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Surface molecules of extracellular vesicles secreted by the helminth pathogen Fasciola hepatica direct their internalisation by host cells.

de la Torre-Escudero E, Gerlach JQ, Bennett APS, Cwiklinski K, Jewhurst HL, Huson KM, Joshi L, Kilcoyne M, O'Neill S, Dalton JP, Robinson MW.

PLoS Negl Trop Dis. 2019 Jan 18;13(1):e0007087. doi: 10.1371/journal.pntd.0007087. eCollection 2019 Jan.


A secreted schistosome cathepsin B1 cysteine protease and acute schistosome infection induce a transient T helper 17 response.

Soloviova K, Fox EC, Dalton JP, Caffrey CR, Davies SJ.

PLoS Negl Trop Dis. 2019 Jan 17;13(1):e0007070. doi: 10.1371/journal.pntd.0007070. eCollection 2019 Jan.


Steered molecular dynamics simulations reveal critical residues for (un)binding of substrates, inhibitors and a product to the malarial M1 aminopeptidase.

Moore DS, Brines C, Jewhurst H, Dalton JP, Tikhonova IG.

PLoS Comput Biol. 2018 Oct 31;14(10):e1006525. doi: 10.1371/journal.pcbi.1006525. eCollection 2018 Oct.


Cysteine proteases during larval migration and development of helminths in their final host.

Grote A, Caffrey CR, Rebello KM, Smith D, Dalton JP, Lustigman S.

PLoS Negl Trop Dis. 2018 Aug 23;12(8):e0005919. doi: 10.1371/journal.pntd.0005919. eCollection 2018 Aug. Review.


Cysteine proteases as digestive enzymes in parasitic helminths.

Caffrey CR, Goupil L, Rebello KM, Dalton JP, Smith D.

PLoS Negl Trop Dis. 2018 Aug 23;12(8):e0005840. doi: 10.1371/journal.pntd.0005840. eCollection 2018 Aug. Review.


Low allelic diversity in vaccine candidates genes from different locations sustain hope for Fasciola hepatica immunization.

Dominguez MF, González-Miguel J, Carmona C, Dalton JP, Cwiklinski K, Tort J, Siles-Lucas M.

Vet Parasitol. 2018 Jul 15;258:46-52. doi: 10.1016/j.vetpar.2018.06.011. Epub 2018 Jun 11.


Immune Mechanisms Involved in Schistosoma mansoni-Cathepsin B Vaccine Induced Protection in Mice.

Ricciardi A, Zelt NH, Visitsunthorn K, Dalton JP, Ndao M.

Front Immunol. 2018 Jul 25;9:1710. doi: 10.3389/fimmu.2018.01710. eCollection 2018.


In silico analyses of protein glycosylating genes in the helminth Fasciola hepatica (liver fluke) predict protein-linked glycan simplicity and reveal temporally-dynamic expression profiles.

McVeigh P, Cwiklinski K, Garcia-Campos A, Mulcahy G, O'Neill SM, Maule AG, Dalton JP.

Sci Rep. 2018 Aug 3;8(1):11700. doi: 10.1038/s41598-018-29673-3.


The parasitic 68-mer peptide FhHDM-1 inhibits mixed granulocytic inflammation and airway hyperreactivity in experimental asthma.

Tanaka A, Allam VSRR, Simpson J, Tiberti N, Shiels J, To J, Lund M, Combes V, Weldon S, Taggart C, Dalton JP, Phipps S, Sukkar MB, Donnelly S.

J Allergy Clin Immunol. 2018 Jun;141(6):2316-2319. doi: 10.1016/j.jaci.2018.01.050. Epub 2018 Mar 6. No abstract available.


Advances in Fasciola hepatica research using 'omics' technologies.

Cwiklinski K, Dalton JP.

Int J Parasitol. 2018 Apr;48(5):321-331. doi: 10.1016/j.ijpara.2017.12.001. Epub 2018 Feb 21. Review.


Antibody recognition of cathepsin L1-derived peptides in Fasciola hepatica-infected and/or vaccinated cattle and identification of protective linear B-cell epitopes.

Garza-Cuartero L, Geurden T, Mahan SM, Hardham JM, Dalton JP, Mulcahy G.

Vaccine. 2018 Feb 8;36(7):958-968. doi: 10.1016/j.vaccine.2018.01.020. Epub 2018 Jan 17.


Infection by the Helminth Parasite Fasciola hepatica Requires Rapid Regulation of Metabolic, Virulence, and Invasive Factors to Adjust to Its Mammalian Host.

Cwiklinski K, Jewhurst H, McVeigh P, Barbour T, Maule AG, Tort J, O'Neill SM, Robinson MW, Donnelly S, Dalton JP.

Mol Cell Proteomics. 2018 Apr;17(4):792-809. doi: 10.1074/mcp.RA117.000445. Epub 2018 Jan 10.


Protection against Schistosoma haematobium infection in hamsters by immunization with Schistosoma mansoni gut-derived cysteine peptidases, SmCB1 and SmCL3.

Tallima H, Abou El Dahab M, Kareem S, Dalton JP, El Ridi R.

Vaccine. 2017 Dec 15;35(50):6977-6983. doi: 10.1016/j.vaccine.2017.10.069. Epub 2017 Nov 6.


Proteomic Analysis of Extracellular HMGB1 Identifies Binding Partners and Exposes Its Potential Role in Airway Epithelial Cell Homeostasis.

Wong SL, To J, Santos J, Allam VSRR, Dalton JP, Djordjevic SP, Donnelly S, Padula MP, Sukkar MB.

J Proteome Res. 2018 Jan 5;17(1):33-45. doi: 10.1021/acs.jproteome.7b00212. Epub 2017 Nov 14.


Do surgical helmet systems affect intraoperative wound contamination? A randomised controlled trial.

Shirley OC, Bayan A, Zhu M, Dalton JP, Wiles S, Young SW.

Arch Orthop Trauma Surg. 2017 Nov;137(11):1565-1569. doi: 10.1007/s00402-017-2795-7. Epub 2017 Sep 16.


Immune signatures of pathogenesis in the peritoneal compartment during early infection of sheep with Fasciola hepatica.

Ruiz-Campillo MT, Molina Hernandez V, Escamilla A, Stevenson M, Perez J, Martinez-Moreno A, Donnelly S, Dalton JP, Cwiklinski K.

Sci Rep. 2017 Jun 5;7(1):2782. doi: 10.1038/s41598-017-03094-0.


The development of sexual stage malaria gametocytes in a Wave Bioreactor.

Demanga CG, Eng JWL, Gardiner DL, Roth A, Butterworth A, Adams JH, Trenholme KR, Dalton JP.

Parasit Vectors. 2017 May 2;10(1):216. doi: 10.1186/s13071-017-2155-z.


A Novel Restraint Device for Injection of Galleria mellonella Larvae that Minimizes the Risk of Accidental Operator Needle Stick Injury.

Dalton JP, Uy B, Swift S, Wiles S.

Front Cell Infect Microbiol. 2017 Mar 28;7:99. doi: 10.3389/fcimb.2017.00099. eCollection 2017.


Protective immune responses against Schistosoma mansoni infection by immunization with functionally active gut-derived cysteine peptidases alone and in combination with glyceraldehyde 3-phosphate dehydrogenase.

Tallima H, Dvořák J, Kareem S, Abou El Dahab M, Abdel Aziz N, Dalton JP, El Ridi R.

PLoS Negl Trop Dis. 2017 Mar 27;11(3):e0005443. doi: 10.1371/journal.pntd.0005443. eCollection 2017 Mar.


Recombinant vacuolar iron transporter family homologue PfVIT from human malaria-causing Plasmodium falciparum is a Fe2+/H+exchanger.

Labarbuta P, Duckett K, Botting CH, Chahrour O, Malone J, Dalton JP, Law CJ.

Sci Rep. 2017 Feb 15;7:42850. doi: 10.1038/srep42850.


Effect of common and experimental anti-tuberculosis treatments on Mycobacterium tuberculosis growing as biofilms.

Dalton JP, Uy B, Phummarin N, Copp BR, Denny WA, Swift S, Wiles S.

PeerJ. 2016 Nov 22;4:e2717. eCollection 2016.


A parasite-derived 68-mer peptide ameliorates autoimmune disease in murine models of Type 1 diabetes and multiple sclerosis.

Lund ME, Greer J, Dixit A, Alvarado R, McCauley-Winter P, To J, Tanaka A, Hutchinson AT, Robinson MW, Simpson AM, O'Brien BA, Dalton JP, Donnelly S.

Sci Rep. 2016 Nov 24;6:37789. doi: 10.1038/srep37789.


Screening of anti-mycobacterial compounds in a naturally infected zebrafish larvae model.

Dalton JP, Uy B, Okuda KS, Hall CJ, Denny WA, Crosier PS, Swift S, Wiles S.

J Antimicrob Chemother. 2017 Feb;72(2):421-427. doi: 10.1093/jac/dkw421. Epub 2016 Oct 24.


The immune modulatory peptide FhHDM-1 secreted by the helminth Fasciola hepatica prevents NLRP3 inflammasome activation by inhibiting endolysosomal acidification in macrophages.

Alvarado R, To J, Lund ME, Pinar A, Mansell A, Robinson MW, O'Brien BA, Dalton JP, Donnelly S.

FASEB J. 2017 Jan;31(1):85-95. doi: 10.1096/fj.201500093R. Epub 2016 Sep 28.


Fasciola hepatica Surface Tegument: Glycoproteins at the Interface of Parasite and Host.

Ravidà A, Cwiklinski K, Aldridge AM, Clarke P, Thompson R, Gerlach JQ, Kilcoyne M, Hokke CH, Dalton JP, O'Neill SM.

Mol Cell Proteomics. 2016 Oct;15(10):3139-3153. Epub 2016 Jul 27.


Unexpected Activity of a Novel Kunitz-type Inhibitor: INHIBITION OF CYSTEINE PROTEASES BUT NOT SERINE PROTEASES.

Smith D, Tikhonova IG, Jewhurst HL, Drysdale OC, Dvořák J, Robinson MW, Cwiklinski K, Dalton JP.

J Biol Chem. 2016 Sep 9;291(37):19220-34. doi: 10.1074/jbc.M116.724344. Epub 2016 Jul 15.


A Plasmodium falciparum S33 proline aminopeptidase is associated with changes in erythrocyte deformability.

da Silva FL, Dixon MW, Stack CM, Teuscher F, Taran E, Jones MK, Lovas E, Tilley L, Brown CL, Trenholme KR, Dalton JP, Gardiner DL, Skinner-Adams TS.

Exp Parasitol. 2016 Oct;169:13-21. doi: 10.1016/j.exppara.2016.06.013. Epub 2016 Jun 30.


A prospective view of animal and human Fasciolosis.

Cwiklinski K, O'Neill SM, Donnelly S, Dalton JP.

Parasite Immunol. 2016 Sep;38(9):558-68. doi: 10.1111/pim.12343. Epub 2016 Jul 8. Review.


Tegument Glycoproteins and Cathepsins of Newly Excysted Juvenile Fasciola hepatica Carry Mannosidic and Paucimannosidic N-glycans.

Garcia-Campos A, Ravidà A, Nguyen DL, Cwiklinski K, Dalton JP, Hokke CH, O'Neill S, Mulcahy G.

PLoS Negl Trop Dis. 2016 May 3;10(5):e0004688. doi: 10.1371/journal.pntd.0004688. eCollection 2016 May.


A vaccine consisting of Schistosoma mansoni cathepsin B formulated in Montanide ISA 720 VG induces high level protection against murine schistosomiasis.

Ricciardi A, Visitsunthorn K, Dalton JP, Ndao M.

BMC Infect Dis. 2016 Mar 5;16:112. doi: 10.1186/s12879-016-1444-z.


Biologically Active Acetylenic Amino Alcohol and N-Hydroxylated 1,2,3,4-Tetrahydro-β-carboline Constituents of the New Zealand Ascidian Pseudodistoma opacum.

Wang J, Pearce AN, Chan ST, Taylor RB, Page MJ, Valentin A, Bourguet-Kondracki ML, Dalton JP, Wiles S, Copp BR.

J Nat Prod. 2016 Mar 25;79(3):607-10. doi: 10.1021/acs.jnatprod.5b00770. Epub 2015 Dec 15.


The Extracellular Vesicles of the Helminth Pathogen, Fasciola hepatica: Biogenesis Pathways and Cargo Molecules Involved in Parasite Pathogenesis.

Cwiklinski K, de la Torre-Escudero E, Trelis M, Bernal D, Dufresne PJ, Brennan GP, O'Neill S, Tort J, Paterson S, Marcilla A, Dalton JP, Robinson MW.

Mol Cell Proteomics. 2015 Dec;14(12):3258-73. doi: 10.1074/mcp.M115.053934. Epub 2015 Oct 20.


Regional Intraosseous Administration of Prophylactic Antibiotics is More Effective Than Systemic Administration in a Mouse Model of TKA.

Young SW, Roberts T, Johnson S, Dalton JP, Coleman B, Wiles S.

Clin Orthop Relat Res. 2015 Nov;473(11):3573-84. doi: 10.1007/s11999-015-4464-x. Epub 2015 Jul 30.


The Fasciola hepatica genome: gene duplication and polymorphism reveals adaptation to the host environment and the capacity for rapid evolution.

Cwiklinski K, Dalton JP, Dufresne PJ, La Course J, Williams DJ, Hodgkinson J, Paterson S.

Genome Biol. 2015 Apr 3;16:71. doi: 10.1186/s13059-015-0632-2.


Induction of Protective Immune Responses Against Schistosomiasis haematobium in Hamsters and Mice Using Cysteine Peptidase-Based Vaccine.

Tallima H, Dalton JP, El Ridi R.

Front Immunol. 2015 Mar 23;6:130. doi: 10.3389/fimmu.2015.00130. eCollection 2015.


Fasciola hepatica vaccine: we may not be there yet but we're on the right road.

Molina-Hernández V, Mulcahy G, Pérez J, Martínez-Moreno Á, Donnelly S, O'Neill SM, Dalton JP, Cwiklinski K.

Vet Parasitol. 2015 Feb 28;208(1-2):101-11. doi: 10.1016/j.vetpar.2015.01.004. Epub 2015 Jan 15.


Inhibitors of the Plasmodium falciparum M17 Leucine Aminopeptidase.

Schoenen FJ, Whipple D, Baillargeon P, Brown CL, Chase P, Ferguson J, Fernandez-Vega V, Hodder P, Mathew R, Neuenswander B, Porubsky P, Rogers S, Skinner-Adams T, Sosa M, Spicer T, To J, Tower NA, Trenholme KR, Wang J, Weiner WS, Aubé J, Rosen H, White EL, Gardiner DL, Dalton JP.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2013 Dec 12 [updated 2014 Sep 18].


Activating the cathepsin B1 of a parasite: a major route with alternative pathways?

Dalton JP, Dvorak J.

Structure. 2014 Dec 2;22(12):1696-1698. doi: 10.1016/j.str.2014.11.003.


A parasitic helminth-derived peptide that targets the macrophage lysosome is a novel therapeutic option for autoimmune disease.

Alvarado R, O'Brien B, Tanaka A, Dalton JP, Donnelly S.

Immunobiology. 2015 Feb;220(2):262-9. doi: 10.1016/j.imbio.2014.11.008. Epub 2014 Nov 18. Review.


Evaluation of the immune response and protective efficacy of Schistosoma mansoni Cathepsin B in mice using CpG dinucleotides as adjuvant.

Ricciardi A, Dalton JP, Ndao M.

Vaccine. 2015 Jan 3;33(2):346-53. doi: 10.1016/j.vaccine.2014.11.016. Epub 2014 Nov 21.


RNAi dynamics in Juvenile Fasciola spp. Liver flukes reveals the persistence of gene silencing in vitro.

McVeigh P, McCammick EM, McCusker P, Morphew RM, Mousley A, Abidi A, Saifullah KM, Muthusamy R, Gopalakrishnan R, Spithill TW, Dalton JP, Brophy PM, Marks NJ, Maule AG.

PLoS Negl Trop Dis. 2014 Sep 25;8(9):e3185. doi: 10.1371/journal.pntd.0003185. eCollection 2014 Sep.


Inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase.

Schoenen FJ, Weiner WS, Baillargeon P, Brown CL, Chase P, Ferguson J, Fernandez-Vega V, Ghosh P, Hodder P, Krise JP, Matharu DS, Neuenswander B, Porubsky P, Rogers S, Skinner-Adams T, Sosa M, Spicer T, To J, Tower NA, Trenholme KR, Wang J, Whipple D, Aubé J, Rosen H, White EL, Dalton JP, Gardiner DL.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2013 Apr 12 [updated 2014 Sep 18].


Induction of protective immune responses against schistosomiasis using functionally active cysteine peptidases.

El Ridi R, Tallima H, Dalton JP, Donnelly S.

Front Genet. 2014 May 8;5:119. doi: 10.3389/fgene.2014.00119. eCollection 2014. Review.


Identification of Potent and Selective Inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (PfM18AAP) of Human Malaria via High-Throughput Screening.

Spicer T, Fernandez-Vega V, Chase P, Scampavia L, To J, Dalton JP, Da Silva FL, Skinner-Adams TS, Gardiner DL, Trenholme KR, Brown CL, Ghosh P, Porubsky P, Wang JL, Whipple DA, Schoenen FJ, Hodder P.

J Biomol Screen. 2014 Aug;19(7):1107-15. doi: 10.1177/1087057114525852. Epub 2014 Mar 11.


Detection of Mycobacterium avium subspecies paratuberculosis in patients with Crohn's disease is unrelated to the presence of single nucleotide polymorphisms rs2241880 (ATG16L1) and rs10045431 (IL12B).

Dalton JP, Desmond A, Shanahan F, Hill C.

Med Microbiol Immunol. 2014 Jun;203(3):195-205. doi: 10.1007/s00430-014-0332-7. Epub 2014 Feb 13.


Secreted proteins from the helminth Fasciola hepatica inhibit the initiation of autoreactive T cell responses and prevent diabetes in the NOD mouse.

Lund ME, O'Brien BA, Hutchinson AT, Robinson MW, Simpson AM, Dalton JP, Donnelly S.

PLoS One. 2014 Jan 21;9(1):e86289. doi: 10.1371/journal.pone.0086289. eCollection 2014.


Cysteine peptidases as schistosomiasis vaccines with inbuilt adjuvanticity.

El Ridi R, Tallima H, Selim S, Donnelly S, Cotton S, Gonzales Santana B, Dalton JP.

PLoS One. 2014 Jan 21;9(1):e85401. doi: 10.1371/journal.pone.0085401. eCollection 2014.


Helminth defence molecules-immunomodulators designed by parasites!

Robinson MW, Donnelly S, Dalton JP.

Front Microbiol. 2013 Oct 1;4:296. doi: 10.3389/fmicb.2013.00296. eCollection 2013. No abstract available.


The diagnosis of human fascioliasis by enzyme-linked immunosorbent assay (ELISA) using recombinant cathepsin L protease.

Gonzales Santana B, Dalton JP, Vasquez Camargo F, Parkinson M, Ndao M.

PLoS Negl Trop Dis. 2013 Sep 19;7(9):e2414. doi: 10.1371/journal.pntd.0002414. eCollection 2013.


Cathelicidin-like helminth defence molecules (HDMs): absence of cytotoxic, anti-microbial and anti-protozoan activities imply a specific adaptation to immune modulation.

Thivierge K, Cotton S, Schaefer DA, Riggs MW, To J, Lund ME, Robinson MW, Dalton JP, Donnelly SM.

PLoS Negl Trop Dis. 2013 Jul 11;7(7):e2307. doi: 10.1371/journal.pntd.0002307. Print 2013.

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