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Safety and Efficacy of the Addition of Lapatinib to Perioperative Chemotherapy for Resectable HER2-Positive Gastroesophageal Adenocarcinoma: A Randomized Phase 2 Clinical Trial.

Smyth EC, Rowley S, Cafferty FH, Allum W, Grabsch HI, Stenning S, Wotherspoon A, Alderson D, Crosby T, Mansoor W, Waters JS, Neville-Webbe H, Darby S, Dent J, Seymour M, Thompson J, Sothi S, Blazeby J, Langley RE, Cunningham D.

JAMA Oncol. 2019 Jun 20. doi: 10.1001/jamaoncol.2019.1179. [Epub ahead of print]


Endocrine therapy in the years following a diagnosis of breast cancer: A proof of concept study using the primary care prescription database linked to cancer registration data.

Emanuel G, Henson KE, Broggio J, Charman J, Horgan K, Dodwell D, Darby SC.

Cancer Epidemiol. 2019 May 21. pii: S1877-7821(18)30565-4. doi: 10.1016/j.canep.2019.04.012. [Epub ahead of print]


International Variation in Criteria for Internal Mammary Chain Radiotherapy.

Duane FK, McGale P, Teoh S, Mortimer C, Broggio J, Darby SC, Dodwell D, Lavery B, Oliveros S, Vallis KA, Taylor CW.

Clin Oncol (R Coll Radiol). 2019 Jul;31(7):453-461. doi: 10.1016/j.clon.2019.04.007. Epub 2019 May 3.


Water quality modelling of the Mekong River basin: Climate change and socioeconomics drive flow and nutrient flux changes to the Mekong Delta.

Whitehead PG, Jin L, Bussi G, Voepel HE, Darby SE, Vasilopoulos G, Manley R, Rodda H, Hutton C, Hackney C, Tri VPD, Hung NN.

Sci Total Environ. 2019 Jul 10;673:218-229. doi: 10.1016/j.scitotenv.2019.03.315. Epub 2019 Apr 6.


Self-sharpening induces jet-like structure in seafloor gravity currents.

Dorrell RM, Peakall J, Darby SE, Parsons DR, Johnson J, Sumner EJ, Wynn RB, Özsoy E, Tezcan D.

Nat Commun. 2019 Mar 27;10(1):1381. doi: 10.1038/s41467-019-09254-2.


Impacts of natural and human drivers on the multi-decadal morphological evolution of tidally-influenced deltas.

Angamuthu B, Darby SE, Nicholls RJ.

Proc Math Phys Eng Sci. 2018 Nov;474(2219):20180396. doi: 10.1098/rspa.2018.0396. Epub 2018 Nov 7.


Clinical Intensity Modulated Proton Therapy for Hodgkin Lymphoma: Which Patients Benefit the Most?

Ntentas G, Dedeckova K, Andrlik M, Aznar MC, George B, Kubeš J, Darby SC, Cutter DJ.

Pract Radiat Oncol. 2019 May;9(3):179-187. doi: 10.1016/j.prro.2019.01.006. Epub 2019 Jan 29.


Cardiac Structure Doses in Women Irradiated for Breast Cancer in the Past and Their Use in Epidemiological Studies.

Duane FK, McGale P, Brønnum D, Cutter DJ, Darby SC, Ewertz M, Hackett S, Hall P, Lorenzen EL, Rahimi K, Wang Z, Warren S, Taylor CW.

Pract Radiat Oncol. 2019 May;9(3):158-171. doi: 10.1016/j.prro.2019.01.004. Epub 2019 Jan 26.


Radiation Dose-Response for Risk of Myocardial Infarction in Breast Cancer Survivors.

Jacobse JN, Duane FK, Boekel NB, Schaapveld M, Hauptmann M, Hooning MJ, Seynaeve CM, Baaijens MHA, Gietema JA, Darby SC, van Leeuwen FE, Aleman BMP, Taylor CW.

Int J Radiat Oncol Biol Phys. 2019 Mar 1;103(3):595-604. doi: 10.1016/j.ijrobp.2018.10.025. Epub 2018 Oct 29.


Recent sediment flux to the Ganges-Brahmaputra-Meghna delta system.

Rahman M, Dustegir M, Karim R, Haque A, Nicholls RJ, Darby SE, Nakagawa H, Hossain M, Dunn FE, Akter M.

Sci Total Environ. 2018 Dec 1;643:1054-1064. doi: 10.1016/j.scitotenv.2018.06.147. Epub 2018 Jun 28.


Cardiovascular disease incidence after internal mammary chain irradiation and anthracycline-based chemotherapy for breast cancer.

Boekel NB, Jacobse JN, Schaapveld M, Hooning MJ, Gietema JA, Duane FK, Taylor CW, Darby SC, Hauptmann M, Seynaeve CM, Baaijens MHA, Sonke GS, Rutgers EJT, Russell NS, Aleman BMP, van Leeuwen FE.

Br J Cancer. 2018 Aug;119(4):408-418. doi: 10.1038/s41416-018-0159-x. Epub 2018 Aug 1.


Projections of historical and 21st century fluvial sediment delivery to the Ganges-Brahmaputra-Meghna, Mahanadi, and Volta deltas.

Dunn FE, Nicholls RJ, Darby SE, Cohen S, Zarfl C, Fekete BM.

Sci Total Environ. 2018 Nov 15;642:105-116. doi: 10.1016/j.scitotenv.2018.06.006. Epub 2018 Jun 14.


Cardiac Structure Injury After Radiotherapy for Breast Cancer: Cross-Sectional Study With Individual Patient Data.

Taylor C, McGale P, Brønnum D, Correa C, Cutter D, Duane FK, Gigante B, Jensen MB, Lorenzen E, Rahimi K, Wang Z, Darby SC, Hall P, Ewertz M.

J Clin Oncol. 2018 Aug 1;36(22):2288-2296. doi: 10.1200/JCO.2017.77.6351. Epub 2018 May 23.


Case Report of Wernicke's Encephalopathy After Sleeve Gastrectomy.

Hamilton LA, Darby SH, Hamilton AJ, Wilkerson MH, Morgan KA.

Nutr Clin Pract. 2018 Aug;33(4):510-514. doi: 10.1177/0884533617722758. Epub 2017 Dec 14.


Reaching a 1.5°C target: socio-technical challenges for a rapid transition to low-carbon electricity systems.

Eyre N, Darby SJ, Grünewald P, McKenna E, Ford R.

Philos Trans A Math Phys Eng Sci. 2018 May 13;376(2119). pii: 20160462. doi: 10.1098/rsta.2016.0462.


Changing sediment budget of the Mekong: Cumulative threats and management strategies for a large river basin.

Kondolf GM, Schmitt RJP, Carling P, Darby S, Arias M, Bizzi S, Castelletti A, Cochrane TA, Gibson S, Kummu M, Oeurng C, Rubin Z, Wild T.

Sci Total Environ. 2018 Jun 1;625:114-134. doi: 10.1016/j.scitotenv.2017.11.361. Epub 2017 Dec 27.


Exposure of the lungs in breast cancer radiotherapy: A systematic review of lung doses published 2010-2015.

Aznar MC, Duane FK, Darby SC, Wang Z, Taylor CW.

Radiother Oncol. 2018 Jan;126(1):148-154. doi: 10.1016/j.radonc.2017.11.022. Epub 2017 Dec 12. Review.


National Testing of the Nursing-Kids Intensity of Care Survey for Pediatric Long-term Care.

Hessels AJ, Darby SW, Simpser E, Saiman L, Larson EL.

J Pediatr Nurs. 2017 Nov - Dec;37:86-90. doi: 10.1016/j.pedn.2017.08.026. Epub 2017 Aug 30.


Risk of heart disease in relation to radiotherapy and chemotherapy with anthracyclines among 19,464 breast cancer patients in Denmark, 1977-2005.

Rehammar JC, Jensen MB, McGale P, Lorenzen EL, Taylor C, Darby SC, Videbæk L, Wang Z, Ewertz M.

Radiother Oncol. 2017 May;123(2):299-305. doi: 10.1016/j.radonc.2017.03.012. Epub 2017 Mar 30.


A cardiac contouring atlas for radiotherapy.

Duane F, Aznar MC, Bartlett F, Cutter DJ, Darby SC, Jagsi R, Lorenzen EL, McArdle O, McGale P, Myerson S, Rahimi K, Vivekanandan S, Warren S, Taylor CW.

Radiother Oncol. 2017 Mar;122(3):416-422. doi: 10.1016/j.radonc.2017.01.008. Epub 2017 Feb 21.


Long-term hospitalisation rates among 5-year survivors of Hodgkin lymphoma in adolescence or young adulthood: A nationwide cohort study.

Rugbjerg K, Maraldo M, Aznar MC, Cutter DJ, Darby SC, Specht L, Olsen JH.

Int J Cancer. 2017 May 15;140(10):2232-2245. doi: 10.1002/ijc.30655. Epub 2017 Mar 14.


Peri-operative chemotherapy with or without bevacizumab in operable oesophagogastric adenocarcinoma (UK Medical Research Council ST03): primary analysis results of a multicentre, open-label, randomised phase 2-3 trial.

Cunningham D, Stenning SP, Smyth EC, Okines AF, Allum WH, Rowley S, Stevenson L, Grabsch HI, Alderson D, Crosby T, Griffin SM, Mansoor W, Coxon FY, Falk SJ, Darby S, Sumpter KA, Blazeby JM, Langley RE.

Lancet Oncol. 2017 Mar;18(3):357-370. doi: 10.1016/S1470-2045(17)30043-8. Epub 2017 Feb 3.


Risk of heart failure in survivors of Hodgkin lymphoma: effects of cardiac exposure to radiation and anthracyclines.

van Nimwegen FA, Ntentas G, Darby SC, Schaapveld M, Hauptmann M, Lugtenburg PJ, Janus CPM, Daniels L, van Leeuwen FE, Cutter DJ, Aleman BMP.

Blood. 2017 Apr 20;129(16):2257-2265. doi: 10.1182/blood-2016-09-740332. Epub 2017 Jan 31.


Comparison of adjuvant gemcitabine and capecitabine with gemcitabine monotherapy in patients with resected pancreatic cancer (ESPAC-4): a multicentre, open-label, randomised, phase 3 trial.

Neoptolemos JP, Palmer DH, Ghaneh P, Psarelli EE, Valle JW, Halloran CM, Faluyi O, O'Reilly DA, Cunningham D, Wadsley J, Darby S, Meyer T, Gillmore R, Anthoney A, Lind P, Glimelius B, Falk S, Izbicki JR, Middleton GW, Cummins S, Ross PJ, Wasan H, McDonald A, Crosby T, Ma YT, Patel K, Sherriff D, Soomal R, Borg D, Sothi S, Hammel P, Hackert T, Jackson R, Büchler MW; European Study Group for Pancreatic Cancer.

Lancet. 2017 Mar 11;389(10073):1011-1024. doi: 10.1016/S0140-6736(16)32409-6. Epub 2017 Jan 25.


Sorafenib for the Treatment of Advanced Hepatocellular Cancer - a UK Audit.

King J, Palmer DH, Johnson P, Ross P, Hubner RA, Sumpter K, Darby S, Braconi C, Iwuji C, Swinson D, Collins P, Patel K, Nobes J, Muazzam I, Blesing C, Kirkwood A, Nash S, Meyer T.

Clin Oncol (R Coll Radiol). 2017 Apr;29(4):256-262. doi: 10.1016/j.clon.2016.11.012. Epub 2016 Dec 10.


Identification of a novel K311 ubiquitination site critical for androgen receptor transcriptional activity.

McClurg UL, Cork DMW, Darby S, Ryan-Munden CA, Nakjang S, Mendes Côrtes L, Treumann A, Gaughan L, Robson CN.

Nucleic Acids Res. 2017 Feb 28;45(4):1793-1804. doi: 10.1093/nar/gkw1162.


Cardiac Mortality Among 200 000 Five-Year Survivors of Cancer Diagnosed at 15 to 39 Years of Age: The Teenage and Young Adult Cancer Survivor Study.

Henson KE, Reulen RC, Winter DL, Bright CJ, Fidler MM, Frobisher C, Guha J, Wong KF, Kelly J, Edgar AB, McCabe MG, Whelan J, Cutter DJ, Darby SC, Hawkins MM.

Circulation. 2016 Nov 15;134(20):1519-1531. Epub 2016 Nov 7.


Fluvial sediment supply to a mega-delta reduced by shifting tropical-cyclone activity.

Darby SE, Hackney CR, Leyland J, Kummu M, Lauri H, Parsons DR, Best JL, Nicholas AP, Aalto R.

Nature. 2016 Nov 10;539(7628):276-279. doi: 10.1038/nature19809. Epub 2016 Oct 19.


Dose and Fractionation in Radiation Therapy of Curative Intent for Non-Small Cell Lung Cancer: Meta-Analysis of Randomized Trials.

Ramroth J, Cutter DJ, Darby SC, Higgins GS, McGale P, Partridge M, Taylor CW.

Int J Radiat Oncol Biol Phys. 2016 Nov 15;96(4):736-747. doi: 10.1016/j.ijrobp.2016.07.022. Epub 2016 Jul 25.


Control of Globular Protein Thermal Stability in Aqueous Formulations by the Positively Charged Amino Acid Excipients.

Platts L, Darby SJ, Falconer RJ.

J Pharm Sci. 2016 Dec;105(12):3532-3536. doi: 10.1016/j.xphs.2016.09.013. Epub 2016 Oct 21.


Cumulative burden of disease: a relevant measure of the late side-effects of cancer treatment.

Aznar MC, Darby S, Collins GP, Cutter D.

Lancet Oncol. 2016 Sep;17(9):1189-90. doi: 10.1016/S1470-2045(16)30283-2. Epub 2016 Jul 25. No abstract available.


Can Observational Data Replace Randomized Trials?

McGale P, Cutter D, Darby SC, Henson KE, Jagsi R, Taylor CW.

J Clin Oncol. 2016 Sep 20;34(27):3355-7. doi: 10.1200/JCO.2016.68.8879. Epub 2016 Jul 25. No abstract available.


A multicentre comparison between Child Pugh and Albumin-Bilirubin scores in patients treated with sorafenib for Hepatocellular Carcinoma.

Edeline J, Blanc JF, Johnson P, Campillo-Gimenez B, Ross P, Ma YT, King J, Hubner RA, Sumpter K, Darby S, Evans J, Iwuji C, Swinson D, Collins P, Patel K, Muazzam I, Palmer DH, Meyer T.

Liver Int. 2016 Dec;36(12):1821-1828. doi: 10.1111/liv.13170. Epub 2016 Jun 22.


Reply to D. Vordermark and T. Pelz and R. Mazzola et al.

van Nimwegen FA, Cutter DJ, Schaapveld M, Darby SC, Aleman BM, van Leeuwen FE.

J Clin Oncol. 2016 Aug 20;34(24):2941-2. doi: 10.1200/JCO.2016.67.4358. Epub 2016 May 2. No abstract available.


Evaluating sustainable adaptation strategies for vulnerable mega-deltas using system dynamics modelling: Rice agriculture in the Mekong Delta's An Giang Province, Vietnam.

Chapman A, Darby S.

Sci Total Environ. 2016 Jul 15;559:326-338. doi: 10.1016/j.scitotenv.2016.02.162. Epub 2016 Apr 12.


Uncertainties in estimating heart doses from 2D-tangential breast cancer radiotherapy.

Lorenzen EL, Brink C, Taylor CW, Darby SC, Ewertz M.

Radiother Oncol. 2016 Apr;119(1):71-6. doi: 10.1016/j.radonc.2016.02.017. Epub 2016 Feb 27.


Inferring the Effects of Cancer Treatment: Divergent Results From Early Breast Cancer Trialists' Collaborative Group Meta-Analyses of Randomized Trials and Observational Data From SEER Registries.

Henson KE, Jagsi R, Cutter D, McGale P, Taylor C, Darby SC.

J Clin Oncol. 2016 Mar 10;34(8):803-9. doi: 10.1200/JCO.2015.62.0294. Epub 2016 Jan 19. Retraction in: J Clin Oncol. 2016 Sep 20;34(27):3358-9.


Radiation Dose-Response Relationship for Risk of Coronary Heart Disease in Survivors of Hodgkin Lymphoma.

van Nimwegen FA, Schaapveld M, Cutter DJ, Janus CP, Krol AD, Hauptmann M, Kooijman K, Roesink J, van der Maazen R, Darby SC, Aleman BM, van Leeuwen FE.

J Clin Oncol. 2016 Jan 20;34(3):235-43. doi: 10.1200/JCO.2015.63.4444. Epub 2015 Nov 16.


Exposure of the Heart in Breast Cancer Radiation Therapy: A Systematic Review of Heart Doses Published During 2003 to 2013.

Taylor CW, Wang Z, Macaulay E, Jagsi R, Duane F, Darby SC.

Int J Radiat Oncol Biol Phys. 2015 Nov 15;93(4):845-53. doi: 10.1016/j.ijrobp.2015.07.2292. Epub 2015 Aug 3. Review.


A first look at the influence of anthropogenic climate change on the future delivery of fluvial sediment to the Ganges-Brahmaputra-Meghna delta.

Darby SE, Dunn FE, Nicholls RJ, Rahman M, Riddy L.

Environ Sci Process Impacts. 2015 Sep;17(9):1587-600. doi: 10.1039/c5em00252d. Epub 2015 Aug 20.


Cardiovascular disease after cancer therapy.

Aleman BM, Moser EC, Nuver J, Suter TM, Maraldo MV, Specht L, Vrieling C, Darby SC.

EJC Suppl. 2014 Jun;12(1):18-28. doi: 10.1016/j.ejcsup.2014.03.002. Epub 2014 May 29.


The complexity of condensed tannin binding to bovine serum albumin--An isothermal titration calorimetry study.

Kilmister RL, Faulkner P, Downey MO, Darby SJ, Falconer RJ.

Food Chem. 2016 Jan 1;190:173-178. doi: 10.1016/j.foodchem.2015.04.144. Epub 2015 May 6.


International Expert Consensus on Primary Systemic Therapy in the Management of Early Breast Cancer: Highlights of the Fifth Symposium on Primary Systemic Therapy in the Management of Operable Breast Cancer, Cremona, Italy (2013).

Amoroso V, Generali D, Buchholz T, Cristofanilli M, Pedersini R, Curigliano G, Daidone MG, Di Cosimo S, Dowsett M, Fox S, Harris AL, Makris A, Vassalli L, Ravelli A, Cappelletti MR, Hatzis C, Hudis CA, Pedrazzoli P, Sapino A, Semiglazov V, Von Minckwitz G, Simoncini EL, Jacobs MA, Barry P, Kühn T, Darby S, Hermelink K, Symmans F, Gennari A, Schiavon G, Dogliotti L, Berruti A, Bottini A.

J Natl Cancer Inst Monogr. 2015 May;2015(51):90-6. doi: 10.1093/jncimonographs/lgv023.


Patient blood management nurse vs transfusion nurse: is it time to merge?

Gallagher T, Darby S, Vodanovich M, Campbell L, Tovey J.

Br J Nurs. 2015 May 14-27;24(9):492-5. doi: 10.12968/bjon.2015.24.9.492.


Simple method to estimate mean heart dose from Hodgkin lymphoma radiation therapy according to simulation X-rays.

van Nimwegen FA, Cutter DJ, Schaapveld M, Rutten A, Kooijman K, Krol AD, Janus CP, Darby SC, van Leeuwen FE, Aleman BM.

Int J Radiat Oncol Biol Phys. 2015 May 1;92(1):153-60. doi: 10.1016/j.ijrobp.2015.02.019.


Risk of valvular heart disease after treatment for Hodgkin lymphoma.

Cutter DJ, Schaapveld M, Darby SC, Hauptmann M, van Nimwegen FA, Krol AD, Janus CP, van Leeuwen FE, Aleman BM.

J Natl Cancer Inst. 2015 Feb 23;107(4). pii: djv008. doi: 10.1093/jnci/djv008. Print 2015 Apr.


AGE-modified basement membrane cooperates with Endo180 to promote epithelial cell invasiveness and decrease prostate cancer survival.

Rodriguez-Teja M, Gronau JH, Breit C, Zhang YZ, Minamidate A, Caley MP, McCarthy A, Cox TR, Erler JT, Gaughan L, Darby S, Robson C, Mauri F, Waxman J, Sturge J.

J Pathol. 2015 Mar;235(4):581-92. doi: 10.1002/path.4485. Epub 2014 Dec 24.


Survival Outcome and EMT Suppression Mediated by a Lectin Domain Interaction of Endo180 and CD147.

Rodriguez-Teja M, Gronau JH, Minamidate A, Darby S, Gaughan L, Robson C, Mauri F, Waxman J, Sturge J.

Mol Cancer Res. 2015 Mar;13(3):538-47. doi: 10.1158/1541-7786.MCR-14-0344-T. Epub 2014 Nov 7.


Report on the international colloquium on cardio-oncology (rome, 12-14 march 2014).

Ewer M, Gianni L, Pane F, Sandri MT, Steiner RK, Wojnowski L, Yeh ET, Carver JR, Lipshultz SE, Minotti G, Armstrong GT, Cardinale D, Colan SD, Darby SC, Force TL, Kremer LC, Lenihan DJ, Sallan SE, Sawyer DB, Suter TM, Swain SM, van Leeuwen FE.

Ecancermedicalscience. 2014 May 29;8:433. doi: 10.3332/ecancer.2014.433. eCollection 2014.


Perventricular closure of pulmonary stump in a 16-kg child.

Darby S, Ilbawi M, Amin Z.

Catheter Cardiovasc Interv. 2015 Feb 1;85(2):271-3. doi: 10.1002/ccd.25497. Epub 2014 Apr 10.


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