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2'-O-methylation within prokaryotic and eukaryotic tRNA inhibits innate immune activation by endosomal Toll-like receptors but does not affect recognition of whole organisms.

Freund I, Buhl DK, Boutin S, Kotter A, Pichot F, Marchand V, Vierbuchen T, Heine H, Motorin Y, Helm M, Dalpke AH, Eigenbrod T.

RNA. 2019 Jul;25(7):869-880. doi: 10.1261/rna.070243.118. Epub 2019 Apr 24.


Crucial Role of Nucleic Acid Sensing via Endosomal Toll-Like Receptors for the Defense of Streptococcus pyogenes in vitro and in vivo.

Hafner A, Kolbe U, Freund I, Castiglia V, Kovarik P, Poth T, Herster F, Weigand MA, Weber ANR, Dalpke AH, Eigenbrod T.

Front Immunol. 2019 Feb 21;10:198. doi: 10.3389/fimmu.2019.00198. eCollection 2019.


Gut microbiome patterns correlate with higher postoperative complication rates after pancreatic surgery.

Schmitt FCF, Brenner T, Uhle F, Loesch S, Hackert T, Ulrich A, Hofer S, Dalpke AH, Weigand MA, Boutin S.

BMC Microbiol. 2019 Feb 18;19(1):42. doi: 10.1186/s12866-019-1399-5.


RNA Modifications Modulate Activation of Innate Toll-Like Receptors.

Freund I, Eigenbrod T, Helm M, Dalpke AH.

Genes (Basel). 2019 Jan 29;10(2). pii: E92. doi: 10.3390/genes10020092. Review.


Secretion of Hepatitis C Virus Replication Intermediates Reduces Activation of Toll-Like Receptor 3 in Hepatocytes.

Grünvogel O, Colasanti O, Lee JY, Klöss V, Belouzard S, Reustle A, Esser-Nobis K, Hesebeck-Brinckmann J, Mutz P, Hoffmann K, Mehrabi A, Koschny R, Vondran FWR, Gotthardt D, Schnitzler P, Neumann-Haefelin C, Thimme R, Binder M, Bartenschlager R, Dubuisson J, Dalpke AH, Lohmann V.

Gastroenterology. 2018 Jun;154(8):2237-2251.e16. doi: 10.1053/j.gastro.2018.03.020. Epub 2018 Mar 11.


Comparison of Oropharyngeal Microbiota from Children with Asthma and Cystic Fibrosis.

Boutin S, Depner M, Stahl M, Graeber SY, Dittrich SA, Legatzki A, von Mutius E, Mall M, Dalpke AH.

Mediators Inflamm. 2017;2017:5047403. doi: 10.1155/2017/5047403. Epub 2017 Dec 27.


One time quantitative PCR detection of Pseudomonas aeruginosa to discriminate intermittent from chronic infection in cystic fibrosis.

Boutin S, Weitnauer M, Hassel S, Graeber SY, Stahl M, Dittrich AS, Mall MA, Dalpke AH.

J Cyst Fibros. 2018 May;17(3):348-355. doi: 10.1016/j.jcf.2017.12.007. Epub 2018 Jan 12.


Interaction and Mutual Activation of Different Innate Immune Cells Is Necessary to Kill and Clear Hepatitis C Virus-Infected Cells.

Klöss V, Grünvogel O, Wabnitz G, Eigenbrod T, Ehrhardt S, Lasitschka F, Lohmann V, Dalpke AH.

Front Immunol. 2017 Sep 29;8:1238. doi: 10.3389/fimmu.2017.01238. eCollection 2017.


Chronic but not intermittent infection with Pseudomonas aeruginosa is associated with global changes of the lung microbiome in cystic fibrosis.

Boutin S, Graeber SY, Stahl M, Dittrich AS, Mall MA, Dalpke AH.

Eur Respir J. 2017 Oct 5;50(4). pii: 1701086. doi: 10.1183/13993003.01086-2017. Print 2017 Oct. No abstract available.


Identification of an optimized 2'-O-methylated trinucleotide RNA motif inhibiting Toll-like receptors 7 and 8.

Schmitt FCF, Freund I, Weigand MA, Helm M, Dalpke AH, Eigenbrod T.

RNA. 2017 Sep;23(9):1344-1351. doi: 10.1261/rna.061952.117. Epub 2017 Jun 2.


Bioconjugation of Small Molecules to RNA Impedes Its Recognition by Toll-Like Receptor 7.

Hellmuth I, Freund I, Schlöder J, Seidu-Larry S, Thüring K, Slama K, Langhanki J, Kaloyanova S, Eigenbrod T, Krumb M, Röhm S, Peneva K, Opatz T, Jonuleit H, Dalpke AH, Helm M.

Front Immunol. 2017 Mar 24;8:312. doi: 10.3389/fimmu.2017.00312. eCollection 2017.


Higher prevalence of colonization with Gardnerella vaginalis and gram-negative anaerobes in patients with recurrent miscarriage and elevated peripheral natural killer cells.

Kuon RJ, Togawa R, Vomstein K, Weber M, Goeggl T, Strowitzki T, Markert UR, Zimmermann S, Daniel V, Dalpke AH, Toth B.

J Reprod Immunol. 2017 Apr;120:15-19. doi: 10.1016/j.jri.2017.03.001. Epub 2017 Mar 30.


Clustering of Subgingival Microbiota Reveals Microbial Disease Ecotypes Associated with Clinical Stages of Periodontitis in a Cross-Sectional Study.

Boutin S, Hagenfeld D, Zimmermann H, El Sayed N, Höpker T, Greiser HK, Becher H, Kim TS, Dalpke AH.

Front Microbiol. 2017 Mar 1;8:340. doi: 10.3389/fmicb.2017.00340. eCollection 2017.


Crosstalk between glucocorticoids and IL-4 modulates Ym1 expression in alternatively activated myeloid cells.

Ng Kuet Leong N, Brombacher F, Dalpke AH, Weitnauer M.

Immunobiology. 2017 May;222(5):759-767. doi: 10.1016/j.imbio.2017.02.003. Epub 2017 Feb 9.


Acquisition and adaptation of the airway microbiota in the early life of cystic fibrosis patients.

Boutin S, Dalpke AH.

Mol Cell Pediatr. 2017 Dec;4(1):1. doi: 10.1186/s40348-016-0067-1. Epub 2017 Jan 17. Review.


Endoplasmic Reticulum Stress Is a Danger Signal Promoting Innate Inflammatory Responses in Bronchial Epithelial Cells.

Mijošek V, Lasitschka F, Warth A, Zabeck H, Dalpke AH, Weitnauer M.

J Innate Immun. 2016;8(5):464-78. doi: 10.1159/000447668. Epub 2016 Jul 16.


Development of a Real-Time PCR Protocol Requiring Minimal Handling for Detection of Vancomycin-Resistant Enterococci with the Fully Automated BD Max System.

Dalpke AH, Hofko M, Zimmermann S.

J Clin Microbiol. 2016 Sep;54(9):2321-9. doi: 10.1128/JCM.00768-16. Epub 2016 Jun 29.


Control of local immunity by airway epithelial cells.

Weitnauer M, Mijošek V, Dalpke AH.

Mucosal Immunol. 2016 Mar;9(2):287-98. doi: 10.1038/mi.2015.126. Epub 2015 Dec 2. Review.


Inhibition of Histone Deacetylases Permits Lipopolysaccharide-Mediated Secretion of Bioactive IL-1β via a Caspase-1-Independent Mechanism.

Stammler D, Eigenbrod T, Menz S, Frick JS, Sweet MJ, Shakespear MR, Jantsch J, Siegert I, Wölfle S, Langer JD, Oehme I, Schaefer L, Fischer A, Knievel J, Heeg K, Dalpke AH, Bode KA.

J Immunol. 2015 Dec 1;195(11):5421-31. doi: 10.4049/jimmunol.1501195. Epub 2015 Oct 30.


Evaluation of the BD Max StaphSR Assay for Rapid Identification of Staphylococcus aureus and Methicillin-Resistant S. aureus in Positive Blood Culture Broths.

Dalpke AH, Hofko M, Hamilton F, Mackenzie L, Zimmermann S, Templeton K.

J Clin Microbiol. 2015 Nov;53(11):3630-2. doi: 10.1128/JCM.01922-15. Epub 2015 Aug 19.


Recognition of Specified RNA Modifications by the Innate Immune System.

Eigenbrod T, Keller P, Kaiser S, Rimbach K, Dalpke AH, Helm M.

Methods Enzymol. 2015;560:73-89. doi: 10.1016/bs.mie.2015.03.006. Epub 2015 Jul 22.


Cell-contact dependent inhibition of monocytes by airway epithelial cells and reversion by infection with Respiratory Syncytial Virus.

Oumouna M, Weitnauer M, Mijošek V, Schmidt LM, Eigenbrod T, Dalpke AH.

Immunobiology. 2015 Nov;220(11):1240-5. doi: 10.1016/j.imbio.2015.06.017. Epub 2015 Jun 27.


Bacterial RNA: An Underestimated Stimulus for Innate Immune Responses.

Eigenbrod T, Dalpke AH.

J Immunol. 2015 Jul 15;195(2):411-8. doi: 10.4049/jimmunol.1500530. Review.


TLR8 Senses Bacterial RNA in Human Monocytes and Plays a Nonredundant Role for Recognition of Streptococcus pyogenes.

Eigenbrod T, Pelka K, Latz E, Kreikemeyer B, Dalpke AH.

J Immunol. 2015 Aug 1;195(3):1092-9. doi: 10.4049/jimmunol.1403173. Epub 2015 Jun 22.


2'-O-Methylation within Bacterial RNA Acts as Suppressor of TLR7/TLR8 Activation in Human Innate Immune Cells.

Rimbach K, Kaiser S, Helm M, Dalpke AH, Eigenbrod T.

J Innate Immun. 2015;7(5):482-93. doi: 10.1159/000375460. Epub 2015 Mar 20.


Increased nuclear suppressor of cytokine signaling 1 in asthmatic bronchial epithelium suppresses rhinovirus induction of innate interferons.

Gielen V, Sykes A, Zhu J, Chan B, Macintyre J, Regamey N, Kieninger E, Gupta A, Shoemark A, Bossley C, Davies J, Saglani S, Walker P, Nicholson SE, Dalpke AH, Kon OM, Bush A, Johnston SL, Edwards MR.

J Allergy Clin Immunol. 2015 Jul;136(1):177-188.e11. doi: 10.1016/j.jaci.2014.11.039. Epub 2015 Jan 25.


Comparison of microbiomes from different niches of upper and lower airways in children and adolescents with cystic fibrosis.

Boutin S, Graeber SY, Weitnauer M, Panitz J, Stahl M, Clausznitzer D, Kaderali L, Einarsson G, Tunney MM, Elborn JS, Mall MA, Dalpke AH.

PLoS One. 2015 Jan 28;10(1):e0116029. doi: 10.1371/journal.pone.0116029. eCollection 2015.


Evaluation of the BD Max MRSA XT assay for use with different swab types.

Dalpke AH, Hofko M, Stock C, Zimmermann S.

J Clin Microbiol. 2014 Dec;52(12):4343-6. doi: 10.1128/JCM.02306-14. Epub 2014 Sep 17.


A modified dinucleotide motif specifies tRNA recognition by TLR7.

Kaiser S, Rimbach K, Eigenbrod T, Dalpke AH, Helm M.

RNA. 2014 Sep;20(9):1351-5. doi: 10.1261/rna.044024.113. Epub 2014 Jul 22.


Bronchial epithelial cells induce alternatively activated dendritic cells dependent on glucocorticoid receptor signaling.

Weitnauer M, Schmidt L, Ng Kuet Leong N, Muenchau S, Lasitschka F, Eckstein V, Hübner S, Tuckermann J, Dalpke AH.

J Immunol. 2014 Aug 1;193(3):1475-84. doi: 10.4049/jimmunol.1400446. Epub 2014 Jun 25.


Lack of neutrophil elastase reduces inflammation, mucus hypersecretion, and emphysema, but not mucus obstruction, in mice with cystic fibrosis-like lung disease.

Gehrig S, Duerr J, Weitnauer M, Wagner CJ, Graeber SY, Schatterny J, Hirtz S, Belaaouaj A, Dalpke AH, Schultz C, Mall MA.

Am J Respir Crit Care Med. 2014 May 1;189(9):1082-92. doi: 10.1164/rccm.201311-1932OC.


Detection of carbapenemases by real-time PCR and melt curve analysis on the BD Max system.

Hofko M, Mischnik A, Kaase M, Zimmermann S, Dalpke AH.

J Clin Microbiol. 2014 May;52(5):1701-4. doi: 10.1128/JCM.00373-14. Epub 2014 Feb 12.


Three years of experience with QuantiFERON-TB gold testing in patients with uveitis.

Jakob E, Max R, Zimmermann S, Dalpke AH, Alle W, Becker M, Mackensen F.

Ocul Immunol Inflamm. 2014 Dec;22(6):478-84. doi: 10.3109/09273948.2013.866255. Epub 2014 Jan 10.


TLR7 inhibition: A novel strategy for pancreatic cancer treatment?

Eigenbrod T, Dalpke AH.

JAKSTAT. 2013 Jan 1;2(1):e23011. doi: 10.4161/jkst.23011.


Development and evaluation of a real-time PCR assay for detection of Pneumocystis jirovecii on the fully automated BD MAX platform.

Dalpke AH, Hofko M, Zimmermann S.

J Clin Microbiol. 2013 Jul;51(7):2337-43. doi: 10.1128/JCM.00616-13. Epub 2013 May 15. Erratum in: J Clin Microbiol. 2014 May;52(5):1809.


Early inhibition of IL-1β expression by IFN-γ is mediated by impaired binding of NF-κB to the IL-1β promoter but is independent of nitric oxide.

Eigenbrod T, Bode KA, Dalpke AH.

J Immunol. 2013 Jun 15;190(12):6533-41. doi: 10.4049/jimmunol.1300324. Epub 2013 May 10.


Evaluation of the fully automated BD MAX Cdiff and Xpert C. difficile assays for direct detection of Clostridium difficile in stool specimens.

Dalpke AH, Hofko M, Zorn M, Zimmermann S.

J Clin Microbiol. 2013 Jun;51(6):1906-8. doi: 10.1128/JCM.00344-13. Epub 2013 Mar 20.


Early blood-based microbiological testing is ineffective in severe stroke patients.

Gumbinger C, Hug A, Mürle B, Berger B, Zorn M, Becker KP, Zimmermann S, Dalpke AH, Veltkamp R.

J Neurol Sci. 2013 Feb 15;325(1-2):46-50. doi: 10.1016/j.jns.2012.11.014. Epub 2012 Dec 28.


Cutting edge: TLR13 is a receptor for bacterial RNA.

Hidmark A, von Saint Paul A, Dalpke AH.

J Immunol. 2012 Sep 15;189(6):2717-21. doi: 10.4049/jimmunol.1200898. Epub 2012 Aug 15.


Dectin-1 stimulation induces suppressor of cytokine signaling 1, thereby modulating TLR signaling and T cell responses.

Eberle ME, Dalpke AH.

J Immunol. 2012 Jun 1;188(11):5644-54. doi: 10.4049/jimmunol.1103068. Epub 2012 Apr 30.


Identification of modifications in microbial, native tRNA that suppress immunostimulatory activity.

Gehrig S, Eberle ME, Botschen F, Rimbach K, Eberle F, Eigenbrod T, Kaiser S, Holmes WM, Erdmann VA, Sprinzl M, Bec G, Keith G, Dalpke AH, Helm M.

J Exp Med. 2012 Feb 13;209(2):225-33. doi: 10.1084/jem.20111044. Epub 2012 Feb 6.


Suppressor of cytokine signaling proteins as regulators of innate immune signaling.

Strebovsky J, Walker P, Dalpke AH.

Front Biosci (Landmark Ed). 2012 Jan 1;17:1627-39. Review.


Cell invasion and strain dependent induction of suppressor of cytokine signaling-1 by Toxoplasma gondii.

Stutz A, Kessler H, Kaschel ME, Meissner M, Dalpke AH.

Immunobiology. 2012 Jan;217(1):28-36. doi: 10.1016/j.imbio.2011.08.008. Epub 2011 Aug 27.


Inactivation of LPS and RNase A on photocatalytically active surfaces.

Kurz J, Eberle F, Graumann T, Kaschel ME, Sähr A, Neumann F, Dalpke AH, Erdinger L.

Chemosphere. 2011 Aug;84(9):1188-93. doi: 10.1016/j.chemosphere.2011.06.048. Epub 2011 Jul 16.


[Vaccination--new facts from basic research].

Dalpke AH.

MMW Fortschr Med. 2010 Jul 1;152 Suppl 2:42-6. Review. German. No abstract available.


Inhibition of lymphocyte trafficking shields the brain against deleterious neuroinflammation after stroke.

Liesz A, Zhou W, Mracskó É, Karcher S, Bauer H, Schwarting S, Sun L, Bruder D, Stegemann S, Cerwenka A, Sommer C, Dalpke AH, Veltkamp R.

Brain. 2011 Mar;134(Pt 3):704-20. doi: 10.1093/brain/awr008.


HDAC inhibitors block innate immunity.

Bode KA, Dalpke AH.

Blood. 2011 Jan 27;117(4):1102-3. doi: 10.1182/blood-2010-11-315820.


PD-L1 expression on tolerogenic APCs is controlled by STAT-3.

Wölfle SJ, Strebovsky J, Bartz H, Sähr A, Arnold C, Kaiser C, Dalpke AH, Heeg K.

Eur J Immunol. 2011 Feb;41(2):413-24. doi: 10.1002/eji.201040979. Epub 2011 Jan 11.


Bronchial epithelial cell-derived prostaglandin E2 dampens the reactivity of dendritic cells.

Schmidt LM, Belvisi MG, Bode KA, Bauer J, Schmidt C, Suchy MT, Tsikas D, Scheuerer J, Lasitschka F, Gröne HJ, Dalpke AH.

J Immunol. 2011 Feb 15;186(4):2095-105. doi: 10.4049/jimmunol.1002414. Epub 2011 Jan 12.

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