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Items: 1 to 50 of 55

1.

Regulation of brain glutamate metabolism by nitric oxide and S-nitrosylation.

Raju K, Doulias PT, Evans P, Krizman EN, Jackson JG, Horyn O, Daikhin Y, Nissim I, Yudkoff M, Nissim I, Sharp KA, Robinson MB, Ischiropoulos H.

Sci Signal. 2015 Jul 7;8(384):ra68. doi: 10.1126/scisignal.aaa4312.

2.

Engineering the gut microbiota to treat hyperammonemia.

Shen TC, Albenberg L, Bittinger K, Chehoud C, Chen YY, Judge CA, Chau L, Ni J, Sheng M, Lin A, Wilkins BJ, Buza EL, Lewis JD, Daikhin Y, Nissim I, Yudkoff M, Bushman FD, Wu GD.

J Clin Invest. 2015 Jul 1;125(7):2841-50. doi: 10.1172/JCI79214. Epub 2015 Jun 22.

3.

Augmenting ureagenesis in patients with partial carbamyl phosphate synthetase 1 deficiency with N-carbamyl-L-glutamate.

Ah Mew N, McCarter R, Daikhin Y, Lichter-Konecki U, Nissim I, Yudkoff M, Tuchman M.

J Pediatr. 2014 Aug;165(2):401-403.e3. doi: 10.1016/j.jpeds.2014.04.012. Epub 2014 May 29.

4.

The molecular and metabolic influence of long term agmatine consumption.

Nissim I, Horyn O, Daikhin Y, Chen P, Li C, Wehrli SL, Nissim I, Yudkoff M.

J Biol Chem. 2014 Apr 4;289(14):9710-29. doi: 10.1074/jbc.M113.544726. Epub 2014 Feb 12.

5.

Regulation of glucagon secretion in normal and diabetic human islets by γ-hydroxybutyrate and glycine.

Li C, Liu C, Nissim I, Chen J, Chen P, Doliba N, Zhang T, Nissim I, Daikhin Y, Stokes D, Yudkoff M, Bennett MJ, Stanley CA, Matschinsky FM, Naji A.

J Biol Chem. 2013 Feb 8;288(6):3938-51. doi: 10.1074/jbc.M112.385682. Epub 2012 Dec 24.

6.

Effects of a glucokinase activator on hepatic intermediary metabolism: study with 13C-isotopomer-based metabolomics.

Nissim I, Horyn O, Nissim I, Daikhin Y, Wehrli SL, Yudkoff M, Matschinsky FM.

Biochem J. 2012 Jun 15;444(3):537-51. doi: 10.1042/BJ20120163.

7.

N-carbamylglutamate enhancement of ureagenesis leads to discovery of a novel deleterious mutation in a newly defined enhancer of the NAGS gene and to effective therapy.

Heibel SK, Ah Mew N, Caldovic L, Daikhin Y, Yudkoff M, Tuchman M.

Hum Mutat. 2011 Oct;32(10):1153-60. doi: 10.1002/humu.21553. Epub 2011 Sep 9.

8.

Down-regulation of hepatic urea synthesis by oxypurines: xanthine and uric acid inhibit N-acetylglutamate synthase.

Nissim I, Horyn O, Nissim I, Daikhin Y, Caldovic L, Barcelona B, Cervera J, Tuchman M, Yudkoff M.

J Biol Chem. 2011 Jun 24;286(25):22055-68. doi: 10.1074/jbc.M110.209023. Epub 2011 May 3.

9.

N-carbamylglutamate augments ureagenesis and reduces ammonia and glutamine in propionic acidemia.

Ah Mew N, McCarter R, Daikhin Y, Nissim I, Yudkoff M, Tuchman M.

Pediatrics. 2010 Jul;126(1):e208-14. doi: 10.1542/peds.2010-0008. Epub 2010 Jun 21.

10.

Measuring in vivo ureagenesis with stable isotopes.

Yudkoff M, Ah Mew N, Daikhin Y, Horyn O, Nissim I, Nissim I, Payan I, Tuchman M.

Mol Genet Metab. 2010;100 Suppl 1:S37-41. doi: 10.1016/j.ymgme.2010.02.017. Epub 2010 Feb 26.

11.

Effects of a single dose of N-carbamylglutamate on the rate of ureagenesis.

Ah Mew N, Payan I, Daikhin Y, Nissim I, Nissim I, Tuchman M, Yudkoff M.

Mol Genet Metab. 2009 Dec;98(4):325-30. doi: 10.1016/j.ymgme.2009.07.010. Epub 2009 Jul 14. Erratum in: Mol Genet Metab. 2010 Apr;99(4):440.

12.

Ketosis and brain handling of glutamate, glutamine, and GABA.

Yudkoff M, Daikhin Y, Horyn O, Nissim I, Nissim I.

Epilepsia. 2008 Nov;49 Suppl 8:73-5. doi: 10.1111/j.1528-1167.2008.01841.x. Review.

13.

Elimination of KATP channels in mouse islets results in elevated [U-13C]glucose metabolism, glutaminolysis, and pyruvate cycling but a decreased gamma-aminobutyric acid shunt.

Li C, Nissim I, Chen P, Buettger C, Najafi H, Daikhin Y, Nissim I, Collins HW, Yudkoff M, Stanley CA, Matschinsky FM.

J Biol Chem. 2008 Jun 20;283(25):17238-49. doi: 10.1074/jbc.M709235200. Epub 2008 Apr 29.

14.

N-carbamylglutamate markedly enhances ureagenesis in N-acetylglutamate deficiency and propionic acidemia as measured by isotopic incorporation and blood biomarkers.

Tuchman M, Caldovic L, Daikhin Y, Horyn O, Nissim I, Nissim I, Korson M, Burton B, Yudkoff M.

Pediatr Res. 2008 Aug;64(2):213-7. doi: 10.1203/PDR.0b013e318179454b.

15.

3-isobutylmethylxanthine inhibits hepatic urea synthesis: protection by agmatine.

Nissim I, Horyn O, Nissim I, Daikhin Y, Wehrli SL, Yudkoff M.

J Biol Chem. 2008 May 30;283(22):15063-71. doi: 10.1074/jbc.M800163200. Epub 2008 Mar 28.

16.

The ketogenic diet and brain metabolism of amino acids: relationship to the anticonvulsant effect.

Yudkoff M, Daikhin Y, Melø TM, Nissim I, Sonnewald U, Nissim I.

Annu Rev Nutr. 2007;27:415-30. Review.

17.

Evaluation of formulas for calculating total energy requirements of preadolescent children with cystic fibrosis.

Trabulsi J, Ittenbach RF, Schall JI, Olsen IE, Yudkoff M, Daikhin Y, Zemel BS, Stallings VA.

Am J Clin Nutr. 2007 Jan;85(1):144-51.

PMID:
17209190
18.

Energy balance and the accuracy of reported energy intake in preadolescent children with cystic fibrosis.

Trabulsi J, Schall JI, Ittenbach RF, Olsen IE, Yudkoff M, Daikhin Y, Zemel BS, Stallings VA.

Am J Clin Nutr. 2006 Sep;84(3):523-30.

PMID:
16960165
19.

Ifosfamide-induced nephrotoxicity: mechanism and prevention.

Nissim I, Horyn O, Daikhin Y, Nissim I, Luhovyy B, Phillips PC, Yudkoff M.

Cancer Res. 2006 Aug 1;66(15):7824-31.

20.

Effects of a GTP-insensitive mutation of glutamate dehydrogenase on insulin secretion in transgenic mice.

Li C, Matter A, Kelly A, Petty TJ, Najafi H, MacMullen C, Daikhin Y, Nissim I, Lazarow A, Kwagh J, Collins HW, Hsu BY, Nissim I, Yudkoff M, Matschinsky FM, Stanley CA.

J Biol Chem. 2006 Jun 2;281(22):15064-72. Epub 2006 Mar 30.

21.

Short-term fasting, seizure control and brain amino acid metabolism.

Yudkoff M, Daikhin Y, Nissim I, Horyn O, Luhovyy B, Lazarow A, Nissim I.

Neurochem Int. 2006 May-Jun;48(6-7):650-6. Epub 2006 Feb 28.

PMID:
16510212
22.

Agmatine stimulates hepatic fatty acid oxidation: a possible mechanism for up-regulation of ureagenesis.

Nissim I, Daikhin Y, Nissim I, Luhovyy B, Horyn O, Wehrli SL, Yudkoff M.

J Biol Chem. 2006 Mar 31;281(13):8486-96. Epub 2006 Feb 1.

23.

Brain amino acid requirements and toxicity: the example of leucine.

Yudkoff M, Daikhin Y, Nissim I, Horyn O, Luhovyy B, Luhovyy B, Lazarow A, Nissim I.

J Nutr. 2005 Jun;135(6 Suppl):1531S-8S. doi: 10.1093/jn/135.6.1531S. Review. Erratum in: J Nutr. 2005 Aug;135(8):2009. Luhovyy, Bogdan [corrected to Luhovyy, Bohdan].

PMID:
15930465
24.

Response of brain amino acid metabolism to ketosis.

Yudkoff M, Daikhin Y, Nissim I, Horyn O, Lazarow A, Luhovyy B, Wehrli S, Nissim I.

Neurochem Int. 2005 Jul;47(1-2):119-28.

PMID:
15888376
25.

The role of mitochondrially bound arginase in the regulation of urea synthesis: studies with [U-15N4]arginine, isolated mitochondria, and perfused rat liver.

Nissim I, Luhovyy B, Horyn O, Daikhin Y, Nissim I, Yudkoff M.

J Biol Chem. 2005 May 6;280(18):17715-24. Epub 2005 Mar 7.

26.

Biosynthesis of agmatine in isolated mitochondria and perfused rat liver: studies with 15N-labelled arginine.

Horyn O, Luhovyy B, Lazarow A, Daikhin Y, Nissim I, Yudkoff M, Nissim I.

Biochem J. 2005 Jun 1;388(Pt 2):419-25.

27.

Restoration of ureagenesis in N-acetylglutamate synthase deficiency by N-carbamylglutamate.

Caldovic L, Morizono H, Daikhin Y, Nissim I, McCarter RJ, Yudkoff M, Tuchman M.

J Pediatr. 2004 Oct;145(4):552-4.

PMID:
15480384
28.

Ketogenic diet, brain glutamate metabolism and seizure control.

Yudkoff M, Daikhin Y, Nissim I, Lazarow A, Nissim I.

Prostaglandins Leukot Essent Fatty Acids. 2004 Mar;70(3):277-85. Review.

PMID:
14769486
29.

A signaling role of glutamine in insulin secretion.

Li C, Buettger C, Kwagh J, Matter A, Daikhin Y, Nissim IB, Collins HW, Yudkoff M, Stanley CA, Matschinsky FM.

J Biol Chem. 2004 Apr 2;279(14):13393-401. Epub 2004 Jan 20.

30.

Role of the glutamate dehydrogenase reaction in furnishing aspartate nitrogen for urea synthesis: studies in perfused rat liver with 15N.

Nissim I, Horyn O, Luhovyy B, Lazarow A, Daikhin Y, Nissim I, Yudkoff M.

Biochem J. 2003 Nov 15;376(Pt 1):179-88.

31.

Metabolism of brain amino acids following pentylenetetrazole treatment.

Yudkoff M, Daikhin Y, Nissim I, Horyn O, Lazarow A, Nissim I.

Epilepsy Res. 2003 Feb;53(1-2):151-62.

PMID:
12576176
32.

Regulation of leucine-stimulated insulin secretion and glutamine metabolism in isolated rat islets.

Li C, Najafi H, Daikhin Y, Nissim IB, Collins HW, Yudkoff M, Matschinsky FM, Stanley CA.

J Biol Chem. 2003 Jan 31;278(5):2853-8. Epub 2002 Nov 19.

33.

Regulation of urea synthesis by agmatine in the perfused liver: studies with 15N.

Nissim I, Horyn O, Daikhin Y, Nissim I, Lazarow A, Yudkoff M.

Am J Physiol Endocrinol Metab. 2002 Dec;283(6):E1123-34. Epub 2002 Aug 13.

34.

Ketogenic diet, amino acid metabolism, and seizure control.

Yudkoff M, Daikhin Y, Nissim I, Lazarow A, Nissim I.

J Neurosci Res. 2001 Dec 1;66(5):931-40. Review.

PMID:
11746421
35.

N(epsilon)-(gamma-L-glutamyl)-L-lysine (GGEL) is increased in cerebrospinal fluid of patients with Huntington's disease.

Jeitner TM, Bogdanov MB, Matson WR, Daikhin Y, Yudkoff M, Folk JE, Steinman L, Browne SE, Beal MF, Blass JP, Cooper AJ.

J Neurochem. 2001 Dec;79(5):1109-12.

36.

Brain amino acid metabolism and ketosis.

Yudkoff M, Daikhin Y, Nissim I, Lazarow A, Nissim I.

J Neurosci Res. 2001 Oct 15;66(2):272-81.

PMID:
11592124
37.

Alanine metabolism in the perfused rat liver. Studies with (15)N.

Brosnan JT, Brosnan ME, Yudkoff M, Nissim I, Daikhin Y, Lazarow A, Horyn O, Nissim I.

J Biol Chem. 2001 Aug 24;276(34):31876-82. Epub 2001 Jun 21.

38.

Compartmentation of brain glutamate metabolism in neurons and glia.

Daikhin Y, Yudkoff M.

J Nutr. 2000 Apr;130(4S Suppl):1026S-31S. doi: 10.1093/jn/130.4.1026S. Review.

PMID:
10736375
39.

Acidosis and astrocyte amino acid metabolism.

Yudkoff M, Daikhin Y, Nissim I, Nissim I.

Neurochem Int. 2000 Apr;36(4-5):329-39.

PMID:
10733000
40.

Rapid method for determining the rate of DNA synthesis and cellular proliferation.

Nissim I, Starr SE, Sullivan KE, Campbell DE, Douglas SD, Daikhin Y, Yudkoff M.

Anal Biochem. 2000 Feb 15;278(2):198-205.

PMID:
10660463
41.

Correction of ureagenesis after gene transfer in an animal model and after liver transplantation in humans with ornithine transcarbamylase deficiency.

Batshaw ML, Robinson MB, Ye X, Pabin C, Daikhin Y, Burton BK, Wilson JM, Yudkoff M.

Pediatr Res. 1999 Nov;46(5):588-93.

PMID:
10541323
42.

Decreased intraplatelet Ca2+ release and ATP secretion in pediatric nephrotic syndrome.

Svetlov SI, Moskaleva ES, Pinelis VG, Daikhin Y, Serebruany VL.

Pediatr Nephrol. 1999 Apr;13(3):205-8.

PMID:
10353406
43.

Ketone bodies and brain glutamate and GABA metabolism.

Daikhin Y, Yudkoff M.

Dev Neurosci. 1998;20(4-5):358-64.

PMID:
9778572
44.

In vivo measurement of ureagenesis with stable isotopes.

Yudkoff M, Daikhin Y, Ye X, Wilson JM, Batshaw ML.

J Inherit Metab Dis. 1998;21 Suppl 1:21-9.

PMID:
9686342
45.

Effects of ketone bodies on astrocyte amino acid metabolism.

Yudkoff M, Daikhin Y, Nissim I, Grunstein R, Nissim I.

J Neurochem. 1997 Aug;69(2):682-92.

46.
47.

In vivo nitrogen metabolism in ornithine transcarbamylase deficiency.

Yudkoff M, Daikhin Y, Nissim I, Jawad A, Wilson J, Batshaw M.

J Clin Invest. 1996 Nov 1;98(9):2167-73.

48.

Neuronal metabolism of branched-chain amino acids: flux through the aminotransferase pathway in synaptosomes.

Yudkoff M, Daikhin Y, Nelson D, Nissim I, Erecińska M.

J Neurochem. 1996 May;66(5):2136-45.

PMID:
8780046
49.

Metabolism of N-acetyl-L-aspartate in rat brain.

Miller SL, Daikhin Y, Yudkoff M.

Neurochem Res. 1996 May;21(5):615-8.

PMID:
8726971
50.

Astrocyte leucine metabolism: significance of branched-chain amino acid transamination.

Yudkoff M, Daikhin Y, Grunstein L, Nissim I, Stern J, Pleasure D, Nissim I.

J Neurochem. 1996 Jan;66(1):378-85.

PMID:
8522978

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