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Noninvasive 11C-rifampin positron emission tomography reveals drug biodistribution in tuberculous meningitis.

Tucker EW, Guglieri-Lopez B, Ordonez AA, Ritchie B, Klunk MH, Sharma R, Chang YS, Sanchez-Bautista J, Frey S, Lodge MA, Rowe SP, Holt DP, Gobburu JVS, Peloquin CA, Mathews WB, Dannals RF, Pardo CA, Kannan S, Ivaturi VD, Jain SK.

Sci Transl Med. 2018 Dec 5;10(470). pii: eaau0965. doi: 10.1126/scitranslmed.aau0965.


Radiosynthesis and validation of [Carboxy-11 C]4-Aminobenzoic acid ([11 C]PABA), a PET radiotracer for imaging bacterial infections.

Holt DP, Kalinda AS, Bambarger LE, Jain SK, Dannals RF.

J Labelled Comp Radiopharm. 2018 Aug 8. doi: 10.1002/jlcr.3674. [Epub ahead of print]


Peptide-Based 68Ga-PET Radiotracer for Imaging PD-L1 Expression in Cancer.

De Silva RA, Kumar D, Lisok A, Chatterjee S, Wharram B, Venkateswara Rao K, Mease R, Dannals RF, Pomper MG, Nimmagadda S.

Mol Pharm. 2018 Sep 4;15(9):3946-3952. doi: 10.1021/acs.molpharmaceut.8b00399. Epub 2018 Aug 10.


Characterization of 3 Novel Tau Radiopharmaceuticals, 11C-RO-963, 11C-RO-643, and 18F-RO-948, in Healthy Controls and in Alzheimer Subjects.

Wong DF, Comley RA, Kuwabara H, Rosenberg PB, Resnick SM, Ostrowitzki S, Vozzi C, Boess F, Oh E, Lyketsos CG, Honer M, Gobbi L, Klein G, George N, Gapasin L, Kitzmiller K, Roberts J, Sevigny J, Nandi A, Brasic J, Mishra C, Thambisetty M, Mogekar A, Mathur A, Albert M, Dannals RF, Borroni E.

J Nucl Med. 2018 Dec;59(12):1869-1876. doi: 10.2967/jnumed.118.209916. Epub 2018 May 4.


An optimized radiosynthesis of [18 F]FNDP, a positron emission tomography radiotracer for imaging soluble epoxide hydrolase (sEH).

Azad BB, Holt DP, Ravert HT, Horti AG, Dannals RF.

J Labelled Comp Radiopharm. 2018 Jun 15;61(7):567-572. doi: 10.1002/jlcr.3620. Epub 2018 May 7.


Brain PET Imaging of α7-nAChR with [18F]ASEM: Reproducibility, Occupancy, Receptor Density, and Changes in Schizophrenia.

Wong DF, Kuwabara H, Horti AG, Roberts JM, Nandi A, Cascella N, Brasic J, Weerts EM, Kitzmiller K, Phan JA, Gapasin L, Sawa A, Valentine H, Wand G, Mishra C, George N, McDonald M, Lesniak W, Holt DP, Azad BB, Dannals RF, Kem W, Freedman R, Gjedde A.

Int J Neuropsychopharmacol. 2018 Jul 1;21(7):656-667. doi: 10.1093/ijnp/pyy021.


Synthesis and Evaluation of a New 18F-Labeled Radiotracer for Studying the GABAB Receptor in the Mouse Brain.

Naik R, Valentine H, Dannals RF, Wong DF, Horti AG.

ACS Chem Neurosci. 2018 Jun 20;9(6):1453-1461. doi: 10.1021/acschemneuro.8b00038. Epub 2018 Mar 9.


18F-XTRA PET for Enhanced Imaging of the Extrathalamic α4β2 Nicotinic Acetylcholine Receptor.

Coughlin JM, Slania S, Du Y, Rosenthal HB, Lesniak WG, Minn I, Smith GS, Dannals RF, Kuwabara H, Wong DF, Wang Y, Horti AG, Pomper MG.

J Nucl Med. 2018 Oct;59(10):1603-1608. doi: 10.2967/jnumed.117.205492. Epub 2018 Mar 1.


Feasibility Evaluation of Myocardial Cannabinoid Type 1 Receptor Imaging in Obesity: A Translational Approach.

Valenta I, Varga ZV, Valentine H, Cinar R, Horti A, Mathews WB, Dannals RF, Steele K, Kunos G, Wahl RL, Pomper MG, Wong DF, Pacher P, Schindler TH.

JACC Cardiovasc Imaging. 2018 Feb;11(2 Pt 2):320-332. doi: 10.1016/j.jcmg.2017.11.019.


The distribution of the alpha7 nicotinic acetylcholine receptor in healthy aging: An in vivo positron emission tomography study with [18F]ASEM.

Coughlin JM, Du Y, Rosenthal HB, Slania S, Min Koo S, Park A, Solomon G, Vranesic M, Antonsdottir I, Speck CL, Rootes-Murdy K, Lerner A, Rowe SP, Wang Y, Lesniak WG, Minn I, Bakker A, Smith GS, Dannals RF, Kuwabara H, Horti A, Wong DF, Pomper MG.

Neuroimage. 2018 Jan 15;165:118-124. doi: 10.1016/j.neuroimage.2017.10.009. Epub 2017 Oct 7.


Preclinical Evaluation of 18F-RO6958948, 11C-RO6931643, and 11C-RO6924963 as Novel PET Radiotracers for Imaging Tau Aggregates in Alzheimer Disease.

Honer M, Gobbi L, Knust H, Kuwabara H, Muri D, Koerner M, Valentine H, Dannals RF, Wong DF, Borroni E.

J Nucl Med. 2018 Apr;59(4):675-681. doi: 10.2967/jnumed.117.196741. Epub 2017 Sep 28.


Development of a radioligand for imaging V1a vasopressin receptors with PET.

Naik R, Valentine H, Hall A, Mathews WB, Harris JC, Carter CS, Dannals RF, Wong DF, Horti AG.

Eur J Med Chem. 2017 Oct 20;139:644-656. doi: 10.1016/j.ejmech.2017.08.037. Epub 2017 Aug 18.


Chemogenetics revealed: DREADD occupancy and activation via converted clozapine.

Gomez JL, Bonaventura J, Lesniak W, Mathews WB, Sysa-Shah P, Rodriguez LA, Ellis RJ, Richie CT, Harvey BK, Dannals RF, Pomper MG, Bonci A, Michaelides M.

Science. 2017 Aug 4;357(6350):503-507. doi: 10.1126/science.aan2475.


Identification of Three Novel Radiotracers for Imaging Aggregated Tau in Alzheimer's Disease with Positron Emission Tomography.

Gobbi LC, Knust H, Körner M, Honer M, Czech C, Belli S, Muri D, Edelmann MR, Hartung T, Erbsmehl I, Grall-Ulsemer S, Koblet A, Rueher M, Steiner S, Ravert HT, Mathews WB, Holt DP, Kuwabara H, Valentine H, Dannals RF, Wong DF, Borroni E.

J Med Chem. 2017 Sep 14;60(17):7350-7370. doi: 10.1021/acs.jmedchem.7b00632. Epub 2017 Jul 12.


Imaging of Glial Cell Activation and White Matter Integrity in Brains of Active and Recently Retired National Football League Players.

Coughlin JM, Wang Y, Minn I, Bienko N, Ambinder EB, Xu X, Peters ME, Dougherty JW, Vranesic M, Koo SM, Ahn HH, Lee M, Cottrell C, Sair HI, Sawa A, Munro CA, Nowinski CJ, Dannals RF, Lyketsos CG, Kassiou M, Smith G, Caffo B, Mori S, Guilarte TR, Pomper MG.

JAMA Neurol. 2017 Jan 1;74(1):67-74. doi: 10.1001/jamaneurol.2016.3764.


18F-FNDP for PET Imaging of Soluble Epoxide Hydrolase.

Horti AG, Wang Y, Minn I, Lan X, Wang J, Koehler RC, Alkayed NJ, Dannals RF, Pomper MG.

J Nucl Med. 2016 Nov;57(11):1817-1822. Epub 2016 Jul 14.


Imaging α4β2 Nicotinic Acetylcholine Receptors (nAChRs) in Baboons with [18F]XTRA, a Radioligand with Improved Specific Binding in Extra-Thalamic Regions.

Kuwabara H, Gao Y, Stabin M, Coughlin J, Nimmagadda S, Dannals RF, Pomper MG, Horti AG.

Mol Imaging Biol. 2017 Apr;19(2):280-288. doi: 10.1007/s11307-016-0999-9.


Development of a High-Affinity PET Radioligand for Imaging Cannabinoid Subtype 2 Receptor.

Moldovan RP, Teodoro R, Gao Y, Deuther-Conrad W, Kranz M, Wang Y, Kuwabara H, Nakano M, Valentine H, Fischer S, Pomper MG, Wong DF, Dannals RF, Brust P, Horti AG.

J Med Chem. 2016 Sep 8;59(17):7840-55. doi: 10.1021/acs.jmedchem.6b00554. Epub 2016 Aug 23.


An improved synthesis of the radiolabeled prostate-specific membrane antigen inhibitor, [(18) F]DCFPyL.

Ravert HT, Holt DP, Chen Y, Mease RC, Fan H, Pomper MG, Dannals RF.

J Labelled Comp Radiopharm. 2016 Sep;59(11):439-50. doi: 10.1002/jlcr.3430. Epub 2016 Jul 29.


Synthesis and quality control of [(18) F]T807 for tau PET imaging.

Holt DP, Ravert HT, Dannals RF.

J Labelled Comp Radiopharm. 2016 Aug;59(10):411-5. doi: 10.1002/jlcr.3425. Epub 2016 Jul 17.


Neuroimaging of translocator protein in patients with systemic lupus erythematosus: a pilot study using [11C]DPA-713 positron emission tomography.

Wang Y, Coughlin JM, Ma S, Endres CJ, Kassiou M, Sawa A, Dannals RF, Petri M, Pomper MG.

Lupus. 2017 Feb;26(2):170-178. doi: 10.1177/0961203316657432. Epub 2016 Jul 11.


PET-measured longitudinal flow gradient correlates with invasive fractional flow reserve in CAD patients.

Valenta I, Antoniou A, Marashdeh W, Leucker T, Kasper E, Jones SR, Dannals RF, Solnes L, Pomper MG, Schindler TH.

Eur Heart J Cardiovasc Imaging. 2017 May 1;18(5):538-548. doi: 10.1093/ehjci/jew116.


PSMA-Based [(18)F]DCFPyL PET/CT Is Superior to Conventional Imaging for Lesion Detection in Patients with Metastatic Prostate Cancer.

Rowe SP, Macura KJ, Mena E, Blackford AL, Nadal R, Antonarakis ES, Eisenberger M, Carducci M, Fan H, Dannals RF, Chen Y, Mease RC, Szabo Z, Pomper MG, Cho SY.

Mol Imaging Biol. 2016 Jun;18(3):411-9. doi: 10.1007/s11307-016-0957-6.


In vivo markers of inflammatory response in recent-onset schizophrenia: a combined study using [(11)C]DPA-713 PET and analysis of CSF and plasma.

Coughlin JM, Wang Y, Ambinder EB, Ward RE, Minn I, Vranesic M, Kim PK, Ford CN, Higgs C, Hayes LN, Schretlen DJ, Dannals RF, Kassiou M, Sawa A, Pomper MG.

Transl Psychiatry. 2016 Apr 12;6:e777. doi: 10.1038/tp.2016.40.


Comparison of Prostate-Specific Membrane Antigen-Based 18F-DCFBC PET/CT to Conventional Imaging Modalities for Detection of Hormone-Naïve and Castration-Resistant Metastatic Prostate Cancer.

Rowe SP, Macura KJ, Ciarallo A, Mena E, Blackford A, Nadal R, Antonarakis ES, Eisenberger MA, Carducci MA, Ross AE, Kantoff PW, Holt DP, Dannals RF, Mease RC, Pomper MG, Cho SY.

J Nucl Med. 2016 Jan;57(1):46-53. doi: 10.2967/jnumed.115.163782. Epub 2015 Oct 22.


Mechanistic Insights into Sympathetic Neuronal Regeneration: Multitracer Molecular Imaging of Catecholamine Handling After Cardiac Transplantation.

Bravo PE, Lautamäki R, Carter D, Holt DP, Nekolla SG, Dannals RF, Russell SD, Bengel FM.

Circ Cardiovasc Imaging. 2015 Aug;8(8):e003507. doi: 10.1161/CIRCIMAGING.115.003507.


Determination of [11C]rifampin pharmacokinetics within Mycobacterium tuberculosis-infected mice by using dynamic positron emission tomography bioimaging.

DeMarco VP, Ordonez AA, Klunk M, Prideaux B, Wang H, Zhuo Z, Tonge PJ, Dannals RF, Holt DP, Lee CK, Weinstein EA, Dartois V, Dooley KE, Jain SK.

Antimicrob Agents Chemother. 2015 Sep;59(9):5768-74. doi: 10.1128/AAC.01146-15. Epub 2015 Jul 13.


Cannabinoid CB2 Receptors in a Mouse Model of Aβ Amyloidosis: Immunohistochemical Analysis and Suitability as a PET Biomarker of Neuroinflammation.

Savonenko AV, Melnikova T, Wang Y, Ravert H, Gao Y, Koppel J, Lee D, Pletnikova O, Cho E, Sayyida N, Hiatt A, Troncoso J, Davies P, Dannals RF, Pomper MG, Horti AG.

PLoS One. 2015 Jun 18;10(6):e0129618. doi: 10.1371/journal.pone.0129618. eCollection 2015.


¹⁸F-DCFBC PET/CT for PSMA-Based Detection and Characterization of Primary Prostate Cancer.

Rowe SP, Gage KL, Faraj SF, Macura KJ, Cornish TC, Gonzalez-Roibon N, Guner G, Munari E, Partin AW, Pavlovich CP, Han M, Carter HB, Bivalacqua TJ, Blackford A, Holt D, Dannals RF, Netto GJ, Lodge MA, Mease RC, Pomper MG, Cho SY.

J Nucl Med. 2015 Jul;56(7):1003-1010. doi: 10.2967/jnumed.115.154336. Epub 2015 Jun 11.


Initial Evaluation of [(18)F]DCFPyL for Prostate-Specific Membrane Antigen (PSMA)-Targeted PET Imaging of Prostate Cancer.

Szabo Z, Mena E, Rowe SP, Plyku D, Nidal R, Eisenberger MA, Antonarakis ES, Fan H, Dannals RF, Chen Y, Mease RC, Vranesic M, Bhatnagar A, Sgouros G, Cho SY, Pomper MG.

Mol Imaging Biol. 2015 Aug;17(4):565-74. doi: 10.1007/s11307-015-0850-8.


Bengt Långström--personal recollections of the gentle giant of short-lived radiotracers.

Dannals RF.

J Labelled Comp Radiopharm. 2015 Mar;58(3):49-50. doi: 10.1002/jlcr.3279. No abstract available.


Microwave-assisted radiosynthesis of [(18) F]ASEM, a radiolabeled α7-nicotinic acetylcholine receptor antagonist.

Ravert HT, Holt DP, Gao Y, Horti AG, Dannals RF.

J Labelled Comp Radiopharm. 2015 Apr;58(4):180-2. doi: 10.1002/jlcr.3275. Epub 2015 Feb 26.


[(125)I]Iodo-ASEM, a specific in vivo radioligand for α7-nAChR.

Gao Y, Mease RC, Olson TT, Kellar KJ, Dannals RF, Pomper MG, Horti AG.

Nucl Med Biol. 2015 May;42(5):488-493. doi: 10.1016/j.nucmedbio.2014.12.008. Epub 2014 Dec 20.


Multiparametric molecular imaging provides mechanistic insights into sympathetic innervation impairment in the viable infarct border zone.

Lautamaki R, Sasano T, Higuchi T, Nekolla SG, Lardo AC, Holt DP, Dannals RF, Abraham MR, Bengel FM.

J Nucl Med. 2015 Mar;56(3):457-63. doi: 10.2967/jnumed.114.149971. Epub 2015 Jan 29.


A microwave radiosynthesis of the 4-[18F]-fluorobenzyltriphenylphosphonium ion.

Ravert HT, Holt DP, Dannals RF.

J Labelled Comp Radiopharm. 2014 Oct;57(12):695-8. doi: 10.1002/jlcr.3241. Epub 2014 Oct 20.


Quantitative Multi-modal Brain Autoradiography of Glutamatergic, Dopaminergic, Cannabinoid, and Nicotinic Receptors in Mutant Disrupted-In-Schizophrenia-1 (DISC1) Mice.

Kim J, Horti AG, Mathews WB, Pogorelov V, Valentine H, Brasic JR, Holt DP, Ravert HT, Dannals RF, Zhou L, Jedynak B, Kamiya A, Pletnikov MV, Wong DF.

Mol Imaging Biol. 2015 Jun;17(3):355-63. doi: 10.1007/s11307-014-0786-4.


Human brain imaging of α7 nAChR with [(18)F]ASEM: a new PET radiotracer for neuropsychiatry and determination of drug occupancy.

Wong DF, Kuwabara H, Pomper M, Holt DP, Brasic JR, George N, Frolov B, Willis W, Gao Y, Valentine H, Nandi A, Gapasin L, Dannals RF, Horti AG.

Mol Imaging Biol. 2014 Oct;16(5):730-8. doi: 10.1007/s11307-014-0779-3.


Dose-dependent, saturable occupancy of the metabotropic glutamate subtype 5 receptor by fenobam as measured with [11 C]ABP688 PET imaging.

Mathews WB, Kuwabara H, Stansfield K, Valentine H, Alexander M, Kumar A, Hilton J, Dannals RF, Wong DF, Gasparini F.

Synapse. 2014 Dec;68(12):565-573. doi: 10.1002/syn.21775. Epub 2014 Aug 19.


18F-ASEM, a radiolabeled antagonist for imaging the α7-nicotinic acetylcholine receptor with PET.

Horti AG, Gao Y, Kuwabara H, Wang Y, Abazyan S, Yasuda RP, Tran T, Xiao Y, Sahibzada N, Holt DP, Kellar KJ, Pletnikov MV, Pomper MG, Wong DF, Dannals RF.

J Nucl Med. 2014 Apr;55(4):672-7. doi: 10.2967/jnumed.113.132068. Epub 2014 Feb 20.


Positron emission tomography radioligands for the opioid system.

Dannals RF.

J Labelled Comp Radiopharm. 2013 Mar-Apr;56(3-4):187-95. doi: 10.1002/jlcr.3005. Review.


Recent PET radioligands with optimal brain kinetics for imaging nicotinic acetylcholine receptors.

Horti AG, Kuwabara H, Holt DP, Dannals RF, Wong DF.

J Labelled Comp Radiopharm. 2013 Mar-Apr;56(3-4):159-66. doi: 10.1002/jlcr.3020. Review.


Derivatives of dibenzothiophene for positron emission tomography imaging of α7-nicotinic acetylcholine receptors.

Gao Y, Kellar KJ, Yasuda RP, Tran T, Xiao Y, Dannals RF, Horti AG.

J Med Chem. 2013 Oct 10;56(19):7574-89. doi: 10.1021/jm401184f. Epub 2013 Sep 19.


PET imaging of high-affinity α4β2 nicotinic acetylcholine receptors in humans with 18F-AZAN, a radioligand with optimal brain kinetics.

Wong DF, Kuwabara H, Kim J, Brasic JR, Chamroonrat W, Gao Y, Valentine H, Willis W, Mathur A, McCaul ME, Wand G, Gean EG, Dannals RF, Horti AG.

J Nucl Med. 2013 Aug;54(8):1308-14. doi: 10.2967/jnumed.112.108001. Epub 2013 Jun 25.


Radiochemical synthesis and in vivo evaluation of [18F]AZ11637326: an agonist probe for the α7 nicotinic acetylcholine receptor.

Ravert HT, Dorff P, Foss CA, Mease RC, Fan H, Holmquist CR, Phillips E, McCarthy DJ, Heys JR, Holt DP, Wang Y, Endres CJ, Dannals RF, Pomper MG.

Nucl Med Biol. 2013 Aug;40(6):731-9. doi: 10.1016/j.nucmedbio.2013.04.005. Epub 2013 May 13.


Discrepant uptake of the radiolabeled norepinephrine analogues hydroxyephedrine (HED) and metaiodobenzylguanidine (MIBG) in rat hearts.

Rischpler C, Fukushima K, Isoda T, Javadi MS, Dannals RF, Abraham R, Wahl R, Bengel FM, Higuchi T.

Eur J Nucl Med Mol Imaging. 2013 Jul;40(7):1077-83. doi: 10.1007/s00259-013-2393-z. Epub 2013 Mar 29.


18F-FPEB, a PET radiopharmaceutical for quantifying metabotropic glutamate 5 receptors: a first-in-human study of radiochemical safety, biokinetics, and radiation dosimetry.

Wong DF, Waterhouse R, Kuwabara H, Kim J, Brašić JR, Chamroonrat W, Stabins M, Holt DP, Dannals RF, Hamill TG, Mozley PD.

J Nucl Med. 2013 Mar;54(3):388-96. doi: 10.2967/jnumed.112.107995. Epub 2013 Feb 12.


Cognition and amyloid load in Alzheimer disease imaged with florbetapir F 18(AV-45) positron emission tomography.

Rosenberg PB, Wong DF, Edell SL, Ross JS, Joshi AD, Brašić JR, Zhou Y, Raymont V, Kumar A, Ravert HT, Dannals RF, Pontecorvo MJ, Skovronsky DM, Lyketsos CG.

Am J Geriatr Psychiatry. 2013 Mar;21(3):272-8. doi: 10.1016/j.jagp.2012.11.016.


Targeting of endothelin receptors in the healthy and infarcted rat heart using the PET tracer 18F-FBzBMS.

Higuchi T, Rischpler C, Fukushima K, Isoda T, Xia J, Javadi MS, Szabo Z, Dannals RF, Mathews WB, Bengel FM.

J Nucl Med. 2013 Feb;54(2):277-82. doi: 10.2967/jnumed.112.106096. Epub 2013 Jan 11.


Synthesis and evaluation of new radioligands [(11)C]A-833834 and [(11)C]A-752274 for positron-emission tomography of α7-nicotinic acetylcholine receptors.

Horti AG, Ravert HT, Gao Y, Holt DP, Bunnelle WH, Schrimpf MR, Li T, Ji J, Valentine H, Scheffel U, Kuwabara H, Wong DF, Dannals RF.

Nucl Med Biol. 2013 Apr;40(3):395-402. doi: 10.1016/j.nucmedbio.2012.11.013. Epub 2013 Jan 5.


Increased synaptic dopamine in the putamen in restless legs syndrome.

Earley CJ, Kuwabara H, Wong DF, Gamaldo C, Salas RE, Brašić JR, Ravert HT, Dannals RF, Allen RP.

Sleep. 2013 Jan 1;36(1):51-7. doi: 10.5665/sleep.2300.

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