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Items: 1 to 50 of 54

1.

Susceptibility of Pseudomonas aeruginosa Recovered from Cystic Fibrosis Patients to Murepavadin and 13 Comparator Antibiotics.

Ekkelenkamp MB, Cantón R, Díez-Aguilar M, Tunney MM, Gilpin DF, Bernardini F, Dale GE, Elborn JS, Bayjanov JR, Fluit A.

Antimicrob Agents Chemother. 2020 Jan 27;64(2). pii: e01541-19. doi: 10.1128/AAC.01541-19. Print 2020 Jan 27.

PMID:
31767727
2.

Author Correction: Chimeric peptidomimetic antibiotics against Gram-negative bacteria.

Luther A, Urfer M, Zahn M, Müller M, Wang SY, Mondal M, Vitale A, Hartmann JB, Sharpe T, Monte FL, Kocherla H, Cline E, Pessi G, Rath P, Modaresi SM, Chiquet P, Stiegeler S, Verbree C, Remus T, Schmitt M, Kolopp C, Westwood MA, Desjonquères N, Brabet E, Hell S, LePoupon K, Vermeulen A, Jaisson R, Rithié V, Upert G, Lederer A, Zbinden P, Wach A, Moehle K, Zerbe K, Locher HH, Bernardini F, Dale GE, Eberl L, Wollscheid B, Hiller S, Robinson JA, Obrecht D.

Nature. 2019 Dec;576(7786):E5. doi: 10.1038/s41586-019-1810-2.

PMID:
31758154
3.

Chimeric peptidomimetic antibiotics against Gram-negative bacteria.

Luther A, Urfer M, Zahn M, Müller M, Wang SY, Mondal M, Vitale A, Hartmann JB, Sharpe T, Monte FL, Kocherla H, Cline E, Pessi G, Rath P, Modaresi SM, Chiquet P, Stiegeler S, Verbree C, Remus T, Schmitt M, Kolopp C, Westwood MA, Desjonquères N, Brabet E, Hell S, LePoupon K, Vermeulen A, Jaisson R, Rithié V, Upert G, Lederer A, Zbinden P, Wach A, Moehle K, Zerbe K, Locher HH, Bernardini F, Dale GE, Eberl L, Wollscheid B, Hiller S, Robinson JA, Obrecht D.

Nature. 2019 Dec;576(7787):452-458. doi: 10.1038/s41586-019-1665-6. Epub 2019 Oct 23. Erratum in: Nature. 2019 Nov 23;:.

PMID:
31645764
4.

Pharmacokinetic-Pharmacodynamic Evaluation of Ertapenem for Patients with Hospital-Acquired or Ventilator-Associated Bacterial Pneumonia.

Bader JC, Lakota EA, Dale GE, Sader HS, Rex JH, Ambrose PG, Bhavnani SM.

Antimicrob Agents Chemother. 2019 May 24;63(6). pii: e00318-19. doi: 10.1128/AAC.00318-19. Print 2019 Jun.

5.

Pharmacokinetics and Pharmacodynamics of Murepavadin in Neutropenic Mouse Models.

Melchers MJ, Teague J, Warn P, Hansen J, Bernardini F, Wach A, Obrecht D, Dale GE, Mouton JW.

Antimicrob Agents Chemother. 2019 Feb 26;63(3). pii: e01699-18. doi: 10.1128/AAC.01699-18. Print 2019 Mar.

6.

Pharmacokinetics, Tolerability, and Safety of Murepavadin, a Novel Antipseudomonal Antibiotic, in Subjects with Mild, Moderate, or Severe Renal Function Impairment.

Dale GE, Halabi A, Petersen-Sylla M, Wach A, Zwingelstein C.

Antimicrob Agents Chemother. 2018 Aug 27;62(9). pii: e00490-18. doi: 10.1128/AAC.00490-18. Print 2018 Sep.

7.

Murepavadin activity tested against contemporary (2016-17) clinical isolates of XDR Pseudomonas aeruginosa.

Sader HS, Flamm RK, Dale GE, Rhomberg PR, Castanheira M.

J Antimicrob Chemother. 2018 Sep 1;73(9):2400-2404. doi: 10.1093/jac/dky227.

PMID:
29901750
8.

Antimicrobial Activity of Murepavadin Tested against Clinical Isolates of Pseudomonas aeruginosa from the United States, Europe, and China.

Sader HS, Dale GE, Rhomberg PR, Flamm RK.

Antimicrob Agents Chemother. 2018 Jun 26;62(7). pii: e00311-18. doi: 10.1128/AAC.00311-18. Print 2018 Jul.

9.

Murepavadin: a new antibiotic class in the pipeline.

Martin-Loeches I, Dale GE, Torres A.

Expert Rev Anti Infect Ther. 2018 Apr;16(4):259-268. doi: 10.1080/14787210.2018.1441024. Epub 2018 Feb 21.

PMID:
29451043
10.

Pharmacokinetics and Safety of Intravenous Murepavadin Infusion in Healthy Adult Subjects Administered Single and Multiple Ascending Doses.

Wach A, Dembowsky K, Dale GE.

Antimicrob Agents Chemother. 2018 Mar 27;62(4). pii: e02355-17. doi: 10.1128/AAC.02355-17. Print 2018 Apr.

11.

The Role of Neutrophil Elastase Inhibitors in Lung Diseases.

Polverino E, Rosales-Mayor E, Dale GE, Dembowsky K, Torres A.

Chest. 2017 Aug;152(2):249-262. doi: 10.1016/j.chest.2017.03.056. Epub 2017 Apr 23. Review.

PMID:
28442313
12.

Efficacy of the Novel Antibiotic POL7001 in Preclinical Models of Pseudomonas aeruginosa Pneumonia.

Cigana C, Bernardini F, Facchini M, Alcalá-Franco B, Riva C, De Fino I, Rossi A, Ranucci S, Misson P, Chevalier E, Brodmann M, Schmitt M, Wach A, Dale GE, Obrecht D, Bragonzi A.

Antimicrob Agents Chemother. 2016 Jul 22;60(8):4991-5000. doi: 10.1128/AAC.00390-16. Print 2016 Aug.

13.

Measurement of the internal stress and electric field in a resonating piezoelectric transformer for high-voltage applications using the electro-optic and photoelastic effects.

VanGordon JA, Kovaleski SD, Norgard P, Gall BB, Dale GE.

Rev Sci Instrum. 2014 Feb;85(2):023101. doi: 10.1063/1.4864052.

PMID:
24593343
14.

Inhibitory properties and X-ray crystallographic study of the binding of AR-101, AR-102 and iclaprim in ternary complexes with NADPH and dihydrofolate reductase from Staphylococcus aureus.

Oefner C, Parisi S, Schulz H, Lociuro S, Dale GE.

Acta Crystallogr D Biol Crystallogr. 2009 Aug;65(Pt 8):751-7. doi: 10.1107/S0907444909013936. Epub 2009 Jul 10.

PMID:
19622858
15.

Increased hydrophobic interactions of iclaprim with Staphylococcus aureus dihydrofolate reductase are responsible for the increase in affinity and antibacterial activity.

Oefner C, Bandera M, Haldimann A, Laue H, Schulz H, Mukhija S, Parisi S, Weiss L, Lociuro S, Dale GE.

J Antimicrob Chemother. 2009 Apr;63(4):687-98. doi: 10.1093/jac/dkp024. Epub 2009 Feb 11.

PMID:
19211577
16.

Structure of human endothelin-converting enzyme I complexed with phosphoramidon.

Schulz H, Dale GE, Karimi-Nejad Y, Oefner C.

J Mol Biol. 2009 Jan 9;385(1):178-87. doi: 10.1016/j.jmb.2008.10.052. Epub 2008 Nov 1.

PMID:
18992253
17.

Structural studies of a bifunctional inhibitor of neprilysin and DPP-IV.

Oefner C, Pierau S, Schulz H, Dale GE.

Acta Crystallogr D Biol Crystallogr. 2007 Sep;63(Pt 9):975-81. Epub 2007 Aug 17.

PMID:
17704566
18.

Mapping the active site of Escherichia coli malonyl-CoA-acyl carrier protein transacylase (FabD) by protein crystallography.

Oefner C, Schulz H, D'Arcy A, Dale GE.

Acta Crystallogr D Biol Crystallogr. 2006 Jun;62(Pt 6):613-8. Epub 2006 May 12.

PMID:
16699188
19.
20.

Opening the bottlenecks.

Dale GE.

Drug Discov Today. 2004 Sep 15;9(18):783-4. No abstract available.

PMID:
15364065
21.

Crystal structures of Staphylococcusaureus methionine aminopeptidase complexed with keto heterocycle and aminoketone inhibitors reveal the formation of a tetrahedral intermediate.

Douangamath A, Dale GE, D'Arcy A, Almstetter M, Eckl R, Frutos-Hoener A, Henkel B, Illgen K, Nerdinger S, Schulz H, Mac Sweeney A, Thormann M, Treml A, Pierau S, Wadman S, Oefner C.

J Med Chem. 2004 Mar 11;47(6):1325-8. Erratum in: J Med Chem. 2005 Jan 13;48(1):336. MacSweeney, Aengus [changed to Mac Sweeney, Aengus.

PMID:
14998322
22.

Structural analysis of neprilysin with various specific and potent inhibitors.

Oefner C, Roques BP, Fournie-Zaluski MC, Dale GE.

Acta Crystallogr D Biol Crystallogr. 2004 Feb;60(Pt 2):392-6. Epub 2004 Jan 23.

PMID:
14747736
23.

The 1.15A crystal structure of the Staphylococcus aureus methionyl-aminopeptidase and complexes with triazole based inhibitors.

Oefner C, Douangamath A, D'Arcy A, Häfeli S, Mareque D, Mac Sweeney A, Padilla J, Pierau S, Schulz H, Thormann M, Wadman S, Dale GE.

J Mol Biol. 2003 Sep 5;332(1):13-21.

PMID:
12946343
24.

A continuous coupled enzyme assay for bacterial malonyl-CoA:acyl carrier protein transacylase (FabD).

Molnos J, Gardiner R, Dale GE, Lange R.

Anal Biochem. 2003 Aug 1;319(1):171-6.

PMID:
12842120
25.

High-resolution structure of human apo dipeptidyl peptidase IV/CD26 and its complex with 1-[([2-[(5-iodopyridin-2-yl)amino]-ethyl]amino)-acetyl]-2-cyano-(S)-pyrrolidine.

Oefner C, D'Arcy A, Mac Sweeney A, Pierau S, Gardiner R, Dale GE.

Acta Crystallogr D Biol Crystallogr. 2003 Jul;59(Pt 7):1206-12. Epub 2003 Jun 27.

PMID:
12832764
26.

The protein as a variable in protein crystallization.

Dale GE, Oefner C, D'Arcy A.

J Struct Biol. 2003 Apr;142(1):88-97. Review.

PMID:
12718922
27.

Specialized osmotic stress response systems involve multiple SigB-like sigma factors in Streptomyces coelicolor.

Viollier PH, Kelemen GH, Dale GE, Nguyen KT, Buttner MJ, Thompson CJ.

Mol Microbiol. 2003 Feb;47(3):699-714.

28.

X-ray structure of junctional adhesion molecule: structural basis for homophilic adhesion via a novel dimerization motif.

Kostrewa D, Brockhaus M, D'Arcy A, Dale GE, Nelboeck P, Schmid G, Mueller F, Bazzoni G, Dejana E, Bartfai T, Winkler FK, Hennig M.

EMBO J. 2001 Aug 15;20(16):4391-8.

29.
30.

Roles of aconitase in growth, metabolism, and morphological differentiation of Streptomyces coelicolor.

Viollier PH, Nguyen KT, Minas W, Folcher M, Dale GE, Thompson CJ.

J Bacteriol. 2001 May;183(10):3193-203.

31.

Role of acid metabolism in Streptomyces coelicolor morphological differentiation and antibiotic biosynthesis.

Viollier PH, Minas W, Dale GE, Folcher M, Thompson CJ.

J Bacteriol. 2001 May;183(10):3184-92.

32.

Purification and crystallization of the extracellular domain of human neutral endopeptidase (neprilysin) expressed in Pichia pastoris.

Dale GE, D'Arcy B, Yuvaniyama C, Wipf B, Oefner C, D'Arcy A.

Acta Crystallogr D Biol Crystallogr. 2000 Jul;56(Pt 7):894-7.

PMID:
10930836
33.

A vibrational structure of 7,8-dihydrobiopterin bound to dihydroneopterin aldolase.

Deng H, Callender R, Dale GE.

J Biol Chem. 2000 Sep 29;275(39):30139-43.

34.

Structure of human neutral endopeptidase (Neprilysin) complexed with phosphoramidon.

Oefner C, D'Arcy A, Hennig M, Winkler FK, Dale GE.

J Mol Biol. 2000 Feb 18;296(2):341-9.

PMID:
10669592
35.

Crystal engineering: deletion mutagenesis of the 24 kDa fragment of the DNA gyrase B subunit from Staphylococcus aureus.

Dale GE, Kostrewa D, Gsell B, Stieger M, D'Arcy A.

Acta Crystallogr D Biol Crystallogr. 1999 Sep;55(Pt 9):1626-9.

PMID:
10489469
36.

The structure and function of the 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Haemophilus influenzae.

Hennig M, Dale GE, D'arcy A, Danel F, Fischer S, Gray CP, Jolidon S, Müller F, Page MG, Pattison P, Oefner C.

J Mol Biol. 1999 Mar 26;287(2):211-9.

PMID:
10080886
37.

Crystal structure and reaction mechanism of 7,8-dihydroneopterin aldolase from Staphylococcus aureus.

Hennig M, D'Arcy A, Hampele IC, Page MG, Oefner C, Dale GE.

Nat Struct Biol. 1998 May;5(5):357-62.

PMID:
9586996
38.

Structure and function of the dihydropteroate synthase from Staphylococcus aureus.

Hampele IC, D'Arcy A, Dale GE, Kostrewa D, Nielsen J, Oefner C, Page MG, Schönfeld HJ, Stüber D, Then RL.

J Mol Biol. 1997 Apr 25;268(1):21-30.

PMID:
9149138
39.

A single amino acid substitution in Staphylococcus aureus dihydrofolate reductase determines trimethoprim resistance.

Dale GE, Broger C, D'Arcy A, Hartman PG, DeHoogt R, Jolidon S, Kompis I, Labhardt AM, Langen H, Locher H, Page MG, Stüber D, Then RL, Wipf B, Oefner C.

J Mol Biol. 1997 Feb 14;266(1):23-30.

PMID:
9054967
40.
42.
44.
46.

Relationships between Lewy bodies and pale bodies in Parkinson's disease.

Dale GE, Probst A, Luthert P, Martin J, Anderton BH, Leigh PN.

Acta Neuropathol. 1992;83(5):525-9.

PMID:
1320323
47.

Stress protein inclusions in cerebral vessels in dialysis encephalopathy.

Martin JE, Mather K, Swash M, Dodd SM, Dale GE, Garofalo O, Leigh PN.

Neuropathol Appl Neurobiol. 1991 Apr;17(2):105-11.

PMID:
1649977
48.

Neurofibrillary tangles in dementia pugilistica are ubiquitinated.

Dale GE, Leigh PN, Luthert P, Anderton BH, Roberts GW.

J Neurol Neurosurg Psychiatry. 1991 Feb;54(2):116-8.

49.

Spinal cord trauma in man: studies of phosphorylated neurofilament and ubiquitin expression.

Martin JE, Mather KS, Swash M, Garofalo O, Dale GE, Leigh PN, Anderton BH.

Brain. 1990 Oct;113 ( Pt 5):1553-62.

PMID:
1700924
50.

Microdissection: a novel method for the study of intracellular inclusion bodies.

Martin JE, Swash M, Mather K, Garofalo O, Dale GE, Leigh PN, Anderton BH.

J Pathol. 1990 Jan;160(1):77-9.

PMID:
2156038

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