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Items: 5


Late activation of stress-activated protein kinases/c-Jun N-terminal kinases triggered by cisplatin-induced DNA damage in repair-defective cells.

Helbig L, Damrot J, Hülsenbeck J, Köberle B, Brozovic A, Osmak M, Fiket Z, Kaina B, Fritz G.

J Biol Chem. 2011 Apr 15;286(15):12991-3001. doi: 10.1074/jbc.M110.190645. Epub 2011 Feb 15.


Cisplatin sensitivity is related to late DNA damage processing and checkpoint control rather than to the early DNA damage response.

Brozovic A, Damrot J, Tsaryk R, Helbig L, Nikolova T, Hartig C, Osmak M, Roos WP, Kaina B, Fritz G.

Mutat Res. 2009 Nov 2;670(1-2):32-41. doi: 10.1016/j.mrfmmm.2009.07.002. Epub 2009 Jul 16.


DNA replication arrest in response to genotoxic stress provokes early activation of stress-activated protein kinases (SAPK/JNK).

Damrot J, Helbig L, Roos WP, Barrantes SQ, Kaina B, Fritz G.

J Mol Biol. 2009 Feb 6;385(5):1409-21. doi: 10.1016/j.jmb.2008.12.015. Epub 2008 Dec 14.


Lovastatin protects human endothelial cells from the genotoxic and cytotoxic effects of the anticancer drugs doxorubicin and etoposide.

Damrot J, Nübel T, Epe B, Roos WP, Kaina B, Fritz G.

Br J Pharmacol. 2006 Dec;149(8):988-97. Epub 2006 Nov 6.


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