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Items: 1 to 50 of 106

1.

The effect of BPIFA1/SPLUNC1 genetic variation on its expression and function in asthmatic airway epithelium.

Schaefer N, Li X, Seibold MA, Jarjour NN, Denlinger LC, Castro M, Coverstone AM, Teague WG, Boomer J, Bleecker ER, Meyers DA, Moore WC, Hawkins GA, Fahy J, Phillips BR, Mauger DT, Dakhama A, Gellatly S, Pavelka N, Berman R, Di YP, Wenzel SE, Chu HW.

JCI Insight. 2019 Apr 18;4(8). pii: 127237. doi: 10.1172/jci.insight.127237. eCollection 2019 Apr 18.

2.

Tollip Inhibits ST2 Signaling in Airway Epithelial Cells Exposed to Type 2 Cytokines and Rhinovirus.

Dakhama A, Al Mubarak R, Pavelka N, Voelker D, Seibold M, Ledford JG, Kraft M, Li L, Chu HW.

J Innate Immun. 2020;12(1):103-115. doi: 10.1159/000497072. Epub 2019 Mar 29.

3.

Afghanistan Particulate Matter Enhances Pro-Inflammatory Responses in IL-13-Exposed Human Airway Epithelium via TLR2 Signaling.

Berman R, Downey GP, Dakhama A, Day BJ, Chu HW.

Toxicol Sci. 2018 Dec 1;166(2):345-353. doi: 10.1093/toxsci/kfy217.

PMID:
30169750
4.

The Use of CRISPR-Cas9 Technology to Reveal Important Aspects of Human Airway Biology.

Dakhama A, Chu HW.

Methods Mol Biol. 2018;1799:371-380. doi: 10.1007/978-1-4939-7896-0_27.

PMID:
29956165
5.

Cytosolic phospholipase A2 contributes to innate immune defense against Candida albicans lung infection.

Jayaraja S, Dakhama A, Yun B, Ghosh M, Lee H, Redente EF, Uhlson CL, Murphy RC, Leslie CC.

BMC Immunol. 2016 Aug 8;17(1):27. doi: 10.1186/s12865-016-0165-9.

6.

In Vivo Assessment of Airway Function in the Mouse Model.

Dakhama A, Gelfand EW.

Methods Mol Biol. 2016;1442:219-30. doi: 10.1007/978-1-4939-3687-8_16.

PMID:
27464698
7.

The lung response to ozone is determined by age and is partially dependent on toll-Like receptor 4.

Gabehart K, Correll KA, Loader JE, White CW, Dakhama A.

Respir Res. 2015 Sep 26;16:117. doi: 10.1186/s12931-015-0279-2.

8.

Human IL-32 expression protects mice against a hypervirulent strain of Mycobacterium tuberculosis.

Bai X, Shang S, Henao-Tamayo M, Basaraba RJ, Ovrutsky AR, Matsuda JL, Takeda K, Chan MM, Dakhama A, Kinney WH, Trostel J, Bai A, Honda JR, Achcar R, Hartney J, Joosten LA, Kim SH, Orme I, Dinarello CA, Ordway DJ, Chan ED.

Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):5111-6. doi: 10.1073/pnas.1424302112. Epub 2015 Mar 27.

9.

JNK2 regulates the functional plasticity of naturally occurring T regulatory cells and the enhancement of lung allergic responses.

Joetham A, Schedel M, Takeda K, Jia Y, Ashino S, Dakhama A, Lluis A, Okamoto M, Gelfand EW.

J Immunol. 2014 Sep 1;193(5):2238-47. doi: 10.4049/jimmunol.1400604. Epub 2014 Jul 28.

10.

Effects of anti-g and anti-f antibodies on airway function after respiratory syncytial virus infection.

Han J, Takeda K, Wang M, Zeng W, Jia Y, Shiraishi Y, Okamoto M, Dakhama A, Gelfand EW.

Am J Respir Cell Mol Biol. 2014 Jul;51(1):143-54. doi: 10.1165/rcmb.2013-0360OC.

11.

Leukotriene B4 receptor 1 is differentially expressed on peripheral T cells of steroid-sensitive and -resistant asthmatics.

Chung EH, Jia Y, Ohnishi H, Takeda K, Leung DY, Sutherland ER, Dakhama A, Martin RJ, Gelfand EW.

Ann Allergy Asthma Immunol. 2014 Mar;112(3):211-216.e1. doi: 10.1016/j.anai.2013.12.006. Epub 2014 Jan 7.

12.

Transcriptome profiling of the newborn mouse lung response to acute ozone exposure.

Gabehart K, Correll KA, Yang J, Collins ML, Loader JE, Leach S, White CW, Dakhama A.

Toxicol Sci. 2014 Mar;138(1):175-90. doi: 10.1093/toxsci/kft276. Epub 2013 Dec 12.

13.

Interleukin-1 receptor-associated kinase M (IRAK-M) promotes human rhinovirus infection in lung epithelial cells via the autophagic pathway.

Wu Q, van Dyk LF, Jiang D, Dakhama A, Li L, White SR, Gross A, Chu HW.

Virology. 2013 Nov;446(1-2):199-206. doi: 10.1016/j.virol.2013.08.005. Epub 2013 Aug 30.

14.

IL-13-producing BLT1-positive CD8 cells are increased in asthma and are associated with airway obstruction.

Dakhama A, Collins ML, Ohnishi H, Goleva E, Leung DY, Alam R, Sutherland ER, Martin RJ, Gelfand EW.

Allergy. 2013;68(5):666-73. doi: 10.1111/all.12135. Epub 2013 Apr 10.

15.

Responsiveness to respiratory syncytial virus in neonates is mediated through thymic stromal lymphopoietin and OX40 ligand.

Han J, Dakhama A, Jia Y, Wang M, Zeng W, Takeda K, Shiraishi Y, Okamoto M, Ziegler SF, Gelfand EW.

J Allergy Clin Immunol. 2012 Nov;130(5):1175-1186.e9. doi: 10.1016/j.jaci.2012.08.033. Epub 2012 Oct 1.

16.

Loss of T regulatory cell suppression following signaling through glucocorticoid-induced tumor necrosis receptor (GITR) is dependent on c-Jun N-terminal kinase activation.

Joetham A, Ohnishi H, Okamoto M, Takeda K, Schedel M, Domenico J, Dakhama A, Gelfand EW.

J Biol Chem. 2012 May 18;287(21):17100-8. doi: 10.1074/jbc.M111.316943. Epub 2012 Mar 29.

17.

New insights into asthma pathogenesis and treatment.

Szefler SJ, Dakhama A.

Curr Opin Immunol. 2011 Dec;23(6):801-7. doi: 10.1016/j.coi.2011.07.014. Epub 2011 Aug 11. Review.

PMID:
21840186
18.

CD8 regulates T regulatory cell production of IL-6 and maintains their suppressive phenotype in allergic lung disease.

Joetham A, Okamoto M, Takeda K, Schedel M, Ohnishi H, Dakhama A, Gelfand EW.

J Immunol. 2011 Jan 1;186(1):113-20. doi: 10.4049/jimmunol.1001663. Epub 2010 Nov 29.

19.

Peanut-induced intestinal allergy is mediated through a mast cell-IgE-FcepsilonRI-IL-13 pathway.

Wang M, Takeda K, Shiraishi Y, Okamoto M, Dakhama A, Joetham A, Gelfand EW.

J Allergy Clin Immunol. 2010 Aug;126(2):306-16, 316.e1-12. doi: 10.1016/j.jaci.2010.05.017. Epub 2010 Jul 10.

20.

Plasticity of invariant NKT cell regulation of allergic airway disease is dependent on IFN-gamma production.

Matsuda H, Takeda K, Koya T, Okamoto M, Shiraishi Y, Miyahara N, Dakhama A, Matsuda JL, Gapin L, Gelfand EW.

J Immunol. 2010 Jul 1;185(1):253-62. doi: 10.4049/jimmunol.0902301. Epub 2010 Jun 4.

21.

Montelukast during primary infection prevents airway hyperresponsiveness and inflammation after reinfection with respiratory syncytial virus.

Han J, Jia Y, Takeda K, Shiraishi Y, Okamoto M, Dakhama A, Gelfand EW.

Am J Respir Crit Care Med. 2010 Aug 15;182(4):455-63. doi: 10.1164/rccm.200912-1811OC. Epub 2010 May 4.

22.

Pulmonary surfactant phosphatidylglycerol inhibits respiratory syncytial virus-induced inflammation and infection.

Numata M, Chu HW, Dakhama A, Voelker DR.

Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):320-5. doi: 10.1073/pnas.0909361107. Epub 2009 Dec 22.

23.

Antigen specificity is not required for modulation of lung allergic responses by naturally occurring regulatory T cells.

Joetham A, Takeda K, Okamoto M, Taube C, Matsuda H, Dakhama A, Gelfand EW.

J Immunol. 2009 Aug 1;183(3):1821-7. doi: 10.4049/jimmunol.0900303. Epub 2009 Jul 10.

24.

Vaccine-induced CD8+ T cell-dependent suppression of airway hyperresponsiveness and inflammation.

Takeda K, Dow SW, Miyahara N, Kodama T, Koya T, Taube C, Joetham A, Park JW, Dakhama A, Kedl RM, Gelfand EW.

J Immunol. 2009 Jul 1;183(1):181-90. doi: 10.4049/jimmunol.0803967.

25.

Differential effects of dendritic cell transfer on airway hyperresponsiveness and inflammation.

Koya T, Matsuda H, Matsubara S, Miyahara N, Dakhama A, Takeda K, Gelfand EW.

Am J Respir Cell Mol Biol. 2009 Sep;41(3):271-80. doi: 10.1165/rcmb.2008-0256OC. Epub 2009 Jan 16.

26.

Mitogen-activated protein kinase/extracellular signal-regulated kinase 1/2-dependent pathways are essential for CD8+ T cell-mediated airway hyperresponsiveness and inflammation.

Ohnishi H, Takeda K, Domenico J, Lucas JJ, Miyahara N, Swasey CH, Dakhama A, Gelfand EW.

J Allergy Clin Immunol. 2009 Jan;123(1):249-57. doi: 10.1016/j.jaci.2008.10.054.

PMID:
19130938
27.

Virus-specific IgE enhances airway responsiveness on reinfection with respiratory syncytial virus in newborn mice.

Dakhama A, Lee YM, Ohnishi H, Jing X, Balhorn A, Takeda K, Gelfand EW.

J Allergy Clin Immunol. 2009 Jan;123(1):138-145.e5. doi: 10.1016/j.jaci.2008.10.012. Epub 2008 Dec 3.

PMID:
19056111
28.

Leukotriene B4 release from mast cells in IgE-mediated airway hyperresponsiveness and inflammation.

Miyahara N, Ohnishi H, Miyahara S, Takeda K, Matsubara S, Matsuda H, Okamoto M, Loader JE, Joetham A, Tanimoto M, Dakhama A, Gelfand EW.

Am J Respir Cell Mol Biol. 2009 Jun;40(6):672-82. doi: 10.1165/rcmb.2008-0095OC. Epub 2008 Nov 21.

29.

Vgamma1+ T cells and tumor necrosis factor-alpha in ozone-induced airway hyperresponsiveness.

Matsubara S, Takeda K, Jin N, Okamoto M, Matsuda H, Shiraishi Y, Park JW, McConville G, Joetham A, O'Brien RL, Dakhama A, Born WK, Gelfand EW.

Am J Respir Cell Mol Biol. 2009 Apr;40(4):454-63. doi: 10.1165/rcmb.2008-0346OC. Epub 2008 Oct 16.

30.

Leukotriene B4 receptor 1 expression on dendritic cells is required for the development of Th2 responses and allergen-induced airway hyperresponsiveness.

Miyahara N, Ohnishi H, Matsuda H, Miyahara S, Takeda K, Koya T, Matsubara S, Okamoto M, Dakhama A, Haribabu B, Gelfand EW.

J Immunol. 2008 Jul 15;181(2):1170-8.

31.

Plasticity of regulatory T cells: subversion of suppressive function and conversion to enhancement of lung allergic responses.

Joetham A, Matsubara S, Okamoto M, Takeda K, Miyahara N, Dakhama A, Gelfand EW.

J Immunol. 2008 Jun 1;180(11):7117-24.

32.

Essential role of Notch signaling in effector memory CD8+ T cell-mediated airway hyperresponsiveness and inflammation.

Okamoto M, Takeda K, Joetham A, Ohnishi H, Matsuda H, Swasey CH, Swanson BJ, Yasutomo K, Dakhama A, Gelfand EW.

J Exp Med. 2008 May 12;205(5):1087-97. doi: 10.1084/jem.20072200. Epub 2008 Apr 21.

33.

Corticosteroids enhance CD8+ T cell-mediated airway hyperresponsiveness and allergic inflammation by upregulating leukotriene B4 receptor 1.

Ohnishi H, Miyahara N, Dakhama A, Takeda K, Mathis S, Haribabu B, Gelfand EW.

J Allergy Clin Immunol. 2008 Apr;121(4):864-71.e4. doi: 10.1016/j.jaci.2008.01.035.

PMID:
18395551
34.

Contribution of allergen-specific and nonspecific nasal responses to early-phase and late-phase nasal responses.

Miyahara S, Miyahara N, Lucas JJ, Joetham A, Matsubara S, Ohnishi H, Dakhama A, Gelfand EW.

J Allergy Clin Immunol. 2008 Mar;121(3):718-24. Epub 2007 Dec 21.

PMID:
18155286
35.

Estrogen determines sex differences in airway responsiveness after allergen exposure.

Matsubara S, Swasey CH, Loader JE, Dakhama A, Joetham A, Ohnishi H, Balhorn A, Miyahara N, Takeda K, Gelfand EW.

Am J Respir Cell Mol Biol. 2008 May;38(5):501-8. Epub 2007 Dec 6.

36.

IFN-gamma production during initial infection determines the outcome of reinfection with respiratory syncytial virus.

Lee YM, Miyahara N, Takeda K, Prpich J, Oh A, Balhorn A, Joetham A, Gelfand EW, Dakhama A.

Am J Respir Crit Care Med. 2008 Jan 15;177(2):208-18. Epub 2007 Oct 25.

37.

Activation of naturally occurring lung CD4(+)CD25(+) regulatory T cells requires CD8 and MHC I interaction.

Joetham A, Takeda K, Miyahara N, Matsubara S, Ohnishi H, Koya T, Dakhama A, Gelfand EW.

Proc Natl Acad Sci U S A. 2007 Sep 18;104(38):15057-62. Epub 2007 Sep 12.

38.

CD8+ T cell-mediated airway hyperresponsiveness and inflammation is dependent on CD4+IL-4+ T cells.

Koya T, Miyahara N, Takeda K, Matsubara S, Matsuda H, Swasey C, Balhorn A, Dakhama A, Gelfand EW.

J Immunol. 2007 Sep 1;179(5):2787-96.

39.

Modulation of airway responses by prostaglandins in young and fully grown rabbits.

Larsen GL, Loader J, Fratelli C, Kang JK, Dakhama A, Colasurdo GN.

Am J Physiol Lung Cell Mol Physiol. 2007 Jul;293(1):L239-44. Epub 2007 May 4.

40.

IL-10-treated dendritic cells decrease airway hyperresponsiveness and airway inflammation in mice.

Koya T, Matsuda H, Takeda K, Matsubara S, Miyahara N, Balhorn A, Dakhama A, Gelfand EW.

J Allergy Clin Immunol. 2007 May;119(5):1241-50. Epub 2007 Mar 13.

PMID:
17353041
41.

Naturally occurring lung CD4(+)CD25(+) T cell regulation of airway allergic responses depends on IL-10 induction of TGF-beta.

Joetham A, Takeda K, Taube C, Miyahara N, Matsubara S, Koya T, Rha YH, Dakhama A, Gelfand EW.

J Immunol. 2007 Feb 1;178(3):1433-42. Erratum in: J Immunol. 2007 Apr 15;178(8):5400. Takada, Katsuyuki [corrected to Takeda, Katsuyuki]; Matsubara, Satoko [corrected to Matsubara, Shigeki].

42.

Critical role of the Fc receptor gamma-chain on APCs in the development of allergen-induced airway hyperresponsiveness and inflammation.

Kitamura K, Takeda K, Koya T, Miyahara N, Kodama T, Dakhama A, Takai T, Hirano A, Tanimoto M, Harada M, Gelfand EW.

J Immunol. 2007 Jan 1;178(1):480-8.

43.

Spontaneous airway hyperresponsiveness in estrogen receptor-alpha-deficient mice.

Carey MA, Card JW, Bradbury JA, Moorman MP, Haykal-Coates N, Gavett SH, Graves JP, Walker VR, Flake GP, Voltz JW, Zhu D, Jacobs ER, Dakhama A, Larsen GL, Loader JE, Gelfand EW, Germolec DR, Korach KS, Zeldin DC.

Am J Respir Crit Care Med. 2007 Jan 15;175(2):126-35. Epub 2006 Nov 9.

44.

Neuropeptide release from airways of young and fully-grown rabbits.

Larsen GL, Fratelli C, Loader J, Kang JK, Dakhama A.

Pediatr Pulmonol. 2006 Dec;41(12):1242-9.

PMID:
17068826
45.

IL-2 and IL-18 attenuation of airway hyperresponsiveness requires STAT4, IFN-gamma, and natural killer cells.

Matsubara S, Takeda K, Kodama T, Joetham A, Miyahara N, Koya T, Swasey CH, Okamoto M, Dakhama A, Gelfand EW.

Am J Respir Cell Mol Biol. 2007 Mar;36(3):324-32. Epub 2006 Oct 12.

46.

Factor B of the alternative complement pathway regulates development of airway hyperresponsiveness and inflammation.

Taube C, Thurman JM, Takeda K, Joetham A, Miyahara N, Carroll MC, Dakhama A, Giclas PC, Holers VM, Gelfand EW.

Proc Natl Acad Sci U S A. 2006 May 23;103(21):8084-9. Epub 2006 May 15.

47.

RANTES (CCL5) regulates airway responsiveness after repeated allergen challenge.

Koya T, Takeda K, Kodama T, Miyahara N, Matsubara S, Balhorn A, Joetham A, Dakhama A, Gelfand EW.

Am J Respir Cell Mol Biol. 2006 Aug;35(2):147-54. Epub 2006 Mar 9.

48.

CD8+ T lymphocytes and leukotriene B4: novel interactions in the persistence and progression of asthma.

Gelfand EW, Dakhama A.

J Allergy Clin Immunol. 2006 Mar;117(3):577-82. Review.

PMID:
16522456
49.

The leukotriene B4 receptor (BLT1) is required for effector CD8+ T cell-mediated, mast cell-dependent airway hyperresponsiveness.

Taube C, Miyahara N, Ott V, Swanson B, Takeda K, Loader J, Shultz LD, Tager AM, Luster AD, Dakhama A, Gelfand EW.

J Immunol. 2006 Mar 1;176(5):3157-64.

50.

Virus-induced airway dysfunction: pathogenesis and biomechanisms.

Dakhama A, Lee YM, Gelfand EW.

Pediatr Infect Dis J. 2005 Nov;24(11 Suppl):S159-69, discussion S166-7. Review.

PMID:
16378041

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