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Items: 1 to 50 of 84

1.

Generation of a Slc39a8 hypomorph mouse: markedly decreased ZIP8 Zn²⁺/(HCO₃⁻)₂ transporter expression.

Wang B, He L, Dong H, Dalton TP, Nebert DW.

Biochem Biophys Res Commun. 2011 Jul 1;410(2):289-94. doi: 10.1016/j.bbrc.2011.05.134. Epub 2011 May 31.

2.

Oral N-acetylcysteine rescues lethality of hepatocyte-specific Gclc-knockout mice, providing a model for hepatic cirrhosis.

Chen Y, Johansson E, Yang Y, Miller ML, Shen D, Orlicky DJ, Shertzer HG, Vasiliou V, Nebert DW, Dalton TP.

J Hepatol. 2010 Dec;53(6):1085-94. doi: 10.1016/j.jhep.2010.05.028. Epub 2010 Aug 11.

3.

Glutathione deficient C57BL/6J mice are not sensitized to ozone-induced lung injury.

Johansson E, Wesselkamper SC, Shertzer HG, Leikauf GD, Dalton TP, Chen Y.

Biochem Biophys Res Commun. 2010 May 28;396(2):407-12. doi: 10.1016/j.bbrc.2010.04.105. Epub 2010 Apr 22.

4.

Redox dysregulation affects the ventral but not dorsal hippocampus: impairment of parvalbumin neurons, gamma oscillations, and related behaviors.

Steullet P, Cabungcal JH, Kulak A, Kraftsik R, Chen Y, Dalton TP, Cuenod M, Do KQ.

J Neurosci. 2010 Feb 17;30(7):2547-58. doi: 10.1523/JNEUROSCI.3857-09.2010.

5.

Early onset senescence occurs when fibroblasts lack the glutamate-cysteine ligase modifier subunit.

Chen Y, Johansson E, Fan Y, Shertzer HG, Vasiliou V, Nebert DW, Dalton TP.

Free Radic Biol Med. 2009 Aug 15;47(4):410-8. doi: 10.1016/j.freeradbiomed.2009.05.003. Epub 2009 May 8.

6.

Curcumin, quercetin, and tBHQ modulate glutathione levels in astrocytes and neurons: importance of the glutamate cysteine ligase modifier subunit.

Lavoie S, Chen Y, Dalton TP, Gysin R, Cuénod M, Steullet P, Do KQ.

J Neurochem. 2009 Mar;108(6):1410-22. doi: 10.1111/j.1471-4159.2009.05908.x. Epub 2009 Jan 22.

7.

Knock-in mouse lines expressing either mitochondrial or microsomal CYP1A1: differing responses to dietary benzo[a]pyrene as proof of principle.

Dong H, Dalton TP, Miller ML, Chen Y, Uno S, Shi Z, Shertzer HG, Bansal S, Avadhani NG, Nebert DW.

Mol Pharmacol. 2009 Mar;75(3):555-67. doi: 10.1124/mol.108.051888. Epub 2008 Dec 1. Erratum in: Mol Pharmacol. 2009 Aug;76(2):452.

8.

Induction of oxidative stress responses by dioxin and other ligands of the aryl hydrocarbon receptor.

Reichard JF, Dalton TP, Shertzer HG, Puga A.

Dose Response. 2006 May 1;3(3):306-31. doi: 10.2203/dose-response.003.03.003.

9.

Slc39a14 gene encodes ZIP14, a metal/bicarbonate symporter: similarities to the ZIP8 transporter.

Girijashanker K, He L, Soleimani M, Reed JM, Li H, Liu Z, Wang B, Dalton TP, Nebert DW.

Mol Pharmacol. 2008 May;73(5):1413-23. doi: 10.1124/mol.107.043588. Epub 2008 Feb 12. Erratum in: Mol Pharmacol. 2008 Sep;74(3):924.

10.

Cd2+ versus Zn2+ uptake by the ZIP8 HCO3--dependent symporter: kinetics, electrogenicity and trafficking.

Liu Z, Li H, Soleimani M, Girijashanker K, Reed JM, He L, Dalton TP, Nebert DW.

Biochem Biophys Res Commun. 2008 Jan 25;365(4):814-20. Epub 2007 Nov 26.

11.

Basal and inducible CYP1 mRNA quantitation and protein localization throughout the mouse gastrointestinal tract.

Uno S, Dragin N, Miller ML, Dalton TP, Gonzalez FJ, Nebert DW.

Free Radic Biol Med. 2008 Feb 15;44(4):570-83. Epub 2007 Nov 12.

12.

Oxidative and electrophilic stress induces multidrug resistance-associated protein transporters via the nuclear factor-E2-related factor-2 transcriptional pathway.

Maher JM, Dieter MZ, Aleksunes LM, Slitt AL, Guo G, Tanaka Y, Scheffer GL, Chan JY, Manautou JE, Chen Y, Dalton TP, Yamamoto M, Klaassen CD.

Hepatology. 2007 Nov;46(5):1597-610.

PMID:
17668877
13.

Generation of 'humanized' hCYP1A1_1A2_Cyp1a1/1a2(-/-) mouse line.

Dragin N, Uno S, Wang B, Dalton TP, Nebert DW.

Biochem Biophys Res Commun. 2007 Aug 3;359(3):635-42. Epub 2007 Jun 6.

14.

Interaction between the catalytic and modifier subunits of glutamate-cysteine ligase.

Yang Y, Chen Y, Johansson E, Schneider SN, Shertzer HG, Nebert DW, Dalton TP.

Biochem Pharmacol. 2007 Jul 15;74(2):372-81. Epub 2007 Feb 12.

PMID:
17517378
15.

Hepatocyte-specific Gclc deletion leads to rapid onset of steatosis with mitochondrial injury and liver failure.

Chen Y, Yang Y, Miller ML, Shen D, Shertzer HG, Stringer KF, Wang B, Schneider SN, Nebert DW, Dalton TP.

Hepatology. 2007 May;45(5):1118-28.

PMID:
17464988
16.

7H-dibenzo[c,g]carbazole metabolism by the mouse and human CYP1 family of enzymes.

Shertzer HG, Genter MB, Talaska G, Curran CP, Nebert DW, Dalton TP.

Carcinogenesis. 2007 Jun;28(6):1371-8. Epub 2006 Dec 13.

PMID:
17166882
17.

The role of cytochrome P450 enzymes in endogenous signalling pathways and environmental carcinogenesis.

Nebert DW, Dalton TP.

Nat Rev Cancer. 2006 Dec;6(12):947-60. Review.

PMID:
17128211
18.

Novel n-3 fatty acid oxidation products activate Nrf2 by destabilizing the association between Keap1 and Cullin3.

Gao L, Wang J, Sekhar KR, Yin H, Yared NF, Schneider SN, Sasi S, Dalton TP, Anderson ME, Chan JY, Morrow JD, Freeman ML.

J Biol Chem. 2007 Jan 26;282(4):2529-37. Epub 2006 Nov 25.

19.

TCDD decreases ATP levels and increases reactive oxygen production through changes in mitochondrial F(0)F(1)-ATP synthase and ubiquinone.

Shertzer HG, Genter MB, Shen D, Nebert DW, Chen Y, Dalton TP.

Toxicol Appl Pharmacol. 2006 Dec 15;217(3):363-74. Epub 2006 Oct 4.

20.

Enhanced cadmium-induced testicular necrosis and renal proximal tubule damage caused by gene-dose increase in a Slc39a8-transgenic mouse line.

Wang B, Schneider SN, Dragin N, Girijashanker K, Dalton TP, He L, Miller ML, Stringer KF, Soleimani M, Richardson DD, Nebert DW.

Am J Physiol Cell Physiol. 2007 Apr;292(4):C1523-35. Epub 2006 Nov 15.

21.

Naphthalene toxicity in mice and aryl hydrocarbon receptor-mediated CYPs.

Genter MB, Marlowe J, Kevin Kerzee J, Dragin N, Puga A, Dalton TP, Nebert DW.

Biochem Biophys Res Commun. 2006 Sep 15;348(1):120-3. Epub 2006 Jul 14.

PMID:
16876762
22.

ZIP8, member of the solute-carrier-39 (SLC39) metal-transporter family: characterization of transporter properties.

He L, Girijashanker K, Dalton TP, Reed J, Li H, Soleimani M, Nebert DW.

Mol Pharmacol. 2006 Jul;70(1):171-80. Epub 2006 Apr 25.

23.

For dioxin-induced birth defects, mouse or human CYP1A2 in maternal liver protects whereas mouse CYP1A1 and CYP1B1 are inconsequential.

Dragin N, Dalton TP, Miller ML, Shertzer HG, Nebert DW.

J Biol Chem. 2006 Jul 7;281(27):18591-600. Epub 2006 Apr 24.

24.

Comparison of mouse hepatic mitochondrial versus microsomal cytochromes P450 following TCDD treatment.

Genter MB, Clay CD, Dalton TP, Dong H, Nebert DW, Shertzer HG.

Biochem Biophys Res Commun. 2006 Apr 21;342(4):1375-81. Epub 2006 Feb 28.

PMID:
16516144
25.

Oral benzo[a]pyrene in Cyp1 knockout mouse lines: CYP1A1 important in detoxication, CYP1B1 metabolism required for immune damage independent of total-body burden and clearance rate.

Uno S, Dalton TP, Dragin N, Curran CP, Derkenne S, Miller ML, Shertzer HG, Gonzalez FJ, Nebert DW.

Mol Pharmacol. 2006 Apr;69(4):1103-14. Epub 2005 Dec 23.

26.

Genetic differences in lethality of newborn mice treated in utero with coplanar versus non-coplanar hexabromobiphenyl.

Curran CP, Miller KA, Dalton TP, Vorhees CV, Miller ML, Shertzer HG, Nebert DW.

Toxicol Sci. 2006 Feb;89(2):454-64. Epub 2005 Nov 16.

PMID:
16291824
27.

The metal-responsive transcription factor-1 contributes to HIF-1 activation during hypoxic stress.

Murphy BJ, Sato BG, Dalton TP, Laderoute KR.

Biochem Biophys Res Commun. 2005 Nov 25;337(3):860-7. Epub 2005 Sep 29.

PMID:
16216223
28.

Differential metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in mice humanized for CYP1A1 and CYP1A2.

Cheung C, Ma X, Krausz KW, Kimura S, Feigenbaum L, Dalton TP, Nebert DW, Idle JR, Gonzalez FJ.

Chem Res Toxicol. 2005 Sep;18(9):1471-8.

PMID:
16167840
29.

The role of metallothionein in the pathogenesis of acute lung injury.

Wesselkamper SC, McDowell SA, Medvedovic M, Dalton TP, Deshmukh HS, Sartor MA, Case LM, Henning LN, Borchers MT, Tomlinson CR, Prows DR, Leikauf GD.

Am J Respir Cell Mol Biol. 2006 Jan;34(1):73-82. Epub 2005 Sep 15.

30.

Glutamate cysteine ligase catalysis: dependence on ATP and modifier subunit for regulation of tissue glutathione levels.

Chen Y, Shertzer HG, Schneider SN, Nebert DW, Dalton TP.

J Biol Chem. 2005 Oct 7;280(40):33766-74. Epub 2005 Aug 4.

31.

Butylhydroquinone protects cells genetically deficient in glutathione biosynthesis from arsenite-induced apoptosis without significantly changing their prooxidant status.

Kann S, Estes C, Reichard JF, Huang MY, Sartor MA, Schwemberger S, Chen Y, Dalton TP, Shertzer HG, Xia Y, Puga A.

Toxicol Sci. 2005 Oct;87(2):365-84. Epub 2005 Jul 13.

PMID:
16014739
32.
33.

Glutathione redox state regulates mitochondrial reactive oxygen production.

Shen D, Dalton TP, Nebert DW, Shertzer HG.

J Biol Chem. 2005 Jul 8;280(27):25305-12. Epub 2005 May 9.

34.

Uroporphyria and hepatic carcinogenesis induced by polychlorinated biphenyls-iron interaction: absence in the Cyp1a2(-/-) knockout mouse.

Greaves P, Clothier B, Davies R, Higginson FM, Edwards RE, Dalton TP, Nebert DW, Smith AG.

Biochem Biophys Res Commun. 2005 May 27;331(1):147-52.

PMID:
15845371
35.

Identification of mouse SLC39A8 as the transporter responsible for cadmium-induced toxicity in the testis.

Dalton TP, He L, Wang B, Miller ML, Jin L, Stringer KF, Chang X, Baxter CS, Nebert DW.

Proc Natl Acad Sci U S A. 2005 Mar 1;102(9):3401-6. Epub 2005 Feb 18.

36.

Toward the evaluation of function in genetic variability: characterizing human SNP frequencies and establishing BAC-transgenic mice carrying the human CYP1A1_CYP1A2 locus.

Jiang Z, Dalton TP, Jin L, Wang B, Tsuneoka Y, Shertzer HG, Deka R, Nebert DW.

Hum Mutat. 2005 Feb;25(2):196-206.

PMID:
15643613
37.

Genetically altered mice to evaluate glutathione homeostasis in health and disease.

Dalton TP, Chen Y, Schneider SN, Nebert DW, Shertzer HG.

Free Radic Biol Med. 2004 Nov 15;37(10):1511-26. Review.

PMID:
15477003
38.

Oral exposure to benzo[a]pyrene in the mouse: detoxication by inducible cytochrome P450 is more important than metabolic activation.

Uno S, Dalton TP, Derkenne S, Curran CP, Miller ML, Shertzer HG, Nebert DW.

Mol Pharmacol. 2004 May;65(5):1225-37.

39.

Cyp1a1(-/-) male mice: protection against high-dose TCDD-induced lethality and wasting syndrome, and resistance to intrahepatocyte lipid accumulation and uroporphyria.

Uno S, Dalton TP, Sinclair PR, Gorman N, Wang B, Smith AG, Miller ML, Shertzer HG, Nebert DW.

Toxicol Appl Pharmacol. 2004 May 1;196(3):410-21.

PMID:
15094312
40.

Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer.

Nebert DW, Dalton TP, Okey AB, Gonzalez FJ.

J Biol Chem. 2004 Jun 4;279(23):23847-50. Epub 2004 Mar 17. Review.

41.

Uncoupling-mediated generation of reactive oxygen by halogenated aromatic hydrocarbons in mouse liver microsomes.

Shertzer HG, Clay CD, Genter MB, Chames MC, Schneider SN, Oakley GG, Nebert DW, Dalton TP.

Free Radic Biol Med. 2004 Mar 1;36(5):618-31.

PMID:
14980705
42.

Cyp1a2 protects against reactive oxygen production in mouse liver microsomes.

Shertzer HG, Clay CD, Genter MB, Schneider SN, Nebert DW, Dalton TP.

Free Radic Biol Med. 2004 Mar 1;36(5):605-17.

PMID:
14980704
43.

Balancer-Cre transgenic mouse germ cells direct the incomplete resolution of a tri-loxP-targeted Cyp1a1 allele, producing a conditional knockout allele.

Uno S, Wang B, Shertzer HG, Nebert DW, Dalton TP.

Biochem Biophys Res Commun. 2003 Dec 12;312(2):494-9.

PMID:
14637164
44.

Antioxidant perturbations in the olfactory mucosa of alachlor-treated rats.

Burman DM, Shertzer HG, Senft AP, Dalton TP, Genter MB.

Biochem Pharmacol. 2003 Nov 1;66(9):1707-15.

PMID:
14563481
45.

4-aminobiphenyl-induced liver and urinary bladder DNA adduct formation in Cyp1a2(-/-) and Cyp1a2(+/+) mice.

Tsuneoka Y, Dalton TP, Miller ML, Clay CD, Shertzer HG, Talaska G, Medvedovic M, Nebert DW.

J Natl Cancer Inst. 2003 Aug 20;95(16):1227-37.

PMID:
12928348
46.

Pharmacological rescue of the 14CoS/14CoS mouse: hepatocyte apoptosis is likely caused by endogenous oxidative stress.

Dieter MZ, Freshwater SL, Miller ML, Shertzer HG, Dalton TP, Nebert DW.

Free Radic Biol Med. 2003 Aug 15;35(4):351-67.

PMID:
12899938
47.

Intrinsic hepatic phenotype associated with the Cyp1a2 gene as shown by cDNA expression microarray analysis of the knockout mouse.

Smith AG, Davies R, Dalton TP, Miller ML, Judah D, Riley J, Gant T, Nebert DW.

EHP Toxicogenomics. 2003 Jan;111(1T):45-51.

PMID:
12735109
48.

Preservation of the negative image of tooth enamel with dental impression material enhances morphometric measurements of gingival overgrowth.

Miller ML, Andringa A, Turner LT, Dalton TP, Derkenne S, Nebert DW.

Microsc Res Tech. 2003 Apr 1;60(5):528-36.

PMID:
12619128
49.

Uroporphyrin accumulation in hepatoma cells expressing human or mouse CYP1A2: relation to the role of CYP1A2 in human porphyria cutanea tarda.

Nichols RC, Cooper S, Trask HW, Gorman N, Dalton TP, Nebert DW, Sinclair JF, Sinclair PR.

Biochem Pharmacol. 2003 Feb 15;65(4):545-50.

PMID:
12566081
50.

Rodent toxicity and nongenotoxic carcinogenesis: knowledge-based human risk assessment based on molecular mechanisms.

Roberts RA, Goodman JI, Shertzer HG, Dalton TP, Farland WH.

Toxicol Mech Methods. 2003;13(1):21-9. doi: 10.1080/15376510309823.

PMID:
20021179

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