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Items: 20


A divergent transcriptional landscape underpins the development and functional branching of MAIT cells.

Koay HF, Su S, Amann-Zalcenstein D, Daley SR, Comerford I, Miosge L, Whyte CE, Konstantinov IE, d'Udekem Y, Baldwin T, Hickey PF, Berzins SP, Mak JYW, Sontani Y, Roots CM, Sidwell T, Kallies A, Chen Z, Nüssing S, Kedzierska K, Mackay LK, McColl SR, Deenick EK, Fairlie DP, McCluskey J, Goodnow CC, Ritchie ME, Belz GT, Naik SH, Pellicci DG, Godfrey DI.

Sci Immunol. 2019 Nov 22;4(41). pii: eaay6039. doi: 10.1126/sciimmunol.aay6039.


Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity.

Zammit NW, Siggs OM, Gray PE, Horikawa K, Langley DB, Walters SN, Daley SR, Loetsch C, Warren J, Yap JY, Cultrone D, Russell A, Malle EK, Villanueva JE, Cowley MJ, Gayevskiy V, Dinger ME, Brink R, Zahra D, Chaudhri G, Karupiah G, Whittle B, Roots C, Bertram E, Yamada M, Jeelall Y, Enders A, Clifton BE, Mabbitt PD, Jackson CJ, Watson SR, Jenne CN, Lanier LL, Wiltshire T, Spitzer MH, Nolan GP, Schmitz F, Aderem A, Porebski BT, Buckle AM, Abbott DW, Ziegler JB, Craig ME, Benitez-Aguirre P, Teo J, Tangye SG, King C, Wong M, Cox MP, Phung W, Tang J, Sandoval W, Wertz IE, Christ D, Goodnow CC, Grey ST.

Nat Immunol. 2019 Oct;20(10):1299-1310. doi: 10.1038/s41590-019-0492-0. Epub 2019 Sep 18.


Cysteine and hydrophobic residues in CDR3 serve as distinct T-cell self-reactivity indices.

Daley SR, Koay HF, Dobbs K, Bosticardo M, Wirasinha RC, Pala F, Castagnoli R, Rowe JH, Ott de Bruin LM, Keles S, Lee YN, Somech R, Holland SM, Delmonte OM, Draper D, Maxwell S, Niemela J, Stoddard J, Rosenzweig SD, Poliani PL, Capo V, Villa A, Godfrey DI, Notarangelo LD.

J Allergy Clin Immunol. 2019 Jul;144(1):333-336. doi: 10.1016/j.jaci.2019.03.022. Epub 2019 Apr 30. No abstract available.


Deletion of self-reactive CCR7- thymocytes in the absence of MHC expression on thymic epithelial cells.

Wirasinha RC, Chan A, Yap JY, Hu DY, Teh CE, Gray DHD, Goodnow CC, Daley SR.

Cell Death Differ. 2019 Dec;26(12):2727-2739. doi: 10.1038/s41418-019-0331-8. Epub 2019 Apr 24.


αβ T-cell receptors with a central CDR3 cysteine are enriched in CD8αα intraepithelial lymphocytes and their thymic precursors.

Wirasinha RC, Singh M, Archer SK, Chan A, Harrison PF, Goodnow CC, Daley SR.

Immunol Cell Biol. 2018 Jul;96(6):553-561. doi: 10.1111/imcb.12047. Epub 2018 May 3.


Understanding the drivers of MHC restriction of T cell receptors.

La Gruta NL, Gras S, Daley SR, Thomas PG, Rossjohn J.

Nat Rev Immunol. 2018 Jul;18(7):467-478. doi: 10.1038/s41577-018-0007-5. Review.


Indirect presentation in the thymus limits naive and regulatory T-cell differentiation by promoting deletion of self-reactive thymocytes.

Yap JY, Wirasinha RC, Chan A, Howard DR, Goodnow CC, Daley SR.

Immunology. 2018 Jul;154(3):522-532. doi: 10.1111/imm.12904. Epub 2018 Feb 27.


Ocular antigen does not cause disease unless presented in the context of inflammation.

Voigt V, Wikstrom ME, Kezic JM, Schuster IS, Fleming P, Makinen K, Daley SR, Andoniou CE, Degli-Esposti MA, Forrester JV.

Sci Rep. 2017 Oct 27;7(1):14226. doi: 10.1038/s41598-017-14618-z.


Cell death and thymic tolerance.

Daley SR, Teh C, Hu DY, Strasser A, Gray DHD.

Immunol Rev. 2017 May;277(1):9-20. doi: 10.1111/imr.12532. Review.


IL-2 prevents deletion of developing T-regulatory cells in the thymus.

Hu DY, Wirasinha RC, Goodnow CC, Daley SR.

Cell Death Differ. 2017 Jun;24(6):1007-1016. doi: 10.1038/cdd.2017.38. Epub 2017 May 12.


A timeline demarcating two waves of clonal deletion and Foxp3 upregulation during thymocyte development.

Hu DY, Yap JY, Wirasinha RC, Howard DR, Goodnow CC, Daley SR.

Immunol Cell Biol. 2016 Apr;94(4):357-66. doi: 10.1038/icb.2015.95. Epub 2015 Oct 29.


MHCI and CD8 lineage commitment. Prolonged access to thymic epithelial MHCI seals CD8⁺ lineage commitment.

Daley SR.

Immunol Cell Biol. 2015 Apr;93(4):326-7. doi: 10.1038/icb.2015.28. Epub 2015 Mar 10. No abstract available.


Quantitative reduction of the TCR adapter protein SLP-76 unbalances immunity and immune regulation.

Siggs OM, Miosge LA, Daley SR, Asquith K, Foster PS, Liston A, Goodnow CC.

J Immunol. 2015 Mar 15;194(6):2587-95. doi: 10.4049/jimmunol.1400326. Epub 2015 Feb 6.


Ndfip1 mediates peripheral tolerance to self and exogenous antigen by inducing cell cycle exit in responding CD4+ T cells.

Altin JA, Daley SR, Howitt J, Rickards HJ, Batkin AK, Horikawa K, Prasad SJ, Nelms KA, Kumar S, Wu LC, Tan SS, Cook MC, Goodnow CC.

Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2067-74. doi: 10.1073/pnas.1322739111. Epub 2014 Jan 13.


Rasgrp1 mutation increases naive T-cell CD44 expression and drives mTOR-dependent accumulation of Helios⁺ T cells and autoantibodies.

Daley SR, Coakley KM, Hu DY, Randall KL, Jenne CN, Limnander A, Myers DR, Polakos NK, Enders A, Roots C, Balakishnan B, Miosge LA, Sjollema G, Bertram EM, Field MA, Shao Y, Andrews TD, Whittle B, Barnes SW, Walker JR, Cyster JG, Goodnow CC, Roose JP.

Elife. 2013 Dec 12;2:e01020. doi: 10.7554/eLife.01020.


Helios marks strongly autoreactive CD4+ T cells in two major waves of thymic deletion distinguished by induction of PD-1 or NF-κB.

Daley SR, Hu DY, Goodnow CC.

J Exp Med. 2013 Feb 11;210(2):269-85. doi: 10.1084/jem.20121458. Epub 2013 Jan 21.


Anti-islet autoantibodies trigger autoimmune diabetes in the presence of an increased frequency of islet-reactive CD4 T cells.

Silva DG, Daley SR, Hogan J, Lee SK, Teh CE, Hu DY, Lam KP, Goodnow CC, Vinuesa CG.

Diabetes. 2011 Aug;60(8):2102-11. doi: 10.2337/db10-1344.


T-cell regulation by casitas B-lineage lymphoma (Cblb) is a critical failsafe against autoimmune disease due to autoimmune regulator (Aire) deficiency.

Teh CE, Daley SR, Enders A, Goodnow CC.

Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14709-14. doi: 10.1073/pnas.1009209107. Epub 2010 Jul 28.


Fc-disabled anti-mouse CD40L antibodies retain efficacy in promoting transplantation tolerance.

Daley SR, Cobbold SP, Waldmann H.

Am J Transplant. 2008 Nov;8(11):2265-71. doi: 10.1111/j.1600-6143.2008.02382.x. Epub 2008 Sep 8.


A key role for TGF-beta signaling to T cells in the long-term acceptance of allografts.

Daley SR, Ma J, Adams E, Cobbold SP, Waldmann H.

J Immunol. 2007 Sep 15;179(6):3648-54.

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