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Structural basis for substrate selectivity and nucleophilic substitution mechanisms in human adenine phosphoribosyltransferase catalyzed reaction.

Ozeir M, Huyet J, Burgevin MC, Pinson B, Chesney F, Remy JM, Siddiqi AR, Lupoli R, Pinon G, Saint-Marc C, Gibert JF, Morales R, Ceballos-Picot I, Barouki R, Daignan-Fornier B, Olivier-Bandini A, Augé F, Nioche P.

J Biol Chem. 2019 Aug 9;294(32):11980-11991. doi: 10.1074/jbc.RA119.009087. Epub 2019 Jun 3.


Dual control of NAD+ synthesis by purine metabolites in yeast.

Pinson B, Ceschin J, Saint-Marc C, Daignan-Fornier B.

Elife. 2019 Mar 12;8. pii: e43808. doi: 10.7554/eLife.43808.


Purine Homeostasis Is Necessary for Developmental Timing, Germline Maintenance and Muscle Integrity in Caenorhabditis elegans.

Marsac R, Pinson B, Saint-Marc C, Olmedo M, Artal-Sanz M, Daignan-Fornier B, Gomes JE.

Genetics. 2019 Apr;211(4):1297-1313. doi: 10.1534/genetics.118.301062. Epub 2019 Jan 30.


Yeast to Study Human Purine Metabolism Diseases.

Daignan-Fornier B, Pinson B.

Cells. 2019 Jan 17;8(1). pii: E67. doi: 10.3390/cells8010067. Review.


Metabolomics and proteomics identify the toxic form and the associated cellular binding targets of the anti-proliferative drug AICAR.

Douillet DC, Pinson B, Ceschin J, Hürlimann HC, Saint-Marc C, Laporte D, Claverol S, Konrad M, Bonneu M, Daignan-Fornier B.

J Biol Chem. 2019 Jan 18;294(3):805-815. doi: 10.1074/jbc.RA118.004964. Epub 2018 Nov 26.


AICAR Antiproliferative Properties Involve the AMPK-Independent Activation of the Tumor Suppressors LATS 1 and 2.

Philippe C, Pinson B, Dompierre J, Pantesco V, Viollet B, Daignan-Fornier B, Moenner M.

Neoplasia. 2018 Jun;20(6):555-562. doi: 10.1016/j.neo.2018.03.006. Epub 2018 May 3.


Multiple chemo-genetic interactions between a toxic metabolite and the ubiquitin pathway in yeast.

Albrecht D, Hürlimann HC, Ceschin J, Saint-Marc C, Pinson B, Daignan-Fornier B.

Curr Genet. 2018 Dec;64(6):1275-1286. doi: 10.1007/s00294-018-0843-7. Epub 2018 May 2.


Structural Insights into the Forward and Reverse Enzymatic Reactions in Human Adenine Phosphoribosyltransferase.

Huyet J, Ozeir M, Burgevin MC, Pinson B, Chesney F, Remy JM, Siddiqi AR, Lupoli R, Pinon G, Saint-Marc C, Gibert JF, Morales R, Ceballos-Picot I, Barouki R, Daignan-Fornier B, Olivier-Bandini A, Augé F, Nioche P.

Cell Chem Biol. 2018 Jun 21;25(6):666-676.e4. doi: 10.1016/j.chembiol.2018.02.011. Epub 2018 Mar 22.


Chemo-Genetic Interactions Between Histone Modification and the Antiproliferation Drug AICAR Are Conserved in Yeast and Humans.

Albrecht D, Ceschin J, Dompierre J, Gueniot F, Pinson B, Daignan-Fornier B.

Genetics. 2016 Dec;204(4):1447-1460. Epub 2016 Oct 5.


Disruption of Nucleotide Homeostasis by the Antiproliferative Drug 5-Aminoimidazole-4-carboxamide-1-β-d-ribofuranoside Monophosphate (AICAR).

Ceschin J, Hürlimann HC, Saint-Marc C, Albrecht D, Violo T, Moenner M, Daignan-Fornier B, Pinson B.

J Biol Chem. 2015 Sep 25;290(39):23947-59. doi: 10.1074/jbc.M115.656017. Epub 2015 Aug 17.


Serine hydroxymethyltransferase: a key player connecting purine, folate and methionine metabolism in Saccharomyces cerevisiae.

Saint-Marc C, Hürlimann HC, Daignan-Fornier B, Pinson B.

Curr Genet. 2015 Nov;61(4):633-40. doi: 10.1007/s00294-015-0489-7. Epub 2015 Apr 17.


New biomarkers for early diagnosis of Lesch-Nyhan disease revealed by metabolic analysis on a large cohort of patients.

Ceballos-Picot I, Le Dantec A, Brassier A, Jaïs JP, Ledroit M, Cahu J, Ea HK, Daignan-Fornier B, Pinson B.

Orphanet J Rare Dis. 2015 Jan 23;10:7. doi: 10.1186/s13023-014-0219-0.


Identification of yeast and human 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAr) transporters.

Ceschin J, Saint-Marc C, Laporte J, Labriet A, Philippe C, Moenner M, Daignan-Fornier B, Pinson B.

J Biol Chem. 2014 Jun 13;289(24):16844-54. doi: 10.1074/jbc.M114.551192. Epub 2014 Apr 28.


A pharmaco-epistasis strategy reveals a new cell size controlling pathway in yeast.

Moretto F, Sagot I, Daignan-Fornier B, Pinson B.

Mol Syst Biol. 2013 Nov 12;9:707. doi: 10.1038/msb.2013.60.


Functional significance of four successive glycine residues in the pyrophosphate binding loop of fungal 6-oxopurine phosphoribosyltransferases.

Moynié L, Giraud MF, Breton A, Boissier F, Daignan-Fornier B, Dautant A.

Protein Sci. 2012 Aug;21(8):1185-96. doi: 10.1002/pro.2098. Epub 2012 Jun 11.


Regulation of amino acid, nucleotide, and phosphate metabolism in Saccharomyces cerevisiae.

Ljungdahl PO, Daignan-Fornier B.

Genetics. 2012 Mar;190(3):885-929. doi: 10.1534/genetics.111.133306.


Tye7 regulates yeast Ty1 retrotransposon sense and antisense transcription in response to adenylic nucleotides stress.

Servant G, Pinson B, Tchalikian-Cosson A, Coulpier F, Lemoine S, Pennetier C, Bridier-Nahmias A, Todeschini AL, Fayol H, Daignan-Fornier B, Lesage P.

Nucleic Acids Res. 2012 Jul;40(12):5271-82. doi: 10.1093/nar/gks166. Epub 2012 Feb 29.


Proliferation/Quiescence: When to start? Where to stop? What to stock?

Daignan-Fornier B, Sagot I.

Cell Div. 2011 Dec 9;6(1):20. doi: 10.1186/1747-1028-6-20.


Physiological and toxic effects of purine intermediate 5-amino-4-imidazolecarboxamide ribonucleotide (AICAR) in yeast.

Hürlimann HC, Laloo B, Simon-Kayser B, Saint-Marc C, Coulpier F, Lemoine S, Daignan-Fornier B, Pinson B.

J Biol Chem. 2011 Sep 2;286(35):30994-1002. doi: 10.1074/jbc.M111.262659. Epub 2011 Jul 12.


Proliferation/quiescence: the controversial "aller-retour".

Daignan-Fornier B, Sagot I.

Cell Div. 2011 May 9;6:10. doi: 10.1186/1747-1028-6-10.


Metabolic status rather than cell cycle signals control quiescence entry and exit.

Laporte D, Lebaudy A, Sahin A, Pinson B, Ceschin J, Daignan-Fornier B, Sagot I.

J Cell Biol. 2011 Mar 21;192(6):949-57. doi: 10.1083/jcb.201009028. Epub 2011 Mar 14.


Reactive oxygen species-mediated regulation of mitochondrial biogenesis in the yeast Saccharomyces cerevisiae.

Chevtzoff C, Yoboue ED, Galinier A, Casteilla L, Daignan-Fornier B, Rigoulet M, Devin A.

J Biol Chem. 2010 Jan 15;285(3):1733-42. doi: 10.1074/jbc.M109.019570. Epub 2009 Nov 6.


Phenotypic consequences of purine nucleotide imbalance in Saccharomyces cerevisiae.

Saint-Marc C, Pinson B, Coulpier F, Jourdren L, Lisova O, Daignan-Fornier B.

Genetics. 2009 Oct;183(2):529-38, 1SI-7SI. doi: 10.1534/genetics.109.105858. Epub 2009 Jul 27.


Metabolic intermediates selectively stimulate transcription factor interaction and modulate phosphate and purine pathways.

Pinson B, Vaur S, Sagot I, Coulpier F, Lemoine S, Daignan-Fornier B.

Genes Dev. 2009 Jun 15;23(12):1399-407. doi: 10.1101/gad.521809.


Dysregulation of purine nucleotide biosynthesis pathways modulates cisplatin cytotoxicity in Saccharomyces cerevisiae.

Kowalski D, Pendyala L, Daignan-Fornier B, Howell SB, Huang RY.

Mol Pharmacol. 2008 Oct;74(4):1092-100. doi: 10.1124/mol.108.048256. Epub 2008 Jul 8.


Polarized growth in the absence of F-actin in Saccharomyces cerevisiae exiting quiescence.

Sahin A, Daignan-Fornier B, Sagot I.

PLoS One. 2008 Jul 2;3(7):e2556. doi: 10.1371/journal.pone.0002556.


Reversible cytoplasmic localization of the proteasome in quiescent yeast cells.

Laporte D, Salin B, Daignan-Fornier B, Sagot I.

J Cell Biol. 2008 Jun 2;181(5):737-45. doi: 10.1083/jcb.200711154. Epub 2008 May 26.


Co-regulation of yeast purine and phosphate pathways in response to adenylic nucleotide variations.

Gauthier S, Coulpier F, Jourdren L, Merle M, Beck S, Konrad M, Daignan-Fornier B, Pinson B.

Mol Microbiol. 2008 Jun;68(6):1583-94. doi: 10.1111/j.1365-2958.2008.06261.x. Epub 2008 Apr 21.


Lethal accumulation of guanylic nucleotides in Saccharomyces cerevisiae HPT1-deregulated mutants.

Breton A, Pinson B, Coulpier F, Giraud MF, Dautant A, Daignan-Fornier B.

Genetics. 2008 Feb;178(2):815-24. doi: 10.1534/genetics.107.083295. Epub 2008 Feb 3.


Skp1-Cullin-F-box-dependent degradation of Aah1p requires its interaction with the F-box protein Saf1p.

Escusa S, Laporte D, Massoni A, Boucherie H, Dautant A, Daignan-Fornier B.

J Biol Chem. 2007 Jul 13;282(28):20097-103. Epub 2007 May 21.


Actin bodies in yeast quiescent cells: an immediately available actin reserve?

Sagot I, Pinson B, Salin B, Daignan-Fornier B.

Mol Biol Cell. 2006 Nov;17(11):4645-55. Epub 2006 Aug 16.


Revisiting purine-histidine cross-pathway regulation in Saccharomyces cerevisiae: a central role for a small molecule.

Rébora K, Laloo B, Daignan-Fornier B.

Genetics. 2005 May;170(1):61-70. Epub 2005 Mar 2.


Low affinity orthophosphate carriers regulate PHO gene expression independently of internal orthophosphate concentration in Saccharomyces cerevisiae.

Pinson B, Merle M, Franconi JM, Daignan-Fornier B.

J Biol Chem. 2004 Aug 20;279(34):35273-80. Epub 2004 Jun 12.


Sub-families of alpha/beta barrel enzymes: a new adenine deaminase family.

Ribard C, Rochet M, Labedan B, Daignan-Fornier B, Alzari P, Scazzocchio C, Oestreicher N.

J Mol Biol. 2003 Dec 12;334(5):1117-31.


The yeast ISN1 (YOR155c) gene encodes a new type of IMP-specific 5'-nucleotidase.

Itoh R, Saint-Marc C, Chaignepain S, Katahira R, Schmitter JM, Daignan-Fornier B.

BMC Biochem. 2003 May 7;4:4.


Screening the yeast "disruptome" for mutants affecting resistance to the immunosuppressive drug, mycophenolic acid.

Desmoucelles C, Pinson B, Saint-Marc C, Daignan-Fornier B.

J Biol Chem. 2002 Jul 26;277(30):27036-44. Epub 2002 May 16.


Yeast AMP pathway genes respond to adenine through regulated synthesis of a metabolic intermediate.

Rébora K, Desmoucelles C, Borne F, Pinson B, Daignan-Fornier B.

Mol Cell Biol. 2001 Dec;21(23):7901-12.


Proteome analysis and morphological studies reveal multiple effects of the immunosuppressive drug mycophenolic acid specifically resulting from guanylic nucleotide depletion.

Escobar-Henriques M, Balguerie A, Monribot C, Boucherie H, Daignan-Fornier B.

J Biol Chem. 2001 Dec 7;276(49):46237-42. Epub 2001 Sep 4.


YLR209c encodes Saccharomyces cerevisiae purine nucleoside phosphorylase.

Lecoq K, Belloc I, Desgranges C, Konrad M, Daignan-Fornier B.

J Bacteriol. 2001 Aug;183(16):4910-3.


Highly conserved features of DNA binding between two divergent members of the Myb family of transcription factors.

Pinson B, Brendeford EM, Gabrielsen OS, Daignan-Fornier B.

Nucleic Acids Res. 2001 Jan 15;29(2):527-35.


Signaling through regulated transcription factor interaction: mapping of a regulatory interaction domain in the Myb-related Bas1p.

Pinson B, Kongsrud TL, Ording E, Johansen L, Daignan-Fornier B, Gabrielsen OS.

Nucleic Acids Res. 2000 Dec 1;28(23):4665-73.


Transcriptional regulation of the yeast gmp synthesis pathway by its end products.

Escobar-Henriques M, Daignan-Fornier B.

J Biol Chem. 2001 Jan 12;276(2):1523-30.

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