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Items: 21

1.

Postdiagnosis Loss of Skeletal Muscle, but Not Adipose Tissue, Is Associated with Shorter Survival of Patients with Advanced Pancreatic Cancer.

Babic A, Rosenthal MH, Bamlet WR, Takahashi N, Sugimoto M, Danai LV, Morales-Oyarvide V, Khalaf N, Dunne RF, Brais LK, Welch MW, Zellers CL, Dennis C, Rifai N, Prado CM, Caan B, Sundaresan TK, Meyerhardt JA, Kulke MH, Clish CB, Ng K, Vander Heiden MG, Petersen GM, Wolpin BM.

Cancer Epidemiol Biomarkers Prev. 2019 Dec;28(12):2062-2069. doi: 10.1158/1055-9965.EPI-19-0370. Epub 2019 Sep 18.

PMID:
31533940
2.

Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability.

Sullivan MR, Danai LV, Lewis CA, Chan SH, Gui DY, Kunchok T, Dennstedt EA, Vander Heiden MG, Muir A.

Elife. 2019 Apr 16;8. pii: e44235. doi: 10.7554/eLife.44235.

3.

PKM2 is not required for pancreatic ductal adenocarcinoma.

Hillis AL, Lau AN, Devoe CX, Dayton TL, Danai LV, Di Vizio D, Vander Heiden MG.

Cancer Metab. 2018 Oct 23;6:17. doi: 10.1186/s40170-018-0188-1. eCollection 2018.

4.

Microenvironmental regulation of cancer cell metabolism: implications for experimental design and translational studies.

Muir A, Danai LV, Vander Heiden MG.

Dis Model Mech. 2018 Aug 7;11(8). pii: dmm035758. doi: 10.1242/dmm.035758. Review.

5.

Aspartate is an endogenous metabolic limitation for tumour growth.

Sullivan LB, Luengo A, Danai LV, Bush LN, Diehl FF, Hosios AM, Lau AN, Elmiligy S, Malstrom S, Lewis CA, Vander Heiden MG.

Nat Cell Biol. 2018 Jul;20(7):782-788. doi: 10.1038/s41556-018-0125-0. Epub 2018 Jun 25.

6.

Altered exocrine function can drive adipose wasting in early pancreatic cancer.

Danai LV, Babic A, Rosenthal MH, Dennstedt EA, Muir A, Lien EC, Mayers JR, Tai K, Lau AN, Jones-Sali P, Prado CM, Petersen GM, Takahashi N, Sugimoto M, Yeh JJ, Lopez N, Bardeesy N, Fernandez-Del Castillo C, Liss AS, Koong AC, Bui J, Yuan C, Welch MW, Brais LK, Kulke MH, Dennis C, Clish CB, Wolpin BM, Vander Heiden MG.

Nature. 2018 Jun;558(7711):600-604. doi: 10.1038/s41586-018-0235-7. Epub 2018 Jun 20.

7.

mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient.

Wyant GA, Abu-Remaileh M, Wolfson RL, Chen WW, Freinkman E, Danai LV, Vander Heiden MG, Sabatini DM.

Cell. 2017 Oct 19;171(3):642-654.e12. doi: 10.1016/j.cell.2017.09.046.

8.

Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibition.

Muir A, Danai LV, Gui DY, Waingarten CY, Lewis CA, Vander Heiden MG.

Elife. 2017 Aug 15;6. pii: e27713. doi: 10.7554/eLife.27713.

9.

Adipocyte lipid synthesis coupled to neuronal control of thermogenic programming.

Guilherme A, Pedersen DJ, Henchey E, Henriques FS, Danai LV, Shen Y, Yenilmez B, Jung D, Kim JK, Lodhi IJ, Semenkovich CF, Czech MP.

Mol Metab. 2017 May 31;6(8):781-796. doi: 10.1016/j.molmet.2017.05.012. eCollection 2017 Aug.

10.

Map4k4 impairs energy metabolism in endothelial cells and promotes insulin resistance in obesity.

Roth Flach RJ, DiStefano MT, Danai LV, Senol-Cosar O, Yawe JC, Kelly M, Garcia Menendez L, Czech MP.

Am J Physiol Endocrinol Metab. 2017 Sep 1;313(3):E303-E313. doi: 10.1152/ajpendo.00037.2017. Epub 2017 Jun 13.

11.

Adipocyte-specific Hypoxia-inducible gene 2 promotes fat deposition and diet-induced insulin resistance.

DiStefano MT, Roth Flach RJ, Senol-Cosar O, Danai LV, Virbasius JV, Nicoloro SM, Straubhaar J, Dagdeviren S, Wabitsch M, Gupta OT, Kim JK, Czech MP.

Mol Metab. 2016 Sep 28;5(12):1149-1161. doi: 10.1016/j.molmet.2016.09.009. eCollection 2016 Dec.

12.

Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers.

Mayers JR, Torrence ME, Danai LV, Papagiannakopoulos T, Davidson SM, Bauer MR, Lau AN, Ji BW, Dixit PD, Hosios AM, Muir A, Chin CR, Freinkman E, Jacks T, Wolpin BM, Vitkup D, Vander Heiden MG.

Science. 2016 Sep 9;353(6304):1161-5. doi: 10.1126/science.aaf5171.

13.

Protein Kinase Mitogen-activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Promotes Obesity-induced Hyperinsulinemia.

Roth Flach RJ, Danai LV, DiStefano MT, Kelly M, Menendez LG, Jurczyk A, Sharma RB, Jung DY, Kim JH, Kim JK, Bortell R, Alonso LC, Czech MP.

J Biol Chem. 2016 Jul 29;291(31):16221-30. doi: 10.1074/jbc.M116.718932. Epub 2016 May 20.

14.

Endothelial Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 Is Critical for Lymphatic Vascular Development and Function.

Roth Flach RJ, Guo CA, Danai LV, Yawe JC, Gujja S, Edwards YJ, Czech MP.

Mol Cell Biol. 2016 May 31;36(12):1740-9. doi: 10.1128/MCB.01121-15. Print 2016 Jun 15.

15.

Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells.

Hosios AM, Hecht VC, Danai LV, Johnson MO, Rathmell JC, Steinhauser ML, Manalis SR, Vander Heiden MG.

Dev Cell. 2016 Mar 7;36(5):540-9. doi: 10.1016/j.devcel.2016.02.012.

16.

Endothelial protein kinase MAP4K4 promotes vascular inflammation and atherosclerosis.

Roth Flach RJ, Skoura A, Matevossian A, Danai LV, Zheng W, Cortes C, Bhattacharya SK, Aouadi M, Hagan N, Yawe JC, Vangala P, Menendez LG, Cooper MP, Fitzgibbons TP, Buckbinder L, Czech MP.

Nat Commun. 2015 Dec 21;6:8995. doi: 10.1038/ncomms9995.

17.

A major role of insulin in promoting obesity-associated adipose tissue inflammation.

Pedersen DJ, Guilherme A, Danai LV, Heyda L, Matevossian A, Cohen J, Nicoloro SM, Straubhaar J, Noh HL, Jung D, Kim JK, Czech MP.

Mol Metab. 2015 May 1;4(7):507-18. doi: 10.1016/j.molmet.2015.04.003. eCollection 2015 Jul.

18.

The Lipid Droplet Protein Hypoxia-inducible Gene 2 Promotes Hepatic Triglyceride Deposition by Inhibiting Lipolysis.

DiStefano MT, Danai LV, Roth Flach RJ, Chawla A, Pedersen DJ, Guilherme A, Czech MP.

J Biol Chem. 2015 Jun 12;290(24):15175-84. doi: 10.1074/jbc.M115.650184. Epub 2015 Apr 28.

19.

Inducible Deletion of Protein Kinase Map4k4 in Obese Mice Improves Insulin Sensitivity in Liver and Adipose Tissues.

Danai LV, Flach RJ, Virbasius JV, Menendez LG, Jung DY, Kim JH, Kim JK, Czech MP.

Mol Cell Biol. 2015 Jul;35(13):2356-65.

20.

The conserved misshapen-warts-Yorkie pathway acts in enteroblasts to regulate intestinal stem cells in Drosophila.

Li Q, Li S, Mana-Capelli S, Roth Flach RJ, Danai LV, Amcheslavsky A, Nie Y, Kaneko S, Yao X, Chen X, Cotton JL, Mao J, McCollum D, Jiang J, Czech MP, Xu L, Ip YT.

Dev Cell. 2014 Nov 10;31(3):291-304. doi: 10.1016/j.devcel.2014.09.012. Epub 2014 Nov 10.

21.

Map4k4 suppresses Srebp-1 and adipocyte lipogenesis independent of JNK signaling.

Danai LV, Guilherme A, Guntur KV, Straubhaar J, Nicoloro SM, Czech MP.

J Lipid Res. 2013 Oct;54(10):2697-707. doi: 10.1194/jlr.M038802. Epub 2013 Aug 7.

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