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Items: 8


CRISPR/Cas9 mediated ELANE knockout enables neutrophilic maturation of primary hematopoietic stem and progenitor cells and induced pluripotent stem cells of severe congenital neutropenia patients.

Nasri M, Ritter M, Mir P, Dannenmann B, Aghaallaei N, Amend D, Makaryan V, Xu Y, Fletcher B, Bernhard R, Steiert I, Hahnel K, Berger J, Koch I, Sailer B, Hipp K, Zeidler C, Klimiankou M, Bajoghli B, Dale DC, Welte K, Skokowa J.

Haematologica. 2019 Jun 27. pii: haematol.2019.221804. doi: 10.3324/haematol.2019.221804. [Epub ahead of print]


Fluorescent labeling of CRISPR/Cas9 RNP for gene knockout in HSPCs and iPSCs reveals an essential role for GADD45b in stress response.

Nasri M, Mir P, Dannenmann B, Amend D, Skroblyn T, Xu Y, Schulze-Osthoff K, Klimiankou M, Welte K, Skokowa J.

Blood Adv. 2019 Jan 8;3(1):63-71. doi: 10.1182/bloodadvances.2017015511.


Human iPSC-based model of severe congenital neutropenia reveals elevated UPR and DNA damage in CD34+ cells preceding leukemic transformation.

Dannenmann B, Zahabi A, Mir P, Oswald B, Bernhard R, Klimiankou M, Morishima T, Schulze-Osthoff K, Zeidler C, Kanz L, Lachmann N, Moritz T, Welte K, Skokowa J.

Exp Hematol. 2019 Mar;71:51-60. doi: 10.1016/j.exphem.2018.12.006. Epub 2019 Jan 4.


Assessment of UV-C-induced water disinfection by differential PCR-based quantification of bacterial DNA damage.

Nocker A, Shah M, Dannenmann B, Schulze-Osthoff K, Wingender J, Probst AJ.

J Microbiol Methods. 2018 Jun;149:89-95. doi: 10.1016/j.mimet.2018.03.007. Epub 2018 Mar 31. No abstract available.


Simultaneous quantification of DNA damage and mitochondrial copy number by long-run DNA-damage quantification (LORD-Q).

Dannenmann B, Lehle S, Lorscheid S, Huber SM, Essmann F, Schulze-Osthoff K.

Oncotarget. 2017 Aug 10;8(68):112417-112425. doi: 10.18632/oncotarget.20112. eCollection 2017 Dec 22.


Genome surveillance in pluripotent stem cells: Low apoptosis threshold and efficient antioxidant defense.

Dannenmann B, Lehle S, Essmann F, Schulze-Osthoff K.

Mol Cell Oncol. 2015 Jun 23;3(2):e1052183. doi: 10.1080/23723556.2015.1052183. eCollection 2016 Mar.


Novel AKT phosphorylation sites identified in the pluripotency factors OCT4, SOX2 and KLF4.

Malak PN, Dannenmann B, Hirth A, Rothfuss OC, Schulze-Osthoff K.

Cell Cycle. 2015;14(23):3748-54. doi: 10.1080/15384101.2015.1104444.


High glutathione and glutathione peroxidase-2 levels mediate cell-type-specific DNA damage protection in human induced pluripotent stem cells.

Dannenmann B, Lehle S, Hildebrand DG, Kübler A, Grondona P, Schmid V, Holzer K, Fröschl M, Essmann F, Rothfuss O, Schulze-Osthoff K.

Stem Cell Reports. 2015 May 12;4(5):886-98. doi: 10.1016/j.stemcr.2015.04.004. Epub 2015 Apr 30.

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