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Reply to Raoult and Rolain, and to Echols and Tillotson.

Kadri SS, Danner RL.

Clin Infect Dis. 2019 Mar 6. pii: ciz186. doi: 10.1093/cid/ciz186. [Epub ahead of print] No abstract available.


Attributable mortality from extensively drug-resistant gram-negative infections using propensity-matched tracer antibiotic algorithms.

Kadri SS, Strich JR, Swihart BJ, Hohmann S, Dekker JP, Palmore T, Bonne S, Freeman B, Raybould J, Shah NG, Patel D, Husson J, Jacobs MD, Duong L, Follmann D, Hooper DC, Timpone J, Danner RL.

Am J Infect Control. 2019 Feb 27. pii: S0196-6553(19)30051-3. doi: 10.1016/j.ajic.2019.01.010. [Epub ahead of print]


Procalcitonin-Guided Antibiotic Discontinuation and Mortality in Critically Ill Adults: A Systematic Review and Meta-analysis.

Pepper DJ, Sun J, Rhee C, Welsh J, Powers JH 3rd, Danner RL, Kadri SS.

Chest. 2019 Jun;155(6):1109-1118. doi: 10.1016/j.chest.2018.12.029. Epub 2019 Feb 14.


Variation in Identifying Sepsis and Organ Dysfunction Using Administrative Versus Electronic Clinical Data and Impact on Hospital Outcome Comparisons.

Rhee C, Jentzsch MS, Kadri SS, Seymour CW, Angus DC, Murphy DJ, Martin GS, Dantes RB, Epstein L, Fiore AE, Jernigan JA, Danner RL, Warren DK, Septimus EJ, Hickok J, Poland RE, Jin R, Fram D, Schaaf R, Wang R, Klompas M; Centers for Disease Control and Prevention (CDC) Prevention Epicenters Program.

Crit Care Med. 2019 Apr;47(4):493-500. doi: 10.1097/CCM.0000000000003554.


Low-dose, short course alteplase treatment of submassive pulmonary embolism: a case series from the National Institutes of Health Clinical Center.

Lozier JN, Elinoff JM, Suffredini AF, Rosing DR, Sidenko S, Sherry RM, Metwalli AR, Sachdev V, Danner RL, Chang R.

Blood Coagul Fibrinolysis. 2018 Dec;29(8):701-707. doi: 10.1097/MBC.0000000000000774.


Difficult-to-Treat Resistance in Gram-negative Bacteremia at 173 US Hospitals: Retrospective Cohort Analysis of Prevalence, Predictors, and Outcome of Resistance to All First-line Agents.

Kadri SS, Adjemian J, Lai YL, Spaulding AB, Ricotta E, Prevots DR, Palmore TN, Rhee C, Klompas M, Dekker JP, Powers JH 3rd, Suffredini AF, Hooper DC, Fridkin S, Danner RL; National Institutes of Health Antimicrobial Resistance Outcomes Research Initiative (NIH–ARORI).

Clin Infect Dis. 2018 Nov 28;67(12):1803-1814. doi: 10.1093/cid/ciy378.


Stability of isoniazid injection in i.v. solutions.

Lee JH, Moriyama B, Henning SA, Danner RL, Walsh TJ, Penzak SR, Grimes GJ, Potti GK.

Am J Health Syst Pharm. 2018 May 15;75(10):622-626. doi: 10.2146/ajhp170268.


Risks of restrictive red blood cell transfusion strategies in patients with cardiovascular disease (CVD): a meta-analysis.

Cortés-Puch I, Wiley BM, Sun J, Klein HG, Welsh J, Danner RL, Eichacker PQ, Natanson C.

Transfus Med. 2018 Oct;28(5):335-345. doi: 10.1111/tme.12535. Epub 2018 Apr 19. Review.


Pseudoneutropenia in lymphangioleiomyomatosis (LAM) patients receiving sirolimus: evaluation in a 100 patient cohort.

Gopalakrishnan V, Jones AM, Julien-Williams P, Machado T, Danner RL, Swigris JJ, Paine R 3rd, Lozier JN, Moss J.

ERJ Open Res. 2018 Mar 20;4(1). pii: 00121-2017. doi: 10.1183/23120541.00121-2017. eCollection 2018 Jan.


Spironolactone-induced degradation of the TFIIH core complex XPB subunit suppresses NF-κB and AP-1 signalling.

Elinoff JM, Chen LY, Dougherty EJ, Awad KS, Wang S, Biancotto A, Siddiqui AH, Weir NA, Cai R, Sun J, Preston IR, Solomon MA, Danner RL.

Cardiovasc Res. 2018 Jan 1;114(1):65-76. doi: 10.1093/cvr/cvx198.


Incidence and Trends of Sepsis in US Hospitals Using Clinical vs Claims Data, 2009-2014.

Rhee C, Dantes R, Epstein L, Murphy DJ, Seymour CW, Iwashyna TJ, Kadri SS, Angus DC, Danner RL, Fiore AE, Jernigan JA, Martin GS, Septimus E, Warren DK, Karcz A, Chan C, Menchaca JT, Wang R, Gruber S, Klompas M; CDC Prevention Epicenter Program.

JAMA. 2017 Oct 3;318(13):1241-1249. doi: 10.1001/jama.2017.13836.


Dietary supplementation with long-chain monounsaturated fatty acid isomers decreases atherosclerosis and alters lipoprotein proteomes in LDLr-/- mice.

Yang ZH, Gordon SM, Sviridov D, Wang S, Danner RL, Pryor M, Vaisman B, Shichijo Y, Doisaki N, Remaley AT.

Atherosclerosis. 2017 Jul;262:31-38. doi: 10.1016/j.atherosclerosis.2017.04.017. Epub 2017 Apr 25.


Impact of Intravenous Immunoglobulin on Survival in Necrotizing Fasciitis With Vasopressor-Dependent Shock: A Propensity Score-Matched Analysis From 130 US Hospitals.

Kadri SS, Swihart BJ, Bonne SL, Hohmann SF, Hennessy LV, Louras P, Evans HL, Rhee C, Suffredini AF, Hooper DC, Follmann DA, Bulger EM, Danner RL.

Clin Infect Dis. 2017 Apr 1;64(7):877-885. doi: 10.1093/cid/ciw871.


Mineralocorticoid Receptor (MR) trans-Activation of Inflammatory AP-1 Signaling: DEPENDENCE ON DNA SEQUENCE, MR CONFORMATION, AND AP-1 FAMILY MEMBER EXPRESSION.

Dougherty EJ, Elinoff JM, Ferreyra GA, Hou A, Cai R, Sun J, Blaine KP, Wang S, Danner RL.

J Biol Chem. 2016 Nov 4;291(45):23628-23644. Epub 2016 Sep 20.


Toxoplasmosis encephalitis with immune-reconstitution inflammatory syndrome in an allogeneic stem cell transplant patient: a case report.

Gatti-Mays ME, Manion M, Bowen LN, Brown GT, Danner RL, Khan O, Nath A, Battiwalla M, Barrett AJ, Ito S.

Bone Marrow Transplant. 2016 Dec;51(12):1622-1624. doi: 10.1038/bmt.2016.230. Epub 2016 Sep 19. No abstract available.


Estimating Ten-Year Trends in Septic Shock Incidence and Mortality in United States Academic Medical Centers Using Clinical Data.

Kadri SS, Rhee C, Strich JR, Morales MK, Hohmann S, Menchaca J, Suffredini AF, Danner RL, Klompas M.

Chest. 2017 Feb;151(2):278-285. doi: 10.1016/j.chest.2016.07.010. Epub 2016 Jul 22.


PPARγ signaling and emerging opportunities for improved therapeutics.

Wang S, Dougherty EJ, Danner RL.

Pharmacol Res. 2016 Sep;111:76-85. doi: 10.1016/j.phrs.2016.02.028. Epub 2016 Jun 4. Review.


Usual Care and Informed Consent in Clinical Trials of Oxygen Management in Extremely Premature Infants.

Cortés-Puch I, Wesley RA, Carome MA, Danner RL, Wolfe SM, Natanson C.

PLoS One. 2016 May 18;11(5):e0155005. doi: 10.1371/journal.pone.0155005. eCollection 2016.


Diagnosing sepsis is subjective and highly variable: a survey of intensivists using case vignettes.

Rhee C, Kadri SS, Danner RL, Suffredini AF, Massaro AF, Kitch BT, Lee G, Klompas M.

Crit Care. 2016 Apr 6;20:89. doi: 10.1186/s13054-016-1266-9.


Severe Meningoencephalitis in a Case of Ebola Virus Disease: A Case Report.

Chertow DS, Nath A, Suffredini AF, Danner RL, Reich DS, Bishop RJ, Childs RW, Arai AE, Palmore TN, Lane HC, Fauci AS, Davey RT.

Ann Intern Med. 2016 Aug 16;165(4):301-4. doi: 10.7326/M15-3066. Epub 2016 Apr 5. No abstract available.


Therapeutic Drug Monitoring and Genotypic Screening in the Clinical Use of Voriconazole.

Moriyama B, Kadri S, Henning SA, Danner RL, Walsh TJ, Penzak SR.

Curr Fungal Infect Rep. 2015 Jun;9(2):74-87. Epub 2015 Apr 16.


Raf/ERK drives the proliferative and invasive phenotype of BMPR2-silenced pulmonary artery endothelial cells.

Awad KS, Elinoff JM, Wang S, Gairhe S, Ferreyra GA, Cai R, Sun J, Solomon MA, Danner RL.

Am J Physiol Lung Cell Mol Physiol. 2016 Jan 15;310(2):L187-201. doi: 10.1152/ajplung.00303.2015. Epub 2015 Nov 20.


G Protein-coupled Receptor 40 (GPR40) and Peroxisome Proliferator-activated Receptor γ (PPARγ): AN INTEGRATED TWO-RECEPTOR SIGNALING PATHWAY.

Wang S, Awad KS, Elinoff JM, Dougherty EJ, Ferreyra GA, Wang JY, Cai R, Sun J, Ptasinska A, Danner RL.

J Biol Chem. 2015 Aug 7;290(32):19544-57. doi: 10.1074/jbc.M115.638924. Epub 2015 Jun 23.


ACP Journal Club: review: in sepsis, the effect of resuscitation with crystalloid and colloid fluids on mortality varies.

Kadri SS, Danner RL.

Ann Intern Med. 2014 Nov 18;161(10):JC12. doi: 10.7326/0003-4819-161-10-201411180-02012. No abstract available.


Hypothalamic-pituitary-adrenal axis in lethal canine Staphylococcus aureus pneumonia.

Cortés-Puch I, Hicks CW, Sun J, Solomon SB, Eichacker PQ, Sweeney DA, Nieman LK, Whitley EM, Behrend EN, Natanson C, Danner RL.

Am J Physiol Endocrinol Metab. 2014 Dec 1;307(11):E994-E1008. doi: 10.1152/ajpendo.00345.2014. Epub 2014 Oct 7.


Tracking colistin-treated patients to monitor the incidence and outcome of carbapenem-resistant Gram-negative infections.

Kadri SS, Hohmann SF, Orav EJ, Bonne SL, Moffa MA, Timpone JG, Strich JR, Palmore T, Christopher KB, Varughese C, Hooper DC, Danner RL.

Clin Infect Dis. 2015 Jan 1;60(1):79-87. doi: 10.1093/cid/ciu741. Epub 2014 Sep 22.


Engraftment of donor cells with germ-line integration of HHV6 mimics HHV6 reactivation following cord blood/haplo transplantation.

Purev E, Winkler T, Danner RL, Fahle GA, Cook L, Zerr DM, Jerome KR, Childs RW.

Blood. 2014 Aug 14;124(7):1198-9. doi: 10.1182/blood-2014-06-577684. No abstract available.


Isolation of a circulating CD45-, CD34dim cell population and validation of their endothelial phenotype.

Tropea MM, Harper BJ, Graninger GM, Phillips TM, Ferreyra G, Mostowski HS, Danner RL, Suffredini AF, Solomon MA.

Thromb Haemost. 2014 Oct;112(4):770-80. doi: 10.1160/TH14-01-0043. Epub 2014 Jul 24.


Persistence of Pseudomonas aeruginosa in a pulmonary nodule with late relapse.

Ronkainen S, Xie Y, Battiwalla M, Barrett AJ, Stock F, Dekker JP, Danner RL.

Transpl Infect Dis. 2014 Aug;16(4):666-71. doi: 10.1111/tid.12253. Epub 2014 Jun 26.


Late multiple organ surge in interferon-regulated target genes characterizes staphylococcal enterotoxin B lethality.

Ferreyra GA, Elinoff JM, Demirkale CY, Starost MF, Buckley M, Munson PJ, Krakauer T, Danner RL.

PLoS One. 2014 Feb 13;9(2):e88756. doi: 10.1371/journal.pone.0088756. eCollection 2014.


Retinoic acid controls the homeostasis of pre-cDC-derived splenic and intestinal dendritic cells.

Klebanoff CA, Spencer SP, Torabi-Parizi P, Grainger JR, Roychoudhuri R, Ji Y, Sukumar M, Muranski P, Scott CD, Hall JA, Ferreyra GA, Leonardi AJ, Borman ZA, Wang J, Palmer DC, Wilhelm C, Cai R, Sun J, Napoli JL, Danner RL, Gattinoni L, Belkaid Y, Restifo NP.

J Exp Med. 2013 Sep 23;210(10):1961-76. doi: 10.1084/jem.20122508. Epub 2013 Sep 2.


Changes in microRNA and mRNA expression with differentiation of human bronchial epithelial cells.

Martinez-Anton A, Sokolowska M, Kern S, Davis AS, Alsaaty S, Taubenberger JK, Sun J, Cai R, Danner RL, Eberlein M, Logun C, Shelhamer JH.

Am J Respir Cell Mol Biol. 2013 Sep;49(3):384-95. doi: 10.1165/rcmb.2012-0368OC.


A pilot study of the effect of spironolactone therapy on exercise capacity and endothelial dysfunction in pulmonary arterial hypertension: study protocol for a randomized controlled trial.

Elinoff JM, Rame JE, Forfia PR, Hall MK, Sun J, Gharib AM, Abd-Elmoniem K, Graninger G, Harper B, Danner RL, Solomon MA.

Trials. 2013 Apr 2;14:91. doi: 10.1186/1745-6215-14-91.


Pharmacokinetics of intravenous voriconazole in obese patients: implications of CYP2C19 homozygous poor metabolizer genotype.

Moriyama B, Jarosinski PF, Figg WD, Henning SA, Danner RL, Penzak SR, Wayne AS, Walsh TJ.

Pharmacotherapy. 2013 Mar;33(3):e19-22. doi: 10.1002/phar.1192. Epub 2013 Feb 11.


Fatigue-related gene networks identified in CD(14)+ cells isolated from HIV-infected patients: part I: research findings.

Voss JG, Dobra A, Morse C, Kovacs JA, Danner RL, Munson PJ, Logan C, Rangel Z, Adelsberger JW, McLaughlin M, Adams LD, Raju R, Dalakas MC.

Biol Res Nurs. 2013 Apr;15(2):137-51. doi: 10.1177/1099800411421957. Epub 2013 Jan 16.


Beneficial effects of stress-dose corticosteroid therapy in canines depend on the severity of staphylococcal pneumonia.

Hicks CW, Sweeney DA, Danner RL, Eichacker PQ, Suffredini AF, Feng J, Sun J, Moriyama B, Wesley R, Behrend EN, Solomon SB, Natanson C.

Intensive Care Med. 2012 Dec;38(12):2063-71. doi: 10.1007/s00134-012-2735-5. Epub 2012 Oct 31.


ACP Journal Club. Hydroxyethyl starch 130/0.42 increased death at 90 days compared with Ringer's acetate in severe sepsis.

Elinoff JM, Danner RL.

Ann Intern Med. 2012 Oct 16;157(8):JC4-6. doi: 10.7326/0003-4819-157-8-201210160-02006. No abstract available.


HIV infection and antiretroviral therapy have divergent effects on mitochondria in adipose tissue.

Morse CG, Voss JG, Rakocevic G, McLaughlin M, Vinton CL, Huber C, Hu X, Yang J, Huang da W, Logun C, Danner RL, Rangel ZG, Munson PJ, Orenstein JM, Rushing EJ, Lempicki RA, Dalakas MC, Kovacs JA.

J Infect Dis. 2012 Jun 15;205(12):1778-87. doi: 10.1093/infdis/jis101. Epub 2012 Apr 3.


Excess deaths associated with tigecycline after approval based on noninferiority trials.

Prasad P, Sun J, Danner RL, Natanson C.

Clin Infect Dis. 2012 Jun;54(12):1699-709. doi: 10.1093/cid/cis270. Epub 2012 Mar 30.


Th17 cells are long lived and retain a stem cell-like molecular signature.

Muranski P, Borman ZA, Kerkar SP, Klebanoff CA, Ji Y, Sanchez-Perez L, Sukumar M, Reger RN, Yu Z, Kern SJ, Roychoudhuri R, Ferreyra GA, Shen W, Durum SK, Feigenbaum L, Palmer DC, Antony PA, Chan CC, Laurence A, Danner RL, Gattinoni L, Restifo NP.

Immunity. 2011 Dec 23;35(6):972-85. doi: 10.1016/j.immuni.2011.09.019. Epub 2011 Dec 15.


Fatigue-related gene networks identified in CD14+ cells isolated from HIV-infected patients: part II: statistical analysis.

Voss JG, Dobra A, Morse C, Kovacs JA, Raju R, Danner RL, Munson PJ, Logan C, Rangel Z, Adelsberger JW, McLaughlin M, Adams LD, Dalakas MC.

Biol Res Nurs. 2013 Apr;15(2):152-9. doi: 10.1177/1099800411423307. Epub 2011 Nov 14.


Efficacy of selective mineralocorticoid and glucocorticoid agonists in canine septic shock.

Hicks CW, Sweeney DA, Danner RL, Eichacker PQ, Suffredini AF, Feng J, Sun J, Behrend EN, Solomon SB, Natanson C.

Crit Care Med. 2012 Jan;40(1):199-207. doi: 10.1097/CCM.0b013e31822efa14.


Cooperative and redundant signaling of leukotriene B4 and leukotriene D4 in human monocytes.

Chen LY, Eberlein M, Alsaaty S, Martinez-Anton A, Barb J, Munson PJ, Danner RL, Liu Y, Logun C, Shelhamer JH, Woszczek G.

Allergy. 2011 Oct;66(10):1304-11. doi: 10.1111/j.1398-9995.2011.02647.x. Epub 2011 May 24.


Caloric restriction in leptin deficiency does not correct myocardial steatosis: failure to normalize PPAR{alpha}/PGC1{alpha} and thermogenic glycerolipid/fatty acid cycling.

Rame JE, Barouch LA, Sack MN, Lynn EG, Abu-Asab M, Tsokos M, Kern SJ, Barb JJ, Munson PJ, Halushka MK, Miller KL, Fox-Talbot K, Zhang J, Hare JM, Solomon MA, Danner RL.

Physiol Genomics. 2011 Jun 28;43(12):726-38. doi: 10.1152/physiolgenomics.00088.2010. Epub 2011 Mar 22.


Pharmacokinetics of anidulafungin in pleural fluid during the treatment of a patient with Candida empyema.

Moriyama B, Ditullio M, Wilson E, Henning SA, Penzak SR, Danner RL, Pennick G, Rinaldi MG, Zelazny AM, Gea-Banacloche J, Barrett AJ, Walsh TJ.

Antimicrob Agents Chemother. 2011 May;55(5):2478-80. doi: 10.1128/AAC.01560-10. Epub 2011 Mar 14.


The effect of heparin administration in animal models of sepsis: a prospective study in Escherichia coli-challenged mice and a systematic review and metaregression analysis of published studies.

Li Y, Sun JF, Cui X, Mani H, Danner RL, Li X, Su JW, Fitz Y, Eichacker PQ.

Crit Care Med. 2011 May;39(5):1104-12. doi: 10.1097/CCM.0b013e31820eb718. Review.


Anthrax lethal and edema toxins produce different patterns of cardiovascular and renal dysfunction and synergistically decrease survival in canines.

Sweeney DA, Cui X, Solomon SB, Vitberg DA, Migone TS, Scher D, Danner RL, Natanson C, Subramanian GM, Eichacker PQ.

J Infect Dis. 2010 Dec 15;202(12):1885-96. doi: 10.1086/657408. Epub 2010 Nov 10.


Walk a mile in whose shoes?

Deans KJ, Minneci P, Eichacker PQ, Danner RL, Natanson C.

Anesth Analg. 2010 Aug;111(2):576-7; author reply 577. doi: 10.1213/ANE.0b013e3181e63976. No abstract available.


An Official ATS/ERS/ESICM/SCCM/SRLF Statement: Prevention and Management of Acute Renal Failure in the ICU Patient: an international consensus conference in intensive care medicine.

Brochard L, Abroug F, Brenner M, Broccard AF, Danner RL, Ferrer M, Laghi F, Magder S, Papazian L, Pelosi P, Polderman KH; ATS/ERS/ESICM/SCCM/SRLF Ad Hoc Committee on Acute Renal Failure.

Am J Respir Crit Care Med. 2010 May 15;181(10):1128-55. doi: 10.1164/rccm.200711-1664ST.


Physical compatibility of magnesium sulfate and sodium bicarbonate in a pharmacy-compounded hemofiltration solution.

Moriyama B, Henning SA, Jin H, Kolf M, Rehak NN, Danner RL, Walsh TJ, Grimes GJ.

Am J Health Syst Pharm. 2010 Apr 1;67(7):562-5. doi: 10.2146/ajhp090342.

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