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Items: 37

1.

Mild Innate Immune Activation Overrides Efficient Nanoparticle-Mediated RNA Delivery.

Lokugamage MP, Gan Z, Zurla C, Levin J, Islam FZ, Kalathoor S, Sato M, Sago CD, Santangelo PJ, Dahlman JE.

Adv Mater. 2019 Nov 19:e1904905. doi: 10.1002/adma.201904905. [Epub ahead of print]

PMID:
31743531
2.

Cell Subtypes Within the Liver Microenvironment Differentially Interact with Lipid Nanoparticles.

Sago CD, Krupczak BR, Lokugamage MP, Gan Z, Dahlman JE.

Cell Mol Bioeng. 2019 May 8;12(5):389-397. doi: 10.1007/s12195-019-00573-4. eCollection 2019 Oct.

PMID:
31719922
3.

Endothelial TGF-β signalling drives vascular inflammation and atherosclerosis.

Chen PY, Qin L, Li G, Wang Z, Dahlman JE, Malagon-Lopez J, Gujja S, Kauffman KJ, Sun L, Sun H, Zhang X, Aryal B, Canfran-Duque A, Liu R, Kusters P, Sehgal A, Jiao Y, Anderson DG, Gulcher J, Fernandez-Hernando C, Lutgens E, Schwartz MA, Pober JS, Chittenden TW, Tellides G, Simons M.

Nat Metab. 2019 Sep;1(9):912-926. doi: 10.1038/s42255-019-0102-3. Epub 2019 Aug 26.

PMID:
31572976
4.

Constrained Nanoparticles Deliver siRNA and sgRNA to T Cells In Vivo without Targeting Ligands.

Lokugamage MP, Sago CD, Gan Z, Krupczak BR, Dahlman JE.

Adv Mater. 2019 Oct;31(41):e1902251. doi: 10.1002/adma.201902251. Epub 2019 Aug 29.

5.

Using Large Datasets to Understand Nanotechnology.

Paunovska K, Loughrey D, Sago CD, Langer R, Dahlman JE.

Adv Mater. 2019 Oct;31(43):e1902798. doi: 10.1002/adma.201902798. Epub 2019 Aug 20. Review.

6.

Ligand Conjugated Multimeric siRNAs Enable Enhanced Uptake and Multiplexed Gene Silencing.

Brown JM, Dahlman JE, Neuman KK, Prata CAH, Krampert MC, Hadwiger PM, Vornlocher HP.

Nucleic Acid Ther. 2019 Oct;29(5):231-244. doi: 10.1089/nat.2019.0782. Epub 2019 Aug 8.

7.

Testing thousands of nanoparticles in vivo using DNA barcodes.

Lokugamage MP, Sago CD, Dahlman JE.

Curr Opin Biomed Eng. 2018 Sep;7:1-8. doi: 10.1016/j.cobme.2018.08.001. Epub 2018 Aug 21.

8.

BOLA (BolA Family Member 3) Deficiency Controls Endothelial Metabolism and Glycine Homeostasis in Pulmonary Hypertension.

Yu Q, Tai YY, Tang Y, Zhao J, Negi V, Culley MK, Pilli J, Sun W, Brugger K, Mayr J, Saggar R, Saggar R, Wallace WD, Ross DJ, Waxman AB, Wendell SG, Mullett SJ, Sembrat J, Rojas M, Khan OF, Dahlman JE, Sugahara M, Kagiyama N, Satoh T, Zhang M, Feng N, Gorcsan J 3rd, Vargas SO, Haley KJ, Kumar R, Graham BB, Langer R, Anderson DG, Wang B, Shiva S, Bertero T, Chan SY.

Circulation. 2019 May 7;139(19):2238-2255. doi: 10.1161/CIRCULATIONAHA.118.035889.

PMID:
30759996
9.

Nanoparticles Containing Oxidized Cholesterol Deliver mRNA to the Liver Microenvironment at Clinically Relevant Doses.

Paunovska K, Da Silva Sanchez AJ, Sago CD, Gan Z, Lokugamage MP, Islam FZ, Kalathoor S, Krupczak BR, Dahlman JE.

Adv Mater. 2019 Apr;31(14):e1807748. doi: 10.1002/adma.201807748. Epub 2019 Feb 12.

10.

Barcoding chemical modifications into nucleic acids improves drug stability in vivo.

Sago CD, Kalathoor S, Fitzgerald JP, Lando GN, Djeddar N, Bryksin AV, Dahlman JE.

J Mater Chem B. 2018 Nov 28;6(44):7197-7203. doi: 10.1039/c8tb01642a. Epub 2018 Aug 28.

11.

Nanoparticles That Deliver RNA to Bone Marrow Identified by in Vivo Directed Evolution.

Sago CD, Lokugamage MP, Islam FZ, Krupczak BR, Sato M, Dahlman JE.

J Am Chem Soc. 2018 Dec 12;140(49):17095-17105. doi: 10.1021/jacs.8b08976. Epub 2018 Nov 16.

12.

Editing nature: Local roots of global governance.

Kofler N, Collins JP, Kuzma J, Marris E, Esvelt K, Nelson MP, Newhouse A, Rothschild LJ, Vigliotti VS, Semenov M, Jacobsen R, Dahlman JE, Prince S, Caccone A, Brown T, Schmitz OJ.

Science. 2018 Nov 2;362(6414):527-529. doi: 10.1126/science.aat4612. Epub 2018 Nov 1. No abstract available.

PMID:
30385564
13.

High-throughput in vivo screen of functional mRNA delivery identifies nanoparticles for endothelial cell gene editing.

Sago CD, Lokugamage MP, Paunovska K, Vanover DA, Monaco CM, Shah NN, Gamboa Castro M, Anderson SE, Rudoltz TG, Lando GN, Munnilal Tiwari P, Kirschman JL, Willett N, Jang YC, Santangelo PJ, Bryksin AV, Dahlman JE.

Proc Natl Acad Sci U S A. 2018 Oct 16;115(42):E9944-E9952. doi: 10.1073/pnas.1811276115. Epub 2018 Oct 1. Erratum in: Proc Natl Acad Sci U S A. 2018 Nov 27;115(48):E11427.

14.

Modifying a Commonly Expressed Endocytic Receptor Retargets Nanoparticles in Vivo.

Sago CD, Lokugamage MP, Lando GN, Djeddar N, Shah NN, Syed C, Bryksin AV, Dahlman JE.

Nano Lett. 2018 Dec 12;18(12):7590-7600. doi: 10.1021/acs.nanolett.8b03149. Epub 2018 Sep 20.

15.

Analyzing 2000 in Vivo Drug Delivery Data Points Reveals Cholesterol Structure Impacts Nanoparticle Delivery.

Paunovska K, Gil CJ, Lokugamage MP, Sago CD, Sato M, Lando GN, Gamboa Castro M, Bryksin AV, Dahlman JE.

ACS Nano. 2018 Aug 28;12(8):8341-8349. doi: 10.1021/acsnano.8b03640. Epub 2018 Jul 20.

16.

A Direct Comparison of in Vitro and in Vivo Nucleic Acid Delivery Mediated by Hundreds of Nanoparticles Reveals a Weak Correlation.

Paunovska K, Sago CD, Monaco CM, Hudson WH, Castro MG, Rudoltz TG, Kalathoor S, Vanover DA, Santangelo PJ, Ahmed R, Bryksin AV, Dahlman JE.

Nano Lett. 2018 Mar 14;18(3):2148-2157. doi: 10.1021/acs.nanolett.8b00432. Epub 2018 Mar 5.

17.

Inhibiting Integrin α5 Cytoplasmic Domain Signaling Reduces Atherosclerosis and Promotes Arteriogenesis.

Budatha M, Zhang J, Zhuang ZW, Yun S, Dahlman JE, Anderson DG, Schwartz MA.

J Am Heart Assoc. 2018 Jan 30;7(3). pii: e007501. doi: 10.1161/JAHA.117.007501.

18.

Barcoded nanoparticles for high throughput in vivo discovery of targeted therapeutics.

Dahlman JE, Kauffman KJ, Xing Y, Shaw TE, Mir FF, Dlott CC, Langer R, Anderson DG, Wang ET.

Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):2060-2065. doi: 10.1073/pnas.1620874114. Epub 2017 Feb 6.

19.

Interaction between integrin α5 and PDE4D regulates endothelial inflammatory signalling.

Yun S, Budatha M, Dahlman JE, Coon BG, Cameron RT, Langer R, Anderson DG, Baillie G, Schwartz MA.

Nat Cell Biol. 2016 Oct;18(10):1043-53. doi: 10.1038/ncb3405. Epub 2016 Sep 5.

20.

Proliferation and Recruitment Contribute to Myocardial Macrophage Expansion in Chronic Heart Failure.

Sager HB, Hulsmans M, Lavine KJ, Moreira MB, Heidt T, Courties G, Sun Y, Iwamoto Y, Tricot B, Khan OF, Dahlman JE, Borodovsky A, Fitzgerald K, Anderson DG, Weissleder R, Libby P, Swirski FK, Nahrendorf M.

Circ Res. 2016 Sep 16;119(7):853-64. doi: 10.1161/CIRCRESAHA.116.309001. Epub 2016 Jul 21.

21.

RNAi targeting multiple cell adhesion molecules reduces immune cell recruitment and vascular inflammation after myocardial infarction.

Sager HB, Dutta P, Dahlman JE, Hulsmans M, Courties G, Sun Y, Heidt T, Vinegoni C, Borodovsky A, Fitzgerald K, Wojtkiewicz GR, Iwamoto Y, Tricot B, Khan OF, Kauffman KJ, Xing Y, Shaw TE, Libby P, Langer R, Weissleder R, Swirski FK, Anderson DG, Nahrendorf M.

Sci Transl Med. 2016 Jun 8;8(342):342ra80. doi: 10.1126/scitranslmed.aaf1435.

22.

Corrigendum: Orthogonal gene knockout and activation with a catalytically active Cas9 nuclease.

Dahlman JE, Abudayyeh OO, Joung J, Gootenberg JS, Zhang F, Konermann S.

Nat Biotechnol. 2016 Apr;34(4):441. doi: 10.1038/nbt0416-441a. No abstract available.

PMID:
27054997
23.

Emerging Frontiers in Drug Delivery.

Tibbitt MW, Dahlman JE, Langer R.

J Am Chem Soc. 2016 Jan 27;138(3):704-17. doi: 10.1021/jacs.5b09974. Epub 2016 Jan 7. Review.

PMID:
26741786
24.

Orthogonal gene knockout and activation with a catalytically active Cas9 nuclease.

Dahlman JE, Abudayyeh OO, Joung J, Gootenberg JS, Zhang F, Konermann S.

Nat Biotechnol. 2015 Nov;33(11):1159-61. Erratum in: Nat Biotechnol. 2016 Apr;34(4):441.

25.

Macrophage Notch Ligand Delta-Like 4 Promotes Vein Graft Lesion Development: Implications for the Treatment of Vein Graft Failure.

Koga JI, Nakano T, Dahlman JE, Figueiredo JL, Zhang H, Decano J, Khan OF, Niida T, Iwata H, Aster JC, Yagita H, Anderson DG, Ozaki CK, Aikawa M.

Arterioscler Thromb Vasc Biol. 2015 Nov;35(11):2343-2353. doi: 10.1161/ATVBAHA.115.305516. Epub 2015 Sep 24. Erratum in: Arterioscler Thromb Vasc Biol. 2016 Mar;36(3):e25.

26.

Genetic and hypoxic alterations of the microRNA-210-ISCU1/2 axis promote iron-sulfur deficiency and pulmonary hypertension.

White K, Lu Y, Annis S, Hale AE, Chau BN, Dahlman JE, Hemann C, Opotowsky AR, Vargas SO, Rosas I, Perrella MA, Osorio JC, Haley KJ, Graham BB, Kumar R, Saggar R, Saggar R, Wallace WD, Ross DJ, Khan OF, Bader A, Gochuico BR, Matar M, Polach K, Johannessen NM, Prosser HM, Anderson DG, Langer R, Zweier JL, Bindoff LA, Systrom D, Waxman AB, Jin RC, Chan SY.

EMBO Mol Med. 2015 Jun;7(6):695-713. doi: 10.15252/emmm.201404511.

27.

Dendrimer-Inspired Nanomaterials for the in Vivo Delivery of siRNA to Lung Vasculature.

Khan OF, Zaia EW, Jhunjhunwala S, Xue W, Cai W, Yun DS, Barnes CM, Dahlman JE, Dong Y, Pelet JM, Webber MJ, Tsosie JK, Jacks TE, Langer R, Anderson DG.

Nano Lett. 2015 May 13;15(5):3008-16. doi: 10.1021/nl5048972. Epub 2015 Apr 2.

28.

Nanotechnology for in vivo targeted siRNA delivery.

Dahlman JE, Kauffman KJ, Langer R, Anderson DG.

Adv Genet. 2014;88:37-69. doi: 10.1016/B978-0-12-800148-6.00003-1. Review.

PMID:
25409603
29.

Loss of α-catenin elicits a cholestatic response and impairs liver regeneration.

Herr KJ, Tsang YH, Ong JW, Li Q, Yap LL, Yu W, Yin H, Bogorad RL, Dahlman JE, Chan YG, Bay BH, Singaraja R, Anderson DG, Koteliansky V, Viasnoff V, Thiery JP.

Sci Rep. 2014 Oct 30;4:6835. doi: 10.1038/srep06835.

30.

Ionizable amphiphilic dendrimer-based nanomaterials with alkyl-chain-substituted amines for tunable siRNA delivery to the liver endothelium in vivo.

Khan OF, Zaia EW, Yin H, Bogorad RL, Pelet JM, Webber MJ, Zhuang I, Dahlman JE, Langer R, Anderson DG.

Angew Chem Int Ed Engl. 2014 Dec 22;53(52):14397-401. doi: 10.1002/anie.201408221. Epub 2014 Oct 29.

31.

CRISPR-Cas9 knockin mice for genome editing and cancer modeling.

Platt RJ, Chen S, Zhou Y, Yim MJ, Swiech L, Kempton HR, Dahlman JE, Parnas O, Eisenhaure TM, Jovanovic M, Graham DB, Jhunjhunwala S, Heidenreich M, Xavier RJ, Langer R, Anderson DG, Hacohen N, Regev A, Feng G, Sharp PA, Zhang F.

Cell. 2014 Oct 9;159(2):440-55. doi: 10.1016/j.cell.2014.09.014. Epub 2014 Sep 25.

32.

Small RNA combination therapy for lung cancer.

Xue W, Dahlman JE, Tammela T, Khan OF, Sood S, Dave A, Cai W, Chirino LM, Yang GR, Bronson R, Crowley DG, Sahay G, Schroeder A, Langer R, Anderson DG, Jacks T.

Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):E3553-61. doi: 10.1073/pnas.1412686111. Epub 2014 Aug 11.

33.

A lesson in communication.

Dahlman JE.

Nat Nanotechnol. 2014 Aug;9(8):656. doi: 10.1038/nnano.2014.162. No abstract available.

PMID:
25091448
34.

In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight.

Dahlman JE, Barnes C, Khan O, Thiriot A, Jhunjunwala S, Shaw TE, Xing Y, Sager HB, Sahay G, Speciner L, Bader A, Bogorad RL, Yin H, Racie T, Dong Y, Jiang S, Seedorf D, Dave A, Sandu KS, Webber MJ, Novobrantseva T, Ruda VM, Lytton-Jean AKR, Levins CG, Kalish B, Mudge DK, Perez M, Abezgauz L, Dutta P, Smith L, Charisse K, Kieran MW, Fitzgerald K, Nahrendorf M, Danino D, Tuder RM, von Andrian UH, Akinc A, Schroeder A, Panigrahy D, Kotelianski V, Langer R, Anderson DG.

Nat Nanotechnol. 2014 Aug;9(8):648-655. doi: 10.1038/nnano.2014.84. Epub 2014 May 11.

35.

Treating metastatic cancer with nanotechnology.

Schroeder A, Heller DA, Winslow MM, Dahlman JE, Pratt GW, Langer R, Jacks T, Anderson DG.

Nat Rev Cancer. 2011 Dec 23;12(1):39-50. doi: 10.1038/nrc3180. Review.

PMID:
22193407
36.

Alkane-modified short polyethyleneimine for siRNA delivery.

Schroeder A, Dahlman JE, Sahay G, Love KT, Jiang S, Eltoukhy AA, Levins CG, Wang Y, Anderson DG.

J Control Release. 2012 Jun 10;160(2):172-6. doi: 10.1016/j.jconrel.2011.11.030. Epub 2011 Dec 2.

37.

Silencing or stimulation? siRNA delivery and the immune system.

Whitehead KA, Dahlman JE, Langer RS, Anderson DG.

Annu Rev Chem Biomol Eng. 2011;2:77-96. doi: 10.1146/annurev-chembioeng-061010-114133. Review.

PMID:
22432611

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