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Items: 32


Interconversion between Tumorigenic and Differentiated States in Acute Myeloid Leukemia.

McKenzie MD, Ghisi M, Oxley EP, Ngo S, Cimmino L, Esnault C, Liu R, Salmon JM, Bell CC, Ahmed N, Erlichster M, Witkowski MT, Liu GJ, Chopin M, Dakic A, Simankowicz E, Pomilio G, Vu T, Krsmanovic P, Su S, Tian L, Baldwin TM, Zalcenstein DA, DiRago L, Wang S, Metcalf D, Johnstone RW, Croker BA, Lancaster GI, Murphy AJ, Naik SH, Nutt SL, Pospisil V, Schroeder T, Wall M, Dawson MA, Wei AH, de Thé H, Ritchie ME, Zuber J, Dickins RA.

Cell Stem Cell. 2019 Aug 1;25(2):258-272.e9. doi: 10.1016/j.stem.2019.07.001.


Interlaboratory study to validate a STR profiling method for intraspecies identification of mouse cell lines.

Almeida JL, Dakic A, Kindig K, Kone M, Letham DLD, Langdon S, Peat R, Holding-Pillai J, Hall EM, Ladd M, Shaffer MD, Berg H, Li J, Wigger G, Lund S, Steffen CR, Fransway BB, Geraghty B, Natoli M, Bauer B, Gollin SM, Lewis DW, Reid Y.

PLoS One. 2019 Jun 20;14(6):e0218412. doi: 10.1371/journal.pone.0218412. eCollection 2019.


Δ133p53α, a natural p53 isoform, contributes to conditional reprogramming and long-term proliferation of primary epithelial cells.

Mondal AM, Zhou H, Horikawa I, Suprynowicz FA, Li G, Dakic A, Rosenthal B, Ye L, Harris CC, Schlegel R, Liu X.

Cell Death Dis. 2018 Jul 3;9(7):750. doi: 10.1038/s41419-018-0767-7.


Time-Dependent Effects of POT1 Knockdown on Proliferation, Tumorigenicity, and HDACi Response of SK-OV3 Ovarian Cancer Cells.

Zhou H, Mondal A, Dakic A, Alhawas L, Liu X, He Z.

Biomed Res Int. 2018 Feb 6;2018:7184253. doi: 10.1155/2018/7184253. eCollection 2018.


Direct HPV E6/Myc interactions induce histone modifications, Pol II phosphorylation, and hTERT promoter activation.

Zhang Y, Dakic A, Chen R, Dai Y, Schlegel R, Liu X.

Oncotarget. 2017 Oct 25;8(56):96323-96339. doi: 10.18632/oncotarget.22036. eCollection 2017 Nov 10.


The Pu.1 target gene Zbtb11 regulates neutrophil development through its integrase-like HHCC zinc finger.

Keightley MC, Carradice DP, Layton JE, Pase L, Bertrand JY, Wittig JG, Dakic A, Badrock AP, Cole NJ, Traver D, Nutt SL, McCoey J, Buckle AM, Heath JK, Lieschke GJ.

Nat Commun. 2017 Apr 6;8:14911. doi: 10.1038/ncomms14911.


HPV positive neuroendocrine cervical cancer cells are dependent on Myc but not E6/E7 viral oncogenes.

Yuan H, Krawczyk E, Blancato J, Albanese C, Zhou D, Wang N, Paul S, Alkhilaiwi F, Palechor-Ceron N, Dakic A, Fang S, Choudhary S, Hou TW, Zheng YL, Haddad BR, Usuda Y, Hartmann D, Symer D, Gillison M, Agarwal S, Wangsa D, Ried T, Liu X, Schlegel R.

Sci Rep. 2017 Apr 5;7:45617. doi: 10.1038/srep45617.


Conditional reprogramming and long-term expansion of normal and tumor cells from human biospecimens.

Liu X, Krawczyk E, Suprynowicz FA, Palechor-Ceron N, Yuan H, Dakic A, Simic V, Zheng YL, Sripadhan P, Chen C, Lu J, Hou TW, Choudhury S, Kallakury B, Tang DG, Darling T, Thangapazham R, Timofeeva O, Dritschilo A, Randell SH, Albanese C, Agarwal S, Schlegel R.

Nat Protoc. 2017 Feb;12(2):439-451. doi: 10.1038/nprot.2016.174. Epub 2017 Jan 26.


Conditionally reprogrammed normal and primary tumor prostate epithelial cells: a novel patient-derived cell model for studies of human prostate cancer.

Timofeeva OA, Palechor-Ceron N, Li G, Yuan H, Krawczyk E, Zhong X, Liu G, Upadhyay G, Dakic A, Yu S, Fang S, Choudhury S, Zhang X, Ju A, Lee MS, Dan HC, Ji Y, Hou Y, Zheng YL, Albanese C, Rhim J, Schlegel R, Dritschilo A, Liu X.

Oncotarget. 2017 Apr 4;8(14):22741-22758. doi: 10.18632/oncotarget.13937.


ROCK inhibitor reduces Myc-induced apoptosis and mediates immortalization of human keratinocytes.

Dakic A, DiVito K, Fang S, Suprynowicz F, Gaur A, Li X, Palechor-Ceron N, Simic V, Choudhury S, Yu S, Simbulan-Rosenthal CM, Rosenthal D, Schlegel R, Liu X.

Oncotarget. 2016 Oct 11;7(41):66740-66753. doi: 10.18632/oncotarget.11458.


Oncogenic fusion protein EWS-FLI1 is a network hub that regulates alternative splicing.

Selvanathan SP, Graham GT, Erkizan HV, Dirksen U, Natarajan TG, Dakic A, Yu S, Liu X, Paulsen MT, Ljungman ME, Wu CH, Lawlor ER, Üren A, Toretsky JA.

Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):E1307-16. doi: 10.1073/pnas.1500536112. Epub 2015 Mar 3.


Stage-specific control of early B cell development by the transcription factor Ikaros.

Schwickert TA, Tagoh H, Gültekin S, Dakic A, Axelsson E, Minnich M, Ebert A, Werner B, Roth M, Cimmino L, Dickins RA, Zuber J, Jaritz M, Busslinger M.

Nat Immunol. 2014 Mar;15(3):283-93. doi: 10.1038/ni.2828. Epub 2014 Feb 9.


Radiation induces diffusible feeder cell factor(s) that cooperate with ROCK inhibitor to conditionally reprogram and immortalize epithelial cells.

Palechor-Ceron N, Suprynowicz FA, Upadhyay G, Dakic A, Minas T, Simic V, Johnson M, Albanese C, Schlegel R, Liu X.

Am J Pathol. 2013 Dec;183(6):1862-1870. doi: 10.1016/j.ajpath.2013.08.009. Epub 2013 Oct 3.


HPV16 E7 protein and hTERT proteins defective for telomere maintenance cooperate to immortalize human keratinocytes.

Miller J, Dakic A, Chen R, Palechor-Ceron N, Dai Y, Kallakury B, Schlegel R, Liu X.

PLoS Pathog. 2013;9(4):e1003284. doi: 10.1371/journal.ppat.1003284. Epub 2013 Apr 4.


ROCK inhibitor and feeder cells induce the conditional reprogramming of epithelial cells.

Liu X, Ory V, Chapman S, Yuan H, Albanese C, Kallakury B, Timofeeva OA, Nealon C, Dakic A, Simic V, Haddad BR, Rhim JS, Dritschilo A, Riegel A, McBride A, Schlegel R.

Am J Pathol. 2012 Feb;180(2):599-607. doi: 10.1016/j.ajpath.2011.10.036. Epub 2011 Dec 18.


The transcription factor PU.1 controls dendritic cell development and Flt3 cytokine receptor expression in a dose-dependent manner.

Carotta S, Dakic A, D'Amico A, Pang SH, Greig KT, Nutt SL, Wu L.

Immunity. 2010 May 28;32(5):628-41. doi: 10.1016/j.immuni.2010.05.005.


HPV E6 protein interacts physically and functionally with the cellular telomerase complex.

Liu X, Dakic A, Zhang Y, Dai Y, Chen R, Schlegel R.

Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18780-5. doi: 10.1073/pnas.0906357106. Epub 2009 Oct 20.


Role of "cancer stem cells" and cell survival in tumor development and maintenance.

Adams JM, Kelly PN, Dakic A, Carotta S, Nutt SL, Strasser A.

Cold Spring Harb Symp Quant Biol. 2008;73:451-9. doi: 10.1101/sqb.2008.73.004. Epub 2008 Nov 6. Review.


Cell-restricted immortalization by human papillomavirus correlates with telomerase activation and engagement of the hTERT promoter by Myc.

Liu X, Dakic A, Chen R, Disbrow GL, Zhang Y, Dai Y, Schlegel R.

J Virol. 2008 Dec;82(23):11568-76. doi: 10.1128/JVI.01318-08. Epub 2008 Sep 25.


HPV E7 contributes to the telomerase activity of immortalized and tumorigenic cells and augments E6-induced hTERT promoter function.

Liu X, Roberts J, Dakic A, Zhang Y, Schlegel R.

Virology. 2008 Jun 5;375(2):611-23. doi: 10.1016/j.virol.2008.02.025. Epub 2008 Mar 26.


Identification of Pax5 target genes in early B cell differentiation.

Pridans C, Holmes ML, Polli M, Wettenhall JM, Dakic A, Corcoran LM, Smyth GK, Nutt SL.

J Immunol. 2008 Feb 1;180(3):1719-28.


Development of plasmacytoid and conventional dendritic cell subtypes from single precursor cells derived in vitro and in vivo.

Naik SH, Sathe P, Park HY, Metcalf D, Proietto AI, Dakic A, Carotta S, O'Keeffe M, Bahlo M, Papenfuss A, Kwak JY, Wu L, Shortman K.

Nat Immunol. 2007 Nov;8(11):1217-26. Epub 2007 Oct 7.


Tumor growth need not be driven by rare cancer stem cells.

Kelly PN, Dakic A, Adams JM, Nutt SL, Strasser A.

Science. 2007 Jul 20;317(5836):337.


Is PU.1 a dosage-sensitive regulator of haemopoietic lineage commitment and leukaemogenesis?

Dakic A, Wu L, Nutt SL.

Trends Immunol. 2007 Mar;28(3):108-14. Epub 2007 Jan 30. Review.


Inactivation of PU.1 in adult mice leads to the development of myeloid leukemia.

Metcalf D, Dakic A, Mifsud S, Di Rago L, Wu L, Nutt S.

Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1486-91. Epub 2006 Jan 23.


Development of dendritic cell system.

Wu L, Dakic A.

Cell Mol Immunol. 2004 Apr;1(2):112-8. Review.


The development of functional B lymphocytes in conditional PU.1 knock-out mice.

Polli M, Dakic A, Light A, Wu L, Tarlinton DM, Nutt SL.

Blood. 2005 Sep 15;106(6):2083-90. Epub 2005 Jun 2.


Cutting edge: generation of splenic CD8+ and CD8- dendritic cell equivalents in Fms-like tyrosine kinase 3 ligand bone marrow cultures.

Naik SH, Proietto AI, Wilson NS, Dakic A, Schnorrer P, Fuchsberger M, Lahoud MH, O'Keeffe M, Shao QX, Chen WF, Villadangos JA, Shortman K, Wu L.

J Immunol. 2005 Jun 1;174(11):6592-7.


PU.1 regulates the commitment of adult hematopoietic progenitors and restricts granulopoiesis.

Dakic A, Metcalf D, Di Rago L, Mifsud S, Wu L, Nutt SL.

J Exp Med. 2005 May 2;201(9):1487-502.


Development of the dendritic cell system during mouse ontogeny.

Dakic A, Shao QX, D'Amico A, O'Keeffe M, Chen WF, Shortman K, Wu L.

J Immunol. 2004 Jan 15;172(2):1018-27.


Hemopoietic precursors and development of dendritic cell populations.

Dakic A, Wu L.

Leuk Lymphoma. 2003 Sep;44(9):1469-75. Review.


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