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Items: 1 to 50 of 51

1.

Quantitative proteomics of acutely-isolated mouse microglia identifies novel immune Alzheimer's disease-related proteins.

Rangaraju S, Dammer EB, Raza SA, Gao T, Xiao H, Betarbet R, Duong DM, Webster JA, Hales CM, Lah JJ, Levey AI, Seyfried NT.

Mol Neurodegener. 2018 Jun 28;13(1):34. doi: 10.1186/s13024-018-0266-4.

2.

RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.

Bishof I, Dammer EB, Duong DM, Kundinger SR, Gearing M, Lah JJ, Levey AI, Seyfried NT.

J Biol Chem. 2018 Jul 13;293(28):11047-11066. doi: 10.1074/jbc.RA118.001747. Epub 2018 May 25.

PMID:
29802200
3.

Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer's disease.

Rangaraju S, Dammer EB, Raza SA, Rathakrishnan P, Xiao H, Gao T, Duong DM, Pennington MW, Lah JJ, Seyfried NT, Levey AI.

Mol Neurodegener. 2018 May 21;13(1):24. doi: 10.1186/s13024-018-0254-8.

4.

Differential Phagocytic Properties of CD45low Microglia and CD45high Brain Mononuclear Phagocytes-Activation and Age-Related Effects.

Rangaraju S, Raza SA, Li NX, Betarbet R, Dammer EB, Duong D, Lah JJ, Seyfried NT, Levey AI.

Front Immunol. 2018 Mar 2;9:405. doi: 10.3389/fimmu.2018.00405. eCollection 2018.

5.

Interactome Analysis Reveals Regulator of G Protein Signaling 14 (RGS14) is a Novel Calcium/Calmodulin (Ca2+/CaM) and CaM Kinase II (CaMKII) Binding Partner.

Evans PR, Gerber KJ, Dammer EB, Duong DM, Goswami D, Lustberg DJ, Zou J, Yang JJ, Dudek SM, Griffin PR, Seyfried NT, Hepler JR.

J Proteome Res. 2018 Apr 6;17(4):1700-1711. doi: 10.1021/acs.jproteome.8b00027. Epub 2018 Mar 20.

PMID:
29518331
6.

A proteomic network approach across the ALS-FTD disease spectrum resolves clinical phenotypes and genetic vulnerability in human brain.

Umoh ME, Dammer EB, Dai J, Duong DM, Lah JJ, Levey AI, Gearing M, Glass JD, Seyfried NT.

EMBO Mol Med. 2018 Jan;10(1):48-62. doi: 10.15252/emmm.201708202.

7.

Characterization of Detergent Insoluble Proteome in Chronic Traumatic Encephalopathy.

Cherry JD, Zeineddin A, Dammer EB, Webster JA, Duong D, Seyfried NT, Levey AI, Alvarez VE, Huber BR, Stein TD, Kiernan PT, McKee AC, Lah JJ, Hales CM.

J Neuropathol Exp Neurol. 2018 Jan 1;77(1):40-49. doi: 10.1093/jnen/nlx100.

PMID:
29145658
8.

Multiscale network modeling of oligodendrocytes reveals molecular components of myelin dysregulation in Alzheimer's disease.

McKenzie AT, Moyon S, Wang M, Katsyv I, Song WM, Zhou X, Dammer EB, Duong DM, Aaker J, Zhao Y, Beckmann N, Wang P, Zhu J, Lah JJ, Seyfried NT, Levey AI, Katsel P, Haroutunian V, Schadt EE, Popko B, Casaccia P, Zhang B.

Mol Neurodegener. 2017 Nov 6;12(1):82. doi: 10.1186/s13024-017-0219-3.

9.

Conserved brain myelination networks are altered in Alzheimer's and other neurodegenerative diseases.

Allen M, Wang X, Burgess JD, Watzlawik J, Serie DJ, Younkin CS, Nguyen T, Malphrus KG, Lincoln S, Carrasquillo MM, Ho C, Chakrabarty P, Strickland S, Murray ME, Swarup V, Geschwind DH, Seyfried NT, Dammer EB, Lah JJ, Levey AI, Golde TE, Funk C, Li H, Price ND, Petersen RC, Graff-Radford NR, Younkin SG, Dickson DW, Crook JR, Asmann YW, Ertekin-Taner N.

Alzheimers Dement. 2018 Mar;14(3):352-366. doi: 10.1016/j.jalz.2017.09.012. Epub 2017 Oct 31.

10.

Integrating Next-Generation Genomic Sequencing and Mass Spectrometry To Estimate Allele-Specific Protein Abundance in Human Brain.

Wingo TS, Duong DM, Zhou M, Dammer EB, Wu H, Cutler DJ, Lah JJ, Levey AI, Seyfried NT.

J Proteome Res. 2017 Sep 1;16(9):3336-3347. doi: 10.1021/acs.jproteome.7b00324. Epub 2017 Aug 9.

PMID:
28691493
11.

A systems pharmacology-based approach to identify novel Kv1.3 channel-dependent mechanisms in microglial activation.

Rangaraju S, Raza SA, Pennati A, Deng Q, Dammer EB, Duong D, Pennington MW, Tansey MG, Lah JJ, Betarbet R, Seyfried NT, Levey AI.

J Neuroinflammation. 2017 Jun 26;14(1):128. doi: 10.1186/s12974-017-0906-6.

12.

Novel mouse models of oculopharyngeal muscular dystrophy (OPMD) reveal early onset mitochondrial defects and suggest loss of PABPN1 may contribute to pathology.

Vest KE, Phillips BL, Banerjee A, Apponi LH, Dammer EB, Xu W, Zheng D, Yu J, Tian B, Pavlath GK, Corbett AH.

Hum Mol Genet. 2017 Sep 1;26(17):3235-3252. doi: 10.1093/hmg/ddx206.

PMID:
28575395
13.

Biochemical isolation of myonuclei employed to define changes to the myonuclear proteome that occur with aging.

Cutler AA, Dammer EB, Doung DM, Seyfried NT, Corbett AH, Pavlath GK.

Aging Cell. 2017 Aug;16(4):738-749. doi: 10.1111/acel.12604. Epub 2017 May 23.

14.

Osteopontin Is a Blood Biomarker for Microglial Activation and Brain Injury in Experimental Hypoxic-Ischemic Encephalopathy.

Li Y, Dammer EB, Zhang-Brotzge X, Chen S, Duong DM, Seyfried NT, Kuan CY, Sun YY.

eNeuro. 2017 Jan 10;4(1). pii: ENEURO.0253-16.2016. doi: 10.1523/ENEURO.0253-16.2016. eCollection 2017 Jan-Feb.

15.

A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer's Disease.

Seyfried NT, Dammer EB, Swarup V, Nandakumar D, Duong DM, Yin L, Deng Q, Nguyen T, Hales CM, Wingo T, Glass J, Gearing M, Thambisetty M, Troncoso JC, Geschwind DH, Lah JJ, Levey AI.

Cell Syst. 2017 Jan 25;4(1):60-72.e4. doi: 10.1016/j.cels.2016.11.006. Epub 2016 Dec 15.

16.

Alpha-2 macroglobulin in Alzheimer's disease: a marker of neuronal injury through the RCAN1 pathway.

Varma VR, Varma S, An Y, Hohman TJ, Seddighi S, Casanova R, Beri A, Dammer EB, Seyfried NT, Pletnikova O, Moghekar A, Wilson MR, Lah JJ, O'Brien RJ, Levey AI, Troncoso JC, Albert MS, Thambisetty M.

Mol Psychiatry. 2017 Jan;22(1):13-23. doi: 10.1038/mp.2016.206. Epub 2016 Nov 22.

17.

Changes in the detergent-insoluble brain proteome linked to amyloid and tau in Alzheimer's Disease progression.

Hales CM, Dammer EB, Deng Q, Duong DM, Gearing M, Troncoso JC, Thambisetty M, Lah JJ, Shulman JM, Levey AI, Seyfried NT.

Proteomics. 2016 Dec;16(23):3042-3053. doi: 10.1002/pmic.201600057.

18.

MicroRNA-146a represses LRP2 translation and leads to cell apoptosis in Alzheimer's disease.

Zhang B, Wang LL, Ren RJ, Dammer EB, Zhang YF, Huang Y, Chen SD, Wang G.

FEBS Lett. 2016 Jul;590(14):2190-200. doi: 10.1002/1873-3468.12229. Epub 2016 Jul 8.

19.

Pseudomonas aeruginosa EftM Is a Thermoregulated Methyltransferase.

Owings JP, Kuiper EG, Prezioso SM, Meisner J, Varga JJ, Zelinskaya N, Dammer EB, Duong DM, Seyfried NT, Albertí S, Conn GL, Goldberg JB.

J Biol Chem. 2016 Feb 12;291(7):3280-90. doi: 10.1074/jbc.M115.706853. Epub 2015 Dec 16.

20.

Peripheral Blood MicroRNA Expression Profiles in Alzheimer's Disease: Screening, Validation, Association with Clinical Phenotype and Implications for Molecular Mechanism.

Ren RJ, Zhang YF, Dammer EB, Zhou Y, Wang LL, Liu XH, Feng BL, Jiang GX, Chen SD, Wang G, Cheng Q.

Mol Neurobiol. 2016 Oct;53(8):5772-81. doi: 10.1007/s12035-015-9484-8. Epub 2015 Oct 26.

PMID:
26497032
21.

The endosomal-lysosomal system: from acidification and cargo sorting to neurodegeneration.

Hu YB, Dammer EB, Ren RJ, Wang G.

Transl Neurodegener. 2015 Sep 30;4:18. doi: 10.1186/s40035-015-0041-1. eCollection 2015. Review.

22.

Consequences of impaired purine recycling on the proteome in a cellular model of Lesch-Nyhan disease.

Dammer EB, Göttle M, Duong DM, Hanfelt J, Seyfried NT, Jinnah HA.

Mol Genet Metab. 2015 Apr;114(4):570-579. doi: 10.1016/j.ymgme.2015.02.007. Epub 2015 Mar 5.

23.

Proteomics of protein post-translational modifications implicated in neurodegeneration.

Ren RJ, Dammer EB, Wang G, Seyfried NT, Levey AI.

Transl Neurodegener. 2014 Oct 30;3(1):23. doi: 10.1186/2047-9158-3-23. eCollection 2014. Review.

24.

Melatonin for sleep disorders and cognition in dementia: a meta-analysis of randomized controlled trials.

Xu J, Wang LL, Dammer EB, Li CB, Xu G, Chen SD, Wang G.

Am J Alzheimers Dis Other Demen. 2015 Aug;30(5):439-47. doi: 10.1177/1533317514568005. Review.

PMID:
25614508
25.

Quantitative phosphoproteomics of Alzheimer's disease reveals cross-talk between kinases and small heat shock proteins.

Dammer EB, Lee AK, Duong DM, Gearing M, Lah JJ, Levey AI, Seyfried NT.

Proteomics. 2015 Jan;15(2-3):508-519. doi: 10.1002/pmic.201400189. Epub 2014 Dec 17.

26.

U1 small nuclear ribonucleoproteins (snRNPs) aggregate in Alzheimer's disease due to autosomal dominant genetic mutations and trisomy 21.

Hales CM, Seyfried NT, Dammer EB, Duong D, Yi H, Gearing M, Troncoso JC, Mufson EJ, Thambisetty M, Levey AI, Lah JJ.

Mol Neurodegener. 2014 Apr 28;9:15. doi: 10.1186/1750-1326-9-15.

27.

Aggregates of small nuclear ribonucleic acids (snRNAs) in Alzheimer's disease.

Hales CM, Dammer EB, Diner I, Yi H, Seyfried NT, Gearing M, Glass JD, Montine TJ, Levey AI, Lah JJ.

Brain Pathol. 2014 Jul;24(4):344-51. doi: 10.1111/bpa.12133. Epub 2014 Apr 14.

28.

Quantitative proteomics reveals significant changes in cell shape and an energy shift after IPTG induction via an optimized SILAC approach for Escherichia coli.

Ping L, Zhang H, Zhai L, Dammer EB, Duong DM, Li N, Yan Z, Wu J, Xu P.

J Proteome Res. 2013 Dec 6;12(12):5978-88. doi: 10.1021/pr400775w. Epub 2013 Nov 14.

PMID:
24224529
29.

Abnormal gephyrin immunoreactivity associated with Alzheimer disease pathologic changes.

Hales CM, Rees H, Seyfried NT, Dammer EB, Duong DM, Gearing M, Montine TJ, Troncoso JC, Thambisetty M, Levey AI, Lah JJ, Wingo TS.

J Neuropathol Exp Neurol. 2013 Nov;72(11):1009-15. doi: 10.1097/01.jnen.0000435847.59828.db.

30.

U1 small nuclear ribonucleoprotein complex and RNA splicing alterations in Alzheimer's disease.

Bai B, Hales CM, Chen PC, Gozal Y, Dammer EB, Fritz JJ, Wang X, Xia Q, Duong DM, Street C, Cantero G, Cheng D, Jones DR, Wu Z, Li Y, Diner I, Heilman CJ, Rees HD, Wu H, Lin L, Szulwach KE, Gearing M, Mufson EJ, Bennett DA, Montine TJ, Seyfried NT, Wingo TS, Sun YE, Jin P, Hanfelt J, Willcock DM, Levey A, Lah JJ, Peng J.

Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16562-7. doi: 10.1073/pnas.1310249110. Epub 2013 Sep 10.

31.

Tissue-type plasminogen activator mediates neuronal detection and adaptation to metabolic stress.

Wu F, Nicholson AD, Haile WB, Torre E, An J, Chen C, Lee AK, Duong DM, Dammer EB, Seyfried NT, Tong FC, Votaw JR, Yepes M.

J Cereb Blood Flow Metab. 2013 Nov;33(11):1761-9. doi: 10.1038/jcbfm.2013.124. Epub 2013 Jul 24.

32.

Neuron enriched nuclear proteome isolated from human brain.

Dammer EB, Duong DM, Diner I, Gearing M, Feng Y, Lah JJ, Levey AI, Seyfried NT.

J Proteome Res. 2013 Jul 5;12(7):3193-206. doi: 10.1021/pr400246t. Epub 2013 Jun 17.

33.

Exploring the potential of the platelet membrane proteome as a source of peripheral biomarkers for Alzheimer's disease.

Donovan LE, Dammer EB, Duong DM, Hanfelt JJ, Levey AI, Seyfried NT, Lah JJ.

Alzheimers Res Ther. 2013 Jun 13;5(3):32. doi: 10.1186/alzrt186. eCollection 2013.

34.

Expression, purification and proteomic analysis of recombinant histone H4 acetylated at lysine 16.

Kallappagoudar S, Dammer EB, Duong DM, Seyfried NT, Lucchesi JC.

Proteomics. 2013 May;13(10-11):1687-91. doi: 10.1002/pmic.201300025. Epub 2013 Apr 26.

35.

The cotranslational function of ribosome-associated Hsp70 in eukaryotic protein homeostasis.

Willmund F, del Alamo M, Pechmann S, Chen T, Albanèse V, Dammer EB, Peng J, Frydman J.

Cell. 2013 Jan 17;152(1-2):196-209. doi: 10.1016/j.cell.2012.12.001.

36.

cAMP-stimulated phosphorylation of diaphanous 1 regulates protein stability and interaction with binding partners in adrenocortical cells.

Li D, Dammer EB, Lucki NC, Sewer MB.

Mol Biol Cell. 2013 Mar;24(6):848-57. doi: 10.1091/mbc.E12-08-0597. Epub 2013 Jan 16.

37.

Protein profiling of active cysteine cathepsins in living cells using an activity-based probe containing a cell-penetrating peptide.

Fan F, Nie S, Dammer EB, Duong DM, Pan D, Ping L, Zhai L, Wu J, Hong X, Qin L, Xu P, Zhang YH.

J Proteome Res. 2012 Dec 7;11(12):5763-72. doi: 10.1021/pr300575u. Epub 2012 Oct 30.

PMID:
23082807
38.

Tissue-type plasminogen activator regulates the neuronal uptake of glucose in the ischemic brain.

Wu F, Wu J, Nicholson AD, Echeverry R, Haile WB, Catano M, An J, Lee AK, Duong D, Dammer EB, Seyfried NT, Tong FC, Votaw JR, Medcalf RL, Yepes M.

J Neurosci. 2012 Jul 18;32(29):9848-58.

39.

Coaggregation of RNA-binding proteins in a model of TDP-43 proteinopathy with selective RGG motif methylation and a role for RRM1 ubiquitination.

Dammer EB, Fallini C, Gozal YM, Duong DM, Rossoll W, Xu P, Lah JJ, Levey AI, Peng J, Bassell GJ, Seyfried NT.

PLoS One. 2012;7(6):e38658. doi: 10.1371/journal.pone.0038658. Epub 2012 Jun 21.

40.

Asparaginyl endopeptidase cleaves TDP-43 in brain.

Herskowitz JH, Gozal YM, Duong DM, Dammer EB, Gearing M, Ye K, Lah JJ, Peng J, Levey AI, Seyfried NT.

Proteomics. 2012 Aug;12(15-16):2455-63. doi: 10.1002/pmic.201200006.

41.

Resveratrol stimulates cortisol biosynthesis by activating SIRT-dependent deacetylation of P450scc.

Li D, Dammer EB, Sewer MB.

Endocrinology. 2012 Jul;153(7):3258-68. doi: 10.1210/en.2011-2088. Epub 2012 May 14.

42.

Analysis of a membrane-enriched proteome from postmortem human brain tissue in Alzheimer's disease.

Donovan LE, Higginbotham L, Dammer EB, Gearing M, Rees HD, Xia Q, Duong DM, Seyfried NT, Lah JJ, Levey AI.

Proteomics Clin Appl. 2012 Apr;6(3-4):201-11. doi: 10.1002/prca.201100068.

43.

Quantitative analysis of the detergent-insoluble brain proteome in frontotemporal lobar degeneration using SILAC internal standards.

Seyfried NT, Gozal YM, Donovan LE, Herskowitz JH, Dammer EB, Xia Q, Ku L, Chang J, Duong DM, Rees HD, Cooper DS, Glass JD, Gearing M, Tansey MG, Lah JJ, Feng Y, Levey AI, Peng J.

J Proteome Res. 2012 May 4;11(5):2721-38. doi: 10.1021/pr2010814. Epub 2012 Apr 4.

44.

Proteomic analysis of hippocampal dentate granule cells in frontotemporal lobar degeneration: application of laser capture technology.

Gozal YM, Dammer EB, Duong DM, Cheng D, Gearing M, Rees HD, Peng J, Lah JJ, Levey AI.

Front Neurol. 2011 Apr 25;2:24. doi: 10.3389/fneur.2011.00024. eCollection 2011.

45.

Polyubiquitin linkage profiles in three models of proteolytic stress suggest the etiology of Alzheimer disease.

Dammer EB, Na CH, Xu P, Seyfried NT, Duong DM, Cheng D, Gearing M, Rees H, Lah JJ, Levey AI, Rush J, Peng J.

J Biol Chem. 2011 Mar 25;286(12):10457-65. doi: 10.1074/jbc.M110.149633. Epub 2011 Jan 28.

46.

Identification of neuronal RNA targets of TDP-43-containing ribonucleoprotein complexes.

Sephton CF, Cenik C, Kucukural A, Dammer EB, Cenik B, Han Y, Dewey CM, Roth FP, Herz J, Peng J, Moore MJ, Yu G.

J Biol Chem. 2011 Jan 14;286(2):1204-15. doi: 10.1074/jbc.M110.190884. Epub 2010 Nov 4.

47.

Multiplex SILAC analysis of a cellular TDP-43 proteinopathy model reveals protein inclusions associated with SUMOylation and diverse polyubiquitin chains.

Seyfried NT, Gozal YM, Dammer EB, Xia Q, Duong DM, Cheng D, Lah JJ, Levey AI, Peng J.

Mol Cell Proteomics. 2010 Apr;9(4):705-18. doi: 10.1074/mcp.M800390-MCP200. Epub 2010 Jan 4.

48.

Phosphorylation of CtBP1 by cAMP-dependent protein kinase modulates induction of CYP17 by stimulating partnering of CtBP1 and 2.

Dammer EB, Sewer MB.

J Biol Chem. 2008 Mar 14;283(11):6925-34. doi: 10.1074/jbc.M708432200. Epub 2008 Jan 9.

49.

Multiple Signaling Pathways Coordinate CYP17 Gene Expression in the Human Adrenal Cortex.

Sewer MB, Li D, Dammer EB, Jagarlapudi S, Lucki N.

Acta Chim Slov. 2008 Jan 1;55(1):53-57.

50.

Transcriptional regulation of adrenocortical steroidogenic gene expression.

Sewer MB, Dammer EB, Jagarlapudi S.

Drug Metab Rev. 2007;39(2-3):371-88. Review.

PMID:
17786627

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