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Items: 1 to 50 of 80

1.

The mGlu7 receptor provides protective effects against epileptogenesis and epileptic seizures.

Girard B, Tuduri P, Moreno MP, Sakkaki S, Barboux C, Bouschet T, Varrault A, Vitre J, McCort-Tranchepain I, Dairou J, Acher F, Fagni L, Marchi N, Perroy J, Bertaso F.

Neurobiol Dis. 2019 Sep;129:13-28. doi: 10.1016/j.nbd.2019.04.016. Epub 2019 Apr 30.

PMID:
31051234
2.

Effects in Cancer Cells of the Recombinant l-Methionine Gamma-Lyase from Brevibacterium aurantiacum. Encapsulation in Human Erythrocytes for Sustained l-Methionine Elimination.

Machover D, Rossi L, Hamelin J, Desterke C, Goldschmidt E, Chadefaux-Vekemans B, Bonnarme P, Briozzo P, Kopečný D, Pierigè F, Magnani M, Mollicone R, Haghighi-Rad F, Gaston-Mathé Y, Dairou J, Boucheix C, Saffroy R.

J Pharmacol Exp Ther. 2019 Jun;369(3):489-502. doi: 10.1124/jpet.119.256537. Epub 2019 Apr 2.

PMID:
30940696
3.

Inhibition of DYRK1A proteolysis modifies its kinase specificity and rescues Alzheimer phenotype in APP/PS1 mice.

Souchet B, Audrain M, Billard JM, Dairou J, Fol R, Orefice NS, Tada S, Gu Y, Dufayet-Chaffaud G, Limanton E, Carreaux F, Bazureau JP, Alves S, Meijer L, Janel N, Braudeau J, Cartier N.

Acta Neuropathol Commun. 2019 Mar 18;7(1):46. doi: 10.1186/s40478-019-0678-6.

4.

Prenatal treatment with EGCG enriched green tea extract rescues GAD67 related developmental and cognitive defects in Down syndrome mouse models.

Souchet B, Duchon A, Gu Y, Dairou J, Chevalier C, Daubigney F, Nalesso V, Créau N, Yu Y, Janel N, Herault Y, Delabar JM.

Sci Rep. 2019 Mar 8;9(1):3914. doi: 10.1038/s41598-019-40328-9.

5.

Alterations in the Serotonin and Dopamine Pathways by Cystathionine Beta Synthase Overexpression in Murine Brain.

London J, Ndiaye FK, Bui LC, Souchet B, Daubigney F, Magnan C, Luquet S, Dairou J, Janel N, Rouch C.

Mol Neurobiol. 2019 Jun;56(6):3958-3971. doi: 10.1007/s12035-018-1323-2. Epub 2018 Sep 20.

PMID:
30238388
6.

AhR signaling pathways and regulatory functions.

Larigot L, Juricek L, Dairou J, Coumoul X.

Biochim Open. 2018 Jun 11;7:1-9. doi: 10.1016/j.biopen.2018.05.001. eCollection 2018 Dec. Review.

7.

Genetic deficiency of indoleamine 2,3-dioxygenase promotes gut microbiota-mediated metabolic health.

Laurans L, Venteclef N, Haddad Y, Chajadine M, Alzaid F, Metghalchi S, Sovran B, Denis RGP, Dairou J, Cardellini M, Moreno-Navarrete JM, Straub M, Jegou S, McQuitty C, Viel T, Esposito B, Tavitian B, Callebert J, Luquet SH, Federici M, Fernandez-Real JM, Burcelin R, Launay JM, Tedgui A, Mallat Z, Sokol H, Taleb S.

Nat Med. 2018 Aug;24(8):1113-1120. doi: 10.1038/s41591-018-0060-4. Epub 2018 Jun 25.

PMID:
29942089
8.

Further characterization of the Maillard deglycase DJ-1 and its prokaryotic homologs, deglycase 1/Hsp31, deglycase 2/YhbO, and deglycase 3/YajL.

Richarme G, Abdallah J, Mathas N, Gautier V, Dairou J.

Biochem Biophys Res Commun. 2018 Sep 5;503(2):703-709. doi: 10.1016/j.bbrc.2018.06.064. Epub 2018 Jun 23.

PMID:
29932913
9.

Enhancement of 5-Fluorouracil Cytotoxicity by Pyridoxal 5'-Phosphate and Folinic Acid in Tandem.

Machover D, Goldschmidt E, Mollicone R, Haghighi-Rad F, Desterke C, Gaston-Mathé Y, Saffroy R, Boucheix C, Dairou J.

J Pharmacol Exp Ther. 2018 Aug;366(2):238-243. doi: 10.1124/jpet.118.249367. Epub 2018 Jun 1.

PMID:
29858389
10.

Indoleamine 2 3-dioxygenase knockout limits angiotensin II-induced aneurysm in low density lipoprotein receptor-deficient mice fed with high fat diet.

Metghalchi S, Vandestienne M, Haddad Y, Esposito B, Dairou J, Tedgui A, Mallat Z, Potteaux S, Taleb S.

PLoS One. 2018 Mar 1;13(3):e0193737. doi: 10.1371/journal.pone.0193737. eCollection 2018.

11.

DYRK1A inhibition and cognitive rescue in a Down syndrome mouse model are induced by new fluoro-DANDY derivatives.

Neumann F, Gourdain S, Albac C, Dekker AD, Bui LC, Dairou J, Schmitz-Afonso I, Hue N, Rodrigues-Lima F, Delabar JM, Potier MC, Le Caër JP, Touboul D, Delatour B, Cariou K, Dodd RH.

Sci Rep. 2018 Feb 12;8(1):2859. doi: 10.1038/s41598-018-20984-z.

12.

Inhibition of central de novo ceramide synthesis restores insulin signaling in hypothalamus and enhances β-cell function of obese Zucker rats.

Campana M, Bellini L, Rouch C, Rachdi L, Coant N, Butin N, Bandet CL, Philippe E, Meneyrol K, Kassis N, Dairou J, Hajduch E, Colsch B, Magnan C, Le Stunff H.

Mol Metab. 2018 Feb;8:23-36. doi: 10.1016/j.molmet.2017.10.013. Epub 2017 Nov 7.

13.

Carbon Black Nanoparticles Inhibit Aromatase Expression and Estradiol Secretion in Human Granulosa Cells Through the ERK1/2 Pathway.

Simon V, Avet C, Grange-Messent V, Wargnier R, Denoyelle C, Pierre A, Dairou J, Dupret JM, Cohen-Tannoudji J.

Endocrinology. 2017 Oct 1;158(10):3200-3211. doi: 10.1210/en.2017-00374.

PMID:
28977593
14.

Original Chemical Series of Pyrimidine Biosynthesis Inhibitors That Boost the Antiviral Interferon Response.

Lucas-Hourani M, Dauzonne D, Munier-Lehmann H, Khiar S, Nisole S, Dairou J, Helynck O, Afonso PV, Tangy F, Vidalain PO.

Antimicrob Agents Chemother. 2017 Sep 22;61(10). pii: e00383-17. doi: 10.1128/AAC.00383-17. Print 2017 Oct.

15.

Guanine glycation repair by DJ-1/Park7 and its bacterial homologs.

Richarme G, Liu C, Mihoub M, Abdallah J, Leger T, Joly N, Liebart JC, Jurkunas UV, Nadal M, Bouloc P, Dairou J, Lamouri A.

Science. 2017 Jul 14;357(6347):208-211. doi: 10.1126/science.aag1095. Epub 2017 Jun 8.

PMID:
28596309
16.

Overexpression of the DYRK1A Gene (Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase 1A) Induces Alterations of the Serotoninergic and Dopaminergic Processing in Murine Brain Tissues.

London J, Rouch C, Bui LC, Assayag E, Souchet B, Daubigney F, Medjaoui H, Luquet S, Magnan C, Delabar JM, Dairou J, Janel N.

Mol Neurobiol. 2018 May;55(5):3822-3831. doi: 10.1007/s12035-017-0591-6. Epub 2017 May 25.

PMID:
28540658
17.

Molecular phenotyping of multiple mouse strains under metabolic challenge uncovers a role for Elovl2 in glucose-induced insulin secretion.

Cruciani-Guglielmacci C, Bellini L, Denom J, Oshima M, Fernandez N, Normandie-Levi P, Berney XP, Kassis N, Rouch C, Dairou J, Gorman T, Smith DM, Marley A, Liechti R, Kuznetsov D, Wigger L, Burdet F, Lefèvre AL, Wehrle I, Uphues I, Hildebrandt T, Rust W, Bernard C, Ktorza A, Rutter GA, Scharfmann R, Xenarios I, Le Stunff H, Thorens B, Magnan C, Ibberson M.

Mol Metab. 2017 Jan 26;6(4):340-351. doi: 10.1016/j.molmet.2017.01.009. eCollection 2017 Apr.

18.

Effect of lyophilized prune extract on hyperhomocysteinemia in mice.

Haddadi-Guemghar H, Tlili A, Dairou J, Paul JL, Madani K, Janel N.

Food Chem Toxicol. 2017 May;103:183-187. doi: 10.1016/j.fct.2017.03.018. Epub 2017 Mar 10.

PMID:
28288933
19.

Increased intestinal permeation and modulation of presystemic metabolism of resveratrol formulated into self-emulsifying drug delivery systems.

Mamadou G, Charrueau C, Dairou J, Limas Nzouzi N, Eto B, Ponchel G.

Int J Pharm. 2017 Apr 15;521(1-2):150-155. doi: 10.1016/j.ijpharm.2017.02.036. Epub 2017 Feb 17.

PMID:
28216465
20.

Parkinsonism-associated protein DJ-1 is a bona fide deglycase.

Richarme G, Dairou J.

Biochem Biophys Res Commun. 2017 Jan 29;483(1):387-391. doi: 10.1016/j.bbrc.2016.12.134. Epub 2016 Dec 21.

PMID:
28013050
21.

Discovery and Function of a General Core Hormetic Stress Response in E. coli Induced by Sublethal Concentrations of Antibiotics.

Mathieu A, Fleurier S, Frénoy A, Dairou J, Bredeche MF, Sanchez-Vizuete P, Song X, Matic I.

Cell Rep. 2016 Sep 27;17(1):46-57. doi: 10.1016/j.celrep.2016.09.001.

22.

Spectral and 3D model studies of the interaction of orphan human cytochrome P450 2U1 with substrates and ligands.

Dhers L, Pietrancosta N, Ducassou L, Ramassamy B, Dairou J, Jaouen M, André F, Mansuy D, Boucher JL.

Biochim Biophys Acta Gen Subj. 2017 Jan;1861(1 Pt A):3144-3153. doi: 10.1016/j.bbagen.2016.07.018. Epub 2016 Jul 25.

PMID:
27456766
23.

Fermentation and alternative respiration compensate for NADH dehydrogenase deficiency in a prokaryotic model of DJ-1-associated Parkinsonism.

Messaoudi N, Gautier V, Dairou J, Mihoub M, Lelandais G, Bouloc P, Landoulsi A, Richarme G.

Microbiology. 2015 Nov;161(11):2220-31. doi: 10.1099/mic.0.000181. Epub 2015 Sep 15.

PMID:
26377309
24.

Pyrimidine Pool Disequilibrium Induced by a Cytidine Deaminase Deficiency Inhibits PARP-1 Activity, Leading to the Under Replication of DNA.

Gemble S, Ahuja A, Buhagiar-Labarchède G, Onclercq-Delic R, Dairou J, Biard DS, Lambert S, Lopes M, Amor-Guéret M.

PLoS Genet. 2015 Jul 16;11(7):e1005384. doi: 10.1371/journal.pgen.1005384. eCollection 2015 Jul.

25.

The DJ-1 superfamily member Hsp31 repairs proteins from glycation by methylglyoxal and glyoxal.

Mihoub M, Abdallah J, Gontero B, Dairou J, Richarme G.

Biochem Biophys Res Commun. 2015 Aug 7;463(4):1305-10. doi: 10.1016/j.bbrc.2015.06.111. Epub 2015 Jun 21.

PMID:
26102038
26.

Screen for soil fungi highly resistant to dichloroaniline uncovers mostly Fusarium species.

Chan Ho Tong L, Dairou J, Bui LC, Bouillon J, Rodrigues-Lima F, Dupret JM, Silar P.

Fungal Genet Biol. 2015 Aug;81:82-7. doi: 10.1016/j.fgb.2015.05.011. Epub 2015 Jun 8.

PMID:
26068093
27.

A RP-UFLC Assay for Protein Tyrosine Phosphatases: Focus on Protein Tyrosine Phosphatase Non-Receptor Type 2 (PTPN2).

Duval R, Bui LC, Berthelet J, Dairou J, Mathieu C, Guidez F, Dupret JM, Cools J, Chomienne C, Rodrigues-Lima F.

Sci Rep. 2015 Jun 4;5:10750. doi: 10.1038/srep10750.

28.

Parkinsonism-associated protein DJ-1/Park7 is a major protein deglycase that repairs methylglyoxal- and glyoxal-glycated cysteine, arginine, and lysine residues.

Richarme G, Mihoub M, Dairou J, Bui LC, Leger T, Lamouri A.

J Biol Chem. 2015 Jan 16;290(3):1885-97. doi: 10.1074/jbc.M114.597815. Epub 2014 Nov 21.

29.

Structural and functional characterization of an arylamine N-acetyltransferase from the pathogen Mycobacterium abscessus: differences from other mycobacterial isoforms and implications for selective inhibition.

Cocaign A, Kubiak X, Xu X, Garnier G, Li de la Sierra-Gallay I, Chi-Bui L, Dairou J, Busi F, Abuhammad A, Haouz A, Dupret JM, Herrmann JL, Rodrigues-Lima F.

Acta Crystallogr D Biol Crystallogr. 2014 Nov;70(Pt 11):3066-79. doi: 10.1107/S1399004714021282. Epub 2014 Oct 29.

PMID:
25372695
30.

Importance of branched-chain amino acid utilization in Francisella intracellular adaptation.

Gesbert G, Ramond E, Tros F, Dairou J, Frapy E, Barel M, Charbit A.

Infect Immun. 2015 Jan;83(1):173-83. doi: 10.1128/IAI.02579-14. Epub 2014 Oct 20.

31.

From arylamine N-acetyltransferase to folate-dependent acetyl CoA hydrolase: impact of folic acid on the activity of (HUMAN)NAT1 and its homologue (MOUSE)NAT2.

Laurieri N, Dairou J, Egleton JE, Stanley LA, Russell AJ, Dupret JM, Sim E, Rodrigues-Lima F.

PLoS One. 2014 May 13;9(5):e96370. doi: 10.1371/journal.pone.0096370. eCollection 2014.

32.

Glutamate utilization couples oxidative stress defense and the tricarboxylic acid cycle in Francisella phagosomal escape.

Ramond E, Gesbert G, Rigard M, Dairou J, Dupuis M, Dubail I, Meibom K, Henry T, Barel M, Charbit A.

PLoS Pathog. 2014 Jan;10(1):e1003893. doi: 10.1371/journal.ppat.1003893. Epub 2014 Jan 16.

33.

A high-performance liquid chromatography assay for Dyrk1a, a Down syndrome-associated kinase.

Bui LC, Tabouy L, Busi F, Dupret JM, Janel N, Planque C, Delabar JM, Rodrigues-Lima F, Dairou J.

Anal Biochem. 2014 Mar 15;449:172-8. doi: 10.1016/j.ab.2013.12.024. Epub 2013 Dec 25.

PMID:
24374000
34.

Skeletal muscle glycogen phosphorylase is irreversibly inhibited by mercury: molecular, cellular and kinetic aspects.

Xu X, Mathieu C, Boitard SE, Dairou J, Dupret JM, Agbulut O, Rodrigues-Lima F.

FEBS Lett. 2014 Jan 3;588(1):138-42. doi: 10.1016/j.febslet.2013.11.021. Epub 2013 Nov 21.

35.

Unsaturated fatty acids disrupt Smad signaling in gonadotrope cells leading to inhibition of FSHβ gene expression.

Garrel G, Simon V, Denoyelle C, Ishaq M, Rouch C, Dairou J, Magnan C, Migrenne S, Cruciani-Guglielmacci C, Cohen-Tannoudji J.

Endocrinology. 2014 Feb;155(2):592-604. doi: 10.1210/en.2013-1833. Epub 2013 Nov 18.

PMID:
24248462
36.

Development of DANDYs, new 3,5-diaryl-7-azaindoles demonstrating potent DYRK1A kinase inhibitory activity.

Gourdain S, Dairou J, Denhez C, Bui LC, Rodrigues-Lima F, Janel N, Delabar JM, Cariou K, Dodd RH.

J Med Chem. 2013 Dec 12;56(23):9569-85. doi: 10.1021/jm401049v. Epub 2013 Nov 19.

PMID:
24188002
37.

Fatty acid transporter CD36 mediates hypothalamic effect of fatty acids on food intake in rats.

Moullé VS, Le Foll C, Philippe E, Kassis N, Rouch C, Marsollier N, Bui LC, Guissard C, Dairou J, Lorsignol A, Pénicaud L, Levin BE, Cruciani-Guglielmacci C, Magnan C.

PLoS One. 2013 Sep 6;8(9):e74021. doi: 10.1371/journal.pone.0074021. eCollection 2013.

38.

A novel color change mechanism for breast cancer biomarker detection: naphthoquinones as specific ligands of human arylamine N-acetyltransferase 1.

Laurieri N, Egleton JE, Varney A, Thinnes CC, Quevedo CE, Seden PT, Thompson S, Rodrigues-Lima F, Dairou J, Dupret JM, Russell AJ, Sim E.

PLoS One. 2013 Aug 5;8(8):e70600. doi: 10.1371/journal.pone.0070600. Print 2013.

39.

Biotransformation of Trichoderma spp. and their tolerance to aromatic amines, a major class of pollutants.

Cocaign A, Bui LC, Silar P, Chan Ho Tong L, Busi F, Lamouri A, Mougin C, Rodrigues-Lima F, Dupret JM, Dairou J.

Appl Environ Microbiol. 2013 Aug;79(15):4719-26. doi: 10.1128/AEM.00989-13. Epub 2013 May 31.

40.

Theileria induces oxidative stress and HIF1α activation that are essential for host leukocyte transformation.

Medjkane S, Perichon M, Marsolier J, Dairou J, Weitzman JB.

Oncogene. 2014 Apr 3;33(14):1809-17. doi: 10.1038/onc.2013.134. Epub 2013 May 13.

PMID:
23665677
41.

Acrolein, an α,β-unsaturated aldehyde, irreversibly inhibits the acetylation of aromatic amine xenobiotics by human arylamine N-acetyltransferase 1.

Bui LC, Manaa A, Xu X, Duval R, Busi F, Dupret JM, Rodrigues-Lima F, Dairou J.

Drug Metab Dispos. 2013 Jul;41(7):1300-5. doi: 10.1124/dmd.113.052258. Epub 2013 Apr 30.

PMID:
23633528
42.

Plasma nitrate levels are increased in adult Down syndrome patients.

Ripoll C, Dairou J, Stora S, Delabar JM, Janel N.

Biomarkers. 2013 Jun;18(4):373-4. doi: 10.3109/1354750X.2013.783117. Epub 2013 Apr 29. No abstract available.

PMID:
23627616
43.

Reduction of dNTP levels enhances DNA replication fidelity in vivo.

Laureti L, Selva M, Dairou J, Matic I.

DNA Repair (Amst). 2013 Apr 1;12(4):300-5. doi: 10.1016/j.dnarep.2013.01.009. Epub 2013 Feb 21.

PMID:
23433812
44.

Hepatocyte-specific Dyrk1a gene transfer rescues plasma apolipoprotein A-I levels and aortic Akt/GSK3 pathways in hyperhomocysteinemic mice.

Tlili A, Jacobs F, de Koning L, Mohamed S, Bui LC, Dairou J, Belin N, Ducros V, Dubois T, Paul JL, Delabar JM, De Geest B, Janel N.

Biochim Biophys Acta. 2013 Jun;1832(6):718-28. doi: 10.1016/j.bbadis.2013.02.008. Epub 2013 Feb 18.

45.

Crystal structure of arylamine N-acetyltransferases: insights into the mechanisms of action and substrate selectivity.

Kubiak X, Dairou J, Dupret JM, Rodrigues-Lima F.

Expert Opin Drug Metab Toxicol. 2013 Mar;9(3):349-62. doi: 10.1517/17425255.2013.742505. Epub 2013 Jan 7. Review.

PMID:
23289949
46.

Hypothalamic AgRP-neurons control peripheral substrate utilization and nutrient partitioning.

Joly-Amado A, Denis RG, Castel J, Lacombe A, Cansell C, Rouch C, Kassis N, Dairou J, Cani PD, Ventura-Clapier R, Prola A, Flamment M, Foufelle F, Magnan C, Luquet S.

EMBO J. 2012 Nov 14;31(22):4276-88. doi: 10.1038/emboj.2012.250. Epub 2012 Sep 18.

47.

Mice deficient in cystathionine beta synthase display increased Dyrk1A and SAHH activities in brain.

Planque C, Dairou J, Noll C, Bui LC, Ripoll C, Guedj F, Delabar JM, Janel N.

J Mol Neurosci. 2013 May;50(1):1-6. doi: 10.1007/s12031-012-9835-0. Epub 2012 Jun 15.

PMID:
22700376
48.

Characterization of an acetyltransferase that detoxifies aromatic chemicals in Legionella pneumophila.

Kubiak X, Dervins-Ravault D, Pluvinage B, Chaffotte AF, Gomez-Valero L, Dairou J, Busi F, Dupret JM, Buchrieser C, Rodrigues-Lima F.

Biochem J. 2012 Jul 15;445(2):219-28. doi: 10.1042/BJ20120528.

PMID:
22545684
49.

The Bacillus anthracis arylamine N-acetyltransferase ((BACAN)NAT1) that inactivates sulfamethoxazole, reveals unusual structural features compared with the other NAT isoenzymes.

Pluvinage B, Li de la Sierra-Gallay I, Kubiak X, Xu X, Dairou J, Dupret JM, Rodrigues-Lima F.

FEBS Lett. 2011 Dec 15;585(24):3947-52. doi: 10.1016/j.febslet.2011.10.041. Epub 2011 Nov 2.

50.

Inactivation of mitochondrial aspartate aminotransferase contributes to the respiratory deficit of yeast frataxin-deficient cells.

Sliwa D, Dairou J, Camadro JM, Santos R.

Biochem J. 2012 Feb 1;441(3):945-53. doi: 10.1042/BJ20111574.

PMID:
22010850

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