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Items: 44


Amine oxidase 3 is a novel pro-inflammatory marker of oxidative stress in peritoneal endometriosis lesions.

Thézénas ML, De Leo B, Laux-Biehlmann A, Bafligil C, Elger B, Tapmeier T, Morten K, Rahmioglu N, Dakin SG, Charles P, Martinez FE, Steers G, Fischer OM, Mueller J, Hess-Stumpp H, Steinmeyer A, Manek S, Zondervan KT, Kennedy S, Becker CM, Shang C, Zollner TM, Kessler BM, Oppermann U.

Sci Rep. 2020 Jan 30;10(1):1495. doi: 10.1038/s41598-020-58362-3.


ERK1/2 drives IL-1β-induced expression of TGF-β1 and BMP-2 in torn tendons.

Morita W, Snelling SJB, Wheway K, Watkins B, Appleton L, Carr AJ, Dakin SG.

Sci Rep. 2019 Dec 12;9(1):19005. doi: 10.1038/s41598-019-55387-1.


Proresolving Mediators LXB4 and RvE1 Regulate Inflammation in Stromal Cells from Patients with Shoulder Tendon Tears.

Dakin SG, Colas RA, Wheway K, Watkins B, Appleton L, Rees J, Gwilym S, Little C, Dalli J, Carr AJ.

Am J Pathol. 2019 Nov;189(11):2258-2268. doi: 10.1016/j.ajpath.2019.07.011. Epub 2019 Aug 19.


Antibiotic treatment and flares of rheumatoid arthritis: a self-controlled case series study analysis using CPRD GOLD.

Nagra NS, Robinson DE, Douglas I, Delmestri A, Dakin SG, Snelling SJB, Carr AJ, Prieto-Alhambra D.

Sci Rep. 2019 Jun 20;9(1):8941. doi: 10.1038/s41598-019-45435-1.


15-Epi-LXA4 and MaR1 counter inflammation in stromal cells from patients with Achilles tendinopathy and rupture.

Dakin SG, Colas RA, Newton J, Gwilym S, Jones N, Reid HAB, Wood S, Appleton L, Wheway K, Watkins B, Dalli J, Carr AJ.

FASEB J. 2019 Jul;33(7):8043-8054. doi: 10.1096/fj.201900196R. Epub 2019 Mar 27.


Divergent roles of prostacyclin and PGE2 in human tendinopathy.

Bergqvist F, Carr AJ, Wheway K, Watkins B, Oppermann U, Jakobsson PJ, Dakin SG.

Arthritis Res Ther. 2019 Mar 13;21(1):74. doi: 10.1186/s13075-019-1855-5.


Tissue inflammation signatures point towards resolution in adhesive capsulitis.

Dakin SG, Rangan A, Martinez F, Brealey S, Northgraves M, Kottam L, Cooper C, Buckley CD, Carr AJ.

Rheumatology (Oxford). 2019 Jun 1;58(6):1109-1111. doi: 10.1093/rheumatology/kez007. No abstract available.


Author Correction: Pathogenic stromal cells as therapeutic targets in joint inflammation.

Dakin SG, Coles M, Sherlock JP, Powrie F, Carr AJ, Buckley CD.

Nat Rev Rheumatol. 2019 Jan;15(1):61. doi: 10.1038/s41584-018-0134-1.


Pathogenic stromal cells as therapeutic targets in joint inflammation.

Dakin SG, Coles M, Sherlock JP, Powrie F, Carr AJ, Buckley CD.

Nat Rev Rheumatol. 2018 Dec;14(12):714-726. doi: 10.1038/s41584-018-0112-7. Review. Erratum in: Nat Rev Rheumatol. 2019 Jan;15(1):61.


Trends in the theory that inflammation plays a causal role in tendinopathy: a systematic review and quantitative analysis of published reviews.

Mosca MJ, Rashid MS, Snelling SJ, Kirtley S, Carr AJ, Dakin SG.

BMJ Open Sport Exerc Med. 2018 Jun 26;4(1):e000332. doi: 10.1136/bmjsem-2017-000332. eCollection 2018.


Bone marrow mesenchymal stem cells do not enhance intra-synovial tendon healing despite engraftment and homing to niches within the synovium.

Khan MR, Dudhia J, David FH, De Godoy R, Mehra V, Hughes G, Dakin SG, Carr AJ, Goodship AE, Smith RKW.

Stem Cell Res Ther. 2018 Jun 19;9(1):169. doi: 10.1186/s13287-018-0900-7.


Translocator Protein as an Imaging Marker of Macrophage and Stromal Activation in Rheumatoid Arthritis Pannus.

Narayan N, Owen DR, Mandhair H, Smyth E, Carlucci F, Saleem A, Gunn RN, Rabiner EA, Wells L, Dakin SG, Sabokbar A, Taylor PC.

J Nucl Med. 2018 Jul;59(7):1125-1132. doi: 10.2967/jnumed.117.202200. Epub 2018 Jan 4.


Cytokines in tendon disease: A Systematic Review.

Morita W, Dakin SG, Snelling SJB, Carr AJ.

Bone Joint Res. 2017 Dec;6(12):656-664. doi: 10.1302/2046-3758.612.BJR-2017-0112.R1.


Chronic inflammation is a feature of Achilles tendinopathy and rupture.

Dakin SG, Newton J, Martinez FO, Hedley R, Gwilym S, Jones N, Reid HAB, Wood S, Wells G, Appleton L, Wheway K, Watkins B, Carr AJ.

Br J Sports Med. 2018 Mar;52(6):359-367. doi: 10.1136/bjsports-2017-098161. Epub 2017 Nov 8.


The macrophage marker translocator protein (TSPO) is down-regulated on pro-inflammatory 'M1' human macrophages.

Narayan N, Mandhair H, Smyth E, Dakin SG, Kiriakidis S, Wells L, Owen D, Sabokbar A, Taylor P.

PLoS One. 2017 Oct 2;12(10):e0185767. doi: 10.1371/journal.pone.0185767. eCollection 2017.


MicroRNA Replacement: A New Era of Molecular Therapy for Tendon Disorders?

Dakin SG.

Mol Ther. 2017 Oct 4;25(10):2243-2244. doi: 10.1016/j.ymthe.2017.09.004. Epub 2017 Sep 20. No abstract available.


Increased 15-PGDH expression leads to dysregulated resolution responses in stromal cells from patients with chronic tendinopathy.

Dakin SG, Ly L, Colas RA, Oppermann U, Wheway K, Watkins B, Dalli J, Carr AJ.

Sci Rep. 2017 Sep 8;7(1):11009. doi: 10.1038/s41598-017-11188-y.


Increasing age and tear size reduce rotator cuff repair healing rate at 1 year.

Rashid MS, Cooper C, Cook J, Cooper D, Dakin SG, Snelling S, Carr AJ.

Acta Orthop. 2017 Dec;88(6):606-611. doi: 10.1080/17453674.2017.1370844. Epub 2017 Sep 7.


Characterizing the macro and micro mechanical properties of scaffolds for rotator cuff repair.

Smith RDJ, Zargar N, Brown CP, Nagra NS, Dakin SG, Snelling SJB, Hakimi O, Carr A.

J Shoulder Elbow Surg. 2017 Nov;26(11):2038-2046. doi: 10.1016/j.jse.2017.06.035. Epub 2017 Aug 31.


Differential expression of alarmins-S100A9, IL-33, HMGB1 and HIF-1α in supraspinatus tendinopathy before and after treatment.

Mosca MJ, Carr AJ, Snelling SJB, Wheway K, Watkins B, Dakin SG.

BMJ Open Sport Exerc Med. 2017 May 31;3(1):e000225. doi: 10.1136/bmjsem-2017-000225. eCollection 2017.


Review: Emerging concepts in the pathogenesis of tendinopathy.

Dean BJF, Dakin SG, Millar NL, Carr AJ.

Surgeon. 2017 Dec;15(6):349-354. doi: 10.1016/j.surge.2017.05.005. Epub 2017 Jun 12. Review.


Presence of IL-17 in synovial fluid identifies a potential inflammatory osteoarthritic phenotype.

Snelling SJ, Bas S, Puskas GJ, Dakin SG, Suva D, Finckh A, Gabay C, Hoffmeyer P, Carr AJ, Lübbeke A.

PLoS One. 2017 Apr 11;12(4):e0175109. doi: 10.1371/journal.pone.0175109. eCollection 2017.


Persistent stromal fibroblast activation is present in chronic tendinopathy.

Dakin SG, Buckley CD, Al-Mossawi MH, Hedley R, Martinez FO, Wheway K, Watkins B, Carr AJ.

Arthritis Res Ther. 2017 Jan 25;19(1):16. doi: 10.1186/s13075-016-1218-4.


Profibrotic mediators in tendon disease: a systematic review.

Morita W, Snelling SJ, Dakin SG, Carr AJ.

Arthritis Res Ther. 2016 Nov 18;18(1):269. Review.


Biocompatibility of implantable materials: An oxidative stress viewpoint.

Mouthuy PA, Snelling SJB, Dakin SG, Milković L, Gašparović AČ, Carr AJ, Žarković N.

Biomaterials. 2016 Dec;109:55-68. doi: 10.1016/j.biomaterials.2016.09.010. Epub 2016 Sep 14. Review.


Inflammation and the continuum model: time to acknowledge the molecular era of tendinopathy.

Millar NL, Dean BJ, Dakin SG.

Br J Sports Med. 2016 Dec;50(23):1486. doi: 10.1136/bjsports-2016-096419. Epub 2016 Jun 3. No abstract available.


Comparison of transforming growth factor beta expression in healthy and diseased human tendon.

Goodier HC, Carr AJ, Snelling SJ, Roche L, Wheway K, Watkins B, Dakin SG.

Arthritis Res Ther. 2016 Feb 17;18:48. doi: 10.1186/s13075-016-0947-8.


The response of tenocytes to commercial scaffolds used for rotator cuff repair.

Smith RD, Carr A, Dakin SG, Snelling SJ, Yapp C, Hakimi O.

Eur Cell Mater. 2016 Jan 27;31:107-18.


Inflammation activation and resolution in human tendon disease.

Dakin SG, Martinez FO, Yapp C, Wells G, Oppermann U, Dean BJ, Smith RD, Wheway K, Watkins B, Roche L, Carr AJ.

Sci Transl Med. 2015 Oct 28;7(311):311ra173. doi: 10.1126/scitranslmed.aac4269.


Platelet-Rich Plasma Injection With Arthroscopic Acromioplasty for Chronic Rotator Cuff Tendinopathy: A Randomized Controlled Trial.

Carr AJ, Murphy R, Dakin SG, Rombach I, Wheway K, Watkins B, Franklin SL.

Am J Sports Med. 2015 Dec;43(12):2891-7. doi: 10.1177/0363546515608485. Epub 2015 Oct 23.


Are inflammatory cells increased in painful human tendinopathy? A systematic review.

Dean BJ, Gettings P, Dakin SG, Carr AJ.

Br J Sports Med. 2016 Feb;50(4):216-20. doi: 10.1136/bjsports-2015-094754. Epub 2015 Aug 5. Review.


Differences in glutamate receptors and inflammatory cell numbers are associated with the resolution of pain in human rotator cuff tendinopathy.

Dean BJ, Snelling SJ, Dakin SG, Murphy RJ, Javaid MK, Carr AJ.

Arthritis Res Ther. 2015 Jul 10;17:176. doi: 10.1186/s13075-015-0691-5.


Translating Regenerative Biomaterials Into Clinical Practice.

Stace ET, Dakin SG, Mouthuy PA, Carr AJ.

J Cell Physiol. 2016 Jan;231(1):36-49. doi: 10.1002/jcp.25071. Review.


In vitro effects of glutamate and N-methyl-D-aspartate receptor (NMDAR) antagonism on human tendon derived cells.

Dean BJ, Snelling SJ, Dakin SG, Javaid MK, Carr AJ.

J Orthop Res. 2015 Oct;33(10):1515-22. doi: 10.1002/jor.22923. Epub 2015 Jun 3.


Relationship between the shape of the central and third tarsal bones and the presence of tarsal osteoarthritis.

Sprackman L, Dakin SG, May SA, Weller R.

Vet J. 2015 Apr;204(1):94-8. doi: 10.1016/j.tvjl.2015.01.006. Epub 2015 Jan 13.


Resolving an inflammatory concept: the importance of inflammation and resolution in tendinopathy.

Dakin SG, Dudhia J, Smith RK.

Vet Immunol Immunopathol. 2014 Apr 15;158(3-4):121-7. doi: 10.1016/j.vetimm.2014.01.007. Epub 2014 Jan 31. Review.


Proteomic analysis of tendon extracellular matrix reveals disease stage-specific fragmentation and differential cleavage of COMP (cartilage oligomeric matrix protein).

Dakin SG, Smith RK, Heinegård D, Önnerfjord P, Khabut A, Dudhia J.

J Biol Chem. 2014 Feb 21;289(8):4919-27. doi: 10.1074/jbc.M113.511972. Epub 2014 Jan 7.


Beneficial effects of autologous bone marrow-derived mesenchymal stem cells in naturally occurring tendinopathy.

Smith RK, Werling NJ, Dakin SG, Alam R, Goodship AE, Dudhia J.

PLoS One. 2013 Sep 25;8(9):e75697. doi: 10.1371/journal.pone.0075697. eCollection 2013.


Science in brief: resolving tendon inflammation. A new perspective.

Dakin SG, Dudhia J, Smith RK.

Equine Vet J. 2013 Jul;45(4):398-400. doi: 10.1111/evj.12030. No abstract available.


Inflamm-aging and arachadonic acid metabolite differences with stage of tendon disease.

Dakin SG, Dudhia J, Werling NJ, Werling D, Abayasekara DR, Smith RK.

PLoS One. 2012;7(11):e48978. doi: 10.1371/journal.pone.0048978. Epub 2012 Nov 14.


Macrophage sub-populations and the lipoxin A4 receptor implicate active inflammation during equine tendon repair.

Dakin SG, Werling D, Hibbert A, Abayasekara DR, Young NJ, Smith RK, Dudhia J.

PLoS One. 2012;7(2):e32333. doi: 10.1371/journal.pone.0032333. Epub 2012 Feb 22.


The relationship between in vivo limb and in vitro tendon mechanics after injury: a potential novel clinical tool for monitoring tendon repair.

Dakin SG, Jespers K, Warner S, O'Hara LK, Dudhia J, Goodship AE, Wilson AM, Smith RK.

Equine Vet J. 2011 Jul;43(4):418-23. doi: 10.1111/j.2042-3306.2010.00303.x. Epub 2010 Sep 29.


Osseous abnormalities associated with collateral desmopathy of the distal interphalangeal joint: part 1.

Dakin SG, Dyson SJ, Murray RC, Tranquille C.

Equine Vet J. 2009 Nov;41(8):786-93.


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