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Items: 1 to 50 of 168

1.

Blockade of nicotinic acetylcholine receptor enhances the responsiveness to bupropion in the mouse forced swim test.

Bagdas D, AlSharari S, Roni MA, Campbell VC, Muldoon PP, Carroll FI, Damaj MI.

Behav Brain Res. 2018 Dec 12. pii: S0166-4328(18)31307-X. doi: 10.1016/j.bbr.2018.12.027. [Epub ahead of print]

PMID:
30552947
2.

B-973, a Novel α7 nAChR Ago-PAM: Racemic and Asymmetric Synthesis, Electrophysiological Studies, and in Vivo Evaluation.

Garai S, Raja KS, Papke RL, Deschamps JR, Damaj MI, Thakur GA.

ACS Med Chem Lett. 2018 Oct 11;9(11):1144-1148. doi: 10.1021/acsmedchemlett.8b00407. eCollection 2018 Nov 8.

PMID:
30429960
3.

Neuronal nicotinic acetylcholine receptors mediate ∆9 -THC dependence: Mouse and human studies.

Donvito G, Muldoon PP, Jackson KJ, Ahmad U, Zaveri NT, McIntosh JM, Chen X, Lichtman AH, Damaj MI.

Addict Biol. 2018 Oct 31. doi: 10.1111/adb.12691. [Epub ahead of print]

PMID:
30378732
4.

Early adolescent nicotine exposure affects later-life hippocampal mu-opioid receptors activity and morphine reward but not physical dependence in male mice.

Kota D, Alajaji M, Bagdas D, Selley DE, Sim-Selley LJ, Damaj MI.

Pharmacol Biochem Behav. 2018 Oct;173:58-64. doi: 10.1016/j.pbb.2018.08.006. Epub 2018 Aug 17.

PMID:
30125591
5.

The Antinociceptive and Anti-Inflammatory Properties of the α7 nAChR Weak Partial Agonist p-CF3 N,N-diethyl-N'-phenylpiperazine.

Quadri M, Bagdas D, Toma W, Stokes C, Horenstein NA, Damaj MI, Papke RL.

J Pharmacol Exp Ther. 2018 Nov;367(2):203-214. doi: 10.1124/jpet.118.249904. Epub 2018 Aug 15.

PMID:
30111636
6.

Knockout of alpha 5 nicotinic acetylcholine receptors subunit alters ethanol-mediated behavioral effects and reward in mice.

Dawson A, Wolstenholme JT, Roni MA, Campbell VC, Jackson A, Slater C, Bagdas D, Perez EE, Bettinger JC, De Biasi M, Miles MF, Damaj MI.

Neuropharmacology. 2018 Aug;138:341-348. doi: 10.1016/j.neuropharm.2018.06.031. Epub 2018 Jun 23.

PMID:
29944862
7.

Reduced intraepidermal nerve fibre density, glial activation, and sensory changes in HIV type-1 Tat-expressing female mice: involvement of Tat during early stages of HIV-associated painful sensory neuropathy.

Wodarski R, Bagdas D, Paris JJ, Pheby T, Toma W, Xu R, Damaj MI, Knapp PE, Rice ASC, Hauser KF.

Pain Rep. 2018 May 14;3(3):e654. doi: 10.1097/PR9.0000000000000654. eCollection 2018 May.

8.

New insights on the effects of varenicline on nicotine reward, withdrawal and hyperalgesia in mice.

Bagdas D, Alkhlaif Y, Jackson A, Carroll FI, Ditre JW, Damaj MI.

Neuropharmacology. 2018 Aug;138:72-79. doi: 10.1016/j.neuropharm.2018.05.025. Epub 2018 May 21.

PMID:
29860196
9.

Effect of nicotine and alpha-7 nicotinic modulators on visceral pain-induced conditioned place aversion in mice.

Bagdas D, Meade JA, Alkhlaif Y, Muldoon PP, Carroll FI, Damaj MI.

Eur J Pain. 2018 Apr 10. doi: 10.1002/ejp.1231. [Epub ahead of print]

PMID:
29633429
10.

N-Oleoyl-glycine reduces nicotine reward and withdrawal in mice.

Donvito G, Piscitelli F, Muldoon P, Jackson A, Vitale RM, D'Aniello E, Giordano C, Ignatowska-Jankowska BM, Mustafa MA, Guida F, Petrie GN, Parker L, Smoum R, Sim-Selley L, Maione S, Lichtman AH, Damaj MI, Di Marzo V, Mechoulam R.

Neuropharmacology. 2018 Mar 19. pii: S0028-3908(18)30131-X. doi: 10.1016/j.neuropharm.2018.03.020. [Epub ahead of print]

PMID:
29567093
11.

Pharmacological modulation of the α7 nicotinic acetylcholine receptor in a mouse model of mecamylamine-precipitated nicotine withdrawal.

Jackson A, Papke RL, Damaj MI.

Psychopharmacology (Berl). 2018 Jul;235(7):1897-1905. doi: 10.1007/s00213-018-4879-7. Epub 2018 Mar 16.

PMID:
29549391
12.

Monoacylglycerol Lipase Inhibitors Reverse Paclitaxel-Induced Nociceptive Behavior and Proinflammatory Markers in a Mouse Model of Chemotherapy-Induced Neuropathy.

Curry ZA, Wilkerson JL, Bagdas D, Kyte SL, Patel N, Donvito G, Mustafa MA, Poklis JL, Niphakis MJ, Hsu KL, Cravatt BF, Gewirtz DA, Damaj MI, Lichtman AH.

J Pharmacol Exp Ther. 2018 Jul;366(1):169-183. doi: 10.1124/jpet.117.245704. Epub 2018 Mar 14.

PMID:
29540562
13.

Nicotinic acetylcholine receptors (nAChRs) are expressed in Trpm5 positive taste receptor cells (TRCs).

Qian J, Mummalaneni S, Grider JR, Damaj MI, Lyall V.

PLoS One. 2018 Jan 2;13(1):e0190465. doi: 10.1371/journal.pone.0190465. eCollection 2018.

14.

Basic Science and Public Policy: Informed Regulation for Nicotine and Tobacco Products.

Fowler CD, Gipson CD, Kleykamp BA, Rupprecht LE, Harrell PT, Rees VW, Gould TJ, Oliver J, Bagdas D, Damaj MI, Schmidt HD, Duncan A, De Biasi M; Basic Science Network (BSN) of the Society for Research on Nicotine and Tobacco (SRNT).

Nicotine Tob Res. 2018 Jun 7;20(7):789-799. doi: 10.1093/ntr/ntx175.

PMID:
29065200
15.

Nicotine Prevents and Reverses Paclitaxel-Induced Mechanical Allodynia in a Mouse Model of CIPN.

Kyte SL, Toma W, Bagdas D, Meade JA, Schurman LD, Lichtman AH, Chen ZJ, Del Fabbro E, Fang X, Bigbee JW, Damaj MI, Gewirtz DA.

J Pharmacol Exp Ther. 2018 Jan;364(1):110-119. doi: 10.1124/jpet.117.243972. Epub 2017 Oct 17.

PMID:
29042416
16.

New Insights on Neuronal Nicotinic Acetylcholine Receptors as Targets for Pain and Inflammation: A Focus on α7 nAChRs.

Bagdas D, Gurun MS, Flood P, Papke RL, Damaj MI.

Curr Neuropharmacol. 2018;16(4):415-425. doi: 10.2174/1570159X15666170818102108. Review.

17.

Allosteric modulation of α4β2* nicotinic acetylcholine receptors: Desformylflustrabromine potentiates antiallodynic response of nicotine in a mouse model of neuropathic pain.

Bagdas D, Ergun D, Jackson A, Toma W, Schulte MK, Damaj MI.

Eur J Pain. 2018 Jan;22(1):84-93. doi: 10.1002/ejp.1092. Epub 2017 Aug 14.

PMID:
28809075
18.

Inhibition of the endocannabinoid-regulating enzyme monoacylglycerol lipase elicits a CB1 receptor-mediated discriminative stimulus in mice.

Owens RA, Mustafa MA, Ignatowska-Jankowska BM, Damaj MI, Beardsley PM, Wiley JL, Niphakis MJ, Cravatt BF, Lichtman AH.

Neuropharmacology. 2017 Oct;125:80-86. doi: 10.1016/j.neuropharm.2017.06.032. Epub 2017 Jun 30.

19.

Persistent activation of α7 nicotinic ACh receptors associated with stable induction of different desensitized states.

Papke RL, Stokes C, Damaj MI, Thakur GA, Manther K, Treinin M, Bagdas D, Kulkarni AR, Horenstein NA.

Br J Pharmacol. 2018 Jun;175(11):1838-1854. doi: 10.1111/bph.13851. Epub 2017 Jun 8.

PMID:
28477386
20.

In vivo interactions between α7 nicotinic acetylcholine receptor and nuclear peroxisome proliferator-activated receptor-α: Implication for nicotine dependence.

Jackson A, Bagdas D, Muldoon PP, Lichtman AH, Carroll FI, Greenwald M, Miles MF, Damaj MI.

Neuropharmacology. 2017 May 15;118:38-45. doi: 10.1016/j.neuropharm.2017.03.005. Epub 2017 Mar 7.

21.

Effects of paclitaxel on the development of neuropathy and affective behaviors in the mouse.

Toma W, Kyte SL, Bagdas D, Alkhlaif Y, Alsharari SD, Lichtman AH, Chen ZJ, Del Fabbro E, Bigbee JW, Gewirtz DA, Damaj MI.

Neuropharmacology. 2017 May 1;117:305-315. doi: 10.1016/j.neuropharm.2017.02.020. Epub 2017 Feb 22.

22.

Effects of Nicotine Metabolites on Nicotine Withdrawal Behaviors in Mice.

Elhassan S, Bagdas D, Damaj MI.

Nicotine Tob Res. 2017 Jun 1;19(6):763-766. doi: 10.1093/ntr/ntx045.

23.

Sex Differences and Drug Dose Influence the Role of the α7 Nicotinic Acetylcholine Receptor in the Mouse Dextran Sodium Sulfate-Induced Colitis Model.

AlSharari SD, Bagdas D, Akbarali HI, Lichtman PA, Raborn ES, Cabral GA, Carroll FI, McGee EA, Damaj MI.

Nicotine Tob Res. 2017 Apr 1;19(4):460-468. doi: 10.1093/ntr/ntw245.

PMID:
27639096
24.

Palmitoylethanolamide Reverses Paclitaxel-Induced Allodynia in Mice.

Donvito G, Wilkerson JL, Damaj MI, Lichtman AH.

J Pharmacol Exp Ther. 2016 Nov;359(2):310-318. Epub 2016 Sep 8.

25.

Synthesis, Nicotinic Acetylcholine Receptor Binding, and in Vitro and in Vivo Pharmacological Properties of 2'-Fluoro-(substituted thiophenyl)deschloroepibatidine Analogues.

Ondachi PW, Castro AH, Sherman B, Luetje CW, Damaj MI, Mascarella SW, Navarro HA, Carroll FI.

ACS Chem Neurosci. 2017 Jan 18;8(1):115-127. doi: 10.1021/acschemneuro.6b00252. Epub 2016 Oct 20.

PMID:
27726337
26.

Oxycodone physical dependence and its oral self-administration in C57BL/6J mice.

Enga RM, Jackson A, Damaj MI, Beardsley PM.

Eur J Pharmacol. 2016 Oct 15;789:75-80. doi: 10.1016/j.ejphar.2016.07.006. Epub 2016 Jul 5.

27.

The α7 nicotinic receptor dual allosteric agonist and positive allosteric modulator GAT107 reverses nociception in mouse models of inflammatory and neuropathic pain.

Bagdas D, Wilkerson JL, Kulkarni A, Toma W, AlSharari S, Gul Z, Lichtman AH, Papke RL, Thakur GA, Damaj MI.

Br J Pharmacol. 2016 Aug;173(16):2506-20. doi: 10.1111/bph.13528. Epub 2016 Jul 18.

28.

Synthesis, Nicotinic Acetylcholine Binding, and in Vitro and in Vivo Pharmacological Properties of 2'-Fluoro-(carbamoylpyridinyl)deschloroepibatidine Analogues.

Ondachi PW, Castro AH, Luetje CW, Wageman CR, Marks MJ, Damaj MI, Mascarella SW, Navarro HA, Carroll FI.

ACS Chem Neurosci. 2016 Jul 20;7(7):1004-12. doi: 10.1021/acschemneuro.6b00107. Epub 2016 May 19.

PMID:
27166021
29.

Enhanced Sensitivity of α3β4 Nicotinic Receptors in Enteric Neurons after Long-Term Morphine: Implication for Opioid-Induced Constipation.

Gade AR, Kang M, Khan F, Grider JR, Damaj MI, Dewey WL, Akbarali HI.

J Pharmacol Exp Ther. 2016 Jun;357(3):520-8. doi: 10.1124/jpet.116.233304. Epub 2016 Apr 11.

30.

Diacylglycerol lipase β inhibition reverses nociceptive behaviour in mouse models of inflammatory and neuropathic pain.

Wilkerson JL, Ghosh S, Bagdas D, Mason BL, Crowe MS, Hsu KL, Wise LE, Kinsey SG, Damaj MI, Cravatt BF, Lichtman AH.

Br J Pharmacol. 2016 May;173(10):1678-92. doi: 10.1111/bph.13469. Epub 2016 Apr 8.

31.

Early adolescent nicotine exposure affects later-life cocaine reward in mice.

Alajaji M, Lazenka MF, Kota D, Wise LE, Younis RM, Carroll FI, Levine A, Selley DE, Sim-Selley LJ, Damaj MI.

Neuropharmacology. 2016 Jun;105:308-317. doi: 10.1016/j.neuropharm.2016.01.032. Epub 2016 Jan 22.

PMID:
26808314
32.

N-acetylcysteine decreased nicotine reward-like properties and withdrawal in mice.

Bowers MS, Jackson A, Maldoon PP, Damaj MI.

Psychopharmacology (Berl). 2016 Mar;233(6):995-1003. doi: 10.1007/s00213-015-4179-4. Epub 2015 Dec 17.

33.

Expression and pharmacological modulation of visceral pain-induced conditioned place aversion in mice.

Bagdas D, Muldoon PP, AlSharari S, Carroll FI, Negus SS, Damaj MI.

Neuropharmacology. 2016 Mar;102:236-43. doi: 10.1016/j.neuropharm.2015.11.024. Epub 2015 Nov 27.

34.

Effects of Menthol on Nicotine Pharmacokinetic, Pharmacology and Dependence in Mice.

Alsharari SD, King JR, Nordman JC, Muldoon PP, Jackson A, Zhu AZ, Tyndale RF, Kabbani N, Damaj MI.

PLoS One. 2015 Sep 10;10(9):e0137070. doi: 10.1371/journal.pone.0137070. eCollection 2015.

35.

Neuronal calcium/calmodulin-dependent protein kinase II mediates nicotine reward in the conditioned place preference test in mice.

Jackson KJ, Muldoon PP, Walters C, Damaj MI.

Behav Pharmacol. 2016 Feb;27(1):50-6. doi: 10.1097/FBP.0000000000000189.

36.

The Antinociceptive and Antiinflammatory Properties of 3-furan-2-yl-N-p-tolyl-acrylamide, a Positive Allosteric Modulator of α7 Nicotinic Acetylcholine Receptors in Mice.

Bagdas D, Targowska-Duda KM, López JJ, Perez EG, Arias HR, Damaj MI.

Anesth Analg. 2015 Nov;121(5):1369-77. doi: 10.1213/ANE.0000000000000902.

37.

Synthesis, nicotinic acetylcholine receptor binding, in vitro and in vivo pharmacology properties of 3'-(substituted pyridinyl)-deschloroepibatidine analogs.

Ondachi PW, Ye Z, Castro AH, Luetje CW, Damaj MI, Mascarella SW, Navarro HA, Carroll FI.

Bioorg Med Chem. 2015 Sep 1;23(17):5693-701. doi: 10.1016/j.bmc.2015.07.021. Epub 2015 Jul 17.

38.

Effects of orally-bioavailable short-acting kappa opioid receptor-selective antagonist LY2456302 on nicotine withdrawal in mice.

Jackson KJ, Jackson A, Carroll FI, Damaj MI.

Neuropharmacology. 2015 Oct;97:270-4. doi: 10.1016/j.neuropharm.2015.05.023. Epub 2015 Jun 1.

39.

The role of alpha5 nicotinic acetylcholine receptors in mouse models of chronic inflammatory and neuropathic pain.

Bagdas D, AlSharari SD, Freitas K, Tracy M, Damaj MI.

Biochem Pharmacol. 2015 Oct 15;97(4):590-600. doi: 10.1016/j.bcp.2015.04.013. Epub 2015 Apr 28.

40.

In vitro and in vivo neuronal nicotinic receptor properties of (+)- and (-)-pyrido[3,4]homotropane [(+)- and (-)-PHT]: (+)-PHT is a potent and selective full agonist at α6β2 containing neuronal nicotinic acetylcholine receptors.

Carroll FI, Navarro HA, Mascarella SW, Castro AH, Luetje CW, Wageman CR, Marks MJ, Jackson A, Damaj MI.

ACS Chem Neurosci. 2015 Jun 17;6(6):920-6. doi: 10.1021/acschemneuro.5b00077. Epub 2015 Apr 30.

41.

Examination of the metabolite hydroxybupropion in the reinforcing and aversive stimulus effects of nicotine in rats.

Malcolm E, Carroll FI, Blough B, Damaj MI, Shoaib M.

Psychopharmacology (Berl). 2015 Aug;232(15):2763-71. doi: 10.1007/s00213-015-3908-z. Epub 2015 Mar 13.

PMID:
25761841
42.

A Role for p38 Mitogen-activated Protein Kinase-mediated Threonine 30-dependent Norepinephrine Transporter Regulation in Cocaine Sensitization and Conditioned Place Preference.

Mannangatti P, NarasimhaNaidu K, Damaj MI, Ramamoorthy S, Jayanthi LD.

J Biol Chem. 2015 Apr 24;290(17):10814-27. doi: 10.1074/jbc.M114.612192. Epub 2015 Feb 27.

43.

The analgesic-like properties of the alpha7 nAChR silent agonist NS6740 is associated with non-conducting conformations of the receptor.

Papke RL, Bagdas D, Kulkarni AR, Gould T, AlSharari SD, Thakur GA, Damaj MI.

Neuropharmacology. 2015 Apr;91:34-42. doi: 10.1016/j.neuropharm.2014.12.002. Epub 2014 Dec 11.

44.

Differential effects of endocannabinoid catabolic inhibitors on morphine withdrawal in mice.

Gamage TF, Ignatowska-Jankowska BM, Muldoon PP, Cravatt BF, Damaj MI, Lichtman AH.

Drug Alcohol Depend. 2015 Jan 1;146:7-16. doi: 10.1016/j.drugalcdep.2014.11.015. Epub 2014 Nov 26.

45.

New mechanisms and perspectives in nicotine withdrawal.

Jackson KJ, Muldoon PP, De Biasi M, Damaj MI.

Neuropharmacology. 2015 Sep;96(Pt B):223-34. doi: 10.1016/j.neuropharm.2014.11.009. Epub 2014 Nov 26. Review.

46.

Inhibition of monoacylglycerol lipase reduces nicotine withdrawal.

Muldoon PP, Chen J, Harenza JL, Abdullah RA, Sim-Selley LJ, Cravatt BF, Miles MF, Chen X, Lichtman AH, Damaj MI.

Br J Pharmacol. 2015 Feb;172(3):869-82. doi: 10.1111/bph.12948.

47.

Nicotine is out: nicotinic agonists may have utility as analgesics.

Flood P, Damaj MI.

Anesth Analg. 2014 Aug;119(2):232-3. doi: 10.1213/ANE.0000000000000304. No abstract available.

PMID:
25046780
48.

Differential roles of α6β2* and α4β2* neuronal nicotinic receptors in nicotine- and cocaine-conditioned reward in mice.

Sanjakdar SS, Maldoon PP, Marks MJ, Brunzell DH, Maskos U, McIntosh JM, Bowers MS, Damaj MI.

Neuropsychopharmacology. 2015 Jan;40(2):350-60. doi: 10.1038/npp.2014.177. Epub 2014 Jul 18.

49.

Effects of methoxsalen, a CYP2A5/6 inhibitor, on nicotine dependence behaviors in mice.

Bagdas D, Muldoon PP, Zhu AZ, Tyndale RF, Damaj MI.

Neuropharmacology. 2014 Oct;85:67-72. doi: 10.1016/j.neuropharm.2014.05.006. Epub 2014 May 21.

50.

The α3β4* nicotinic ACh receptor subtype mediates physical dependence to morphine: mouse and human studies.

Muldoon PP, Jackson KJ, Perez E, Harenza JL, Molas S, Rais B, Anwar H, Zaveri NT, Maldonado R, Maskos U, McIntosh JM, Dierssen M, Miles MF, Chen X, De Biasi M, Damaj MI.

Br J Pharmacol. 2014 Aug;171(16):3845-57. doi: 10.1111/bph.12741.

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