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Items: 48

1.

The novel hybrid agonist HyNDA-1 targets the D3R-nAChR heteromeric complex in dopaminergic neurons.

Matera C, Bono F, Pelucchi S, Collo G, Bontempi L, Gotti C, Zoli M, De Amici M, Missale C, Fiorentini C, Dallanoce C.

Biochem Pharmacol. 2019 Feb 14. pii: S0006-2952(19)30057-7. doi: 10.1016/j.bcp.2019.02.019. [Epub ahead of print]

PMID:
30772268
2.

Novel 5-(quinuclidin-3-ylmethyl)-1,2,4-oxadiazoles to investigate the activation of the α7 nicotinic acetylcholine receptor subtype: Synthesis and electrophysiological evaluation.

Quadri M, Silnović A, Matera C, Horenstein NA, Stokes C, De Amici M, Papke RL, Dallanoce C.

Eur J Med Chem. 2018 Dec 5;160:207-228. doi: 10.1016/j.ejmech.2018.10.015. Epub 2018 Oct 11.

PMID:
30342362
3.

A Small Library of 1,2,3-Triazole Analogs of CAP-55: Synthesis and Binding Affinity at Nicotinic Acetylcholine Receptors.

Rizzi L, Gotti C, De Amici M, Dallanoce C, Matera C.

Chem Biodivers. 2018 Sep;15(9):e1800210. doi: 10.1002/cbdv.201800210. Epub 2018 Jul 27.

PMID:
29953725
4.

Activation of M2 muscarinic acetylcholine receptors by a hybrid agonist enhances cytotoxic effects in GB7 glioblastoma cancer stem cells.

Cristofaro I, Spinello Z, Matera C, Fiore M, Conti L, De Amici M, Dallanoce C, Tata AM.

Neurochem Int. 2018 Sep;118:52-60. doi: 10.1016/j.neuint.2018.04.010. Epub 2018 Apr 24.

PMID:
29702145
5.

In vivo and in vitro ADMET profiling and in vivo pharmacodynamic investigations of a selective α7 nicotinic acetylcholine receptor agonist with a spirocyclic Δ2-isoxazoline molecular skeleton.

Matera C, Dondio G, Braida D, Ponzoni L, De Amici M, Sala M, Dallanoce C.

Eur J Pharmacol. 2018 Feb 5;820:265-273. doi: 10.1016/j.ejphar.2017.12.047. Epub 2017 Dec 21.

PMID:
29275158
6.

Identification of α7 Nicotinic Acetylcholine Receptor Silent Agonists Based on the Spirocyclic Quinuclidine-Δ2 -Isoxazoline Scaffold: Synthesis and Electrophysiological Evaluation.

Quadri M, Matera C, Silnović A, Pismataro MC, Horenstein NA, Stokes C, Papke RL, Dallanoce C.

ChemMedChem. 2017 Aug 22;12(16):1335-1348. doi: 10.1002/cmdc.201700162. Epub 2017 Jun 12.

7.

Novel bipharmacophoric inhibitors of the cholinesterases with affinity to the muscarinic receptors M1 and M2.

Messerer R, Dallanoce C, Matera C, Wehle S, Flammini L, Chirinda B, Bock A, Irmen M, Tränkle C, Barocelli E, Decker M, Sotriffer C, De Amici M, Holzgrabe U.

Medchemcomm. 2017 Apr 27;8(6):1346-1359. doi: 10.1039/c7md00149e. eCollection 2017 Jun 1.

8.

A New Molecular Mechanism To Engineer Protean Agonism at a G Protein-Coupled Receptor.

De Min A, Matera C, Bock A, Holze J, Kloeckner J, Muth M, Traenkle C, De Amici M, Kenakin T, Holzgrabe U, Dallanoce C, Kostenis E, Mohr K, Schrage R.

Mol Pharmacol. 2017 Apr;91(4):348-356. doi: 10.1124/mol.116.107276. Epub 2017 Feb 6.

PMID:
28167741
9.

In vivo study of the role of α6-containing nicotinic acetylcholine receptor in retinal function using subtype-specific RDP-MII(E11R) toxin.

Barloscio D, Cerri E, Domenici L, Longhi R, Dallanoce C, Moretti M, Vilella A, Zoli M, Gotti C, Origlia N.

FASEB J. 2017 Jan;31(1):192-202. doi: 10.1096/fj.201600855R. Epub 2016 Sep 28.

PMID:
27682206
10.

Ligand Binding Ensembles Determine Graded Agonist Efficacies at a G Protein-coupled Receptor.

Bock A, Bermudez M, Krebs F, Matera C, Chirinda B, Sydow D, Dallanoce C, Holzgrabe U, De Amici M, Lohse MJ, Wolber G, Mohr K.

J Biol Chem. 2016 Jul 29;291(31):16375-89. doi: 10.1074/jbc.M116.735431. Epub 2016 Jun 13.

11.

Modification of the anabaseine pyridine nucleus allows achieving binding and functional selectivity for the α3β4 nicotinic acetylcholine receptor subtype.

Matera C, Quadri M, Sciaccaluga M, Pomè DY, Fasoli F, De Amici M, Fucile S, Gotti C, Dallanoce C, Grazioso G.

Eur J Med Chem. 2016 Jan 27;108:392-405. doi: 10.1016/j.ejmech.2015.11.045. Epub 2015 Dec 5.

PMID:
26706350
12.

Allosteric Modulation of Alpha7 Nicotinic Receptors: Mechanistic Insight through Metadynamics and Essential Dynamics.

Grazioso G, Sgrignani J, Capelli R, Matera C, Dallanoce C, De Amici M, Cavalli A.

J Chem Inf Model. 2015 Dec 28;55(12):2528-39. doi: 10.1021/acs.jcim.5b00459. Epub 2015 Nov 20.

PMID:
26569022
13.

Bifunctional compounds targeting both D2 and non-α7 nACh receptors: design, synthesis and pharmacological characterization.

Matera C, Pucci L, Fiorentini C, Fucile S, Missale C, Grazioso G, Clementi F, Zoli M, De Amici M, Gotti C, Dallanoce C.

Eur J Med Chem. 2015 Aug 28;101:367-83. doi: 10.1016/j.ejmech.2015.06.039. Epub 2015 Jun 20.

PMID:
26164842
14.

On the selection of an opioid for local skin analgesia: Structure-skin permeability relationships.

Musazzi UM, Matera C, Dallanoce C, Vacondio F, De Amici M, Vistoli G, Cilurzo F, Minghetti P.

Int J Pharm. 2015 Jul 15;489(1-2):177-85. doi: 10.1016/j.ijpharm.2015.04.071. Epub 2015 Apr 28.

PMID:
25934430
15.

Bis(ammonio)alkane-type agonists of muscarinic acetylcholine receptors: synthesis, in vitro functional characterization, and in vivo evaluation of their analgesic activity.

Matera C, Flammini L, Quadri M, Vivo V, Ballabeni V, Holzgrabe U, Mohr K, De Amici M, Barocelli E, Bertoni S, Dallanoce C.

Eur J Med Chem. 2014 Mar 21;75:222-32. doi: 10.1016/j.ejmech.2014.01.032. Epub 2014 Jan 25.

PMID:
24534538
16.

Investigating the hydrogen-bond acceptor site of the nicotinic pharmacophore model: a computational and experimental study using epibatidine-related molecular probes.

Dallanoce C, Grazioso G, Pomè DY, Sciaccaluga M, Matera C, Gotti C, Fucile S, De Amici M.

J Comput Aided Mol Des. 2013 Nov;27(11):975-87. doi: 10.1007/s10822-013-9694-y. Epub 2013 Nov 26.

PMID:
24276616
17.

Involvement of α7 nAChR subtype in rat oxaliplatin-induced neuropathy: effects of selective activation.

Di Cesare Mannelli L, Pacini A, Matera C, Zanardelli M, Mello T, De Amici M, Dallanoce C, Ghelardini C.

Neuropharmacology. 2014 Apr;79:37-48. doi: 10.1016/j.neuropharm.2013.10.034. Epub 2013 Nov 10.

PMID:
24225197
18.

Dynamic ligand binding dictates partial agonism at a G protein-coupled receptor.

Bock A, Chirinda B, Krebs F, Messerer R, Bätz J, Muth M, Dallanoce C, Klingenthal D, Tränkle C, Hoffmann C, De Amici M, Holzgrabe U, Kostenis E, Mohr K.

Nat Chem Biol. 2014 Jan;10(1):18-20. doi: 10.1038/nchembio.1384. Epub 2013 Nov 10.

PMID:
24212135
19.

Agonists with supraphysiological efficacy at the muscarinic M2 ACh receptor.

Schrage R, Seemann WK, Klöckner J, Dallanoce C, Racké K, Kostenis E, De Amici M, Holzgrabe U, Mohr K.

Br J Pharmacol. 2013 May;169(2):357-70. doi: 10.1111/bph.12003.

20.

A novel spirocyclic tropanyl-Δ²-isoxazoline derivative enhances citalopram and paroxetine binding to serotonin transporters as well as serotonin uptake.

Dallanoce C, Canovi M, Matera C, Mennini T, De Amici M, Gobbi M, De Micheli C.

Bioorg Med Chem. 2012 Nov 1;20(21):6344-55. doi: 10.1016/j.bmc.2012.09.004. Epub 2012 Sep 10.

PMID:
23022052
21.

The allosteric vestibule of a seven transmembrane helical receptor controls G-protein coupling.

Bock A, Merten N, Schrage R, Dallanoce C, Bätz J, Klöckner J, Schmitz J, Matera C, Simon K, Kebig A, Peters L, Müller A, Schrobang-Ley J, Tränkle C, Hoffmann C, De Amici M, Holzgrabe U, Kostenis E, Mohr K.

Nat Commun. 2012;3:1044. doi: 10.1038/ncomms2028.

22.

The enantiomers of epiboxidine and of two related analogs: synthesis and estimation of their binding affinity at α4β2 and α7 neuronal nicotinic acetylcholine receptors.

Dallanoce C, Matera C, De Amici M, Rizzi L, Pucci L, Gotti C, Clementi F, De Micheli C.

Chirality. 2012 Jul;24(7):543-51. doi: 10.1002/chir.22052. Epub 2012 May 5.

PMID:
22566097
23.

Synthesis and binding affinity at α4β2 and α7 nicotinic acetylcholine receptors of new analogs of epibatidine and epiboxidine containing the 7-azabicyclo[2.2.1]hept-2-ene ring system.

Dallanoce C, Matera C, Pucci L, Gotti C, Clementi F, Amici MD, Micheli CD.

Bioorg Med Chem Lett. 2012 Jan 15;22(2):829-32. doi: 10.1016/j.bmcl.2011.12.052. Epub 2011 Dec 16.

PMID:
22222032
24.

New spirocyclic Δ²-isoxazoline derivatives related to selective agonists of α7 neuronal nicotinic acetylcholine receptors.

Dallanoce C, Frigerio F, Grazioso G, Matera C, Visconti GL, De Amici M, Pucci L, Pistillo F, Fucile S, Gotti C, Clementi F, De Micheli C.

Eur J Med Chem. 2011 Dec;46(12):5790-9. doi: 10.1016/j.ejmech.2011.09.028. Epub 2011 Sep 24.

PMID:
22014558
25.

Engineering of α-conotoxin MII-derived peptides with increased selectivity for native α6β2* nicotinic acetylcholine receptors.

Pucci L, Grazioso G, Dallanoce C, Rizzi L, De Micheli C, Clementi F, Bertrand S, Bertrand D, Longhi R, De Amici M, Gotti C.

FASEB J. 2011 Nov;25(11):3775-89. doi: 10.1096/fj.10-179853. Epub 2011 Jul 21.

PMID:
21778325
26.

Design, synthesis, and pharmacological characterization of novel spirocyclic quinuclidinyl-Δ2-isoxazoline derivatives as potent and selective agonists of α7 nicotinic acetylcholine receptors.

Dallanoce C, Magrone P, Matera C, Frigerio F, Grazioso G, De Amici M, Fucile S, Piccari V, Frydenvang K, Pucci L, Gotti C, Clementi F, De Micheli C.

ChemMedChem. 2011 May 2;6(5):889-903. doi: 10.1002/cmdc.201000514. Epub 2011 Mar 1.

PMID:
21365765
27.

Synthesis of novel chiral Δ2-isoxazoline derivatives related to ABT-418 and estimation of their affinity at neuronal nicotinic acetylcholine receptor subtypes.

Dallanoce C, Magrone P, Matera C, Lo Presti L, De Amici M, Riganti L, Clementi F, Gotti C, De Micheli C.

Eur J Med Chem. 2010 Dec;45(12):5594-601. doi: 10.1016/j.ejmech.2010.09.009. Epub 2010 Sep 17.

PMID:
20932609
28.

Novel tricyclic Delta(2)-isoxazoline and 3-oxo-2-methyl-isoxazolidine derivatives: synthesis and binding affinity at neuronal nicotinic acetylcholine receptor subtypes.

Dallanoce C, Frigerio F, Martelli G, Grazioso G, Matera C, Pomè DY, Pucci L, Clementi F, Gotti C, De Amici M.

Bioorg Med Chem. 2010 Jun 15;18(12):4498-508. doi: 10.1016/j.bmc.2010.04.065. Epub 2010 Apr 27.

PMID:
20478710
30.

Design of novel alpha7-subtype-preferring nicotinic acetylcholine receptor agonists: application of docking and MM-PBSA computational approaches, synthetic and pharmacological studies.

Grazioso G, Pomè DY, Matera C, Frigerio F, Pucci L, Gotti C, Dallanoce C, De Amici M.

Bioorg Med Chem Lett. 2009 Nov 15;19(22):6353-7. doi: 10.1016/j.bmcl.2009.09.073. Epub 2009 Sep 24.

PMID:
19804970
31.

Allosteric ligands for G protein-coupled receptors: a novel strategy with attractive therapeutic opportunities.

De Amici M, Dallanoce C, Holzgrabe U, Tränkle C, Mohr K.

Med Res Rev. 2010 May;30(3):463-549. doi: 10.1002/med.20166. Review.

PMID:
19557759
32.

New analogues of epiboxidine incorporating the 4,5-dihydroisoxazole nucleus: synthesis, binding affinity at neuronal nicotinic acetylcholine receptors, and molecular modeling investigations.

Dallanoce C, Magrone P, Bazza P, Grazioso G, Rizzi L, Riganti L, Gotti C, Clementi F, Frydenvang K, De Amici M.

Chem Biodivers. 2009 Feb;6(2):244-59. doi: 10.1002/cbdv.200800077.

PMID:
19235154
33.

Dualsteric GPCR targeting: a novel route to binding and signaling pathway selectivity.

Antony J, Kellershohn K, Mohr-Andrä M, Kebig A, Prilla S, Muth M, Heller E, Disingrini T, Dallanoce C, Bertoni S, Schrobang J, Tränkle C, Kostenis E, Christopoulos A, Höltje HD, Barocelli E, De Amici M, Holzgrabe U, Mohr K.

FASEB J. 2009 Feb;23(2):442-50. doi: 10.1096/fj.08-114751. Epub 2008 Oct 8.

PMID:
18842964
34.

Epiboxidine and novel-related analogues: a convenient synthetic approach and estimation of their affinity at neuronal nicotinic acetylcholine receptor subtypes.

Rizzi L, Dallanoce C, Matera C, Magrone P, Pucci L, Gotti C, Clementi F, De Amici M.

Bioorg Med Chem Lett. 2008 Aug 15;18(16):4651-4. doi: 10.1016/j.bmcl.2008.07.016. Epub 2008 Jul 10.

35.

Novel oxotremorine-related heterocyclic derivatives: Synthesis and in vitro pharmacology at the muscarinic receptor subtypes.

Dallanoce C, De Amici M, Barocelli E, Bertoni S, Roth BL, Ernsberger P, De Micheli C.

Bioorg Med Chem. 2007 Dec 15;15(24):7626-37. Epub 2007 Sep 11.

PMID:
17889543
36.

Novel chiral isoxazole derivatives: synthesis and pharmacological characterization at human beta-adrenergic receptor subtypes.

Dallanoce C, Frigerio F, De Amici M, Dorsch S, Klotz KN, De Micheli C.

Bioorg Med Chem. 2007 Apr 1;15(7):2533-43. Epub 2007 Feb 2.

PMID:
17303428
37.

Synthesis of enantiopure Delta2-isoxazoline derivatives and evaluation of their affinity and efficacy profiles at human beta-adrenergic receptor subtypes.

Dallanoce C, Meroni G, De Amici M, Hoffmann C, Klotz KN, De Micheli C.

Bioorg Med Chem. 2006 Jul 1;14(13):4393-401. Epub 2006 Mar 10.

PMID:
16530417
38.

Design, synthesis, and action of oxotremorine-related hybrid-type allosteric modulators of muscarinic acetylcholine receptors.

Disingrini T, Muth M, Dallanoce C, Barocelli E, Bertoni S, Kellershohn K, Mohr K, De Amici M, Holzgrabe U.

J Med Chem. 2006 Jan 12;49(1):366-72.

PMID:
16392821
39.

New analogues of oxotremorine and oxotremorine-M: estimation of their in vitro affinity and efficacy at muscarinic receptor subtypes.

Barocelli E, Ballabeni V, Bertoni S, Dallanoce C, De Amici M, De Micheli C, Impicciatore M.

Life Sci. 2000 Jun 30;67(6):717-23.

PMID:
12659177
40.

Synthesis and pharmacological characterization of new chiral derivatives of muscarine and allo-muscarine.

De Amici M, Dallanoce C, Angeli P, Marucci G, Cantalamessa F, De Micheli C.

Farmaco. 2000 Aug;55(8):535-43.

PMID:
11132731
41.

Pharmacological profile of enantiomerically pure chiral muscarinic agonists: desoxymuscarines.

De Amici M, Dallanoce C, De Micheli C, Angeli P, Marucci G, Cantalamessa F, Sparapassi L.

Life Sci. 2000 Jun 8;67(3):317-26.

PMID:
10983875
42.

Synthesis and functional characterization of novel derivatives related to oxotremorine and oxotremorine-M.

Dallanoce C, Conti P, De Amici M, De Micheli C, Barocelli E, Chiavarini M, Ballabeni V, Bertoni S, Impicciatore M.

Bioorg Med Chem. 1999 Aug;7(8):1539-47.

PMID:
10482446
43.

Synthesis of new delta 2-isoxazoline derivatives and their pharmacological characterization as beta-adrenergic receptor antagonists.

Conti P, Dallanoce C, De Amici M, De Micheli C, Klotz KN.

Bioorg Med Chem. 1998 Apr;6(4):401-8.

PMID:
9597184
44.

Semisynthetic derivatives of purpuromycin as potential topical agents for vaginal infections.

Trani A, Dallanoce C, Panzone G, Ripamonti F, Goldstein BP, Ciabatti R.

J Med Chem. 1997 Mar 14;40(6):967-71.

PMID:
9083486
45.

Synthesis and biological evaluation of new fragments from kirromycin antibiotic.

Tavecchia P, Marazzi A, Dallanoce C, Trani A, Ciciliato I, Ferrari P, Selva E, Ciabatti R.

J Antibiot (Tokyo). 1996 Dec;49(12):1249-57.

46.

Synthesis and antimicrobial activities of 4-purpuromycin derivatives.

Trani A, Dallanoce C, Ferrari P, Goldstein B, Ripamonti F, Ciabatti R.

Farmaco. 1996 Jul;51(7):503-12.

PMID:
8765673
47.

Synthesis and pharmacological investigation of the enantiomers of muscarone and allomuscarone.

De Amici M, Dallanoce C, De Micheli C, Grana E, Barbieri A, Ladinsky H, Schiavi G, Zonta F.

J Med Chem. 1992 May 15;35(10):1915-20.

PMID:
1588567
48.

Synthesis and pharmacological investigation of stereoisomeric muscarines.

De Amici M, Dallanoce C, De Micheli C, Grana E, Dondi G, Ladinsky H, Schiavi G, Zonta F.

Chirality. 1992;4(4):230-9.

PMID:
1389960

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