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Items: 36

1.

Using Genetically Modified Rodent Models in Drug Development to Explore Target Physiology and Potential Drug Effects.

Zhong Y, Dambach DM, Maher JM.

Vet Pathol. 2018 Mar;55(2):193-194. doi: 10.1177/0300985817747328. No abstract available.

PMID:
29457566
2.

Current nonclinical testing paradigm enables safe entry to First-In-Human clinical trials: The IQ consortium nonclinical to clinical translational database.

Monticello TM, Jones TW, Dambach DM, Potter DM, Bolt MW, Liu M, Keller DA, Hart TK, Kadambi VJ.

Toxicol Appl Pharmacol. 2017 Nov 1;334:100-109. doi: 10.1016/j.taap.2017.09.006. Epub 2017 Sep 8.

PMID:
28893587
3.

Bruton's Tyrosine Kinase Small Molecule Inhibitors Induce a Distinct Pancreatic Toxicity in Rats.

Erickson RI, Schutt LK, Tarrant JM, McDowell M, Liu L, Johnson AR, Lewin-Koh SC, Hedehus M, Ross J, Carano RA, Staflin K, Zhong F, Crawford JJ, Zhong S, Reif K, Katewa A, Wong H, Young WB, Dambach DM, Misner DL.

J Pharmacol Exp Ther. 2017 Jan;360(1):226-238. Epub 2016 Nov 7.

PMID:
27821712
4.

Key Challenges and Opportunities Associated with the Use of In Vitro Models to Detect Human DILI: Integrated Risk Assessment and Mitigation Plans.

Atienzar FA, Blomme EA, Chen M, Hewitt P, Kenna JG, Labbe G, Moulin F, Pognan F, Roth AB, Suter-Dick L, Ukairo O, Weaver RJ, Will Y, Dambach DM.

Biomed Res Int. 2016;2016:9737920. Epub 2016 Sep 5. Review.

5.

Nonclinical Evaluations of Small-Molecule Oncology Drugs: Integration into Clinical Dose Optimization and Toxicity Management.

Dambach DM, Simpson NE, Jones TW, Brennan RJ, Pazdur R, Palmby TR.

Clin Cancer Res. 2016 Jun 1;22(11):2618-22. doi: 10.1158/1078-0432.CCR-15-2645.

6.

Therapeutic Antibody-Induced Vascular Toxicity Due to Off-Target Activation of Nitric Oxide in Cynomolgus Monkeys.

Pai R, Ma N, Connor AV, Danilenko DM, Tarrant JM, Salvail D, Wong L, Hartley DP, Misner D, Stefanich E, Wu Y, Chen Y, Wang H, Dambach DM.

Toxicol Sci. 2016 Jun;151(2):245-60. doi: 10.1093/toxsci/kfw037. Epub 2016 Feb 25.

PMID:
26917699
7.

Safety Lead Optimization and Candidate Identification: Integrating New Technologies into Decision-Making.

Dambach DM, Misner D, Brock M, Fullerton A, Proctor W, Maher J, Lee D, Ford K, Diaz D.

Chem Res Toxicol. 2016 Apr 18;29(4):452-72. doi: 10.1021/acs.chemrestox.5b00396. Epub 2015 Dec 16. Review.

PMID:
26625186
8.

An algorithm for evaluating potential tissue drug distribution in toxicology studies from readily available pharmacokinetic parameters.

Poulin P, Dambach DM, Hartley DH, Ford K, Theil FP, Harstad E, Halladay J, Choo E, Boggs J, Liederer BM, Dean B, Diaz D.

J Pharm Sci. 2013 Oct;102(10):3816-29. doi: 10.1002/jps.23670. Epub 2013 Jul 22.

PMID:
23878104
9.

Pharmacokinetic drivers of toxicity for basic molecules: strategy to lower pKa results in decreased tissue exposure and toxicity for a small molecule Met inhibitor.

Diaz D, Ford KA, Hartley DP, Harstad EB, Cain GR, Achilles-Poon K, Nguyen T, Peng J, Zheng Z, Merchant M, Sutherlin DP, Gaudino JJ, Kaus R, Lewin-Koh SC, Choo EF, Liederer BM, Dambach DM.

Toxicol Appl Pharmacol. 2013 Jan 1;266(1):86-94. doi: 10.1016/j.taap.2012.10.026. Epub 2012 Nov 7.

PMID:
23142475
10.

Improving risk assessment.

Dambach DM, Uppal H.

Sci Transl Med. 2012 Nov 7;4(159):159ps22. doi: 10.1126/scitranslmed.3003497.

PMID:
23136041
11.

Phosphorous dysregulation induced by MEK small molecule inhibitors in the rat involves blockade of FGF-23 signaling in the kidney.

Diaz D, Allamneni K, Tarrant JM, Lewin-Koh SC, Pai R, Dhawan P, Cain GR, Kozlowski C, Hiraragi H, La N, Hartley DP, Ding X, Dean BJ, Bheddah S, Dambach DM.

Toxicol Sci. 2012 Jan;125(1):187-95. doi: 10.1093/toxsci/kfr263. Epub 2011 Oct 5.

PMID:
21976371
12.

Cloning, expression and characterization of monkey (Macaca fascicularis) CD137.

Chen SJ, Foster WR, Jure-Kunkel MN, Girit E, Abraham R, Hefta LJ, Gao S, Yonan CR, Lin JH, Dambach DM.

Vet Immunol Immunopathol. 2008 Dec 15;126(3-4):377-81. doi: 10.1016/j.vetimm.2008.07.009. Epub 2008 Jul 31.

PMID:
18771806
13.

A retrospective analysis of toxicogenomics in the safety assessment of drug candidates.

Foster WR, Chen SJ, He A, Truong A, Bhaskaran V, Nelson DM, Dambach DM, Lehman-McKeeman LD, Car BD.

Toxicol Pathol. 2007 Aug;35(5):621-35. Review.

PMID:
17654404
14.

Potential adverse effects associated with inhibition of p38alpha/beta MAP kinases.

Dambach DM.

Curr Top Med Chem. 2005;5(10):929-39. Review.

PMID:
16178738
15.

Distinct roles of NF-kappaB p50 in the regulation of acetaminophen-induced inflammatory mediator production and hepatotoxicity.

Dambach DM, Durham SK, Laskin JD, Laskin DL.

Toxicol Appl Pharmacol. 2006 Mar 1;211(2):157-65. Epub 2005 Aug 2.

PMID:
16081117
16.

New technologies and screening strategies for hepatotoxicity: use of in vitro models.

Dambach DM, Andrews BA, Moulin F.

Toxicol Pathol. 2005;33(1):17-26. Review.

PMID:
15805052
17.

Biomarker discovery in biological fluids.

Gao J, Garulacan LA, Storm SM, Opiteck GJ, Dubaquie Y, Hefta SA, Dambach DM, Dongre AR.

Methods. 2005 Mar;35(3):291-302. Epub 2005 Jan 12.

PMID:
15722225
18.

Familial glomerulonephropathy in the Bullmastiff.

Casal ML, Dambach DM, Meister T, Jezyk PF, Patterson DF, Henthorn PS.

Vet Pathol. 2004 Jul;41(4):319-25.

PMID:
15232131
19.

Identification of in vitro protein biomarkers of idiosyncratic liver toxicity.

Gao J, Ann Garulacan L, Storm SM, Hefta SA, Opiteck GJ, Lin JH, Moulin F, Dambach DM.

Toxicol In Vitro. 2004 Aug;18(4):533-41.

PMID:
15130611
20.

An inhibitor of IkappaB kinase, BMS-345541, blocks endothelial cell adhesion molecule expression and reduces the severity of dextran sulfate sodium-induced colitis in mice.

MacMaster JF, Dambach DM, Lee DB, Berry KK, Qiu Y, Zusi FC, Burke JR.

Inflamm Res. 2003 Dec;52(12):508-11. Epub 2003 Nov 13.

PMID:
14991079
21.

Role of tumor necrosis factor receptor 1 (p55) in hepatocyte proliferation during acetaminophen-induced toxicity in mice.

Chiu H, Gardner CR, Dambach DM, Durham SK, Brittingham JA, Laskin JD, Laskin DL.

Toxicol Appl Pharmacol. 2003 Dec 1;193(2):218-27.

PMID:
14644624
22.

Exaggerated hepatotoxicity of acetaminophen in mice lacking tumor necrosis factor receptor-1. Potential role of inflammatory mediators.

Gardner CR, Laskin JD, Dambach DM, Chiu H, Durham SK, Zhou P, Bruno M, Gerecke DR, Gordon MK, Laskin DL.

Toxicol Appl Pharmacol. 2003 Oct 15;192(2):119-30.

PMID:
14550746
23.

A highly selective inhibitor of I kappa B kinase, BMS-345541, blocks both joint inflammation and destruction in collagen-induced arthritis in mice.

McIntyre KW, Shuster DJ, Gillooly KM, Dambach DM, Pattoli MA, Lu P, Zhou XD, Qiu Y, Zusi FC, Burke JR.

Arthritis Rheum. 2003 Sep;48(9):2652-9.

24.

Role of p55 tumor necrosis factor receptor 1 in acetaminophen-induced antioxidant defense.

Chiu H, Gardner CR, Dambach DM, Brittingham JA, Durham SK, Laskin JD, Laskin DL.

Am J Physiol Gastrointest Liver Physiol. 2003 Nov;285(5):G959-66. Epub 2003 Jul 3.

25.

Reduced hepatotoxicity of acetaminophen in mice lacking inducible nitric oxide synthase: potential role of tumor necrosis factor-alpha and interleukin-10.

Gardner CR, Laskin JD, Dambach DM, Sacco M, Durham SK, Bruno MK, Cohen SD, Gordon MK, Gerecke DR, Zhou P, Laskin DL.

Toxicol Appl Pharmacol. 2002 Oct 1;184(1):27-36.

PMID:
12392966
26.

A murine model of cigarette smoke-induced pulmonary inflammation using intranasally administered smoke-conditioned medium.

Miller LM, Foster WM, Dambach DM, Doebler D, McKinnon M, Killar L, Longphre M.

Exp Lung Res. 2002 Sep;28(6):435-55.

PMID:
12217211
27.

Role of CCR2 in macrophage migration into the liver during acetaminophen-induced hepatotoxicity in the mouse.

Dambach DM, Watson LM, Gray KR, Durham SK, Laskin DL.

Hepatology. 2002 May;35(5):1093-103.

PMID:
11981759
28.

Dilated cardiomyopathy in juvenile Portuguese Water Dogs.

Sleeper MM, Henthorn PS, Vijayasarathy C, Dambach DM, Bowers T, Tijskens P, Armstrong CF, Lankford EB.

J Vet Intern Med. 2002 Jan-Feb;16(1):52-62.

29.

Familial protein-losing enteropathy and protein-losing nephropathy in Soft Coated Wheaten Terriers: 222 cases (1983-1997).

Littman MP, Dambach DM, Vaden SL, Giger U.

J Vet Intern Med. 2000 Jan-Feb;14(1):68-80.

30.

Familial dilated cardiomyopathy of young Portuguese water dogs.

Dambach DM, Lannon A, Sleeper MM, Buchanan J.

J Vet Intern Med. 1999 Jan-Feb;13(1):65-71.

31.

Captopril prevents nephropathy in HIV-transgenic mice.

Bird JE, Durham SK, Giancarli MR, Gitlitz PH, Pandya DG, Dambach DM, Mozes MM, Kopp JB.

J Am Soc Nephrol. 1998 Aug;9(8):1441-7.

32.

Polycystic kidney and liver disease in two related West Highland White Terrier litters.

McAloose D, Casal M, Patterson DF, Dambach DM.

Vet Pathol. 1998 Jan;35(1):77-81.

PMID:
9545140
33.

Extraskeletal osteosarcomas in dogs: a retrospective study of 169 cases (1986-1996).

Langenbach A, Anderson MA, Dambach DM, Sorenmo KU, Shofer FD.

J Am Anim Hosp Assoc. 1998 Mar-Apr;34(2):113-20.

PMID:
9507423
35.

Aggressive, undifferentiated sarcoma with widespread metastasis in a six-month-old Neopolitan mastiff.

Sanders NA, Kerlin RL, Dambach DM.

J Am Anim Hosp Assoc. 1996 Mar-Apr;32(2):97-101. Review.

PMID:
8680927
36.

Coronavirus mouse hepatitis virus (MHV)-A59 causes a persistent, productive infection in primary glial cell cultures.

Lavi E, Suzumura A, Hirayama M, Highkin MK, Dambach DM, Silberberg DH, Weiss SR.

Microb Pathog. 1987 Aug;3(2):79-86.

PMID:
2849019

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