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A protocatechuate biosensor for Pseudomonas putida KT2440 via promoter and protein evolution.

Jha RK, Bingen JM, Johnson CW, Kern TL, Khanna P, Trettel DS, Strauss CEM, Beckham GT, Dale T.

Metab Eng Commun. 2018 Mar 7;6:33-38. doi: 10.1016/j.meteno.2018.03.001. eCollection 2018 Jun.


Total elbow arthroplasty in haemophilia.

Dale TM, Saucedo JM, Rodriguez-Merchan EC.

Haemophilia. 2018 Jul;24(4):548-556. doi: 10.1111/hae.13498. Epub 2018 Apr 30. Review.


Oregon Elks Children's Eye Clinic vision screening results for astigmatism.

Vaughan J, Dale T, Herrera D, Karr D.

J AAPOS. 2018 Jun;22(3):207-210. doi: 10.1016/j.jaapos.2018.01.012. Epub 2018 Apr 19.


Ectopic Telomerase Expression Fails to Maintain Chondrogenic Capacity in Three-Dimensional Cultures of Clinically Relevant Cell Types.

Dale TP, Forsyth NR.

Biores Open Access. 2018 Feb 1;7(1):10-24. doi: 10.1089/biores.2018.0008. eCollection 2018.


Acute lion's mane jellyfish, Cyanea capillata (Cnideria: Scyphozoa), exposure to Atlantic salmon (Salmo salar L.).

Powell MD, Åtland Å, Dale T.

J Fish Dis. 2018 May;41(5):751-759. doi: 10.1111/jfd.12771. Epub 2018 Jan 18.


Cell Permeable Stapled Peptide Inhibitor of Wnt Signaling that Targets β-Catenin Protein-Protein Interactions.

Dietrich L, Rathmer B, Ewan K, Bange T, Heinrichs S, Dale TC, Schade D, Grossmann TN.

Cell Chem Biol. 2017 Aug 17;24(8):958-968.e5. doi: 10.1016/j.chembiol.2017.06.013. Epub 2017 Jul 27.


Tenogenic Differentiation of Human Embryonic Stem Cells.

Dale TP, Mazher S, Webb WR, Zhou J, Maffulli N, Chen GQ, El Haj AJ, Forsyth NR.

Tissue Eng Part A. 2018 Mar;24(5-6):361-368. doi: 10.1089/ten.TEA.2017.0017. Epub 2017 Jul 7.


The role of the Hes1 crosstalk hub in Notch-Wnt interactions of the intestinal crypt.

Kay SK, Harrington HA, Shepherd S, Brennan K, Dale T, Osborne JM, Gavaghan DJ, Byrne HM.

PLoS Comput Biol. 2017 Feb 28;13(2):e1005400. doi: 10.1371/journal.pcbi.1005400. eCollection 2017 Feb.


Assessing the mechanism and therapeutic potential of modulators of the human Mediator complex-associated protein kinases.

Clarke PA, Ortiz-Ruiz MJ, TePoele R, Adeniji-Popoola O, Box G, Court W, Czasch S, El Bawab S, Esdar C, Ewan K, Gowan S, De Haven Brandon A, Hewitt P, Hobbs SM, Kaufmann W, Mallinger A, Raynaud F, Roe T, Rohdich F, Schiemann K, Simon S, Schneider R, Valenti M, Weigt S, Blagg J, Blaukat A, Dale TC, Eccles SA, Hecht S, Urbahns K, Workman P, Wienke D.

Elife. 2016 Dec 9;5. pii: e20722. doi: 10.7554/eLife.20722.


Pluripotent and Multipotent Stem Cells Display Distinct Hypoxic miRNA Expression Profiles.

Agrawal R, Dale TP, Al-Zubaidi MA, Benny Malgulwar P, Forsyth NR, Kulshreshtha R.

PLoS One. 2016 Oct 26;11(10):e0164976. doi: 10.1371/journal.pone.0164976. eCollection 2016.


Wnt and Neuregulin1/ErbB signalling extends 3D culture of hormone responsive mammary organoids.

Jardé T, Lloyd-Lewis B, Thomas M, Kendrick H, Melchor L, Bougaret L, Watson PD, Ewan K, Smalley MJ, Dale TC.

Nat Commun. 2016 Oct 26;7:13207. doi: 10.1038/ncomms13207.


Wnt signalling modulates transcribed-ultraconserved regions in hepatobiliary cancers.

Carotenuto P, Fassan M, Pandolfo R, Lampis A, Vicentini C, Cascione L, Paulus-Hock V, Boulter L, Guest R, Quagliata L, Hahne JC, Ridgway R, Jamieson T, Athineos D, Veronese A, Visone R, Murgia C, Ferrari G, Guzzardo V, Evans TRJ, MacLeod M, Feng GJ, Dale T, Negrini M, Forbes SJ, Terracciano L, Scarpa A, Patel T, Valeri N, Workman P, Sansom O, Braconi C.

Gut. 2017 Jul;66(7):1268-1277. doi: 10.1136/gutjnl-2016-312278. Epub 2016 Sep 12.


Structure-Based Optimization of Potent, Selective, and Orally Bioavailable CDK8 Inhibitors Discovered by High-Throughput Screening.

Czodrowski P, Mallinger A, Wienke D, Esdar C, Pöschke O, Busch M, Rohdich F, Eccles SA, Ortiz-Ruiz MJ, Schneider R, Raynaud FI, Clarke PA, Musil D, Schwarz D, Dale T, Urbahns K, Blagg J, Schiemann K.

J Med Chem. 2016 Oct 27;59(20):9337-9349. Epub 2016 Oct 7.


Situational awareness - what it means for clinicians, its recognition and importance in patient safety.

Green B, Parry D, Oeppen RS, Plint S, Dale T, Brennan PA.

Oral Dis. 2017 Sep;23(6):721-725. doi: 10.1111/odi.12547. Epub 2016 Aug 8. Review.


Discovery of Bioactive Metabolites in Biofuel Microalgae That Offer Protection against Predatory Bacteria.

Bagwell CE, Abernathy A, Barnwell R, Milliken CE, Noble PA, Dale T, Beauchesne KR, Moeller PD.

Front Microbiol. 2016 Apr 18;7:516. doi: 10.3389/fmicb.2016.00516. eCollection 2016.


Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19.

Mallinger A, Schiemann K, Rink C, Stieber F, Calderini M, Crumpler S, Stubbs M, Adeniji-Popoola O, Poeschke O, Busch M, Czodrowski P, Musil D, Schwarz D, Ortiz-Ruiz MJ, Schneider R, Thai C, Valenti M, de Haven Brandon A, Burke R, Workman P, Dale T, Wienke D, Clarke PA, Esdar C, Raynaud FI, Eccles SA, Rohdich F, Blagg J.

J Med Chem. 2016 Feb 11;59(3):1078-101. doi: 10.1021/acs.jmedchem.5b01685. Epub 2016 Jan 21.


A functional connectome: regulation of Wnt/TCF-dependent transcription by pairs of pathway activators.

Freeman J, Smith D, Latinkic B, Ewan K, Samuel L, Zollo M, Marino N, Tyas L, Jones N, Dale TC.

Mol Cancer. 2015 Dec 8;14:206. doi: 10.1186/s12943-015-0475-1.


Self-renewal of human embryonic stem cells on defined synthetic electrospun nanofibers.

Kumar D, Dale TP, Yang Y, Forsyth NR.

Biomed Mater. 2015 Nov 27;10(6):065017. doi: 10.1088/1748-6041/10/6/065017.


A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease.

Dale T, Clarke PA, Esdar C, Waalboer D, Adeniji-Popoola O, Ortiz-Ruiz MJ, Mallinger A, Samant RS, Czodrowski P, Musil D, Schwarz D, Schneider K, Stubbs M, Ewan K, Fraser E, TePoele R, Court W, Box G, Valenti M, de Haven Brandon A, Gowan S, Rohdich F, Raynaud F, Schneider R, Poeschke O, Blaukat A, Workman P, Schiemann K, Eccles SA, Wienke D, Blagg J.

Nat Chem Biol. 2015 Dec;11(12):973-980. doi: 10.1038/nchembio.1952. Epub 2015 Oct 26.


Hemophilic arthropathy of the elbow: prophylaxis, imaging, and the role of invasive management.

Dale TM, Saucedo JM, Rodríguez-Merchán EC.

J Shoulder Elbow Surg. 2015 Oct;24(10):1669-78. doi: 10.1016/j.jse.2015.06.018. Review.


Immortalisation with hTERT Impacts on Sulphated Glycosaminoglycan Secretion and Immunophenotype in a Variable and Cell Specific Manner.

Dale TP, de Castro A, Kuiper NJ, Parkinson EK, Forsyth NR.

PLoS One. 2015 Jul 21;10(7):e0133745. doi: 10.1371/journal.pone.0133745. eCollection 2015.


Tunable Riboregulator Switches for Post-transcriptional Control of Gene Expression.

Krishnamurthy M, Hennelly SP, Dale T, Starkenburg SR, Martí-Arbona R, Fox DT, Twary SN, Sanbonmatsu KY, Unkefer CJ.

ACS Synth Biol. 2015 Dec 18;4(12):1326-34. doi: 10.1021/acssynbio.5b00041. Epub 2015 Jul 27.


Side errors in neurosurgery and human factors training.

Mitchell P, Dale T.

Acta Neurochir (Wien). 2015 Jul;157(7):1155-6; discussion 1156. doi: 10.1007/s00701-015-2419-3. Epub 2015 May 2. No abstract available.


BMP2 repression and optimized culture conditions promote human bone marrow-derived mesenchymal stem cell isolation.

Kay AG, Dale TP, Akram KM, Mohan P, Hampson K, Maffulli N, Spiteri MA, El Haj AJ, Forsyth NR.

Regen Med. 2015;10(2):109-25. doi: 10.2217/rme.14.67.


Discovery of potent, orally bioavailable, small-molecule inhibitors of WNT signaling from a cell-based pathway screen.

Mallinger A, Crumpler S, Pichowicz M, Waalboer D, Stubbs M, Adeniji-Popoola O, Wood B, Smith E, Thai C, Henley AT, Georgi K, Court W, Hobbs S, Box G, Ortiz-Ruiz MJ, Valenti M, De Haven Brandon A, TePoele R, Leuthner B, Workman P, Aherne W, Poeschke O, Dale T, Wienke D, Esdar C, Rohdich F, Raynaud F, Clarke PA, Eccles SA, Stieber F, Schiemann K, Blagg J.

J Med Chem. 2015 Feb 26;58(4):1717-35. doi: 10.1021/jm501436m. Epub 2015 Feb 13.


A High-Throughput Electrophysiology Assay Identifies Inhibitors of the Inwardly Rectifying Potassium Channel Kir7.1.

Wright PD, Kanumilli S, Tickle D, Cartland J, Bouloc N, Dale T, Tresize DJ, McCloskey C, McCavera S, Blanks AM, Kettleborough C, Jerman JC.

J Biomol Screen. 2015 Jul;20(6):739-47. doi: 10.1177/1087057115569156. Epub 2015 Feb 5.


European red squirrel population dynamics driven by squirrelpox at a gray squirrel invasion interface.

Chantrey J, Dale TD, Read JM, White S, Whitfield F, Jones D, McInnes CJ, Begon M.

Ecol Evol. 2014 Oct;4(19):3788-99. doi: 10.1002/ece3.1216. Epub 2014 Sep 11.


Side errors in neurosurgery and human factors training.

Mitchell P, Dale T.

Acta Neurochir (Wien). 2015 Mar;157(3):487-91. doi: 10.1007/s00701-014-2326-z. Epub 2015 Jan 15.


WNT-3A regulates an Axin1/NRF2 complex that regulates antioxidant metabolism in hepatocytes.

Rada P, Rojo AI, Offergeld A, Feng GJ, Velasco-Martín JP, González-Sancho JM, Valverde ÁM, Dale T, Regadera J, Cuadrado A.

Antioxid Redox Signal. 2015 Mar 1;22(7):555-71. doi: 10.1089/ars.2014.6040. Epub 2014 Dec 9.


Rapid scavenging of jellyfish carcasses reveals the importance of gelatinous material to deep-sea food webs.

Sweetman AK, Smith CR, Dale T, Jones DO.

Proc Biol Sci. 2014 Dec 7;281(1796):20142210. doi: 10.1098/rspb.2014.2210.


The inwardly rectifying K+ channel KIR7.1 controls uterine excitability throughout pregnancy.

McCloskey C, Rada C, Bailey E, McCavera S, van den Berg HA, Atia J, Rand DA, Shmygol A, Chan YW, Quenby S, Brosens JJ, Vatish M, Zhang J, Denton JS, Taggart MJ, Kettleborough C, Tickle D, Jerman J, Wright P, Dale T, Kanumilli S, Trezise DJ, Thornton S, Brown P, Catalano R, Lin N, England SK, Blanks AM.

EMBO Mol Med. 2014 Sep;6(9):1161-74. doi: 10.15252/emmm.201403944.


H-Prune through GSK-3β interaction sustains canonical WNT/β-catenin signaling enhancing cancer progression in NSCLC.

Carotenuto M, De Antonellis P, Liguori L, Benvenuto G, Magliulo D, Alonzi A, Turino C, Attanasio C, Damiani V, Bello AM, Vitiello F, Pasquinelli R, Terracciano L, Federico A, Fusco A, Freeman J, Dale TC, Decraene C, Chiappetta G, Piantedosi F, Calabrese C, Zollo M.

Oncotarget. 2014 Jul 30;5(14):5736-49.


Huwe1-mediated ubiquitylation of dishevelled defines a negative feedback loop in the Wnt signaling pathway.

de Groot RE, Ganji RS, Bernatik O, Lloyd-Lewis B, Seipel K, Šedová K, Zdráhal Z, Dhople VM, Dale TC, Korswagen HC, Bryja V.

Sci Signal. 2014 Mar 18;7(317):ra26. doi: 10.1126/scisignal.2004985.


The novel alkylating prodrug melflufen (J1) inhibits angiogenesis in vitro and in vivo.

Strese S, Wickström M, Fuchs PF, Fryknäs M, Gerwins P, Dale T, Larsson R, Gullbo J.

Biochem Pharmacol. 2013 Oct 1;86(7):888-95. doi: 10.1016/j.bcp.2013.07.026. Epub 2013 Aug 8.


The application of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) scaffolds for tendon repair in the rat model.

Webb WR, Dale TP, Lomas AJ, Zeng G, Wimpenny I, El Haj AJ, Forsyth NR, Chen GQ.

Biomaterials. 2013 Sep;34(28):6683-94. doi: 10.1016/j.biomaterials.2013.05.041. Epub 2013 Jun 13.


Experience of head and neck theatre staff and attitudes to human factors using an aviation-based analysis and classification system--a pilot survey.

Konieczny KM, Seager L, Scott J, Colbert S, Dale T, Brennan PA.

Br J Oral Maxillofac Surg. 2014 Jan;52(1):38-42. doi: 10.1016/j.bjoms.2013.04.005. Epub 2013 May 2.


Toward a quantitative understanding of the Wnt/β-catenin pathway through simulation and experiment.

Lloyd-Lewis B, Fletcher AG, Dale TC, Byrne HM.

Wiley Interdiscip Rev Syst Biol Med. 2013 Jul-Aug;5(4):391-407. doi: 10.1002/wsbm.1221. Epub 2013 Mar 29.


Caring about sharing.

Blount C, Dale T, Darbyshire E, Nagee L, McLellan A.

Health Serv J. 2013 Jan 24;123(6336):19-22. No abstract available.


Catalytic detoxification of nerve agent and pesticide organophosphates by butyrylcholinesterase assisted with non-pyridinium oximes.

Radić Z, Dale T, Kovarik Z, Berend S, Garcia E, Zhang L, Amitai G, Green C, Radić B, Duggan BM, Ajami D, Rebek J, Taylor P.

Biochem J. 2013 Feb 15;450(1):231-42. doi: 10.1042/BJ20121612.


Conditional disruption of Axin1 leads to development of liver tumors in mice.

Feng GJ, Cotta W, Wei XQ, Poetz O, Evans R, Jardé T, Reed K, Meniel V, Williams GT, Clarke AR, Dale TC.

Gastroenterology. 2012 Dec;143(6):1650-9. doi: 10.1053/j.gastro.2012.08.047. Epub 2012 Sep 6.


Evolutionary routes from a prebiotic ANA-world.

Braun S, Humphreys C, Dale TC.

Commun Integr Biol. 2012 Mar 1;5(2):199-202. doi: 10.4161/cib.18892.


Performing to a world class standard under pressure--can we learn lessons from the Olympians?

Colbert SD, Scott J, Dale T, Brennan PA.

Br J Oral Maxillofac Surg. 2012 Jun;50(4):291-7. doi: 10.1016/j.bjoms.2012.04.263.


In vivo and in vitro models for the therapeutic targeting of Wnt signaling using a Tet-OΔN89β-catenin system.

Jardé T, Evans RJ, McQuillan KL, Parry L, Feng GJ, Alvares B, Clarke AR, Dale TC.

Oncogene. 2013 Feb 14;32(7):883-93. doi: 10.1038/onc.2012.103. Epub 2012 Apr 2.


Doing more with less: a method for low total mass, affinity measurement using variable-length nanotethers.

Perrins RD, Orchard C, Zavodszky M, Kasry A, Nikolaev N, Harwood A, Borri P, Dale T.

Anal Chem. 2011 Dec 1;83(23):8900-5. doi: 10.1021/ac2012569. Epub 2011 Nov 8.


Intestinal renin-angiotensin system is stimulated after deletion of Lkb1.

Shorning BY, Jardé T, McCarthy A, Ashworth A, de Leng WW, Offerhaus GJ, Resta N, Dale T, Clarke AR.

Gut. 2012 Feb;61(2):202-13. doi: 10.1136/gutjnl-2011-300046. Epub 2011 Aug 3.


Amyloid-associated nucleic acid hybridisation.

Braun S, Humphreys C, Fraser E, Brancale A, Bochtler M, Dale TC.

PLoS One. 2011;6(5):e19125. doi: 10.1371/journal.pone.0019125. Epub 2011 May 19.


Human factors and error prevention in emergency medicine.

Bleetman A, Sanusi S, Dale T, Brace S.

Emerg Med J. 2012 May;29(5):389-93. doi: 10.1136/emj.2010.107698. Epub 2011 May 12. Review.


Wnt signalling in murine postnatal mammary gland development.

Jardé T, Dale T.

Acta Physiol (Oxf). 2012 Jan;204(1):118-27. doi: 10.1111/j.1748-1716.2011.02283.x. Epub 2011 Apr 22. Review.


Cyclopropenylidene carbene ligands in palladium catalysed coupling reactions: carbene ligand rotation and application to the Stille reaction.

Chotima R, Dale T, Green M, Hey TW, McMullin CL, Nunns A, Orpen AG, Shishkov IV, Wass DF, Wingad RL.

Dalton Trans. 2011 May 21;40(19):5316-23. doi: 10.1039/c1dt10109a. Epub 2011 Apr 7.


Vibrational spectroscopy differentiates between multipotent and pluripotent stem cells.

Pijanka JK, Kumar D, Dale T, Yousef I, Parkes G, Untereiner V, Yang Y, Dumas P, Collins D, Manfait M, Sockalingum GD, Forsyth NR, Sulé-Suso J.

Analyst. 2010 Dec;135(12):3126-32. doi: 10.1039/c0an00525h. Epub 2010 Oct 18.


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