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Items: 20

1.

Transcriptome analysis of the adult human Klinefelter testis and cellularity-matched controls reveals disturbed differentiation of Sertoli- and Leydig cells.

Winge SB, Dalgaard MD, Belling KG, Jensen JM, Nielsen JE, Aksglaede L, Schierup MH, Brunak S, Skakkebæk NE, Juul A, Rajpert-De Meyts E, Almstrup K.

Cell Death Dis. 2018 May 22;9(6):586. doi: 10.1038/s41419-018-0671-1.

2.

Ibuprofen alters human testicular physiology to produce a state of compensated hypogonadism.

Kristensen DM, Desdoits-Lethimonier C, Mackey AL, Dalgaard MD, De Masi F, Munkbøl CH, Styrishave B, Antignac JP, Le Bizec B, Platel C, Hay-Schmidt A, Jensen TK, Lesné L, Mazaud-Guittot S, Kristiansen K, Brunak S, Kjaer M, Juul A, Jégou B.

Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E715-E724. doi: 10.1073/pnas.1715035115. Epub 2018 Jan 8. Erratum in: Proc Natl Acad Sci U S A. 2018 Apr 16;:.

3.

Transcriptome profiling of fetal Klinefelter testis tissue reveals a possible involvement of long non-coding RNAs in gonocyte maturation.

Winge SB, Dalgaard MD, Jensen JM, Graem N, Schierup MH, Juul A, Rajpert-De Meyts E, Almstrup K.

Hum Mol Genet. 2018 Feb 1;27(3):430-439. doi: 10.1093/hmg/ddx411.

PMID:
29186436
4.

Whole grain-rich diet reduces body weight and systemic low-grade inflammation without inducing major changes of the gut microbiome: a randomised cross-over trial.

Roager HM, Vogt JK, Kristensen M, Hansen LBS, Ibrügger S, Mærkedahl RB, Bahl MI, Lind MV, Nielsen RL, Frøkiær H, Gøbel RJ, Landberg R, Ross AB, Brix S, Holck J, Meyer AS, Sparholt MH, Christensen AF, Carvalho V, Hartmann B, Holst JJ, Rumessen JJ, Linneberg A, Sicheritz-Pontén T, Dalgaard MD, Blennow A, Frandsen HL, Villas-Bôas S, Kristiansen K, Vestergaard H, Hansen T, Ekstrøm CT, Ritz C, Nielsen HB, Pedersen OB, Gupta R, Lauritzen L, Licht TR.

Gut. 2017 Nov 1. pii: gutjnl-2017-314786. doi: 10.1136/gutjnl-2017-314786. [Epub ahead of print]

5.

Genomic GC-Content Affects the Accuracy of 16S rRNA Gene Sequencing Based Microbial Profiling due to PCR Bias.

Laursen MF, Dalgaard MD, Bahl MI.

Front Microbiol. 2017 Oct 5;8:1934. doi: 10.3389/fmicb.2017.01934. eCollection 2017.

6.

Meta-analysis of five genome-wide association studies identifies multiple new loci associated with testicular germ cell tumor.

Wang Z, McGlynn KA, Rajpert-De Meyts E, Bishop DT, Chung CC, Dalgaard MD, Greene MH, Gupta R, Grotmol T, Haugen TB, Karlsson R, Litchfield K, Mitra N, Nielsen K, Pyle LC, Schwartz SM, Thorsson V, Vardhanabhuti S, Wiklund F, Turnbull C, Chanock SJ, Kanetsky PA, Nathanson KL; Testicular Cancer Consortium.

Nat Genet. 2017 Jul;49(7):1141-1147. doi: 10.1038/ng.3879. Epub 2017 Jun 12.

7.

High throughput resistance profiling of Plasmodium falciparum infections based on custom dual indexing and Illumina next generation sequencing-technology.

Nag S, Dalgaard MD, Kofoed PE, Ursing J, Crespo M, Andersen LO, Aarestrup FM, Lund O, Alifrangis M.

Sci Rep. 2017 May 25;7(1):2398. doi: 10.1038/s41598-017-02724-x.

8.

Obesity is associated with depot-specific alterations in adipocyte DNA methylation and gene expression.

Sonne SB, Yadav R, Yin G, Dalgaard MD, Myrmel LS, Gupta R, Wang J, Madsen L, Kajimura S, Kristiansen K.

Adipocyte. 2017 Apr 3;6(2):124-133. doi: 10.1080/21623945.2017.1320002. Epub 2017 Apr 18.

9.

Klinefelter syndrome comorbidities linked to increased X chromosome gene dosage and altered protein interactome activity.

Belling K, Russo F, Jensen AB, Dalgaard MD, Westergaard D, Rajpert-De Meyts E, Skakkebæk NE, Juul A, Brunak S.

Hum Mol Genet. 2017 Apr 1;26(7):1219-1229. doi: 10.1093/hmg/ddx014.

10.

Comparison of global gene expression profiles of microdissected human foetal Leydig cells with their normal and hyperplastic adult equivalents.

Lottrup G, Belling K, Leffers H, Nielsen JE, Dalgaard MD, Juul A, Skakkebæk NE, Brunak S, Rajpert-De Meyts E.

Mol Hum Reprod. 2017 May 1;23(5):339-354. doi: 10.1093/molehr/gax012.

PMID:
28333300
11.

Colonic transit time is related to bacterial metabolism and mucosal turnover in the gut.

Roager HM, Hansen LB, Bahl MI, Frandsen HL, Carvalho V, Gøbel RJ, Dalgaard MD, Plichta DR, Sparholt MH, Vestergaard H, Hansen T, Sicheritz-Pontén T, Nielsen HB, Pedersen O, Lauritzen L, Kristensen M, Gupta R, Licht TR.

Nat Microbiol. 2016 Jun 27;1(9):16093. doi: 10.1038/nmicrobiol.2016.93.

PMID:
27562254
12.

The vaginal microbiome is stable in prepubertal and sexually mature Ellegaard Göttingen Minipigs throughout an estrous cycle.

Lorenzen E, Kudirkiene E, Gutman N, Grossi AB, Agerholm JS, Erneholm K, Skytte C, Dalgaard MD, Bojesen AM.

Vet Res. 2015 Oct 28;46:125. doi: 10.1186/s13567-015-0274-0.

13.

Genomic profiling of thousands of candidate polymorphisms predicts risk of relapse in 778 Danish and German childhood acute lymphoblastic leukemia patients.

Wesołowska-Andersen A, Borst L, Dalgaard MD, Yadav R, Rasmussen KK, Wehner PS, Rasmussen M, Ørntoft TF, Nordentoft I, Koehler R, Bartram CR, Schrappe M, Sicheritz-Ponten T, Gautier L, Marquart H, Madsen HO, Brunak S, Stanulla M, Gupta R, Schmiegelow K.

Leukemia. 2015 Feb;29(2):297-303. doi: 10.1038/leu.2014.205. Epub 2014 Jul 3.

14.

Transcriptome profiling of mice testes following low dose irradiation.

Belling KC, Tanaka M, Dalgaard MD, Nielsen JE, Nielsen HB, Brunak S, Almstrup K, Leffers H.

Reprod Biol Endocrinol. 2013 May 28;11:50. doi: 10.1186/1477-7827-11-50.

15.

Genome-wide assessment of the association of rare and common copy number variations to testicular germ cell cancer.

Edsgärd D, Dalgaard MD, Weinhold N, Wesolowska-Andersen A, Rajpert-De Meyts E, Ottesen AM, Juul A, Skakkebæk NE, Skøt Jensen T, Gupta R, Leffers H, Brunak S.

Front Endocrinol (Lausanne). 2013 Jan 29;4:2. doi: 10.3389/fendo.2013.00002. eCollection 2013.

16.

A genome-wide association study of men with symptoms of testicular dysgenesis syndrome and its network biology interpretation.

Dalgaard MD, Weinhold N, Edsgärd D, Silver JD, Pers TH, Nielsen JE, Jørgensen N, Juul A, Gerds TA, Giwercman A, Giwercman YL, Cohn-Cedermark G, Virtanen HE, Toppari J, Daugaard G, Jensen TS, Brunak S, Rajpert-De Meyts E, Skakkebæk NE, Leffers H, Gupta R.

J Med Genet. 2012 Jan;49(1):58-65. doi: 10.1136/jmedgenet-2011-100174. Epub 2011 Dec 3.

17.

Microdissection of gonadal tissues for gene expression analyses.

Jørgensen A, Dalgaard MD, Sonne SB.

Methods Mol Biol. 2011;755:307-13. doi: 10.1007/978-1-61779-163-5_26.

PMID:
21761315
18.

Cost-effective multiplexing before capture allows screening of 25 000 clinically relevant SNPs in childhood acute lymphoblastic leukemia.

Wesolowska A, Dalgaard MD, Borst L, Gautier L, Bak M, Weinhold N, Nielsen BF, Helt LR, Audouze K, Nersting J, Tommerup N, Brunak S, Sicheritz-Ponten T, Leffers H, Schmiegelow K, Gupta R.

Leukemia. 2011 Jun;25(6):1001-6. doi: 10.1038/leu.2011.32. Epub 2011 Mar 18.

PMID:
21415851
19.

OCT4 and downstream factors are expressed in human somatic urogenital epithelia and in culture of epididymal spheres.

Kristensen DM, Nielsen JE, Kalisz M, Dalgaard MD, Audouze K, Larsen ME, Jacobsen GK, Horn T, Brunak S, Skakkebaek NE, Leffers H.

Mol Hum Reprod. 2010 Nov;16(11):835-45. doi: 10.1093/molehr/gaq008. Epub 2010 Jan 31.

PMID:
20123703
20.

Optimizing staining protocols for laser microdissection of specific cell types from the testis including carcinoma in situ.

Sonne SB, Dalgaard MD, Nielsen JE, Hoei-Hansen CE, Rajpert-De Meyts E, Gjerdrum LM, Leffers H.

PLoS One. 2009;4(5):e5536. doi: 10.1371/journal.pone.0005536. Epub 2009 May 14.

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