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Items: 1 to 50 of 301

1.

MEF2B Instructs Germinal Center Development and Acts as an Oncogene in B Cell Lymphomagenesis.

Brescia P, Schneider C, Holmes AB, Shen Q, Hussein S, Pasqualucci L, Basso K, Dalla-Favera R.

Cancer Cell. 2018 Sep 10;34(3):453-465.e9. doi: 10.1016/j.ccell.2018.08.006.

PMID:
30205047
2.

Genetics of diffuse large B-cell lymphoma.

Pasqualucci L, Dalla-Favera R.

Blood. 2018 May 24;131(21):2307-2319. doi: 10.1182/blood-2017-11-764332. Epub 2018 Apr 17. Review.

3.

Molecular genetics of aggressive B-cell lymphoma.

Dalla-Favera R.

Hematol Oncol. 2017 Jun;35 Suppl 1:76-79. doi: 10.1002/hon.2405. Review. No abstract available.

PMID:
28591417
4.

Common nonmutational NOTCH1 activation in chronic lymphocytic leukemia.

Fabbri G, Holmes AB, Viganotti M, Scuoppo C, Belver L, Herranz D, Yan XJ, Kieso Y, Rossi D, Gaidano G, Chiorazzi N, Ferrando AA, Dalla-Favera R.

Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):E2911-E2919. doi: 10.1073/pnas.1702564114. Epub 2017 Mar 17.

5.

The CREBBP Acetyltransferase Is a Haploinsufficient Tumor Suppressor in B-cell Lymphoma.

Zhang J, Vlasevska S, Wells VA, Nataraj S, Holmes AB, Duval R, Meyer SN, Mo T, Basso K, Brindle PK, Hussein S, Dalla-Favera R, Pasqualucci L.

Cancer Discov. 2017 Mar;7(3):322-337. doi: 10.1158/2159-8290.CD-16-1417. Epub 2017 Jan 9.

6.

FBXO11 inactivation leads to abnormal germinal-center formation and lymphoproliferative disease.

Schneider C, Kon N, Amadori L, Shen Q, Schwartz FH, Tischler B, Bossennec M, Dominguez-Sola D, Bhagat G, Gu W, Basso K, Dalla-Favera R.

Blood. 2016 Aug 4;128(5):660-6. doi: 10.1182/blood-2015-11-684357. Epub 2016 May 10.

7.

Genetic basis of PD-L1 overexpression in diffuse large B-cell lymphomas.

Georgiou K, Chen L, Berglund M, Ren W, de Miranda NF, Lisboa S, Fangazio M, Zhu S, Hou Y, Wu K, Fang W, Wang X, Meng B, Zhang L, Zeng Y, Bhagat G, Nordenskjöld M, Sundström C, Enblad G, Dalla-Favera R, Zhang H, Teixeira MR, Pasqualucci L, Peng R, Pan-Hammarström Q.

Blood. 2016 Jun 16;127(24):3026-34. doi: 10.1182/blood-2015-12-686550. Epub 2016 Mar 30.

8.

The molecular pathogenesis of chronic lymphocytic leukaemia.

Fabbri G, Dalla-Favera R.

Nat Rev Cancer. 2016 Mar;16(3):145-62. doi: 10.1038/nrc.2016.8. Review.

PMID:
26911189
9.

The FOXO1 Transcription Factor Instructs the Germinal Center Dark Zone Program.

Dominguez-Sola D, Kung J, Holmes AB, Wells VA, Mo T, Basso K, Dalla-Favera R.

Immunity. 2015 Dec 15;43(6):1064-74. doi: 10.1016/j.immuni.2015.10.015. Epub 2015 Nov 24.

10.

Disruption of KMT2D perturbs germinal center B cell development and promotes lymphomagenesis.

Zhang J, Dominguez-Sola D, Hussein S, Lee JE, Holmes AB, Bansal M, Vlasevska S, Mo T, Tang H, Basso K, Ge K, Dalla-Favera R, Pasqualucci L.

Nat Med. 2015 Oct;21(10):1190-8. doi: 10.1038/nm.3940. Epub 2015 Sep 14.

11.

An oncogenic role for alternative NF-κB signaling in DLBCL revealed upon deregulated BCL6 expression.

Zhang B, Calado DP, Wang Z, Fröhler S, Köchert K, Qian Y, Koralov SB, Schmidt-Supprian M, Sasaki Y, Unitt C, Rodig S, Chen W, Dalla-Favera R, Alt FW, Pasqualucci L, Rajewsky K.

Cell Rep. 2015 May 5;11(5):715-26. doi: 10.1016/j.celrep.2015.03.059. Epub 2015 Apr 23.

12.

A roadmap for discovery and translation in lymphoma.

Weinstock DM, Dalla-Favera R, Gascoyne RD, Leonard JP, Levy R, Lossos IS, Melnick AM, Nowakowski GS, Press OW, Savage KJ, Shipp MA, Staudt LM.

Blood. 2015 Mar 26;125(13):2175-7. doi: 10.1182/blood-2015-01-623777. No abstract available.

13.

The genetic landscape of diffuse large B-cell lymphoma.

Pasqualucci L, Dalla-Favera R.

Semin Hematol. 2015 Apr;52(2):67-76. doi: 10.1053/j.seminhematol.2015.01.005. Epub 2015 Jan 17. Review.

14.

Germinal centres and B cell lymphomagenesis.

Basso K, Dalla-Favera R.

Nat Rev Immunol. 2015 Mar;15(3):172-84. doi: 10.1038/nri3814. Review.

PMID:
25712152
15.

Genome-wide mapping and characterization of Notch-regulated long noncoding RNAs in acute leukemia.

Trimarchi T, Bilal E, Ntziachristos P, Fabbri G, Dalla-Favera R, Tsirigos A, Aifantis I.

Cell. 2014 Jul 31;158(3):593-606. doi: 10.1016/j.cell.2014.05.049.

16.

MicroRNA 28 controls cell proliferation and is down-regulated in B-cell lymphomas.

Schneider C, Setty M, Holmes AB, Maute RL, Leslie CS, Mussolin L, Rosolen A, Dalla-Favera R, Basso K.

Proc Natl Acad Sci U S A. 2014 Jun 3;111(22):8185-90. doi: 10.1073/pnas.1322466111. Epub 2014 May 19.

17.

Genetic lesions associated with chronic lymphocytic leukemia chemo-refractoriness.

Messina M, Del Giudice I, Khiabanian H, Rossi D, Chiaretti S, Rasi S, Spina V, Holmes AB, Marinelli M, Fabbri G, Piciocchi A, Mauro FR, Guarini A, Gaidano G, Dalla-Favera R, Pasqualucci L, Rabadan R, Foà R.

Blood. 2014 Apr 10;123(15):2378-88. doi: 10.1182/blood-2013-10-534271. Epub 2014 Feb 18.

18.

SnapShot: diffuse large B cell lymphoma.

Pasqualucci L, Dalla-Favera R.

Cancer Cell. 2014 Jan 13;25(1):132-132.e1. doi: 10.1016/j.ccr.2013.12.012. Review. No abstract available.

19.

Genetics of follicular lymphoma transformation.

Pasqualucci L, Khiabanian H, Fangazio M, Vasishtha M, Messina M, Holmes AB, Ouillette P, Trifonov V, Rossi D, Tabbò F, Ponzoni M, Chadburn A, Murty VV, Bhagat G, Gaidano G, Inghirami G, Malek SN, Rabadan R, Dalla-Favera R.

Cell Rep. 2014 Jan 16;6(1):130-40. doi: 10.1016/j.celrep.2013.12.027. Epub 2014 Jan 2.

20.

Genetic lesions associated with chronic lymphocytic leukemia transformation to Richter syndrome.

Fabbri G, Khiabanian H, Holmes AB, Wang J, Messina M, Mullighan CG, Pasqualucci L, Rabadan R, Dalla-Favera R.

J Exp Med. 2013 Oct 21;210(11):2273-88. doi: 10.1084/jem.20131448. Epub 2013 Oct 14.

21.

RNAs with multiple personalities.

Maute RL, Dalla-Favera R, Basso K.

Wiley Interdiscip Rev RNA. 2014 Jan-Feb;5(1):1-13. doi: 10.1002/wrna.1193. Epub 2013 Aug 20. Review.

PMID:
24039180
22.

MEF2B mutations lead to deregulated expression of the oncogene BCL6 in diffuse large B cell lymphoma.

Ying CY, Dominguez-Sola D, Fabi M, Lorenz IC, Hussein S, Bansal M, Califano A, Pasqualucci L, Basso K, Dalla-Favera R.

Nat Immunol. 2013 Oct;14(10):1084-92. doi: 10.1038/ni.2688. Epub 2013 Aug 25.

23.

MutComFocal: an integrative approach to identifying recurrent and focal genomic alterations in tumor samples.

Trifonov V, Pasqualucci L, Dalla Favera R, Rabadan R.

BMC Syst Biol. 2013 Mar 25;7:25. doi: 10.1186/1752-0509-7-25.

24.

tRNA-derived microRNA modulates proliferation and the DNA damage response and is down-regulated in B cell lymphoma.

Maute RL, Schneider C, Sumazin P, Holmes A, Califano A, Basso K, Dalla-Favera R.

Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):1404-9. doi: 10.1073/pnas.1206761110. Epub 2013 Jan 7.

25.

Integrated mutational and cytogenetic analysis identifies new prognostic subgroups in chronic lymphocytic leukemia.

Rossi D, Rasi S, Spina V, Bruscaggin A, Monti S, Ciardullo C, Deambrogi C, Khiabanian H, Serra R, Bertoni F, Forconi F, Laurenti L, Marasca R, Dal-Bo M, Rossi FM, Bulian P, Nomdedeu J, Del Poeta G, Gattei V, Pasqualucci L, Rabadan R, Foà R, Dalla-Favera R, Gaidano G.

Blood. 2013 Feb 21;121(8):1403-12. doi: 10.1182/blood-2012-09-458265. Epub 2012 Dec 13.

26.

BCL6 positively regulates AID and germinal center gene expression via repression of miR-155.

Basso K, Schneider C, Shen Q, Holmes AB, Setty M, Leslie C, Dalla-Favera R.

J Exp Med. 2012 Dec 17;209(13):2455-65. doi: 10.1084/jem.20121387. Epub 2012 Nov 19.

27.

Molecular pathogenesis of chronic lymphocytic leukemia.

Gaidano G, Foà R, Dalla-Favera R.

J Clin Invest. 2012 Oct;122(10):3432-8. doi: 10.1172/JCI64101. Epub 2012 Oct 1. Review.

28.

Lymphoid malignancies: many tumor types, many altered genes, many therapeutic challenges.

Dalla-Favera R.

J Clin Invest. 2012 Oct;122(10):3396-7. doi: 10.1172/JCI66307. Epub 2012 Oct 1.

29.

The proto-oncogene MYC is required for selection in the germinal center and cyclic reentry.

Dominguez-Sola D, Victora GD, Ying CY, Phan RT, Saito M, Nussenzweig MC, Dalla-Favera R.

Nat Immunol. 2012 Nov;13(11):1083-91. doi: 10.1038/ni.2428. Epub 2012 Sep 23.

30.

Burkitt lymphoma: much more than MYC.

Dominguez-Sola D, Dalla-Favera R.

Cancer Cell. 2012 Aug 14;22(2):141-2. doi: 10.1016/j.ccr.2012.07.018.

31.

The coding genome of splenic marginal zone lymphoma: activation of NOTCH2 and other pathways regulating marginal zone development.

Rossi D, Trifonov V, Fangazio M, Bruscaggin A, Rasi S, Spina V, Monti S, Vaisitti T, Arruga F, Famà R, Ciardullo C, Greco M, Cresta S, Piranda D, Holmes A, Fabbri G, Messina M, Rinaldi A, Wang J, Agostinelli C, Piccaluga PP, Lucioni M, Tabbò F, Serra R, Franceschetti S, Deambrogi C, Daniele G, Gattei V, Marasca R, Facchetti F, Arcaini L, Inghirami G, Bertoni F, Pileri SA, Deaglio S, Foà R, Dalla-Favera R, Pasqualucci L, Rabadan R, Gaidano G.

J Exp Med. 2012 Aug 27;209(9):1537-51. doi: 10.1084/jem.20120904. Epub 2012 Aug 13.

32.

Identification of human germinal center light and dark zone cells and their relationship to human B-cell lymphomas.

Victora GD, Dominguez-Sola D, Holmes AB, Deroubaix S, Dalla-Favera R, Nussenzweig MC.

Blood. 2012 Sep 13;120(11):2240-8. doi: 10.1182/blood-2012-03-415380. Epub 2012 Jun 26. Erratum in: Blood. 2015 Sep 3;126(10):1262.

33.

IRTA1 is selectively expressed in nodal and extranodal marginal zone lymphomas.

Falini B, Agostinelli C, Bigerna B, Pucciarini A, Pacini R, Tabarrini A, Falcinelli F, Piccioli M, Paulli M, Gambacorta M, Ponzoni M, Tiacci E, Ascani S, Martelli MP, Dalla Favera R, Stein H, Pileri SA.

Histopathology. 2012 Nov;61(5):930-41. doi: 10.1111/j.1365-2559.2012.04289.x. Epub 2012 Jun 20.

PMID:
22716304
34.

A microRNA signature specific for hairy cell leukemia and associated with modulation of the MAPK-JNK pathways.

Kitagawa Y, Brahmachary M, Tiacci E, Dalla-Favera R, Falini B, Basso K.

Leukemia. 2012 Dec;26(12):2564-7. doi: 10.1038/leu.2012.149. Epub 2012 Jun 4. No abstract available.

PMID:
22660186
35.

Roles of BCL6 in normal and transformed germinal center B cells.

Basso K, Dalla-Favera R.

Immunol Rev. 2012 May;247(1):172-83. doi: 10.1111/j.1600-065X.2012.01112.x. Review.

PMID:
22500840
36.

Fractal-like distributions over the rational numbers in high-throughput biological and clinical data.

Trifonov V, Pasqualucci L, Dalla-Favera R, Rabadan R.

Sci Rep. 2011;1:191. doi: 10.1038/srep00191. Epub 2011 Dec 13.

37.

Disruption of BIRC3 associates with fludarabine chemorefractoriness in TP53 wild-type chronic lymphocytic leukemia.

Rossi D, Fangazio M, Rasi S, Vaisitti T, Monti S, Cresta S, Chiaretti S, Del Giudice I, Fabbri G, Bruscaggin A, Spina V, Deambrogi C, Marinelli M, Famà R, Greco M, Daniele G, Forconi F, Gattei V, Bertoni F, Deaglio S, Pasqualucci L, Guarini A, Dalla-Favera R, Foà R, Gaidano G.

Blood. 2012 Mar 22;119(12):2854-62. doi: 10.1182/blood-2011-12-395673. Epub 2012 Feb 3.

38.

Functional dissection of the chromosome 13q14 tumor-suppressor locus using transgenic mouse lines.

Lia M, Carette A, Tang H, Shen Q, Mo T, Bhagat G, Dalla-Favera R, Klein U.

Blood. 2012 Mar 29;119(13):2981-90. doi: 10.1182/blood-2011-09-381814. Epub 2011 Dec 15.

39.

Combined genetic inactivation of β2-Microglobulin and CD58 reveals frequent escape from immune recognition in diffuse large B cell lymphoma.

Challa-Malladi M, Lieu YK, Califano O, Holmes AB, Bhagat G, Murty VV, Dominguez-Sola D, Pasqualucci L, Dalla-Favera R.

Cancer Cell. 2011 Dec 13;20(6):728-40. doi: 10.1016/j.ccr.2011.11.006. Epub 2011 Dec 1.

40.

Mutations of NOTCH1 are an independent predictor of survival in chronic lymphocytic leukemia.

Rossi D, Rasi S, Fabbri G, Spina V, Fangazio M, Forconi F, Marasca R, Laurenti L, Bruscaggin A, Cerri M, Monti S, Cresta S, Famà R, De Paoli L, Bulian P, Gattei V, Guarini A, Deaglio S, Capello D, Rabadan R, Pasqualucci L, Dalla-Favera R, Foà R, Gaidano G.

Blood. 2012 Jan 12;119(2):521-9. doi: 10.1182/blood-2011-09-379966. Epub 2011 Nov 10.

41.

Mutations of the SF3B1 splicing factor in chronic lymphocytic leukemia: association with progression and fludarabine-refractoriness.

Rossi D, Bruscaggin A, Spina V, Rasi S, Khiabanian H, Messina M, Fangazio M, Vaisitti T, Monti S, Chiaretti S, Guarini A, Del Giudice I, Cerri M, Cresta S, Deambrogi C, Gargiulo E, Gattei V, Forconi F, Bertoni F, Deaglio S, Rabadan R, Pasqualucci L, Foà R, Dalla-Favera R, Gaidano G.

Blood. 2011 Dec 22;118(26):6904-8. doi: 10.1182/blood-2011-08-373159. Epub 2011 Oct 28.

42.

Genomic analysis of non-splenic marginal zone lymphomas (MZL) indicates similarities between nodal and extranodal MZL and supports their derivation from memory B-cells.

Novak U, Basso K, Pasqualucci L, Dalla-Favera R, Bhagat G.

Br J Haematol. 2011 Nov;155(3):362-5. doi: 10.1111/j.1365-2141.2011.08841.x. Epub 2011 Aug 25.

PMID:
21883140
43.

Alteration of BIRC3 and multiple other NF-κB pathway genes in splenic marginal zone lymphoma.

Rossi D, Deaglio S, Dominguez-Sola D, Rasi S, Vaisitti T, Agostinelli C, Spina V, Bruscaggin A, Monti S, Cerri M, Cresta S, Fangazio M, Arcaini L, Lucioni M, Marasca R, Thieblemont C, Capello D, Facchetti F, Kwee I, Pileri SA, Foà R, Bertoni F, Dalla-Favera R, Pasqualucci L, Gaidano G.

Blood. 2011 Nov 3;118(18):4930-4. doi: 10.1182/blood-2011-06-359166. Epub 2011 Aug 31.

44.

Molecular pathogenesis of diffuse large B-cell lymphoma.

Schneider C, Pasqualucci L, Dalla-Favera R.

Semin Diagn Pathol. 2011 May;28(2):167-77. Review.

45.

Analysis of the coding genome of diffuse large B-cell lymphoma.

Pasqualucci L, Trifonov V, Fabbri G, Ma J, Rossi D, Chiarenza A, Wells VA, Grunn A, Messina M, Elliot O, Chan J, Bhagat G, Chadburn A, Gaidano G, Mullighan CG, Rabadan R, Dalla-Favera R.

Nat Genet. 2011 Jul 31;43(9):830-7. doi: 10.1038/ng.892.

46.

Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation.

Fabbri G, Rasi S, Rossi D, Trifonov V, Khiabanian H, Ma J, Grunn A, Fangazio M, Capello D, Monti S, Cresta S, Gargiulo E, Forconi F, Guarini A, Arcaini L, Paulli M, Laurenti L, Larocca LM, Marasca R, Gattei V, Oscier D, Bertoni F, Mullighan CG, Foá R, Pasqualucci L, Rabadan R, Dalla-Favera R, Gaidano G.

J Exp Med. 2011 Jul 4;208(7):1389-401. doi: 10.1084/jem.20110921. Epub 2011 Jun 13.

47.

Inactivating mutations of acetyltransferase genes in B-cell lymphoma.

Pasqualucci L, Dominguez-Sola D, Chiarenza A, Fabbri G, Grunn A, Trifonov V, Kasper LH, Lerach S, Tang H, Ma J, Rossi D, Chadburn A, Murty VV, Mullighan CG, Gaidano G, Rabadan R, Brindle PK, Dalla-Favera R.

Nature. 2011 Mar 10;471(7337):189-95. doi: 10.1038/nature09730.

48.

Signatures of murine B-cell development implicate Yy1 as a regulator of the germinal center-specific program.

Green MR, Monti S, Dalla-Favera R, Pasqualucci L, Walsh NC, Schmidt-Supprian M, Kutok JL, Rodig SJ, Neuberg DS, Rajewsky K, Golub TR, Alt FW, Shipp MA, Manis JP.

Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2873-8. doi: 10.1073/pnas.1019537108. Epub 2011 Jan 31.

49.

BLIMP1 is a tumor suppressor gene frequently disrupted in activated B cell-like diffuse large B cell lymphoma.

Mandelbaum J, Bhagat G, Tang H, Mo T, Brahmachary M, Shen Q, Chadburn A, Rajewsky K, Tarakhovsky A, Pasqualucci L, Dalla-Favera R.

Cancer Cell. 2010 Dec 14;18(6):568-79. doi: 10.1016/j.ccr.2010.10.030.

50.

Genome-wide DNA profiling of marginal zone lymphomas identifies subtype-specific lesions with an impact on the clinical outcome.

Rinaldi A, Mian M, Chigrinova E, Arcaini L, Bhagat G, Novak U, Rancoita PM, De Campos CP, Forconi F, Gascoyne RD, Facchetti F, Ponzoni M, Govi S, Ferreri AJ, Mollejo M, Piris MA, Baldini L, Soulier J, Thieblemont C, Canzonieri V, Gattei V, Marasca R, Franceschetti S, Gaidano G, Tucci A, Uccella S, Tibiletti MG, Dirnhofer S, Tripodo C, Doglioni C, Dalla Favera R, Cavalli F, Zucca E, Kwee I, Bertoni F.

Blood. 2011 Feb 3;117(5):1595-604. doi: 10.1182/blood-2010-01-264275. Epub 2010 Nov 29.

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