveridge MG, Sood RF, Sutton HG, Beckett MA, Mauceri HJ, Posner MC, Weichselbaum RR.

PLoS One. 2009 Jun 8;4(6):e5821. doi: 10.1371/journal.pone.0005821.


Radioresistance of Stat1 over-expressing tumour cells is associated with suppressed apoptotic response to cytotoxic agents and increased IL6-IL8 signalling.

Efimova EV, Liang H, Pitroda SP, Labay E, Darga TE, Levina V, Lokshin A, Roizman B, Weichselbaum RR, Khodarev NN.

Int J Radiat Biol. 2009 May;85(5):421-31. doi: 10.1080/09553000902838566. Erratum in: Int J Radiat Biol. 2009 Jul;85(7):642.


Translational strategies exploiting TNF-alpha that sensitize tumors to radiation therapy.

Mauceri HJ, Beckett MA, Liang H, Sutton HG, Pitroda S, Galka E, Efimova E, Darga T, Khodarev NN, King CR, Posner MC, Hellman S, Kufe DW, Weichselbaum RR.

Cancer Gene Ther. 2009 Apr;16(4):373-81. doi: 10.1038/cgt.2008.86. Epub 2008 Oct 31.


Diverse TNFalpha-induced death pathways are enhanced by inhibition of NF-kappaB.

Katdare M, Efimova EV, Labay E, Khodarev NN, Darga TE, Garofalo M, Nakamura S, Kufe DW, Posner MC, Weichselbaum RR.

Int J Oncol. 2007 Dec;31(6):1519-28.


Signal transducer and activator of transcription 1 regulates both cytotoxic and prosurvival functions in tumor cells.

Khodarev NN, Minn AJ, Efimova EV, Darga TE, Labay E, Beckett M, Mauceri HJ, Roizman B, Weichselbaum RR.

Cancer Res. 2007 Oct 1;67(19):9214-20.


Inhibition of nuclear factor-kappaB activity by temozolomide involves O6-methylguanine induced inhibition of p65 DNA binding.

Yamini B, Yu X, Dolan ME, Wu MH, Darga TE, Kufe DW, Weichselbaum RR.

Cancer Res. 2007 Jul 15;67(14):6889-98. Erratum in: Cancer Res. 2009 Feb 15;69(4):1695. Darga, Thomas E [added].


Ionizing radiation activates late herpes simplex virus 1 promoters via the p38 pathway in tumors treated with oncolytic viruses.

Mezhir JJ, Advani SJ, Smith KD, Darga TE, Poon AP, Schmidt H, Posner MC, Roizman B, Weichselbaum RR.

Cancer Res. 2005 Oct 15;65(20):9479-84.


Progression of Barrett's metaplasia to adenocarcinoma is associated with the suppression of the transcriptional programs of epidermal differentiation.

Kimchi ET, Posner MC, Park JO, Darga TE, Kocherginsky M, Karrison T, Hart J, Smith KD, Mezhir JJ, Weichselbaum RR, Khodarev NN.

Cancer Res. 2005 Apr 15;65(8):3146-54.


Glioblastoma cells block radiation-induced programmed cell death of endothelial cells.

Brown CK, Khodarev NN, Yu J, Moo-Young T, Labay E, Darga TE, Posner MC, Weichselbaum RR, Mauceri HJ.

FEBS Lett. 2004 May 7;565(1-3):167-70.


STAT1 is overexpressed in tumors selected for radioresistance and confers protection from radiation in transduced sensitive cells.

Khodarev NN, Beckett M, Labay E, Darga T, Roizman B, Weichselbaum RR.

Proc Natl Acad Sci U S A. 2004 Feb 10;101(6):1714-9. Epub 2004 Jan 30.


Endothelial cells co-cultured with wild-type and dominant/negative p53-transfected glioblastoma cells exhibit differential sensitivity to radiation-induced apoptosis.

Khodarev NN, Labay E, Darga T, Yu J, Mauceri H, Gupta N, Kataoka Y, Weichselbaum RR.

Int J Cancer. 2004 Mar 20;109(2):214-9.


Tumour-endothelium interactions in co-culture: coordinated changes of gene expression profiles and phenotypic properties of endothelial cells.

Khodarev NN, Yu J, Labay E, Darga T, Brown CK, Mauceri HJ, Yassari R, Gupta N, Weichselbaum RR.

J Cell Sci. 2003 Mar 15;116(Pt 6):1013-22.


Transcriptional control of viral gene therapy by cisplatin.

Park JO, Lopez CA, Gupta VK, Brown CK, Mauceri HJ, Darga TE, Manan A, Hellman S, Posner MC, Kufe DW, Weichselbaum RR.

J Clin Invest. 2002 Aug;110(3):403-10.

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