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Items: 45

1.

Menin inhibitor MI-3454 induces remission in MLL1-rearranged and NPM1-mutated models of leukemia.

Klossowski S, Miao H, Kempinska K, Wu T, Purohit T, Kim E, Linhares BM, Chen D, Jih G, Perkey E, Huang H, He M, Wen B, Wang Y, Yu K, Lee SC, Danet-Desnoyers G, Trotman W, Kandarpa M, Cotton A, Abdel-Wahab O, Lei H, Dou Y, Guzman M, Peterson L, Gruber T, Choi S, Sun D, Ren P, Li LS, Liu Y, Burrows F, Maillard I, Cierpicki T, Grembecka J.

J Clin Invest. 2020 Feb 3;130(2):981-997. doi: 10.1172/JCI129126.

2.

Human acute myeloid leukemia blast-derived exosomes in patient-derived xenograft mice mediate immune suppression.

Hong CS, Danet-Desnoyers G, Shan X, Sharma P, Whiteside TL, Boyiadzis M.

Exp Hematol. 2019 Aug;76:60-66.e2. doi: 10.1016/j.exphem.2019.07.005. Epub 2019 Jul 29.

PMID:
31369790
3.

Human tumor-associated monocytes/macrophages and their regulation of T cell responses in early-stage lung cancer.

Singhal S, Stadanlick J, Annunziata MJ, Rao AS, Bhojnagarwala PS, O'Brien S, Moon EK, Cantu E, Danet-Desnoyers G, Ra HJ, Litzky L, Akimova T, Beier UH, Hancock WW, Albelda SM, Eruslanov EB.

Sci Transl Med. 2019 Feb 13;11(479). pii: eaat1500. doi: 10.1126/scitranslmed.aat1500.

4.

Culture-independent Profiling of the Fecal Microbiome to Identify Microbial Species Associated with a Diarrheal Outbreak in Immunocompromised Mice.

Misic AM, Miedel EL, Brice AK, Cole S, Zhang GF, Dyer CD, Secreto A, Smith AL, Danet-Desnoyers G, Beiting DP.

Comp Med. 2018 Aug 1;68(4):261-268. doi: 10.30802/AALAS-CM-17-000084. Epub 2018 Jun 13.

5.

Replication study: androgen receptor splice variants determine taxane sensitivity in prostate cancer.

Shan X, Danet-Desnoyers G, Aird F, Kandela I, Tsui R, Perfito N, Iorns E.

PeerJ. 2018 Apr 16;6:e4661. doi: 10.7717/peerj.4661. eCollection 2018.

6.

Cytokines increase engraftment of human acute myeloid leukemia cells in immunocompromised mice but not engraftment of human myelodysplastic syndrome cells.

Krevvata M, Shan X, Zhou C, Dos Santos C, Habineza Ndikuyeze G, Secreto A, Glover J, Trotman W, Brake-Silla G, Nunez-Cruz S, Wertheim G, Ra HJ, Griffiths E, Papachristou C, Danet-Desnoyers G, Carroll M.

Haematologica. 2018 Jun;103(6):959-971. doi: 10.3324/haematol.2017.183202. Epub 2018 Mar 15.

7.

Dexamethasone in hyperleukocytic acute myeloid leukemia.

Bertoli S, Picard M, Bérard E, Griessinger E, Larrue C, Mouchel PL, Vergez F, Tavitian S, Yon E, Ruiz J, Delabesse E, Luquet I, Linares LK, Saland E, Carroll M, Danet-Desnoyers G, Sarry A, Huguet F, Sarry JE, Récher C.

Haematologica. 2018 Jun;103(6):988-998. doi: 10.3324/haematol.2017.184267. Epub 2018 Mar 8.

8.

Correction: Replication Study: Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia.

Shan X, Fung JJ, Kosaka A, Danet-Desnoyers G; Reproducibility Project: Cancer Biology.

Elife. 2018 Jan 8;7. pii: e34573. doi: 10.7554/eLife.34573. No abstract available.

9.

Signaling mechanisms that regulate ex vivo survival of human acute myeloid leukemia initiating cells.

Bhavanasi D, Wen KW, Liu X, Vergez F, Danet-Desnoyers G, Carroll M, Huang J, Klein PS.

Blood Cancer J. 2017 Nov 30;7(12):636. doi: 10.1038/s41408-017-0003-1. No abstract available.

10.

The clinical and immunological performance of 28 days survival model of cecal ligation and puncture in humanized mice.

Laudanski K, Lapko N, Zawadka M, Zhou BX, Danet-Desnoyers G, Worthen GS.

PLoS One. 2017 Jul 17;12(7):e0180377. doi: 10.1371/journal.pone.0180377. eCollection 2017.

11.

Replication Study: Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia.

Shan X, Fung JJ, Kosaka A, Danet-Desnoyers G; Reproducibility Project: Cancer Biology.

Elife. 2017 Jun 27;6. pii: e25306. doi: 10.7554/eLife.25306. Erratum in: Elife. 2018 Jan 08;7:.

12.
13.

Chemotherapy-Resistant Human Acute Myeloid Leukemia Cells Are Not Enriched for Leukemic Stem Cells but Require Oxidative Metabolism.

Farge T, Saland E, de Toni F, Aroua N, Hosseini M, Perry R, Bosc C, Sugita M, Stuani L, Fraisse M, Scotland S, Larrue C, Boutzen H, Féliu V, Nicolau-Travers ML, Cassant-Sourdy S, Broin N, David M, Serhan N, Sarry A, Tavitian S, Kaoma T, Vallar L, Iacovoni J, Linares LK, Montersino C, Castellano R, Griessinger E, Collette Y, Duchamp O, Barreira Y, Hirsch P, Palama T, Gales L, Delhommeau F, Garmy-Susini BH, Portais JC, Vergez F, Selak M, Danet-Desnoyers G, Carroll M, Récher C, Sarry JE.

Cancer Discov. 2017 Jul;7(7):716-735. doi: 10.1158/2159-8290.CD-16-0441. Epub 2017 Apr 17.

14.

Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge.

Pardi N, Secreto AJ, Shan X, Debonera F, Glover J, Yi Y, Muramatsu H, Ni H, Mui BL, Tam YK, Shaheen F, Collman RG, Karikó K, Danet-Desnoyers GA, Madden TD, Hope MJ, Weissman D.

Nat Commun. 2017 Mar 2;8:14630. doi: 10.1038/ncomms14630.

15.

Anti-leukemic activity and tolerability of anti-human CD47 monoclonal antibodies.

Pietsch EC, Dong J, Cardoso R, Zhang X, Chin D, Hawkins R, Dinh T, Zhou M, Strake B, Feng PH, Rocca M, Santos CD, Shan X, Danet-Desnoyers G, Shi F, Kaiser E, Millar HJ, Fenton S, Swanson R, Nemeth JA, Attar RM.

Blood Cancer J. 2017 Feb 24;7(2):e536. doi: 10.1038/bcj.2017.7.

16.

Integrative Development of a TLR8 Agonist for Ovarian Cancer Chemoimmunotherapy.

Monk BJ, Facciabene A, Brady WE, Aghajanian CA, Fracasso PM, Walker JL, Lankes HA, Manjarrez KL, Danet-Desnoyers GH, Bell-McGuinn KM, McCourt CK, Malykhin A, Hershberg RM, Coukos G.

Clin Cancer Res. 2017 Apr 15;23(8):1955-1966. doi: 10.1158/1078-0432.CCR-16-1453. Epub 2016 Oct 4.

17.

Registered report: androgen receptor splice variants determine taxane sensitivity in prostate cancer.

Shan X, Danet-Desnoyers G, Fung JJ, Kosaka AH, Tan F, Perfito N, Lomax J, Iorns E.

PeerJ. 2015 Sep 15;3:e1232. doi: 10.7717/peerj.1232. eCollection 2015.

18.

Registered report: Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukemia.

Fung JJ, Kosaka A, Shan X, Danet-Desnoyers G, Gormally M, Owen K; Reproducibility Project: Cancer Biology; Reproducibility Project Cancer Biology.

Elife. 2015 Sep 1;4. doi: 10.7554/eLife.08997.

19.

Menin-MLL inhibitors block oncogenic transformation by MLL-fusion proteins in a fusion partner-independent manner.

He S, Malik B, Borkin D, Miao H, Shukla S, Kempinska K, Purohit T, Wang J, Chen L, Parkin B, Malek SN, Danet-Desnoyers G, Muntean AG, Cierpicki T, Grembecka J.

Leukemia. 2016 Feb;30(2):508-13. doi: 10.1038/leu.2015.144. Epub 2015 Jun 18. No abstract available.

20.

Pharmacologic inhibition of the Menin-MLL interaction blocks progression of MLL leukemia in vivo.

Borkin D, He S, Miao H, Kempinska K, Pollock J, Chase J, Purohit T, Malik B, Zhao T, Wang J, Wen B, Zong H, Jones M, Danet-Desnoyers G, Guzman ML, Talpaz M, Bixby DL, Sun D, Hess JL, Muntean AG, Maillard I, Cierpicki T, Grembecka J.

Cancer Cell. 2015 Apr 13;27(4):589-602. doi: 10.1016/j.ccell.2015.02.016. Epub 2015 Mar 26.

21.

A robust and rapid xenograft model to assess efficacy of chemotherapeutic agents for human acute myeloid leukemia.

Saland E, Boutzen H, Castellano R, Pouyet L, Griessinger E, Larrue C, de Toni F, Scotland S, David M, Danet-Desnoyers G, Vergez F, Barreira Y, Collette Y, Récher C, Sarry JE.

Blood Cancer J. 2015 Mar 20;5:e297. doi: 10.1038/bcj.2015.19.

22.

OKT3 prevents xenogeneic GVHD and allows reliable xenograft initiation from unfractionated human hematopoietic tissues.

Wunderlich M, Brooks RA, Panchal R, Rhyasen GW, Danet-Desnoyers G, Mulloy JC.

Blood. 2014 Jun 12;123(24):e134-44. doi: 10.1182/blood-2014-02-556340. Epub 2014 Apr 28.

23.

Preclinical targeting of human acute myeloid leukemia and myeloablation using chimeric antigen receptor-modified T cells.

Gill S, Tasian SK, Ruella M, Shestova O, Li Y, Porter DL, Carroll M, Danet-Desnoyers G, Scholler J, Grupp SA, June CH, Kalos M.

Blood. 2014 Apr 10;123(15):2343-54. doi: 10.1182/blood-2013-09-529537. Epub 2014 Mar 4. Erratum in: Blood. 2016 Nov 24;128(21):2585.

24.

The potent oncogene NPM-ALK mediates malignant transformation of normal human CD4(+) T lymphocytes.

Zhang Q, Wei F, Wang HY, Liu X, Roy D, Xiong QB, Jiang S, Medvec A, Danet-Desnoyers G, Watt C, Tomczak E, Kalos M, Riley JL, Wasik MA.

Am J Pathol. 2013 Dec;183(6):1971-80.

25.

Simultaneous zinc-finger nuclease editing of the HIV coreceptors ccr5 and cxcr4 protects CD4+ T cells from HIV-1 infection.

Didigu CA, Wilen CB, Wang J, Duong J, Secreto AJ, Danet-Desnoyers GA, Riley JL, Gregory PD, June CH, Holmes MC, Doms RW.

Blood. 2014 Jan 2;123(1):61-9. doi: 10.1182/blood-2013-08-521229. Epub 2013 Oct 25.

26.

Novel recombinant human b7-h4 antibodies overcome tumoral immune escape to potentiate T-cell antitumor responses.

Dangaj D, Lanitis E, Zhao A, Joshi S, Cheng Y, Sandaltzopoulos R, Ra HJ, Danet-Desnoyers G, Powell DJ Jr, Scholler N.

Cancer Res. 2013 Aug 1;73(15):4820-9. doi: 10.1158/0008-5472.CAN-12-3457. Epub 2013 May 30.

27.

Mitochondrial energetic and AKT status mediate metabolic effects and apoptosis of metformin in human leukemic cells.

Scotland S, Saland E, Skuli N, de Toni F, Boutzen H, Micklow E, Sénégas I, Peyraud R, Peyriga L, Théodoro F, Dumon E, Martineau Y, Danet-Desnoyers G, Bono F, Rocher C, Levade T, Manenti S, Junot C, Portais JC, Alet N, Récher C, Selak MA, Carroll M, Sarry JE.

Leukemia. 2013 Nov;27(11):2129-38. doi: 10.1038/leu.2013.107. Epub 2013 Apr 9.

PMID:
23568147
28.

Maintenance of hematopoietic stem cells through regulation of Wnt and mTOR pathways.

Huang J, Nguyen-McCarty M, Hexner EO, Danet-Desnoyers G, Klein PS.

Nat Med. 2012 Dec;18(12):1778-85. doi: 10.1038/nm.2984. Epub 2012 Nov 11.

29.

Engineering HIV-resistant human CD4+ T cells with CXCR4-specific zinc-finger nucleases.

Wilen CB, Wang J, Tilton JC, Miller JC, Kim KA, Rebar EJ, Sherrill-Mix SA, Patro SC, Secreto AJ, Jordan AP, Lee G, Kahn J, Aye PP, Bunnell BA, Lackner AA, Hoxie JA, Danet-Desnoyers GA, Bushman FD, Riley JL, Gregory PD, June CH, Holmes MC, Doms RW.

PLoS Pathog. 2011 Apr;7(4):e1002020. doi: 10.1371/journal.ppat.1002020. Epub 2011 Apr 14.

30.

Human acute myelogenous leukemia stem cells are rare and heterogeneous when assayed in NOD/SCID/IL2Rγc-deficient mice.

Sarry JE, Murphy K, Perry R, Sanchez PV, Secreto A, Keefer C, Swider CR, Strzelecki AC, Cavelier C, Récher C, Mansat-De Mas V, Delabesse E, Danet-Desnoyers G, Carroll M.

J Clin Invest. 2011 Jan;121(1):384-95. doi: 10.1172/JCI41495. Epub 2010 Dec 13.

31.

TAT-mediated transduction of NF-Ya peptide induces the ex vivo proliferation and engraftment potential of human hematopoietic progenitor cells.

Domashenko AD, Danet-Desnoyers G, Aron A, Carroll MP, Emerson SG.

Blood. 2010 Oct 14;116(15):2676-83. doi: 10.1182/blood-2010-03-273441. Epub 2010 Jul 8.

32.

Increased immunogenicity of surviving tumor cells enables cooperation between liposomal doxorubicin and IL-18.

Alagkiozidis I, Facciabene A, Carpenito C, Benencia F, Jonak Z, Adams S, Carroll RG, Gimotty PA, Hammond R, Danet-Desnoyers GÄ, June CH, Powell DJ Jr, Coukos G.

J Transl Med. 2009 Dec 10;7:104. doi: 10.1186/1479-5876-7-104.

33.

A robust xenotransplantation model for acute myeloid leukemia.

Sanchez PV, Perry RL, Sarry JE, Perl AE, Murphy K, Swider CR, Bagg A, Choi JK, Biegel JA, Danet-Desnoyers G, Carroll M.

Leukemia. 2009 Nov;23(11):2109-17. doi: 10.1038/leu.2009.143. Epub 2009 Jul 23.

34.

Chimeric receptors containing CD137 signal transduction domains mediate enhanced survival of T cells and increased antileukemic efficacy in vivo.

Milone MC, Fish JD, Carpenito C, Carroll RG, Binder GK, Teachey D, Samanta M, Lakhal M, Gloss B, Danet-Desnoyers G, Campana D, Riley JL, Grupp SA, June CH.

Mol Ther. 2009 Aug;17(8):1453-64. doi: 10.1038/mt.2009.83. Epub 2009 Apr 21. Erratum in: Mol Ther. 2015 Jul;23(7):1278.

35.

Distinct effects of IL-18 on the engraftment and function of human effector CD8 T cells and regulatory T cells.

Carroll RG, Carpenito C, Shan X, Danet-Desnoyers G, Liu R, Jiang S, Albelda SM, Golovina T, Coukos G, Riley JL, Jonak ZL, June CH.

PLoS One. 2008 Sep 26;3(9):e3289. doi: 10.1371/journal.pone.0003289.

36.

Trisomy 21 enhances human fetal erythro-megakaryocytic development.

Chou ST, Opalinska JB, Yao Y, Fernandes MA, Kalota A, Brooks JS, Choi JK, Gewirtz AM, Danet-Desnoyers GA, Nemiroff RL, Weiss MJ.

Blood. 2008 Dec 1;112(12):4503-6. doi: 10.1182/blood-2008-05-157859. Epub 2008 Sep 23.

37.

Umbilical cord blood xenografts in immunodeficient mice reveal that T cells enhance hematopoietic engraftment beyond overcoming immune barriers by stimulating stem cell differentiation.

Hexner EO, Danet-Desnoyers GA, Zhang Y, Frank DM, Riley JL, Levine BL, Porter DL, June CH, Emerson SG.

Biol Blood Marrow Transplant. 2007 Oct;13(10):1135-44.

38.

Immunosurveillance and survivin-specific T-cell immunity in children with high-risk neuroblastoma.

Coughlin CM, Fleming MD, Carroll RG, Pawel BR, Hogarty MD, Shan X, Vance BA, Cohen JN, Jairaj S, Lord EM, Wexler MH, Danet-Desnoyers GA, Pinkus JL, Pinkus GS, Maris JM, Grupp SA, Vonderheide RH.

J Clin Oncol. 2006 Dec 20;24(36):5725-34.

PMID:
17179106
39.

Telomerase vaccination has no detectable effect on SCID-repopulating and colony-forming activities in the bone marrow of cancer patients.

Danet-Desnoyers GA, Luongo JL, Bonnet DA, Domchek SM, Vonderheide RH.

Exp Hematol. 2005 Nov;33(11):1275-80.

PMID:
16263411
40.

Hematopoietic stem cells express multiple myeloid markers: implications for the origin and targeted therapy of acute myeloid leukemia.

Taussig DC, Pearce DJ, Simpson C, Rohatiner AZ, Lister TA, Kelly G, Luongo JL, Danet-Desnoyers GA, Bonnet D.

Blood. 2005 Dec 15;106(13):4086-92. Epub 2005 Aug 30.

41.

Regulation of endometrial prostaglandin synthesis during early pregnancy in cattle: effects of phospholipases and calcium in vitro.

Danet-Desnoyers G, Meyer MD, Gross TS, Johnson JW, Thatcher WW.

Prostaglandins. 1995 Nov-Dec;50(5-6):313-30.

PMID:
8838241
42.

Maternal recognition of pregnancy.

Thatcher WW, Meyer MD, Danet-Desnoyers G.

J Reprod Fertil Suppl. 1995;49:15-28. Review.

PMID:
7623310
44.

Regulation of bovine endometrial prostaglandin secretion and the role of bovine trophoblast protein-1 complex.

Thatcher WW, Danet-Desnoyers G, Wetzels C.

Reprod Fertil Dev. 1992;4(3):329-34. No abstract available.

PMID:
1438964
45.

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