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Items: 1 to 50 of 54

1.

Pharmaceutical industry perspective on combination toxicity studies: Results from an intra-industry survey conducted by IQ DruSafe Leadership Group.

Birkebak J, Buckley LA, Dambach D, Musvasva E, Price K, Ralston S, Sacaan A.

Regul Toxicol Pharmacol. 2019 Mar;102:40-46. doi: 10.1016/j.yrtph.2018.12.012. Epub 2018 Dec 19.

2.

Using Genetically Modified Rodent Models in Drug Development to Explore Target Physiology and Potential Drug Effects.

Zhong Y, Dambach DM, Maher JM.

Vet Pathol. 2018 Mar;55(2):193-194. doi: 10.1177/0300985817747328. No abstract available.

PMID:
29457566
3.

Carcinogenicity assessment of the Hedgehog pathway inhibitor, vismodegib in Tg.rasH2 mice and Sprague-Dawley rats.

Li J, Morinello E, Larsen T, Frost D, Caro I, Gould S, Wong L, Hendricks A, Dybdal N, Dambach D, Schutten M.

Regul Toxicol Pharmacol. 2018 Feb;92:382-389. doi: 10.1016/j.yrtph.2017.12.015. Epub 2017 Dec 24.

PMID:
29278695
4.

Current nonclinical testing paradigm enables safe entry to First-In-Human clinical trials: The IQ consortium nonclinical to clinical translational database.

Monticello TM, Jones TW, Dambach DM, Potter DM, Bolt MW, Liu M, Keller DA, Hart TK, Kadambi VJ.

Toxicol Appl Pharmacol. 2017 Nov 1;334:100-109. doi: 10.1016/j.taap.2017.09.006. Epub 2017 Sep 8.

PMID:
28893587
5.

Bruton's Tyrosine Kinase Small Molecule Inhibitors Induce a Distinct Pancreatic Toxicity in Rats.

Erickson RI, Schutt LK, Tarrant JM, McDowell M, Liu L, Johnson AR, Lewin-Koh SC, Hedehus M, Ross J, Carano RA, Staflin K, Zhong F, Crawford JJ, Zhong S, Reif K, Katewa A, Wong H, Young WB, Dambach DM, Misner DL.

J Pharmacol Exp Ther. 2017 Jan;360(1):226-238. Epub 2016 Nov 7.

PMID:
27821712
6.

Key Challenges and Opportunities Associated with the Use of In Vitro Models to Detect Human DILI: Integrated Risk Assessment and Mitigation Plans.

Atienzar FA, Blomme EA, Chen M, Hewitt P, Kenna JG, Labbe G, Moulin F, Pognan F, Roth AB, Suter-Dick L, Ukairo O, Weaver RJ, Will Y, Dambach DM.

Biomed Res Int. 2016;2016:9737920. Epub 2016 Sep 5. Review.

7.

MEK and ERK Kinase Inhibitors Increase Circulating Ceruloplasmin and Cause Green Serum in Rats.

Diaz D, Pai R, Cain G, La N, Dambach D, Schwartz J, Tarrant JM.

Toxicol Pathol. 2017 Feb;45(2):353-361. doi: 10.1177/0192623316664590. Epub 2016 Sep 28.

PMID:
27565173
8.

Nonclinical Evaluations of Small-Molecule Oncology Drugs: Integration into Clinical Dose Optimization and Toxicity Management.

Dambach DM, Simpson NE, Jones TW, Brennan RJ, Pazdur R, Palmby TR.

Clin Cancer Res. 2016 Jun 1;22(11):2618-22. doi: 10.1158/1078-0432.CCR-15-2645.

9.

Therapeutic Antibody-Induced Vascular Toxicity Due to Off-Target Activation of Nitric Oxide in Cynomolgus Monkeys.

Pai R, Ma N, Connor AV, Danilenko DM, Tarrant JM, Salvail D, Wong L, Hartley DP, Misner D, Stefanich E, Wu Y, Chen Y, Wang H, Dambach DM.

Toxicol Sci. 2016 Jun;151(2):245-60. doi: 10.1093/toxsci/kfw037. Epub 2016 Feb 25.

PMID:
26917699
10.

Discovery of highly potent and selective Bruton's tyrosine kinase inhibitors: Pyridazinone analogs with improved metabolic stability.

Young WB, Barbosa J, Blomgren P, Bremer MC, Crawford JJ, Dambach D, Eigenbrot C, Gallion S, Johnson AR, Kropf JE, Lee SH, Liu L, Lubach JW, Macaluso J, Maciejewski P, Mitchell SA, Ortwine DF, Di Paolo J, Reif K, Scheerens H, Schmitt A, Wang X, Wong H, Xiong JM, Xu J, Yu C, Zhao Z, Currie KS.

Bioorg Med Chem Lett. 2016 Jan 15;26(2):575-579. doi: 10.1016/j.bmcl.2015.11.076. Epub 2015 Nov 24.

PMID:
26675441
11.

Safety Lead Optimization and Candidate Identification: Integrating New Technologies into Decision-Making.

Dambach DM, Misner D, Brock M, Fullerton A, Proctor W, Maher J, Lee D, Ford K, Diaz D.

Chem Res Toxicol. 2016 Apr 18;29(4):452-72. doi: 10.1021/acs.chemrestox.5b00396. Epub 2015 Dec 16. Review.

PMID:
26625186
12.

Mitigation of opioid off-target effects and identification of structural drivers of opioid receptor engagement for BACE-1 small molecule inhibitors.

Diaz D, Dambach D, Siu M, Hunt K, Thomas A, Lyssikatos J, Liu X, Lewin-Koh S, McCray B, Ford K.

Toxicol Mech Methods. 2015;25(6):478-86. Epub 2015 Aug 14.

PMID:
26275124
13.

Computational predictions of the site of metabolism of cytochrome P450 2D6 substrates: comparative analysis, molecular docking, bioactivation and toxicological implications.

Ford KA, Ryslik G, Sodhi J, Halladay J, Diaz D, Dambach D, Masuda M.

Drug Metab Rev. 2015 Aug;47(3):291-319. doi: 10.3109/03602532.2015.1047026. Epub 2015 May 29. Review.

PMID:
26024250
14.

Integrated risk assessment of suicidal ideation and behavior in drug development.

Muller PY, Dambach D, Gemzik B, Hartmann A, Ratcliffe S, Trendelenburg C, Urban L.

Drug Discov Today. 2015 Sep;20(9):1135-42. doi: 10.1016/j.drudis.2015.05.010. Epub 2015 May 27. Review.

PMID:
26022402
15.

Preclinical models of nicotinamide phosphoribosyltransferase inhibitor-mediated hematotoxicity and mitigation by co-treatment with nicotinic acid.

Tarrant JM, Dhawan P, Singh J, Zabka TS, Clarke E, DosSantos G, Dragovich PS, Sampath D, Lin T, McCray B, La N, Nguyen T, Kauss A, Dambach D, Misner DL, Diaz D, Uppal H.

Toxicol Mech Methods. 2015 Mar;25(3):201-11. doi: 10.3109/15376516.2015.1014080. Epub 2015 Apr 20.

PMID:
25894564
16.

Potent and selective Bruton's tyrosine kinase inhibitors: discovery of GDC-0834.

Young WB, Barbosa J, Blomgren P, Bremer MC, Crawford JJ, Dambach D, Gallion S, Hymowitz SG, Kropf JE, Lee SH, Liu L, Lubach JW, Macaluso J, Maciejewski P, Maurer B, Mitchell SA, Ortwine DF, Di Paolo J, Reif K, Scheerens H, Schmitt A, Sowell CG, Wang X, Wong H, Xiong JM, Xu J, Zhao Z, Currie KS.

Bioorg Med Chem Lett. 2015 Mar 15;25(6):1333-7. doi: 10.1016/j.bmcl.2015.01.032. Epub 2015 Feb 7.

PMID:
25701252
17.

Potential mechanisms for thrombocytopenia development with trastuzumab emtansine (T-DM1).

Uppal H, Doudement E, Mahapatra K, Darbonne WC, Bumbaca D, Shen BQ, Du X, Saad O, Bowles K, Olsen S, Lewis Phillips GD, Hartley D, Sliwkowski MX, Girish S, Dambach D, Ramakrishnan V.

Clin Cancer Res. 2015 Jan 1;21(1):123-33. doi: 10.1158/1078-0432.CCR-14-2093. Epub 2014 Nov 4.

18.

An algorithm for evaluating potential tissue drug distribution in toxicology studies from readily available pharmacokinetic parameters.

Poulin P, Dambach DM, Hartley DH, Ford K, Theil FP, Harstad E, Halladay J, Choo E, Boggs J, Liederer BM, Dean B, Diaz D.

J Pharm Sci. 2013 Oct;102(10):3816-29. doi: 10.1002/jps.23670. Epub 2013 Jul 22.

PMID:
23878104
19.

Pharmacokinetic drivers of toxicity for basic molecules: strategy to lower pKa results in decreased tissue exposure and toxicity for a small molecule Met inhibitor.

Diaz D, Ford KA, Hartley DP, Harstad EB, Cain GR, Achilles-Poon K, Nguyen T, Peng J, Zheng Z, Merchant M, Sutherlin DP, Gaudino JJ, Kaus R, Lewin-Koh SC, Choo EF, Liederer BM, Dambach DM.

Toxicol Appl Pharmacol. 2013 Jan 1;266(1):86-94. doi: 10.1016/j.taap.2012.10.026. Epub 2012 Nov 7.

PMID:
23142475
20.

Improving risk assessment.

Dambach DM, Uppal H.

Sci Transl Med. 2012 Nov 7;4(159):159ps22. doi: 10.1126/scitranslmed.3003497.

PMID:
23136041
21.

Toxicity profile of small-molecule IAP antagonist GDC-0152 is linked to TNF-α pharmacology.

Erickson RI, Tarrant J, Cain G, Lewin-Koh SC, Dybdal N, Wong H, Blackwood E, West K, Steigerwalt R, Mamounas M, Flygare JA, Amemiya K, Dambach D, Fairbrother WJ, Diaz D.

Toxicol Sci. 2013 Jan;131(1):247-58. doi: 10.1093/toxsci/kfs265. Epub 2012 Sep 5.

PMID:
22956632
22.

Antibody-mediated inhibition of fibroblast growth factor 19 results in increased bile acids synthesis and ileal malabsorption of bile acids in cynomolgus monkeys.

Pai R, French D, Ma N, Hotzel K, Plise E, Salphati L, Setchell KD, Ware J, Lauriault V, Schutt L, Hartley D, Dambach D.

Toxicol Sci. 2012 Apr;126(2):446-56. doi: 10.1093/toxsci/kfs011. Epub 2012 Jan 19.

PMID:
22268002
23.

Phosphorous dysregulation induced by MEK small molecule inhibitors in the rat involves blockade of FGF-23 signaling in the kidney.

Diaz D, Allamneni K, Tarrant JM, Lewin-Koh SC, Pai R, Dhawan P, Cain GR, Kozlowski C, Hiraragi H, La N, Hartley DP, Ding X, Dean BJ, Bheddah S, Dambach DM.

Toxicol Sci. 2012 Jan;125(1):187-95. doi: 10.1093/toxsci/kfr263. Epub 2011 Oct 5.

PMID:
21976371
24.

Cloning, expression and characterization of monkey (Macaca fascicularis) CD137.

Chen SJ, Foster WR, Jure-Kunkel MN, Girit E, Abraham R, Hefta LJ, Gao S, Yonan CR, Lin JH, Dambach DM.

Vet Immunol Immunopathol. 2008 Dec 15;126(3-4):377-81. doi: 10.1016/j.vetimm.2008.07.009. Epub 2008 Jul 31.

PMID:
18771806
25.

A retrospective analysis of toxicogenomics in the safety assessment of drug candidates.

Foster WR, Chen SJ, He A, Truong A, Bhaskaran V, Nelson DM, Dambach DM, Lehman-McKeeman LD, Car BD.

Toxicol Pathol. 2007 Aug;35(5):621-35. Review.

PMID:
17654404
26.

Acridone-based inhibitors of inosine 5'-monophosphate dehydrogenase: discovery and SAR leading to the identification of N-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-yl)propan-2-yl)-2- fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide (BMS-566419).

Watterson SH, Chen P, Zhao Y, Gu HH, Dhar TG, Xiao Z, Ballentine SK, Shen Z, Fleener CA, Rouleau KA, Obermeier M, Yang Z, McIntyre KW, Shuster DJ, Witmer M, Dambach D, Chao S, Mathur A, Chen BC, Barrish JC, Robl JA, Townsend R, Iwanowicz EJ.

J Med Chem. 2007 Jul 26;50(15):3730-42. Epub 2007 Jun 22.

PMID:
17585753
27.

Clinical pathology laboratory values of rats housed in wire-bottom cages compared with those of rats housed in solid-bottom cages.

Sauer MB, Dulac H, Clark S, Moffitt KM, Price J, Dambach D, Mosher H, Bounous D, Keller L.

J Am Assoc Lab Anim Sci. 2006 Jan;45(1):30-5.

PMID:
16539332
28.

Potential adverse effects associated with inhibition of p38alpha/beta MAP kinases.

Dambach DM.

Curr Top Med Chem. 2005;5(10):929-39. Review.

PMID:
16178738
29.

Distinct roles of NF-kappaB p50 in the regulation of acetaminophen-induced inflammatory mediator production and hepatotoxicity.

Dambach DM, Durham SK, Laskin JD, Laskin DL.

Toxicol Appl Pharmacol. 2006 Mar 1;211(2):157-65. Epub 2005 Aug 2.

PMID:
16081117
30.

New technologies and screening strategies for hepatotoxicity: use of in vitro models.

Dambach DM, Andrews BA, Moulin F.

Toxicol Pathol. 2005;33(1):17-26. Review.

PMID:
15805052
31.

Biomarker discovery in biological fluids.

Gao J, Garulacan LA, Storm SM, Opiteck GJ, Dubaquie Y, Hefta SA, Dambach DM, Dongre AR.

Methods. 2005 Mar;35(3):291-302. Epub 2005 Jan 12.

PMID:
15722225
32.

Familial glomerulonephropathy in the Bullmastiff.

Casal ML, Dambach DM, Meister T, Jezyk PF, Patterson DF, Henthorn PS.

Vet Pathol. 2004 Jul;41(4):319-25.

PMID:
15232131
33.

Identification of in vitro protein biomarkers of idiosyncratic liver toxicity.

Gao J, Ann Garulacan L, Storm SM, Hefta SA, Opiteck GJ, Lin JH, Moulin F, Dambach DM.

Toxicol In Vitro. 2004 Aug;18(4):533-41.

PMID:
15130611
34.

An inhibitor of IkappaB kinase, BMS-345541, blocks endothelial cell adhesion molecule expression and reduces the severity of dextran sulfate sodium-induced colitis in mice.

MacMaster JF, Dambach DM, Lee DB, Berry KK, Qiu Y, Zusi FC, Burke JR.

Inflamm Res. 2003 Dec;52(12):508-11. Epub 2003 Nov 13.

PMID:
14991079
35.

Role of tumor necrosis factor receptor 1 (p55) in hepatocyte proliferation during acetaminophen-induced toxicity in mice.

Chiu H, Gardner CR, Dambach DM, Durham SK, Brittingham JA, Laskin JD, Laskin DL.

Toxicol Appl Pharmacol. 2003 Dec 1;193(2):218-27.

PMID:
14644624
36.

Exaggerated hepatotoxicity of acetaminophen in mice lacking tumor necrosis factor receptor-1. Potential role of inflammatory mediators.

Gardner CR, Laskin JD, Dambach DM, Chiu H, Durham SK, Zhou P, Bruno M, Gerecke DR, Gordon MK, Laskin DL.

Toxicol Appl Pharmacol. 2003 Oct 15;192(2):119-30.

PMID:
14550746
37.

A highly selective inhibitor of I kappa B kinase, BMS-345541, blocks both joint inflammation and destruction in collagen-induced arthritis in mice.

McIntyre KW, Shuster DJ, Gillooly KM, Dambach DM, Pattoli MA, Lu P, Zhou XD, Qiu Y, Zusi FC, Burke JR.

Arthritis Rheum. 2003 Sep;48(9):2652-9.

38.

Role of p55 tumor necrosis factor receptor 1 in acetaminophen-induced antioxidant defense.

Chiu H, Gardner CR, Dambach DM, Brittingham JA, Durham SK, Laskin JD, Laskin DL.

Am J Physiol Gastrointest Liver Physiol. 2003 Nov;285(5):G959-66. Epub 2003 Jul 3.

39.

Reduced hepatotoxicity of acetaminophen in mice lacking inducible nitric oxide synthase: potential role of tumor necrosis factor-alpha and interleukin-10.

Gardner CR, Laskin JD, Dambach DM, Sacco M, Durham SK, Bruno MK, Cohen SD, Gordon MK, Gerecke DR, Zhou P, Laskin DL.

Toxicol Appl Pharmacol. 2002 Oct 1;184(1):27-36.

PMID:
12392966
40.

A murine model of cigarette smoke-induced pulmonary inflammation using intranasally administered smoke-conditioned medium.

Miller LM, Foster WM, Dambach DM, Doebler D, McKinnon M, Killar L, Longphre M.

Exp Lung Res. 2002 Sep;28(6):435-55.

PMID:
12217211
41.

Role of CCR2 in macrophage migration into the liver during acetaminophen-induced hepatotoxicity in the mouse.

Dambach DM, Watson LM, Gray KR, Durham SK, Laskin DL.

Hepatology. 2002 May;35(5):1093-103.

PMID:
11981759
42.

Dilated cardiomyopathy in juvenile Portuguese Water Dogs.

Sleeper MM, Henthorn PS, Vijayasarathy C, Dambach DM, Bowers T, Tijskens P, Armstrong CF, Lankford EB.

J Vet Intern Med. 2002 Jan-Feb;16(1):52-62.

43.

Familial protein-losing enteropathy and protein-losing nephropathy in Soft Coated Wheaten Terriers: 222 cases (1983-1997).

Littman MP, Dambach DM, Vaden SL, Giger U.

J Vet Intern Med. 2000 Jan-Feb;14(1):68-80.

44.

Sry-negative XX sex reversal in a family of Norwegian Elkhounds.

Melniczek JR, Dambach D, Prociuk U, Jezyk PF, Henthorn PS, Patterson DF, Giger U.

J Vet Intern Med. 1999 Nov-Dec;13(6):564-9. Review.

45.

Familial dilated cardiomyopathy of young Portuguese water dogs.

Dambach DM, Lannon A, Sleeper MM, Buchanan J.

J Vet Intern Med. 1999 Jan-Feb;13(1):65-71.

46.

Functional redundancy of the nuclear factor kappa B inhibitors I kappa B alpha and I kappa B beta.

Cheng JD, Ryseck RP, Attar RM, Dambach D, Bravo R.

J Exp Med. 1998 Sep 21;188(6):1055-62.

47.

Captopril prevents nephropathy in HIV-transgenic mice.

Bird JE, Durham SK, Giancarli MR, Gitlitz PH, Pandya DG, Dambach DM, Mozes MM, Kopp JB.

J Am Soc Nephrol. 1998 Aug;9(8):1441-7.

48.

Chronic inflammation and susceptibility to bacterial infections in mice lacking the polypeptide (p)105 precursor (NF-kappaB1) but expressing p50.

Ishikawa H, Claudio E, Dambach D, Raventós-Suárez C, Ryan C, Bravo R.

J Exp Med. 1998 Apr 6;187(7):985-96.

49.

Polycystic kidney and liver disease in two related West Highland White Terrier litters.

McAloose D, Casal M, Patterson DF, Dambach DM.

Vet Pathol. 1998 Jan;35(1):77-81.

PMID:
9545140
50.

Extraskeletal osteosarcomas in dogs: a retrospective study of 169 cases (1986-1996).

Langenbach A, Anderson MA, Dambach DM, Sorenmo KU, Shofer FD.

J Am Anim Hosp Assoc. 1998 Mar-Apr;34(2):113-20.

PMID:
9507423

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