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Items: 1 to 50 of 75

1.

The deubiquitylating enzyme Ubp12 regulates Rad23-dependent proteasomal degradation.

Gödderz D, Giovannucci TA, Laláková J, Menéndez-Benito V, Dantuma NP.

J Cell Sci. 2017 Oct 1;130(19):3336-3346. doi: 10.1242/jcs.202622. Epub 2017 Aug 9.

2.

Ataxin-3 consolidates the MDC1-dependent DNA double-strand break response by counteracting the SUMO-targeted ubiquitin ligase RNF4.

Pfeiffer A, Luijsterburg MS, Acs K, Wiegant WW, Helfricht A, Herzog LK, Minoia M, Böttcher C, Salomons FA, van Attikum H, Dantuma NP.

EMBO J. 2017 Apr 13;36(8):1066-1083. doi: 10.15252/embj.201695151. Epub 2017 Mar 8.

3.

Independent mechanisms recruit the cohesin loader protein NIPBL to sites of DNA damage.

Bot C, Pfeiffer A, Giordano F, Manjeera DE, Dantuma NP, Ström L.

J Cell Sci. 2017 Mar 15;130(6):1134-1146. doi: 10.1242/jcs.197236. Epub 2017 Feb 6.

4.

The polyglutamine-expanded androgen receptor responsible for spinal and bulbar muscular atrophy inhibits the APC/C(Cdh1) ubiquitin ligase complex.

Bott LC, Salomons FA, Maric D, Liu Y, Merry D, Fischbeck KH, Dantuma NP.

Sci Rep. 2016 Jun 17;6:27703. doi: 10.1038/srep27703.

5.

Real Estate in the DNA Damage Response: Ubiquitin and SUMO Ligases Home in on DNA Double-Strand Breaks.

Dantuma NP, Pfeiffer A.

Front Genet. 2016 Apr 11;7:58. doi: 10.3389/fgene.2016.00058. eCollection 2016. Review.

6.

Ubiquitin versus misfolding: The minimal requirements for inclusion body formation.

Dantuma NP, Salomons FA.

J Cell Biol. 2016 Apr 25;213(2):147-9. doi: 10.1083/jcb.201603095.

7.

A small-molecule Nrf1 and Nrf2 activator mitigates polyglutamine toxicity in spinal and bulbar muscular atrophy.

Bott LC, Badders NM, Chen KL, Harmison GG, Bautista E, Shih CC, Katsuno M, Sobue G, Taylor JP, Dantuma NP, Fischbeck KH, Rinaldi C.

Hum Mol Genet. 2016 May 15;25(10):1979-1989. Epub 2016 Mar 8.

8.

Spatiotemporal regulation of posttranslational modifications in the DNA damage response.

Dantuma NP, van Attikum H.

EMBO J. 2016 Jan 4;35(1):6-23. doi: 10.15252/embj.201592595. Epub 2015 Dec 1. Review.

9.

Cdc48-independent proteasomal degradation coincides with a reduced need for ubiquitylation.

Gödderz D, Heinen C, Marchese FP, Kurz T, Acs K, Dantuma NP.

Sci Rep. 2015 Jan 5;5:7615. doi: 10.1038/srep07615.

10.

Expression of progerin in aging mouse brains reveals structural nuclear abnormalities without detectible significant alterations in gene expression, hippocampal stem cells or behavior.

Baek JH, Schmidt E, Viceconte N, Strandgren C, Pernold K, Richard TJ, Van Leeuwen FW, Dantuma NP, Damberg P, Hultenby K, Ulfhake B, Mugnaini E, Rozell B, Eriksson M.

Hum Mol Genet. 2015 Mar 1;24(5):1305-21. doi: 10.1093/hmg/ddu541. Epub 2014 Oct 24.

11.

The chromosomal association of the Smc5/6 complex depends on cohesion and predicts the level of sister chromatid entanglement.

Jeppsson K, Carlborg KK, Nakato R, Berta DG, Lilienthal I, Kanno T, Lindqvist A, Brink MC, Dantuma NP, Katou Y, Shirahige K, Sjögren C.

PLoS Genet. 2014 Oct 16;10(10):e1004680. doi: 10.1371/journal.pgen.1004680. eCollection 2014 Oct.

12.

Should I stay or should I go: VCP/p97-mediated chromatin extraction in the DNA damage response.

Dantuma NP, Acs K, Luijsterburg MS.

Exp Cell Res. 2014 Nov 15;329(1):9-17. doi: 10.1016/j.yexcr.2014.08.025. Epub 2014 Aug 27. Review.

PMID:
25169698
13.

The ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solution.

Dantuma NP, Bott LC.

Front Mol Neurosci. 2014 Jul 31;7:70. doi: 10.3389/fnmol.2014.00070. eCollection 2014. Review.

14.

The Epstein-Barr virus nuclear antigen-1 reprograms transcription by mimicry of high mobility group A proteins.

Coppotelli G, Mughal N, Callegari S, Sompallae R, Caja L, Luijsterburg MS, Dantuma NP, Moustakas A, Masucci MG.

Nucleic Acids Res. 2013 Mar 1;41(5):2950-62. doi: 10.1093/nar/gkt032. Epub 2013 Jan 28.

15.

Growing sphere of influence: Cdc48/p97 orchestrates ubiquitin-dependent extraction from chromatin.

Dantuma NP, Hoppe T.

Trends Cell Biol. 2012 Sep;22(9):483-91. doi: 10.1016/j.tcb.2012.06.003. Epub 2012 Jul 19. Review.

PMID:
22818974
16.

A new non-catalytic role for ubiquitin ligase RNF8 in unfolding higher-order chromatin structure.

Luijsterburg MS, Acs K, Ackermann L, Wiegant WW, Bekker-Jensen S, Larsen DH, Khanna KK, van Attikum H, Mailand N, Dantuma NP.

EMBO J. 2012 May 30;31(11):2511-27. doi: 10.1038/emboj.2012.104. Epub 2012 Apr 24.

17.

DDB2 promotes chromatin decondensation at UV-induced DNA damage.

Luijsterburg MS, Lindh M, Acs K, Vrouwe MG, Pines A, van Attikum H, Mullenders LH, Dantuma NP.

J Cell Biol. 2012 Apr 16;197(2):267-81. doi: 10.1083/jcb.201106074. Epub 2012 Apr 9.

18.

Recognition of DNA damage by XPC coincides with disruption of the XPC-RAD23 complex.

Bergink S, Toussaint W, Luijsterburg MS, Dinant C, Alekseev S, Hoeijmakers JH, Dantuma NP, Houtsmuller AB, Vermeulen W.

J Cell Biol. 2012 Mar 19;196(6):681-8. doi: 10.1083/jcb.201107050.

19.

The AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing L3MBTL1 from DNA double-strand breaks.

Acs K, Luijsterburg MS, Ackermann L, Salomons FA, Hoppe T, Dantuma NP.

Nat Struct Mol Biol. 2011 Nov 27;18(12):1345-50. doi: 10.1038/nsmb.2188.

PMID:
22120668
20.

Involvement of ubiquilin-1 transcript variants in protein degradation and accumulation.

Haapasalo A, Viswanathan J, Kurkinen KM, Bertram L, Soininen H, Dantuma NP, Tanzi RE, Hiltunen M.

Commun Integr Biol. 2011 Jul;4(4):428-32. doi: 10.4161/cib.4.4.15283. Epub 2011 Jul 1.

21.

Mutant ubiquitin (UBB+1) associated with neurodegenerative disorders is hydrolyzed by ubiquitin C-terminal hydrolase L3 (UCH-L3).

Dennissen FJ, Kholod N, Hermes DJ, Kemmerling N, Steinbusch HW, Dantuma NP, van Leeuwen FW.

FEBS Lett. 2011 Aug 19;585(16):2568-74. doi: 10.1016/j.febslet.2011.06.037. Epub 2011 Jul 6.

22.

C-terminal UBA domains protect ubiquitin receptors by preventing initiation of protein degradation.

Heinen C, Acs K, Hoogstraten D, Dantuma NP.

Nat Commun. 2011 Feb 8;2:191. doi: 10.1038/ncomms1179.

23.

Alzheimer's disease-associated ubiquilin-1 regulates presenilin-1 accumulation and aggresome formation.

Viswanathan J, Haapasalo A, Böttcher C, Miettinen R, Kurkinen KM, Lu A, Thomas A, Maynard CJ, Romano D, Hyman BT, Berezovska O, Bertram L, Soininen H, Dantuma NP, Tanzi RE, Hiltunen M.

Traffic. 2011 Mar;12(3):330-48. doi: 10.1111/j.1600-0854.2010.01149.x. Epub 2011 Jan 7.

24.

Mutant p62/SQSTM1 UBA domains linked to Paget's disease of bone differ in their abilities to function as stabilization signals.

Heinen C, Garner TP, Long J, Böttcher C, Ralston SH, Cavey JR, Searle MS, Layfield R, Dantuma NP.

FEBS Lett. 2010 Apr 16;584(8):1585-90. doi: 10.1016/j.febslet.2010.03.018. Epub 2010 Mar 15.

25.

Acute polyglutamine expression in inducible mouse model unravels ubiquitin/proteasome system impairment and permanent recovery attributable to aggregate formation.

Ortega Z, Díaz-Hernández M, Maynard CJ, Hernández F, Dantuma NP, Lucas JJ.

J Neurosci. 2010 Mar 10;30(10):3675-88. doi: 10.1523/JNEUROSCI.5673-09.2010.

26.

Illuminating the ubiquitin/proteasome system.

Salomons FA, Acs K, Dantuma NP.

Exp Cell Res. 2010 May 1;316(8):1289-95. doi: 10.1016/j.yexcr.2010.02.003. Epub 2010 Feb 10. Review.

PMID:
20149791
27.

VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD.

Tresse E, Salomons FA, Vesa J, Bott LC, Kimonis V, Yao TP, Dantuma NP, Taylor JP.

Autophagy. 2010 Feb;6(2):217-27. Epub 2010 Feb 22.

28.

Nucleotide excision repair-induced H2A ubiquitination is dependent on MDC1 and RNF8 and reveals a universal DNA damage response.

Marteijn JA, Bekker-Jensen S, Mailand N, Lans H, Schwertman P, Gourdin AM, Dantuma NP, Lukas J, Vermeulen W.

J Cell Biol. 2009 Sep 21;186(6):835-47. doi: 10.1083/jcb.200902150.

29.

A conserved unfoldase activity for the p97 AAA-ATPase in proteasomal degradation.

Beskow A, Grimberg KB, Bott LC, Salomons FA, Dantuma NP, Young P.

J Mol Biol. 2009 Dec 11;394(4):732-46. doi: 10.1016/j.jmb.2009.09.050. Epub 2009 Sep 24.

PMID:
19782090
30.

Accumulation of ubiquitin conjugates in a polyglutamine disease model occurs without global ubiquitin/proteasome system impairment.

Maynard CJ, Böttcher C, Ortega Z, Smith R, Florea BI, Díaz-Hernández M, Brundin P, Overkleeft HS, Li JY, Lucas JJ, Dantuma NP.

Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13986-91. doi: 10.1073/pnas.0906463106. Epub 2009 Jul 30.

31.

Stressing the ubiquitin-proteasome system.

Dantuma NP, Lindsten K.

Cardiovasc Res. 2010 Jan 15;85(2):263-71. doi: 10.1093/cvr/cvp255. Epub 2009 Jul 25. Review.

PMID:
19633314
32.

Heterochromatin protein 1 is recruited to various types of DNA damage.

Luijsterburg MS, Dinant C, Lans H, Stap J, Wiernasz E, Lagerwerf S, Warmerdam DO, Lindh M, Brink MC, Dobrucki JW, Aten JA, Fousteri MI, Jansen G, Dantuma NP, Vermeulen W, Mullenders LH, Houtsmuller AB, Verschure PJ, van Driel R.

J Cell Biol. 2009 May 18;185(4):577-86. doi: 10.1083/jcb.200810035.

33.

The ubiquitin receptor Rad23: at the crossroads of nucleotide excision repair and proteasomal degradation.

Dantuma NP, Heinen C, Hoogstraten D.

DNA Repair (Amst). 2009 Apr 5;8(4):449-60. doi: 10.1016/j.dnarep.2009.01.005. Epub 2009 Feb 14. Review.

PMID:
19223247
34.

Selective accumulation of aggregation-prone proteasome substrates in response to proteotoxic stress.

Salomons FA, Menéndez-Benito V, Böttcher C, McCray BA, Taylor JP, Dantuma NP.

Mol Cell Biol. 2009 Apr;29(7):1774-85. doi: 10.1128/MCB.01485-08. Epub 2009 Jan 21.

35.

Functional alterations of the ubiquitin-proteasome system in motor neurons of a mouse model of familial amyotrophic lateral sclerosis.

Cheroni C, Marino M, Tortarolo M, Veglianese P, De Biasi S, Fontana E, Zuccarello LV, Maynard CJ, Dantuma NP, Bendotti C.

Hum Mol Genet. 2009 Jan 1;18(1):82-96. doi: 10.1093/hmg/ddn319. Epub 2008 Sep 29.

36.

Minimal length requirement for proteasomal degradation of ubiquitin-dependent substrates.

Verhoef LG, Heinen C, Selivanova A, Halff EF, Salomons FA, Dantuma NP.

FASEB J. 2009 Jan;23(1):123-33. doi: 10.1096/fj.08-115055. Epub 2008 Sep 16.

PMID:
18796559
37.

Proteasome inhibition up-regulates p53 and apoptosis-inducing factor in chondrocytes causing severe growth retardation in mice.

Zaman F, Menendez-Benito V, Eriksson E, Chagin AS, Takigawa M, Fadeel B, Dantuma NP, Chrysis D, Sävendahl L.

Cancer Res. 2007 Oct 15;67(20):10078-86.

38.

Disease-associated prion protein oligomers inhibit the 26S proteasome.

Kristiansen M, Deriziotis P, Dimcheff DE, Jackson GS, Ovaa H, Naumann H, Clarke AR, van Leeuwen FW, Menéndez-Benito V, Dantuma NP, Portis JL, Collinge J, Tabrizi SJ.

Mol Cell. 2007 Apr 27;26(2):175-88.

39.

Biogenesis and processing of the amyloid precursor protein in the early secretory pathway.

Selivanova A, Winblad B, Dantuma NP, Farmery MR.

Biochem Biophys Res Commun. 2007 Jun 15;357(4):1034-9. Epub 2007 Apr 19.

PMID:
17466275
40.

Dose-dependent inhibition of proteasome activity by a mutant ubiquitin associated with neurodegenerative disease.

van Tijn P, de Vrij FM, Schuurman KG, Dantuma NP, Fischer DF, van Leeuwen FW, Hol EM.

J Cell Sci. 2007 May 1;120(Pt 9):1615-23. Epub 2007 Apr 3.

41.

A fluorescent broad-spectrum proteasome inhibitor for labeling proteasomes in vitro and in vivo.

Verdoes M, Florea BI, Menendez-Benito V, Maynard CJ, Witte MD, van der Linden WA, van den Nieuwendijk AM, Hofmann T, Berkers CR, van Leeuwen FW, Groothuis TA, Leeuwenburgh MA, Ovaa H, Neefjes JJ, Filippov DV, van der Marel GA, Dantuma NP, Overkleeft HS.

Chem Biol. 2006 Nov;13(11):1217-26.

42.

Ubiquitin crosstalk connecting cellular processes.

Groothuis TA, Dantuma NP, Neefjes J, Salomons FA.

Cell Div. 2006 Sep 28;1:21.

43.

COPI-mediated retrograde transport is required for efficient gamma-secretase cleavage of the amyloid precursor protein.

Selivanova A, Winblad B, Farmery MR, Dantuma NP, Ankarcrona M.

Biochem Biophys Res Commun. 2006 Nov 10;350(1):220-6. Epub 2006 Sep 18.

PMID:
16999935
44.

DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A.

Bergink S, Salomons FA, Hoogstraten D, Groothuis TA, de Waard H, Wu J, Yuan L, Citterio E, Houtsmuller AB, Neefjes J, Hoeijmakers JH, Vermeulen W, Dantuma NP.

Genes Dev. 2006 May 15;20(10):1343-52.

45.

GFP reporter mouse models of UPS proteolytic function.

Lindsten K, Menéndez-Benito V, Masucci MG, Dantuma NP, Kumarapeli AR, Horak KM, Zheng H, Wang X.

FASEB J. 2006 May;20(7):1027; author reply 1027-8. No abstract available.

PMID:
16675852
46.

A dynamic ubiquitin equilibrium couples proteasomal activity to chromatin remodeling.

Dantuma NP, Groothuis TA, Salomons FA, Neefjes J.

J Cell Biol. 2006 Apr 10;173(1):19-26.

47.

Non-infectious fluorimetric assay for phenotyping of drug-resistant HIV proteinase mutants.

Majerová-Uhlíková T, Dantuma NP, Lindsten K, Masucci MG, Konvalinka J.

J Clin Virol. 2006 May;36(1):50-9. Epub 2006 Mar 9.

PMID:
16527535
48.

Monitoring of ubiquitin-dependent proteolysis with green fluorescent protein substrates.

Menéndez-Benito V, Heessen S, Dantuma NP.

Methods Enzymol. 2005;399:490-511.

PMID:
16338378
49.

Fluorescent reporters for the ubiquitin-proteasome system.

Salomons FA, Verhoef LG, Dantuma NP.

Essays Biochem. 2005;41:113-28. Review.

PMID:
16250901
50.

Endoplasmic reticulum stress compromises the ubiquitin-proteasome system.

Menéndez-Benito V, Verhoef LG, Masucci MG, Dantuma NP.

Hum Mol Genet. 2005 Oct 1;14(19):2787-99. Epub 2005 Aug 15.

PMID:
16103128

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