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Gene therapy for retinal dystrophy.

Sahel JA, Dalkara D.

Nat Med. 2019 Feb;25(2):198-199. doi: 10.1038/s41591-019-0346-1. No abstract available.


Optogenetic Light Sensors in Human Retinal Organoids.

Garita-Hernandez M, Guibbal L, Toualbi L, Routet F, Chaffiol A, Winckler C, Harinquet M, Robert C, Fouquet S, Bellow S, Sahel JA, Goureau O, Duebel J, Dalkara D.

Front Neurosci. 2018 Nov 2;12:789. doi: 10.3389/fnins.2018.00789. eCollection 2018.


Loss of CRB2 in Müller glial cells modifies a CRB1-associated retinitis pigmentosa phenotype into a Leber congenital amaurosis phenotype.

Quinn PM, Mulder AA, Henrique Alves C, Desrosiers M, de Vries SI, Klooster J, Dalkara D, Koster AJ, Jost CR, Wijnholds J.

Hum Mol Genet. 2019 Jan 1;28(1):105-123. doi: 10.1093/hmg/ddy337.


Dosage Thresholds and Influence of Transgene Cassette in Adeno-Associated Virus-Related Toxicity.

Khabou H, Cordeau C, Pacot L, Fisson S, Dalkara D.

Hum Gene Ther. 2018 Nov;29(11):1235-1241. doi: 10.1089/hum.2018.144. Epub 2018 Oct 31.


Noninvasive gene delivery to foveal cones for vision restoration.

Khabou H, Garita-Hernandez M, Chaffiol A, Reichman S, Jaillard C, Brazhnikova E, Bertin S, Forster V, Desrosiers M, Winckler C, Goureau O, Picaud S, Duebel J, Sahel JA, Dalkara D.

JCI Insight. 2018 Jan 25;3(2). pii: 96029. doi: 10.1172/jci.insight.96029. [Epub ahead of print]


Sphingosine 1-Phosphate Receptor 1 Modulates CNTF-Induced Axonal Growth and Neuroprotection in the Mouse Visual System.

Joly S, Dalkara D, Pernet V.

Neural Plast. 2017;2017:6818970. doi: 10.1155/2017/6818970. Epub 2017 Nov 6.


Neutralizing Antibodies Against Adeno-Associated Virus (AAV): Measurement and Influence on Retinal Gene Delivery.

Desrosiers M, Dalkara D.

Methods Mol Biol. 2018;1715:225-238. doi: 10.1007/978-1-4939-7522-8_16.


Vectors and Gene Delivery to the Retina.

Planul A, Dalkara D.

Annu Rev Vis Sci. 2017 Sep 15;3:121-140. doi: 10.1146/annurev-vision-102016-061413. Review.


A New Promoter Allows Optogenetic Vision Restoration with Enhanced Sensitivity in Macaque Retina.

Chaffiol A, Caplette R, Jaillard C, Brazhnikova E, Desrosiers M, Dubus E, Duhamel L, Macé E, Marre O, Benoit P, Hantraye P, Bemelmans AP, Bamberg E, Duebel J, Sahel JA, Picaud S, Dalkara D.

Mol Ther. 2017 Nov 1;25(11):2546-2560. doi: 10.1016/j.ymthe.2017.07.011. Epub 2017 Jul 20.


Histone H3.3 regulates mitotic progression in mouse embryonic fibroblasts.

Ors A, Papin C, Favier B, Roulland Y, Dalkara D, Ozturk M, Hamiche A, Dimitrov S, Padmanabhan K.

Biochem Cell Biol. 2017 Aug;95(4):491-499. doi: 10.1139/bcb-2016-0190. Epub 2017 Feb 1.


Emerging therapies for inherited retinal degeneration.

Scholl HP, Strauss RW, Singh MS, Dalkara D, Roska B, Picaud S, Sahel JA.

Sci Transl Med. 2016 Dec 7;8(368):368rv6. Review.


Red-shifted channelrhodopsin stimulation restores light responses in blind mice, macaque retina, and human retina.

Sengupta A, Chaffiol A, Macé E, Caplette R, Desrosiers M, Lampič M, Forster V, Marre O, Lin JY, Sahel JA, Picaud S, Dalkara D, Duebel J.

EMBO Mol Med. 2016 Nov 2;8(11):1248-1264. doi: 10.15252/emmm.201505699. Print 2016 Nov.


Insight into the mechanisms of enhanced retinal transduction by the engineered AAV2 capsid variant -7m8.

Khabou H, Desrosiers M, Winckler C, Fouquet S, Auregan G, Bemelmans AP, Sahel JA, Dalkara D.

Biotechnol Bioeng. 2016 Dec;113(12):2712-2724. doi: 10.1002/bit.26031. Epub 2016 Jun 30.


AAV-mediated gene therapy in Dystrophin-Dp71 deficient mouse leads to blood-retinal barrier restoration and oedema reabsorption.

Vacca O, Charles-Messance H, El Mathari B, Sene A, Barbe P, Fouquet S, Aragón J, Darche M, Giocanti-Aurégan A, Paques M, Sahel JA, Tadayoni R, Montañez C, Dalkara D, Rendon A.

Hum Mol Genet. 2016 Jul 15;25(14):3070-3079. Epub 2016 Jun 10.


Melanopsin Variants as Intrinsic Optogenetic On and Off Switches for Transient versus Sustained Activation of G Protein Pathways.

Spoida K, Eickelbeck D, Karapinar R, Eckhardt T, Mark MD, Jancke D, Ehinger BV, König P, Dalkara D, Herlitze S, Masseck OA.

Curr Biol. 2016 May 9;26(9):1206-12. doi: 10.1016/j.cub.2016.03.007. Epub 2016 Apr 7.


The Thioredoxin Encoded by the Rod-Derived Cone Viability Factor Gene Protects Cone Photoreceptors Against Oxidative Stress.

Mei X, Chaffiol A, Kole C, Yang Y, Millet-Puel G, Clérin E, Aït-Ali N, Bennett J, Dalkara D, Sahel JA, Duebel J, Léveillard T.

Antioxid Redox Signal. 2016 Jun 1;24(16):909-23. doi: 10.1089/ars.2015.6509. Epub 2016 May 12.


Let There Be Light: Gene and Cell Therapy for Blindness.

Dalkara D, Goureau O, Marazova K, Sahel JA.

Hum Gene Ther. 2016 Feb;27(2):134-47. doi: 10.1089/hum.2015.147. Review.


Spinocerebellar ataxia type 6 protein aggregates cause deficits in motor learning and cerebellar plasticity.

Mark MD, Krause M, Boele HJ, Kruse W, Pollok S, Kuner T, Dalkara D, Koekkoek S, De Zeeuw CI, Herlitze S.

J Neurosci. 2015 Jun 10;35(23):8882-95. doi: 10.1523/JNEUROSCI.0891-15.2015. Erratum in: J Neurosci. 2015 Sep 9;35(36):12606-7.


[Developments in gene delivery vectors for ocular gene therapy].

Khabou H, Dalkara D.

Med Sci (Paris). 2015 May;31(5):529-37. doi: 10.1051/medsci/20153105015. Epub 2015 Jun 9. Review. French.


Genotypic and phenotypic characterization of P23H line 1 rat model.

Orhan E, Dalkara D, Neuillé M, Lechauve C, Michiels C, Picaud S, Léveillard T, Sahel JA, Naash MI, Lavail MM, Zeitz C, Audo I.

PLoS One. 2015 May 26;10(5):e0127319. doi: 10.1371/journal.pone.0127319. eCollection 2015.


Rod-derived cone viability factor promotes cone survival by stimulating aerobic glycolysis.

Aït-Ali N, Fridlich R, Millet-Puel G, Clérin E, Delalande F, Jaillard C, Blond F, Perrocheau L, Reichman S, Byrne LC, Olivier-Bandini A, Bellalou J, Moyse E, Bouillaud F, Nicol X, Dalkara D, van Dorsselaer A, Sahel JA, Léveillard T.

Cell. 2015 May 7;161(4):817-32. doi: 10.1016/j.cell.2015.03.023.


Using Adeno-associated Virus as a Tool to Study Retinal Barriers in Disease.

Vacca O, El Mathari B, Darche M, Sahel JA, Rendon A, Dalkara D.

J Vis Exp. 2015 Apr 19;(98). doi: 10.3791/52451.


Gene therapy for the eye focus on mutation-independent approaches.

Dalkara D, Duebel J, Sahel JA.

Curr Opin Neurol. 2015 Feb;28(1):51-60. doi: 10.1097/WCO.0000000000000168. Review.


Intracisternal delivery of NFκB-inducible scAAV2/9 reveals locoregional neuroinflammation induced by systemic kainic acid treatment.

Bockstael O, Tenenbaum L, Dalkara D, Melas C, De Witte O, Levivier M, Chtarto A.

Front Mol Neurosci. 2014 Dec 2;7:92. doi: 10.3389/fnmol.2014.00092. eCollection 2014.


Viral-mediated RdCVF and RdCVFL expression protects cone and rod photoreceptors in retinal degeneration.

Byrne LC, Dalkara D, Luna G, Fisher SK, Clérin E, Sahel JA, Léveillard T, Flannery JG.

J Clin Invest. 2015 Jan;125(1):105-16. doi: 10.1172/JCI65654. Epub 2014 Nov 21.


Cell type-specific Nogo-A gene ablation promotes axonal regeneration in the injured adult optic nerve.

Vajda F, Jordi N, Dalkara D, Joly S, Christ F, Tews B, Schwab ME, Pernet V.

Cell Death Differ. 2015 Feb;22(2):323-35. doi: 10.1038/cdd.2014.147. Epub 2014 Sep 26.


Targeting channelrhodopsin-2 to ON-bipolar cells with vitreally administered AAV Restores ON and OFF visual responses in blind mice.

Macé E, Caplette R, Marre O, Sengupta A, Chaffiol A, Barbe P, Desrosiers M, Bamberg E, Sahel JA, Picaud S, Duebel J, Dalkara D.

Mol Ther. 2015 Jan;23(1):7-16. doi: 10.1038/mt.2014.154. Epub 2014 Aug 6.


Imaging light responses of foveal ganglion cells in the living macaque eye.

Yin L, Masella B, Dalkara D, Zhang J, Flannery JG, Schaffer DV, Williams DR, Merigan WH.

J Neurosci. 2014 May 7;34(19):6596-605. doi: 10.1523/JNEUROSCI.4438-13.2014.


Gene therapy for inherited retinal degenerations.

Dalkara D, Sahel JA.

C R Biol. 2014 Mar;337(3):185-92. doi: 10.1016/j.crvi.2014.01.002. Epub 2014 Mar 11. Review.


Retinoschisin gene therapy in photoreceptors, Müller glia or all retinal cells in the Rs1h-/- mouse.

Byrne LC, Oztürk BE, Lee T, Fortuny C, Visel M, Dalkara D, Schaffer DV, Flannery JG.

Gene Ther. 2014 Jun;21(6):585-92. doi: 10.1038/gt.2014.31. Epub 2014 Apr 3.


Vertebrate cone opsins enable sustained and highly sensitive rapid control of Gi/o signaling in anxiety circuitry.

Masseck OA, Spoida K, Dalkara D, Maejima T, Rubelowski JM, Wallhorn L, Deneris ES, Herlitze S.

Neuron. 2014 Mar 19;81(6):1263-1273. doi: 10.1016/j.neuron.2014.01.041.


AAV-mediated gene delivery in Dp71-null mouse model with compromised barriers.

Vacca O, Darche M, Schaffer DV, Flannery JG, Sahel JA, Rendon A, Dalkara D.

Glia. 2014 Mar;62(3):468-76. doi: 10.1002/glia.22617. Epub 2013 Dec 31.


Misguidance and modulation of axonal regeneration by Stat3 and Rho/ROCK signaling in the transparent optic nerve.

Pernet V, Joly S, Jordi N, Dalkara D, Guzik-Kornacka A, Flannery JG, Schwab ME.

Cell Death Dis. 2013 Jul 18;4:e734. doi: 10.1038/cddis.2013.266.


In vivo-directed evolution of a new adeno-associated virus for therapeutic outer retinal gene delivery from the vitreous.

Dalkara D, Byrne LC, Klimczak RR, Visel M, Yin L, Merigan WH, Flannery JG, Schaffer DV.

Sci Transl Med. 2013 Jun 12;5(189):189ra76. doi: 10.1126/scitranslmed.3005708.


Functional rescue of cone photoreceptors in retinitis pigmentosa.

Sahel JA, Léveillard T, Picaud S, Dalkara D, Marazova K, Safran A, Paques M, Duebel J, Roska B, Mohand-Said S.

Graefes Arch Clin Exp Ophthalmol. 2013 Jul;251(7):1669-77. doi: 10.1007/s00417-013-2314-7. Review. No abstract available.


Long-distance axonal regeneration induced by CNTF gene transfer is impaired by axonal misguidance in the injured adult optic nerve.

Pernet V, Joly S, Dalkara D, Jordi N, Schwarz O, Christ F, Schaffer DV, Flannery JG, Schwab ME.

Neurobiol Dis. 2013 Mar;51:202-13. doi: 10.1016/j.nbd.2012.11.011. Epub 2012 Nov 27.


Systemic scAAV9 variant mediates brain transduction in newborn rhesus macaques.

Dehay B, Dalkara D, Dovero S, Li Q, Bezard E.

Sci Rep. 2012;2:253. doi: 10.1038/srep00253. Epub 2012 Feb 9.


Rapid optical control of nociception with an ion-channel photoswitch.

Mourot A, Fehrentz T, Le Feuvre Y, Smith CM, Herold C, Dalkara D, Nagy F, Trauner D, Kramer RH.

Nat Methods. 2012 Feb 19;9(4):396-402. doi: 10.1038/nmeth.1897.


Neuronal Nogo-A upregulation does not contribute to ER stress-associated apoptosis but participates in the regenerative response in the axotomized adult retina.

Pernet V, Joly S, Dalkara D, Schwarz O, Christ F, Schaffer D, Flannery JG, Schwab ME.

Cell Death Differ. 2012 Jul;19(7):1096-108. doi: 10.1038/cdd.2011.191. Epub 2011 Dec 23.


Enhanced gene delivery to the neonatal retina through systemic administration of tyrosine-mutated AAV9.

Dalkara D, Byrne LC, Lee T, Hoffmann NV, Schaffer DV, Flannery JG.

Gene Ther. 2012 Feb;19(2):176-81. doi: 10.1038/gt.2011.163. Epub 2011 Oct 20.


LiGluR restores visual responses in rodent models of inherited blindness.

Caporale N, Kolstad KD, Lee T, Tochitsky I, Dalkara D, Trauner D, Kramer R, Dan Y, Isacoff EY, Flannery JG.

Mol Ther. 2011 Jul;19(7):1212-9. doi: 10.1038/mt.2011.103. Epub 2011 May 24.


AAV mediated GDNF secretion from retinal glia slows down retinal degeneration in a rat model of retinitis pigmentosa.

Dalkara D, Kolstad KD, Guerin KI, Hoffmann NV, Visel M, Klimczak RR, Schaffer DV, Flannery JG.

Mol Ther. 2011 Sep;19(9):1602-8. doi: 10.1038/mt.2011.62. Epub 2011 Apr 26.


Intravitreal injection of AAV2 transduces macaque inner retina.

Yin L, Greenberg K, Hunter JJ, Dalkara D, Kolstad KD, Masella BD, Wolfe R, Visel M, Stone D, Libby RT, Diloreto D Jr, Schaffer D, Flannery J, Williams DR, Merigan WH.

Invest Ophthalmol Vis Sci. 2011 Apr 25;52(5):2775-83. doi: 10.1167/iovs.10-6250.


Changes in adeno-associated virus-mediated gene delivery in retinal degeneration.

Kolstad KD, Dalkara D, Guerin K, Visel M, Hoffmann N, Schaffer DV, Flannery JG.

Hum Gene Ther. 2010 May;21(5):571-8. doi: 10.1089/hum.2009.194.


A novel adeno-associated viral variant for efficient and selective intravitreal transduction of rat Müller cells.

Klimczak RR, Koerber JT, Dalkara D, Flannery JG, Schaffer DV.

PLoS One. 2009 Oct 14;4(10):e7467. doi: 10.1371/journal.pone.0007467.


Inner limiting membrane barriers to AAV-mediated retinal transduction from the vitreous.

Dalkara D, Kolstad KD, Caporale N, Visel M, Klimczak RR, Schaffer DV, Flannery JG.

Mol Ther. 2009 Dec;17(12):2096-102. doi: 10.1038/mt.2009.181. Epub 2009 Aug 11.


Molecular evolution of adeno-associated virus for enhanced glial gene delivery.

Koerber JT, Klimczak R, Jang JH, Dalkara D, Flannery JG, Schaffer DV.

Mol Ther. 2009 Dec;17(12):2088-95. doi: 10.1038/mt.2009.184. Epub 2009 Aug 11.


Suppression of cervical carcinoma cell growth by intracytoplasmic codelivery of anti-oncoprotein E6 antibody and small interfering RNA.

Courtête J, Sibler AP, Zeder-Lutz G, Dalkara D, Oulad-Abdelghani M, Zuber G, Weiss E.

Mol Cancer Ther. 2007 Jun;6(6):1728-35.


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