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Items: 45

1.

Cell Permeable Stapled Peptide Inhibitor of Wnt Signaling that Targets β-Catenin Protein-Protein Interactions.

Dietrich L, Rathmer B, Ewan K, Bange T, Heinrichs S, Dale TC, Schade D, Grossmann TN.

Cell Chem Biol. 2017 Aug 17;24(8):958-968.e5. doi: 10.1016/j.chembiol.2017.06.013. Epub 2017 Jul 27.

2.

Assessing the mechanism and therapeutic potential of modulators of the human Mediator complex-associated protein kinases.

Clarke PA, Ortiz-Ruiz MJ, TePoele R, Adeniji-Popoola O, Box G, Court W, Czasch S, El Bawab S, Esdar C, Ewan K, Gowan S, De Haven Brandon A, Hewitt P, Hobbs SM, Kaufmann W, Mallinger A, Raynaud F, Roe T, Rohdich F, Schiemann K, Simon S, Schneider R, Valenti M, Weigt S, Blagg J, Blaukat A, Dale TC, Eccles SA, Hecht S, Urbahns K, Workman P, Wienke D.

Elife. 2016 Dec 9;5. pii: e20722. doi: 10.7554/eLife.20722.

3.

Wnt and Neuregulin1/ErbB signalling extends 3D culture of hormone responsive mammary organoids.

Jardé T, Lloyd-Lewis B, Thomas M, Kendrick H, Melchor L, Bougaret L, Watson PD, Ewan K, Smalley MJ, Dale TC.

Nat Commun. 2016 Oct 26;7:13207. doi: 10.1038/ncomms13207.

4.

A functional connectome: regulation of Wnt/TCF-dependent transcription by pairs of pathway activators.

Freeman J, Smith D, Latinkic B, Ewan K, Samuel L, Zollo M, Marino N, Tyas L, Jones N, Dale TC.

Mol Cancer. 2015 Dec 8;14:206. doi: 10.1186/s12943-015-0475-1.

5.

H-Prune through GSK-3β interaction sustains canonical WNT/β-catenin signaling enhancing cancer progression in NSCLC.

Carotenuto M, De Antonellis P, Liguori L, Benvenuto G, Magliulo D, Alonzi A, Turino C, Attanasio C, Damiani V, Bello AM, Vitiello F, Pasquinelli R, Terracciano L, Federico A, Fusco A, Freeman J, Dale TC, Decraene C, Chiappetta G, Piantedosi F, Calabrese C, Zollo M.

Oncotarget. 2014 Jul 30;5(14):5736-49.

6.

Huwe1-mediated ubiquitylation of dishevelled defines a negative feedback loop in the Wnt signaling pathway.

de Groot RE, Ganji RS, Bernatik O, Lloyd-Lewis B, Seipel K, Šedová K, Zdráhal Z, Dhople VM, Dale TC, Korswagen HC, Bryja V.

Sci Signal. 2014 Mar 18;7(317):ra26. doi: 10.1126/scisignal.2004985.

PMID:
24643799
7.

Toward a quantitative understanding of the Wnt/β-catenin pathway through simulation and experiment.

Lloyd-Lewis B, Fletcher AG, Dale TC, Byrne HM.

Wiley Interdiscip Rev Syst Biol Med. 2013 Jul-Aug;5(4):391-407. doi: 10.1002/wsbm.1221. Epub 2013 Mar 29.

PMID:
23554326
8.

Conditional disruption of Axin1 leads to development of liver tumors in mice.

Feng GJ, Cotta W, Wei XQ, Poetz O, Evans R, Jardé T, Reed K, Meniel V, Williams GT, Clarke AR, Dale TC.

Gastroenterology. 2012 Dec;143(6):1650-9. doi: 10.1053/j.gastro.2012.08.047. Epub 2012 Sep 6.

PMID:
22960659
9.

Evolutionary routes from a prebiotic ANA-world.

Braun S, Humphreys C, Dale TC.

Commun Integr Biol. 2012 Mar 1;5(2):199-202. doi: 10.4161/cib.18892.

10.

In vivo and in vitro models for the therapeutic targeting of Wnt signaling using a Tet-OΔN89β-catenin system.

Jardé T, Evans RJ, McQuillan KL, Parry L, Feng GJ, Alvares B, Clarke AR, Dale TC.

Oncogene. 2013 Feb 14;32(7):883-93. doi: 10.1038/onc.2012.103. Epub 2012 Apr 2.

11.

Amyloid-associated nucleic acid hybridisation.

Braun S, Humphreys C, Fraser E, Brancale A, Bochtler M, Dale TC.

PLoS One. 2011;6(5):e19125. doi: 10.1371/journal.pone.0019125. Epub 2011 May 19.

12.

The potential for targeting oncogenic WNT/beta-catenin signaling in therapy.

Ewan KB, Dale TC.

Curr Drug Targets. 2008 Jul;9(7):532-47. Review.

PMID:
18673239
13.

Deficiency of Mbd2 attenuates Wnt signaling.

Phesse TJ, Parry L, Reed KR, Ewan KB, Dale TC, Sansom OJ, Clarke AR.

Mol Cell Biol. 2008 Oct;28(19):6094-103. doi: 10.1128/MCB.00539-08. Epub 2008 Jul 21.

14.

Two functionally distinct Axin-like proteins regulate canonical Wnt signaling in C. elegans.

Oosterveen T, Coudreuse DY, Yang PT, Fraser E, Bergsma J, Dale TC, Korswagen HC.

Dev Biol. 2007 Aug 15;308(2):438-48. Epub 2007 Jun 6.

15.

Glycogen synthase kinase 3: a key regulator of cellular fate.

Forde JE, Dale TC.

Cell Mol Life Sci. 2007 Aug;64(15):1930-44. Review.

PMID:
17530463
16.

Dishevelled (Dvl-2) activates canonical Wnt signalling in the absence of cytoplasmic puncta.

Smalley MJ, Signoret N, Robertson D, Tilley A, Hann A, Ewan K, Ding Y, Paterson H, Dale TC.

J Cell Sci. 2005 Nov 15;118(Pt 22):5279-89. Epub 2005 Nov 1.

17.

Contribution of the ABC transporters Bcrp1 and Mdr1a/1b to the side population phenotype in mammary gland and bone marrow of mice.

Jonker JW, Freeman J, Bolscher E, Musters S, Alvi AJ, Titley I, Schinkel AH, Dale TC.

Stem Cells. 2005 Sep;23(8):1059-65. Epub 2005 Jul 7.

18.

The breast cancer resistance protein BCRP (ABCG2) concentrates drugs and carcinogenic xenotoxins into milk.

Jonker JW, Merino G, Musters S, van Herwaarden AE, Bolscher E, Wagenaar E, Mesman E, Dale TC, Schinkel AH.

Nat Med. 2005 Feb;11(2):127-9. Epub 2005 Jan 30.

19.

Protein kinase B/Akt acts via glycogen synthase kinase 3 to regulate recycling of alpha v beta 3 and alpha 5 beta 1 integrins.

Roberts MS, Woods AJ, Dale TC, Van Der Sluijs P, Norman JC.

Mol Cell Biol. 2004 Feb;24(4):1505-15.

20.
21.

Functional and molecular characterisation of mammary side population cells.

Alvi AJ, Clayton H, Joshi C, Enver T, Ashworth A, Vivanco Md, Dale TC, Smalley MJ.

Breast Cancer Res. 2003;5(1):R1-8. Epub 2002 Oct 14.

22.

Structural basis for recruitment of glycogen synthase kinase 3beta to the axin-APC scaffold complex.

Dajani R, Fraser E, Roe SM, Yeo M, Good VM, Thompson V, Dale TC, Pearl LH.

EMBO J. 2003 Feb 3;22(3):494-501.

23.

The regulation of glycogen synthase kinase-3 nuclear export by Frat/GBP.

Franca-Koh J, Yeo M, Fraser E, Young N, Dale TC.

J Biol Chem. 2002 Nov 15;277(46):43844-8. Epub 2002 Sep 9.

24.

Identification of the Axin and Frat binding region of glycogen synthase kinase-3.

Fraser E, Young N, Dajani R, Franca-Koh J, Ryves J, Williams RS, Yeo M, Webster MT, Richardson C, Smalley MJ, Pearl LH, Harwood A, Dale TC.

J Biol Chem. 2002 Jan 18;277(3):2176-85. Epub 2001 Nov 13.

25.

Wnt signaling and mammary tumorigenesis.

Smalley MJ, Dale TC.

J Mammary Gland Biol Neoplasia. 2001 Jan;6(1):37-52. Review.

PMID:
11467451
26.

Crystal structure of glycogen synthase kinase 3 beta: structural basis for phosphate-primed substrate specificity and autoinhibition.

Dajani R, Fraser E, Roe SM, Young N, Good V, Dale TC, Pearl LH.

Cell. 2001 Jun 15;105(6):721-32.

27.

A mutation in the Gsk3-binding domain of zebrafish Masterblind/Axin1 leads to a fate transformation of telencephalon and eyes to diencephalon.

Heisenberg CP, Houart C, Take-Uchi M, Rauch GJ, Young N, Coutinho P, Masai I, Caneparo L, Concha ML, Geisler R, Dale TC, Wilson SW, Stemple DL.

Genes Dev. 2001 Jun 1;15(11):1427-34.

28.

Sequence variants of the axin gene in breast, colon, and other cancers: an analysis of mutations that interfere with GSK3 binding.

Webster MT, Rozycka M, Sara E, Davis E, Smalley M, Young N, Dale TC, Wooster R.

Genes Chromosomes Cancer. 2000 Aug;28(4):443-53.

PMID:
10862053
29.

Retroviral expression of Wnt-1 and Wnt-7b produces different effects in mouse mammary epithelium.

Naylor S, Smalley MJ, Robertson D, Gusterson BA, Edwards PA, Dale TC.

J Cell Sci. 2000 Jun;113 ( Pt 12):2129-38.

30.

Wnt signalling in mammalian development and cancer.

Smalley MJ, Dale TC.

Cancer Metastasis Rev. 1999;18(2):215-30. Review.

PMID:
10728985
31.

Interaction of axin and Dvl-2 proteins regulates Dvl-2-stimulated TCF-dependent transcription.

Smalley MJ, Sara E, Paterson H, Naylor S, Cook D, Jayatilake H, Fryer LG, Hutchinson L, Fry MJ, Dale TC.

EMBO J. 1999 May 17;18(10):2823-35.

32.

Signal transduction by the Wnt family of ligands.

Dale TC.

Biochem J. 1998 Jan 15;329 ( Pt 2):209-23. Review.

33.

Compartment switching of WNT-2 expression in human breast tumors.

Dale TC, Weber-Hall SJ, Smith K, Huguet EL, Jayatilake H, Gusterson BA, Shuttleworth G, O'Hare M, Harris AL.

Cancer Res. 1996 Oct 1;56(19):4320-3.

34.

Wingless inactivates glycogen synthase kinase-3 via an intracellular signalling pathway which involves a protein kinase C.

Cook D, Fry MJ, Hughes K, Sumathipala R, Woodgett JR, Dale TC.

EMBO J. 1996 Sep 2;15(17):4526-36.

35.

Regulation of Msx-1, Msx-2, Bmp-2 and Bmp-4 during foetal and postnatal mammary gland development.

Phippard DJ, Weber-Hall SJ, Sharpe PT, Naylor MS, Jayatalake H, Maas R, Woo I, Roberts-Clark D, Francis-West PH, Liu YH, Maxson R, Hill RE, Dale TC.

Development. 1996 Sep;122(9):2729-37.

36.

Wnt-4 expression induces a pregnancy-like growth pattern in reconstituted mammary glands in virgin mice.

Bradbury JM, Edwards PA, Niemeyer CC, Dale TC.

Dev Biol. 1995 Aug;170(2):553-63.

37.

Expression patterns of the novel receptor-like tyrosine kinase, DDR, in human breast tumours.

Barker KT, Martindale JE, Mitchell PJ, Kamalati T, Page MJ, Phippard DJ, Dale TC, Gusterson BA, Crompton MR.

Oncogene. 1995 Feb 2;10(3):569-75.

PMID:
7845682
38.

Alterations of the growth characteristics of the fibroblast cell line C3H 10T1/2 by members of the Wnt gene family.

Bradbury JM, Niemeyer CC, Dale TC, Edwards PA.

Oncogene. 1994 Sep;9(9):2597-603.

PMID:
8058323
39.

Developmental and hormonal regulation of Wnt gene expression in the mouse mammary gland.

Weber-Hall SJ, Phippard DJ, Niemeyer CC, Dale TC.

Differentiation. 1994 Sep;57(3):205-14.

PMID:
7988795
40.

Localization and quantification of Wnt-2 gene expression in mouse mammary development.

Bühler TA, Dale TC, Kieback C, Humphreys RC, Rosen JM.

Dev Biol. 1993 Jan;155(1):87-96.

PMID:
8416847
41.

High-level expression of the rat whey acidic protein gene is mediated by elements in the promoter and 3' untranslated region.

Dale TC, Krnacik MJ, Schmidhauser C, Yang CL, Bissell MJ, Rosen JM.

Mol Cell Biol. 1992 Mar;12(3):905-14.

42.

Transcription factors induced by interferons alpha and gamma.

Imam AM, Ackrill AM, Dale TC, Kerr IM, Stark GR.

Nucleic Acids Res. 1990 Nov 25;18(22):6573-80.

43.

Overlapping sites for constitutive and induced DNA binding factors involved in interferon-stimulated transcription.

Dale TC, Rosen JM, Guille MJ, Lewin AR, Porter AG, Kerr IM, Stark GR.

EMBO J. 1989 Mar;8(3):831-9.

44.

Rapid activation by interferon alpha of a latent DNA-binding protein present in the cytoplasm of untreated cells.

Dale TC, Imam AM, Kerr IM, Stark GR.

Proc Natl Acad Sci U S A. 1989 Feb;86(4):1203-7.

45.

Interferon response element of the human gene 6-16.

Porter AC, Chernajovsky Y, Dale TC, Gilbert CS, Stark GR, Kerr IM.

EMBO J. 1988 Jan;7(1):85-92.

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