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Items: 38


Pleomorphic Adenoma Gene 1 Is Needed For Timely Zygotic Genome Activation and Early Embryo Development.

Madissoon E, Damdimopoulos A, Katayama S, Krjutškov K, Einarsdottir E, Mamia K, De Groef B, Hovatta O, Kere J, Damdimopoulou P.

Sci Rep. 2019 Jun 10;9(1):8411. doi: 10.1038/s41598-019-44882-0.


Implications of the mitochondrial interactome of mammalian thioredoxin 2 for normal cellular function and disease.

Chasapis CT, Makridakis M, Damdimopoulos AE, Zoidakis J, Lygirou V, Mavroidis M, Vlahou A, Miranda-Vizuete A, Spyrou G, Vlamis-Gardikas A.

Free Radic Biol Med. 2019 Jun;137:59-73. doi: 10.1016/j.freeradbiomed.2019.04.018. Epub 2019 Apr 21.


Hepatocyte-specific loss of GPS2 in mice reduces non-alcoholic steatohepatitis via activation of PPARα.

Liang N, Damdimopoulos A, Goñi S, Huang Z, Vedin LL, Jakobsson T, Giudici M, Ahmed O, Pedrelli M, Barilla S, Alzaid F, Mendoza A, Schröder T, Kuiper R, Parini P, Hollenberg A, Lefebvre P, Francque S, Van Gaal L, Staels B, Venteclef N, Treuter E, Fan R.

Nat Commun. 2019 Apr 11;10(1):1684. doi: 10.1038/s41467-019-09524-z.


G protein pathway suppressor 2 (GPS2) links inflammation and cholesterol efflux by controlling lipopolysaccharide-induced ATP-binding cassette transporter A1 expression in macrophages.

Huang Z, Liang N, Damdimopoulos A, Fan R, Treuter E.

FASEB J. 2019 Feb;33(2):1631-1643. doi: 10.1096/fj.201801123R. Epub 2018 Aug 28.


The Hydroxysteroid (17β) Dehydrogenase Family Gene HSD17B12 Is Involved in the Prostaglandin Synthesis Pathway, the Ovarian Function, and Regulation of Fertility.

Kemiläinen H, Adam M, Mäki-Jouppila J, Damdimopoulou P, Damdimopoulos AE, Kere J, Hovatta O, Laajala TD, Aittokallio T, Adamski J, Ryberg H, Ohlsson C, Strauss L, Poutanen M.

Endocrinology. 2016 Oct;157(10):3719-3730. Epub 2016 Aug 4.


Loss of the co-repressor GPS2 sensitizes macrophage activation upon metabolic stress induced by obesity and type 2 diabetes.

Fan R, Toubal A, Goñi S, Drareni K, Huang Z, Alzaid F, Ballaire R, Ancel P, Liang N, Damdimopoulos A, Hainault I, Soprani A, Aron-Wisnewsky J, Foufelle F, Lawrence T, Gautier JF, Venteclef N, Treuter E.

Nat Med. 2016 Jul;22(7):780-91. doi: 10.1038/nm.4114. Epub 2016 Jun 6.


The expression and activity of thioredoxin reductase 1 splice variants v1 and v2 regulate the expression of genes associated with differentiation and adhesion.

Nalvarte I, Damdimopoulos AE, Rüegg J, Spyrou G.

Biosci Rep. 2015 Oct 13;35(6). pii: e00269. doi: 10.1042/BSR20150236.


Members of the murine Pate family are predominantly expressed in the epididymis in a segment-specific fashion and regulated by androgens and other testicular factors.

Turunen HT, Sipilä P, Pujianto DA, Damdimopoulos AE, Björkgren I, Huhtaniemi I, Poutanen M.

Reprod Biol Endocrinol. 2011 Sep 26;9(1):128. doi: 10.1186/1477-7827-9-128.


A single dose of enterolactone activates estrogen signaling and regulates expression of circadian clock genes in mice.

Damdimopoulou P, Nurmi T, Salminen A, Damdimopoulos AE, Kotka M, van der Saag P, Strauss L, Poutanen M, Pongratz I, Mäkelä S.

J Nutr. 2011 Sep;141(9):1583-9. doi: 10.3945/jn.111.140277. Epub 2011 Jul 13.


GPS2-dependent corepressor/SUMO pathways govern anti-inflammatory actions of LRH-1 and LXRbeta in the hepatic acute phase response.

Venteclef N, Jakobsson T, Ehrlund A, Damdimopoulos A, Mikkonen L, Ellis E, Nilsson LM, Parini P, Jänne OA, Gustafsson JA, Steffensen KR, Treuter E.

Genes Dev. 2010 Feb 15;24(4):381-95. doi: 10.1101/gad.545110.


The human thioredoxin reductase-1 splice variant TXNRD1_v3 is an atypical inducer of cytoplasmic filaments and cell membrane filopodia.

Damdimopoulou PE, Miranda-Vizuete A, Arnér ES, Gustafsson JA, Damdimopoulos AE.

Biochim Biophys Acta. 2009 Oct;1793(10):1588-96. doi: 10.1016/j.bbamcr.2009.07.007. Epub 2009 Aug 3.


GPS2 is required for cholesterol efflux by triggering histone demethylation, LXR recruitment, and coregulator assembly at the ABCG1 locus.

Jakobsson T, Venteclef N, Toresson G, Damdimopoulos AE, Ehrlund A, Lou X, Sanyal S, Steffensen KR, Gustafsson JA, Treuter E.

Mol Cell. 2009 May 14;34(4):510-8. doi: 10.1016/j.molcel.2009.05.006.


E3 ubiquitin ligase RNF31 cooperates with DAX-1 in transcriptional repression of steroidogenesis.

Ehrlund A, Anthonisen EH, Gustafsson N, Venteclef N, Robertson Remen K, Damdimopoulos AE, Galeeva A, Pelto-Huikko M, Lalli E, Steffensen KR, Gustafsson JA, Treuter E.

Mol Cell Biol. 2009 Apr;29(8):2230-42. doi: 10.1128/MCB.00743-08. Epub 2009 Feb 23.


Induction of cell membrane protrusions by the N-terminal glutaredoxin domain of a rare splice variant of human thioredoxin reductase 1.

Dammeyer P, Damdimopoulos AE, Nordman T, Jiménez A, Miranda-Vizuete A, Arnér ES.

J Biol Chem. 2008 Feb 1;283(5):2814-21. Epub 2007 Nov 27.


Ligands differentially modify the nuclear mobility of estrogen receptors alpha and beta.

Damdimopoulos AE, Spyrou G, Gustafsson JA.

Endocrinology. 2008 Jan;149(1):339-45. Epub 2007 Sep 20.


Diet-derived polyphenol metabolite enterolactone is a tissue-specific estrogen receptor activator.

Penttinen P, Jaehrling J, Damdimopoulos AE, Inzunza J, Lemmen JG, van der Saag P, Pettersson K, Gauglitz G, Mäkelä S, Pongratz I.

Endocrinology. 2007 Oct;148(10):4875-86. Epub 2007 Jul 12.


Nuclear immobilization of DsRed1 tagged proteins: a novel tool for studying DNA-protein interactions?

Damdimopoulos AE, Gustafsson JA, Spyrou G.

Biochim Biophys Acta. 2007 Jun;1773(6):687-90. Epub 2007 Apr 6.


Bfk, a novel member of the bcl2 gene family, is highly expressed in principal cells of the mouse epididymis and demonstrates a predominant nuclear localization.

Pujianto DA, Damdimopoulos AE, Sipilä P, Jalkanen J, Huhtaniemi I, Poutanen M.

Endocrinology. 2007 Jul;148(7):3196-204. Epub 2007 Apr 5.


Thioredoxin 1 and thioredoxin 2 have opposed regulatory functions on hypoxia-inducible factor-1alpha.

Zhou J, Damdimopoulos AE, Spyrou G, Brüne B.

J Biol Chem. 2007 Mar 9;282(10):7482-90. Epub 2007 Jan 12.


The role of thioredoxin reductase activity in selenium-induced cytotoxicity.

Madeja Z, Sroka J, Nyström C, Björkhem-Bergman L, Nordman T, Damdimopoulos A, Nalvarte I, Eriksson LC, Spyrou G, Olsson JM, Björnstedt M.

Biochem Pharmacol. 2005 Jun 15;69(12):1765-72.


Overexpression of enzymatically active human cytosolic and mitochondrial thioredoxin reductase in HEK-293 cells. Effect on cell growth and differentiation.

Nalvarte I, Damdimopoulos AE, Nystöm C, Nordman T, Miranda-Vizuete A, Olsson JM, Eriksson L, Björnstedt M, Arnér ES, Spyrou G.

J Biol Chem. 2004 Dec 24;279(52):54510-7. Epub 2004 Oct 7.


An alternative splicing variant of the selenoprotein thioredoxin reductase is a modulator of estrogen signaling.

Damdimopoulos AE, Miranda-Vizuete A, Treuter E, Gustafsson JA, Spyrou G.

J Biol Chem. 2004 Sep 10;279(37):38721-9. Epub 2004 Jun 14.


Human mitochondrial thioredoxin reductase reduces cytochrome c and confers resistance to complex III inhibition.

Nalvarte I, Damdimopoulos AE, Spyrou G.

Free Radic Biol Med. 2004 May 15;36(10):1270-8.


Regeneration of the antioxidant ubiquinol by lipoamide dehydrogenase, thioredoxin reductase and glutathione reductase.

Nordman T, Xia L, Björkhem-Bergman L, Damdimopoulos A, Nalvarte I, Arnér ES, Spyrou G, Eriksson LC, Björnstedt M, Olsson JM.

Biofactors. 2003;18(1-4):45-50. Review.


Characterization of human thioredoxin-like 2. A novel microtubule-binding thioredoxin expressed predominantly in the cilia of lung airway epithelium and spermatid manchette and axoneme.

Sadek CM, Jiménez A, Damdimopoulos AE, Kieselbach T, Nord M, Gustafsson JA, Spyrou G, Davis EC, Oko R, van der Hoorn FA, Miranda-Vizuete A.

J Biol Chem. 2003 Apr 11;278(15):13133-42. Epub 2003 Feb 4.


The mammalian cytosolic selenoenzyme thioredoxin reductase reduces ubiquinone. A novel mechanism for defense against oxidative stress.

Xia L, Nordman T, Olsson JM, Damdimopoulos A, Björkhem-Bergman L, Nalvarte I, Eriksson LC, Arnér ES, Spyrou G, Björnstedt M.

J Biol Chem. 2003 Jan 24;278(4):2141-6. Epub 2002 Nov 14.


ERdj5, an endoplasmic reticulum (ER)-resident protein containing DnaJ and thioredoxin domains, is expressed in secretory cells or following ER stress.

Cunnea PM, Miranda-Vizuete A, Bertoli G, Simmen T, Damdimopoulos AE, Hermann S, Leinonen S, Huikko MP, Gustafsson JA, Sitia R, Spyrou G.

J Biol Chem. 2003 Jan 10;278(2):1059-66. Epub 2002 Oct 30.


Human mitochondrial thioredoxin. Involvement in mitochondrial membrane potential and cell death.

Damdimopoulos AE, Miranda-Vizuete A, Pelto-Huikko M, Gustafsson JA, Spyrou G.

J Biol Chem. 2002 Sep 6;277(36):33249-57. Epub 2002 Jun 21.


Sptrx-2, a fusion protein composed of one thioredoxin and three tandemly repeated NDP-kinase domains is expressed in human testis germ cells.

Sadek CM, Damdimopoulos AE, Pelto-Huikko M, Gustafsson JA, Spyrou G, Miranda-Vizuete A.

Genes Cells. 2001 Dec;6(12):1077-90.


Characterization of Sptrx, a novel member of the thioredoxin family specifically expressed in human spermatozoa.

Miranda-Vizuete A, Ljung J, Damdimopoulos AE, Gustafsson JA, Oko R, Pelto-Huikko M, Spyrou G.

J Biol Chem. 2001 Aug 24;276(34):31567-74. Epub 2001 Jun 8.


The mitochondrial thioredoxin system.

Miranda-Vizuete A, Damdimopoulos AE, Spyrou G.

Antioxid Redox Signal. 2000 Winter;2(4):801-10. Review.


Isolation and characterization of AINT: a novel ARNT interacting protein expressed during murine embryonic development.

Sadek CM, Jalaguier S, Feeney EP, Aitola M, Damdimopoulos AE, Pelto-Huikko M, Gustafsson JA.

Mech Dev. 2000 Oct;97(1-2):13-26.


Expression of novel antioxidant thioredoxin-2 in the rat brain.

Rybnikova E, Damdimopoulos AE, Gustafsson JA, Spyrou G, Pelto-Huikko M.

Eur J Neurosci. 2000 May;12(5):1669-78.


Cloning and sequencing of mouse glutaredoxin (grx) cDNA.

Miranda-Vizuete A, Pedrajas JR, Damdimopoulos AE, Spyrou G.

DNA Seq. 1999;10(3):179-82.


cDNA cloning, expression and chromosomal localization of the mouse mitochondrial thioredoxin reductase gene(1).

Miranda-Vizuete A, Damdimopoulos AE, Spyrou G.

Biochim Biophys Acta. 1999 Oct 6;1447(1):113-8.


Human mitochondrial thioredoxin reductase cDNA cloning, expression and genomic organization.

Miranda-Vizuete A, Damdimopoulos AE, Pedrajas JR, Gustafsson JA, Spyrou G.

Eur J Biochem. 1999 Apr;261(2):405-12.


The orphan nuclear receptor SHP inhibits agonist-dependent transcriptional activity of estrogen receptors ERalpha and ERbeta.

Johansson L, Thomsen JS, Damdimopoulos AE, Spyrou G, Gustafsson JA, Treuter E.

J Biol Chem. 1999 Jan 1;274(1):345-53.


Cloning, expression, and characterization of a novel Escherichia coli thioredoxin.

Miranda-Vizuete A, Damdimopoulos AE, Gustafsson J, Spyrou G.

J Biol Chem. 1997 Dec 5;272(49):30841-7.

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