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Items: 1 to 50 of 153

1.

Selective deletion of glutamine synthetase in the mouse cerebral cortex induces glial dysfunction and vascular impairment that precede epilepsy and neurodegeneration.

Zhou Y, Dhaher R, Parent M, Hu QX, Hassel B, Yee SP, Hyder F, Gruenbaum SE, Eid T, Danbolt NC.

Neurochem Int. 2019 Feb;123:22-33. doi: 10.1016/j.neuint.2018.07.009. Epub 2018 Jul 24.

PMID:
30053506
2.

Genetic deletion of xCT attenuates peripheral and central inflammation and mitigates LPS-induced sickness and depressive-like behavior in mice.

Albertini G, Deneyer L, Ottestad-Hansen S, Zhou Y, Ates G, Walrave L, Demuyser T, Bentea E, Sato H, De Bundel D, Danbolt NC, Massie A, Smolders I.

Glia. 2018 Sep;66(9):1845-1861. doi: 10.1002/glia.23343. Epub 2018 Apr 25.

PMID:
29693305
3.

Axon-terminals expressing EAAT2 (GLT-1; Slc1a2) are common in the forebrain and not limited to the hippocampus.

Zhou Y, Hassel B, Eid T, Danbolt NC.

Neurochem Int. 2019 Feb;123:101-113. doi: 10.1016/j.neuint.2018.03.006. Epub 2018 Mar 9.

PMID:
29530756
4.

The cystine-glutamate exchanger (xCT, Slc7a11) is expressed in significant concentrations in a subpopulation of astrocytes in the mouse brain.

Ottestad-Hansen S, Hu QX, Follin-Arbelet VV, Bentea E, Sato H, Massie A, Zhou Y, Danbolt NC.

Glia. 2018 May;66(5):951-970. doi: 10.1002/glia.23294. Epub 2018 Jan 19.

PMID:
29350434
5.

Expression of Glutamate Transporters in Mouse Liver, Kidney, and Intestine.

Hu QX, Ottestad-Hansen S, Holmseth S, Hassel B, Danbolt NC, Zhou Y.

J Histochem Cytochem. 2018 Mar;66(3):189-202. doi: 10.1369/0022155417749828. Epub 2018 Jan 5.

6.

Slc7a11 (xCT) protein expression is not altered in the depressed brain and system xc- deficiency does not affect depression-associated behaviour in the corticosterone mouse model.

Demuyser T, Deneyer L, Bentea E, Albertini G, Femenia T, Walrave L, Sato H, Danbolt NC, De Bundel D, Michotte A, Lindskog M, Massie A, Smolders I.

World J Biol Psychiatry. 2019 Jun;20(5):381-392. doi: 10.1080/15622975.2017.1371332. Epub 2017 Sep 27.

PMID:
28882088
7.

The Glutamate-Glutamine Cycle in Epilepsy.

Eid T, Gruenbaum SE, Dhaher R, Lee TW, Zhou Y, Danbolt NC.

Adv Neurobiol. 2016;13:351-400. Review.

PMID:
27885637
8.

Strategies for immunohistochemical protein localization using antibodies: What did we learn from neurotransmitter transporters in glial cells and neurons.

Danbolt NC, Zhou Y, Furness DN, Holmseth S.

Glia. 2016 Dec;64(12):2045-2064. doi: 10.1002/glia.23027. Epub 2016 Jul 26. Review.

PMID:
27458697
9.

A large-scale quantitative EM study on activation of olfactory glands shows no effect of cholinergic agents.

Li Y, Hessvik NP, Danbolt NC, Holen T.

Microscopy (Oxf). 2016 Oct;65(5):438-443. Epub 2016 Jul 26.

PMID:
27460022
10.

Neuronal vs glial glutamate uptake: Resolving the conundrum.

Danbolt NC, Furness DN, Zhou Y.

Neurochem Int. 2016 Sep;98:29-45. doi: 10.1016/j.neuint.2016.05.009. Epub 2016 May 26. Review.

PMID:
27235987
11.

Astrocyte membrane properties are altered in a rat model of developmental cortical malformation but single-cell astrocytic glutamate uptake is robust.

Hanson E, Danbolt NC, Dulla CG.

Neurobiol Dis. 2016 May;89:157-68. doi: 10.1016/j.nbd.2016.02.012. Epub 2016 Feb 10.

12.

Comparative analysis of antibodies to xCT (Slc7a11): Forewarned is forearmed.

Van Liefferinge J, Bentea E, Demuyser T, Albertini G, Follin-Arbelet V, Holmseth S, Merckx E, Sato H, Aerts JL, Smolders I, Arckens L, Danbolt NC, Massie A.

J Comp Neurol. 2016 Apr 1;524(5):1015-32. doi: 10.1002/cne.23889. Epub 2015 Oct 23.

PMID:
26494316
13.

Astrocytic glutamate uptake is slow and does not limit neuronal NMDA receptor activation in the neonatal neocortex.

Hanson E, Armbruster M, Cantu D, Andresen L, Taylor A, Danbolt NC, Dulla CG.

Glia. 2015 Oct;63(10):1784-96. doi: 10.1002/glia.22844. Epub 2015 Apr 27.

14.

Conditional deletion of the glutamate transporter GLT-1 reveals that astrocytic GLT-1 protects against fatal epilepsy while neuronal GLT-1 contributes significantly to glutamate uptake into synaptosomes.

Petr GT, Sun Y, Frederick NM, Zhou Y, Dhamne SC, Hameed MQ, Miranda C, Bedoya EA, Fischer KD, Armsen W, Wang J, Danbolt NC, Rotenberg A, Aoki CJ, Rosenberg PA.

J Neurosci. 2015 Apr 1;35(13):5187-201. doi: 10.1523/JNEUROSCI.4255-14.2015.

15.

Reactive astrogliosis causes the development of spontaneous seizures.

Robel S, Buckingham SC, Boni JL, Campbell SL, Danbolt NC, Riedemann T, Sutor B, Sontheimer H.

J Neurosci. 2015 Feb 25;35(8):3330-45. doi: 10.1523/JNEUROSCI.1574-14.2015.

16.

EAAT2 (GLT-1; slc1a2) glutamate transporters reconstituted in liposomes argues against heteroexchange being substantially faster than net uptake.

Zhou Y, Wang X, Tzingounis AV, Danbolt NC, Larsson HP.

J Neurosci. 2014 Oct 1;34(40):13472-85. doi: 10.1523/JNEUROSCI.2282-14.2014.

17.

Human OXR1 maintains mitochondrial DNA integrity and counteracts hydrogen peroxide-induced oxidative stress by regulating antioxidant pathways involving p21.

Yang M, Luna L, Sørbø JG, Alseth I, Johansen RF, Backe PH, Danbolt NC, Eide L, Bjørås M.

Free Radic Biol Med. 2014 Dec;77:41-8. doi: 10.1016/j.freeradbiomed.2014.09.003. Epub 2014 Sep 16.

18.

The betaine/GABA transporter and betaine: roles in brain, kidney, and liver.

Kempson SA, Zhou Y, Danbolt NC.

Front Physiol. 2014 Apr 24;5:159. doi: 10.3389/fphys.2014.00159. eCollection 2014. Review.

19.

Glutamate as a neurotransmitter in the healthy brain.

Zhou Y, Danbolt NC.

J Neural Transm (Vienna). 2014 Aug;121(8):799-817. doi: 10.1007/s00702-014-1180-8. Epub 2014 Mar 1. Review.

20.

Proteome analysis and conditional deletion of the EAAT2 glutamate transporter provide evidence against a role of EAAT2 in pancreatic insulin secretion in mice.

Zhou Y, Waanders LF, Holmseth S, Guo C, Berger UV, Li Y, Lehre AC, Lehre KP, Danbolt NC.

J Biol Chem. 2014 Jan 17;289(3):1329-44. doi: 10.1074/jbc.M113.529065. Epub 2013 Nov 26.

21.

GABA and Glutamate Transporters in Brain.

Zhou Y, Danbolt NC.

Front Endocrinol (Lausanne). 2013 Nov 11;4:165. doi: 10.3389/fendo.2013.00165. eCollection 2013. Review.

22.

The GLT-1 (EAAT2; slc1a2) glutamate transporter is essential for glutamate homeostasis in the neocortex of the mouse.

Bjørnsen LP, Hadera MG, Zhou Y, Danbolt NC, Sonnewald U.

J Neurochem. 2014 Mar;128(5):641-9. doi: 10.1111/jnc.12509. Epub 2013 Nov 14.

23.

A novel glutamate transporter blocker, LL-TBOA, attenuates ischaemic injury in the isolated, perfused rat heart despite low transporter levels.

Martinov V, Dehnes Y, Holmseth S, Shimamoto K, Danbolt NC, Valen G.

Eur J Cardiothorac Surg. 2014 Apr;45(4):710-6. doi: 10.1093/ejcts/ezt487. Epub 2013 Oct 6.

PMID:
24099732
24.

Deletion of the γ-aminobutyric acid transporter 2 (GAT2 and SLC6A13) gene in mice leads to changes in liver and brain taurine contents.

Zhou Y, Holmseth S, Guo C, Hassel B, Höfner G, Huitfeldt HS, Wanner KT, Danbolt NC.

J Biol Chem. 2012 Oct 12;287(42):35733-46. doi: 10.1074/jbc.M112.368175. Epub 2012 Aug 15.

25.

The rates of postmortem proteolysis of glutamate transporters differ dramatically between cells and between transporter subtypes.

Li Y, Zhou Y, Danbolt NC.

J Histochem Cytochem. 2012 Nov;60(11):811-21. doi: 10.1369/0022155412458589. Epub 2012 Aug 2.

26.

The density of EAAC1 (EAAT3) glutamate transporters expressed by neurons in the mammalian CNS.

Holmseth S, Dehnes Y, Huang YH, Follin-Arbelet VV, Grutle NJ, Mylonakou MN, Plachez C, Zhou Y, Furness DN, Bergles DE, Lehre KP, Danbolt NC.

J Neurosci. 2012 Apr 25;32(17):6000-13. doi: 10.1523/JNEUROSCI.5347-11.2012.

27.

Specificity controls for immunocytochemistry: the antigen preadsorption test can lead to inaccurate assessment of antibody specificity.

Holmseth S, Zhou Y, Follin-Arbelet VV, Lehre KP, Bergles DE, Danbolt NC.

J Histochem Cytochem. 2012 Mar;60(3):174-87. doi: 10.1369/0022155411434828. Epub 2012 Jan 3.

28.

The betaine-GABA transporter (BGT1, slc6a12) is predominantly expressed in the liver and at lower levels in the kidneys and at the brain surface.

Zhou Y, Holmseth S, Hua R, Lehre AC, Olofsson AM, Poblete-Naredo I, Kempson SA, Danbolt NC.

Am J Physiol Renal Physiol. 2012 Feb 1;302(3):F316-28. doi: 10.1152/ajprenal.00464.2011. Epub 2011 Nov 9.

29.

The sodium-dependent inorganic phosphate transporter SLC34A1 (NaPi-IIa) is not localized in the mouse brain: a case of tissue-specific antigenic cross-reactivity.

Larsson M, Morland C, Poblete-Naredo I, Biber J, Danbolt NC, Gundersen V.

J Histochem Cytochem. 2011 Sep;59(9):807-12. doi: 10.1369/0022155411411713. Epub 2011 May 23.

30.

Deletion of the betaine-GABA transporter (BGT1; slc6a12) gene does not affect seizure thresholds of adult mice.

Lehre AC, Rowley NM, Zhou Y, Holmseth S, Guo C, Holen T, Hua R, Laake P, Olofsson AM, Poblete-Naredo I, Rusakov DA, Madsen KK, Clausen RP, Schousboe A, White HS, Danbolt NC.

Epilepsy Res. 2011 Jun;95(1-2):70-81. doi: 10.1016/j.eplepsyres.2011.02.014. Epub 2011 Apr 3.

31.

The perivascular astroglial sheath provides a complete covering of the brain microvessels: an electron microscopic 3D reconstruction.

Mathiisen TM, Lehre KP, Danbolt NC, Ottersen OP.

Glia. 2010 Jul;58(9):1094-103. doi: 10.1002/glia.20990.

PMID:
20468051
32.

The concentrations and distributions of three C-terminal variants of the GLT1 (EAAT2; slc1a2) glutamate transporter protein in rat brain tissue suggest differential regulation.

Holmseth S, Scott HA, Real K, Lehre KP, Leergaard TB, Bjaalie JG, Danbolt NC.

Neuroscience. 2009 Sep 15;162(4):1055-71. doi: 10.1016/j.neuroscience.2009.03.048. Epub 2009 Mar 27.

PMID:
19328838
33.

Greater intrasex phenotype variability in males than in females is a fundamental aspect of the gender differences in humans.

Lehre AC, Lehre KP, Laake P, Danbolt NC.

Dev Psychobiol. 2009 Mar;51(2):198-206. doi: 10.1002/dev.20358.

PMID:
19031491
34.

A quantitative assessment of glutamate uptake into hippocampal synaptic terminals and astrocytes: new insights into a neuronal role for excitatory amino acid transporter 2 (EAAT2).

Furness DN, Dehnes Y, Akhtar AQ, Rossi DJ, Hamann M, Grutle NJ, Gundersen V, Holmseth S, Lehre KP, Ullensvang K, Wojewodzic M, Zhou Y, Attwell D, Danbolt NC.

Neuroscience. 2008 Nov 11;157(1):80-94. doi: 10.1016/j.neuroscience.2008.08.043. Epub 2008 Aug 27.

35.

Low-affinity excitatory amino acid uptake in hippocampal astrocytes: a possible role of Na+/dicarboxylate cotransporters.

Holten AT, Danbolt NC, Shimamoto K, Gundersen V.

Glia. 2008 Jul;56(9):990-7. doi: 10.1002/glia.20672. Erratum in: Glia. 2009 Jan 1;57(1):118. Talgøy, Haolten Aleksander [corrected to Holten, Aleksander Talgøy]; Christian, Danbolt Niels [corrected to Danbolt, Niels Christian]; Vidar, Gundersen [corrected to Gundersen, Vidar].

PMID:
18442087
36.

Enhancing glutamate transport: mechanism of action of Parawixin1, a neuroprotective compound from Parawixia bistriata spider venom.

Fontana AC, de Oliveira Beleboni R, Wojewodzic MW, Ferreira Dos Santos W, Coutinho-Netto J, Grutle NJ, Watts SD, Danbolt NC, Amara SG.

Mol Pharmacol. 2007 Nov;72(5):1228-37. Epub 2007 Jul 23.

PMID:
17646426
37.

Changes in glial glutamate transporters in human epileptogenic hippocampus: inadequate explanation for high extracellular glutamate during seizures.

Bjørnsen LP, Eid T, Holmseth S, Danbolt NC, Spencer DD, de Lanerolle NC.

Neurobiol Dis. 2007 Feb;25(2):319-30. Epub 2006 Nov 16.

PMID:
17112731
38.

Effects of lipopolysaccharide on glial phenotype and activity of glutamate transporters: Evidence for delayed up-regulation and redistribution of GLT-1.

O'Shea RD, Lau CL, Farso MC, Diwakarla S, Zagami CJ, Svendsen BB, Feeney SJ, Callaway JK, Jones NM, Pow DV, Danbolt NC, Jarrott B, Beart PM.

Neurochem Int. 2006 May-Jun;48(6-7):604-10. Epub 2006 Mar 10.

PMID:
16530295
39.

Specificity controls for immunocytochemistry.

Holmseth S, Lehre KP, Danbolt NC.

Anat Embryol (Berl). 2006 Aug;211(4):257-66. Epub 2006 Jan 25.

PMID:
16435108
40.

Specificity of antibodies: unexpected cross-reactivity of antibodies directed against the excitatory amino acid transporter 3 (EAAT3).

Holmseth S, Dehnes Y, Bjørnsen LP, Boulland JL, Furness DN, Bergles D, Danbolt NC.

Neuroscience. 2005;136(3):649-60.

PMID:
16344142
41.

Glycine, GABA and their transporters in pancreatic islets of Langerhans: evidence for a paracrine transmitter interplay.

Gammelsaeter R, Frøyland M, Aragón C, Danbolt NC, Fortin D, Storm-Mathisen J, Davanger S, Gundersen V.

J Cell Sci. 2004 Aug 1;117(Pt 17):3749-58. Epub 2004 Jul 13.

42.

Loss of glutamine synthetase in the human epileptogenic hippocampus: possible mechanism for raised extracellular glutamate in mesial temporal lobe epilepsy.

Eid T, Thomas MJ, Spencer DD, Rundén-Pran E, Lai JC, Malthankar GV, Kim JH, Danbolt NC, Ottersen OP, de Lanerolle NC.

Lancet. 2004 Jan 3;363(9402):28-37.

PMID:
14723991
43.

Cellular distribution of a high-affinity glutamate transporter in the nervous system of the cabbage looper Trichoplusia ni.

Gardiner RB, Ullensvang K, Danbolt NC, Caveney S, Donly BC.

J Exp Biol. 2002 Sep;205(Pt 17):2605-13.

44.

Cell-specific expression of the glutamine transporter SN1 suggests differences in dependence on the glutamine cycle.

Boulland JL, Osen KK, Levy LM, Danbolt NC, Edwards RH, Storm-Mathisen J, Chaudhry FA.

Eur J Neurosci. 2002 May;15(10):1615-31.

PMID:
12059969
45.

Evaluation of drugs acting at glutamate transporters in organotypic hippocampal cultures: new evidence on substrates and blockers in excitotoxicity.

O'Shea RD, Fodera MV, Apricó K, Dehnes Y, Danbolt NC, Crawford D, Beart PM.

Neurochem Res. 2002 Feb;27(1-2):5-13.

PMID:
11926276
46.
47.

Glutamate uptake.

Danbolt NC.

Prog Neurobiol. 2001 Sep;65(1):1-105. Review.

PMID:
11369436
48.

Amyotrophic lateral sclerosis-linked glutamate transporter mutant has impaired glutamate clearance capacity.

Trotti D, Aoki M, Pasinelli P, Berger UV, Danbolt NC, Brown RH Jr, Hediger MA.

J Biol Chem. 2001 Jan 5;276(1):576-82.

49.

The high-affinity glutamate transporters GLT1, GLAST, and EAAT4 are regulated via different signalling mechanisms.

Gegelashvili G, Dehnes Y, Danbolt NC, Schousboe A.

Neurochem Int. 2000 Aug-Sep;37(2-3):163-70.

PMID:
10812201
50.

Transient expression of the glial glutamate transporters GLAST and GLT in hippocampal neurons in primary culture.

Plachez C, Danbolt NC, Récasens M.

J Neurosci Res. 2000 Mar 1;59(5):587-93.

PMID:
10686586

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