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Items: 27

1.

3,3'-Disubstituted 5,5'-Bi(1,2,4-triazine) Derivatives with Potent in Vitro and in Vivo Antimalarial Activity.

Xue L, Shi DH, Harjani JR, Huang F, Beveridge JG, Dingjan T, Ban K, Diab S, Duffy S, Lucantoni L, Fletcher S, Chiu FCK, Blundell S, Ellis K, Ralph SA, Wirjanata G, Teguh S, Noviyanti R, Chavchich M, Creek D, Price RN, Marfurt J, Charman SA, Cuellar ME, Strasser JM, Dahlin JL, Walters MA, Edstein MD, Avery VM, Baell JB.

J Med Chem. 2019 Mar 14;62(5):2485-2498. doi: 10.1021/acs.jmedchem.8b01799. Epub 2019 Mar 5.

PMID:
30715882
2.

Clinical Benefits of Direct-to-Definitive Testing for Monitoring Compliance in Pain Management.

Gencheva R, Petrides A, Kantartjis M, Tanasijevic M, Dahlin JL, Melanson S.

Pain Physician. 2018 Nov;21(6):E583-E592. Review.

3.

Risk Management in Early Discovery Medicinal Chemistry.

Singh G, Dahlin JL, Walters MA.

Methods Enzymol. 2018;610:1-25. doi: 10.1016/bs.mie.2018.09.012. Epub 2018 Oct 19.

PMID:
30390795
4.

ALARM NMR for HTS triage and chemical probe validation.

Dahlin JL, Cuellar M, Singh G, Nelson KM, Strasser J, Rappe T, Xia Y, Veglia G, Walters MA.

Curr Protoc Chem Biol. 2018 Mar;10(1):91-117. doi: 10.1002/cpch.35. Epub 2018 Apr 9.

6.

Modeling Small-Molecule Reactivity Identifies Promiscuous Bioactive Compounds.

Matlock MK, Hughes TB, Dahlin JL, Swamidass SJ.

J Chem Inf Model. 2018 Aug 27;58(8):1483-1500. doi: 10.1021/acs.jcim.8b00104. Epub 2018 Jul 23.

PMID:
29990427
7.

Histone Acetyltransferase Assays in Drug and Chemical Probe Discovery.

Gadhia S, Shrimp JH, Meier JL, McGee JE, Dahlin JL.

In: Sittampalam GS, Coussens NP, Brimacombe K, Grossman A, Arkin M, Auld D, Austin C, Baell J, Bejcek B, Caaveiro JMM, Chung TDY, Dahlin JL, Devanaryan V, Foley TL, Glicksman M, Hall MD, Haas JV, Inglese J, Iversen PW, Kahl SD, Kales SC, Lal-Nag M, Li Z, McGee J, McManus O, Riss T, Trask OJ Jr., Weidner JR, Wildey MJ, Xia M, Xu X, editors. Assay Guidance Manual [Internet]. Bethesda (MD): Eli Lilly & Company and the National Center for Advancing Translational Sciences; 2004-.
2017 Jul 26 [updated 2018 Jul 1].

8.

Assay Guidance Manual: Quantitative Biology and Pharmacology in Preclinical Drug Discovery.

Coussens NP, Sittampalam GS, Guha R, Brimacombe K, Grossman A, Chung TDY, Weidner JR, Riss T, Trask OJ, Auld D, Dahlin JL, Devanaryan V, Foley TL, McGee J, Kahl SD, Kales SC, Arkin M, Baell J, Bejcek B, Gal-Edd N, Glicksman M, Haas JV, Iversen PW, Hoeppner M, Lathrop S, Sayers E, Liu H, Trawick B, McVey J, Lemmon VP, Li Z, McManus O, Minor L, Napper A, Wildey MJ, Pacifici R, Chin WW, Xia M, Xu X, Lal-Nag M, Hall MD, Michael S, Inglese J, Simeonov A, Austin CP.

Clin Transl Sci. 2018 Sep;11(5):461-470. doi: 10.1111/cts.12570. Epub 2018 Jul 24.

9.

Reviewing Hit Discovery Literature for Difficult Targets: Glutathione Transferase Omega-1 as an Example.

Xie Y, Dahlin JL, Oakley AJ, Casarotto MG, Board PG, Baell JB.

J Med Chem. 2018 Sep 13;61(17):7448-7470. doi: 10.1021/acs.jmedchem.8b00318. Epub 2018 May 10.

PMID:
29652143
10.

GSTO1-1 plays a pro-inflammatory role in models of inflammation, colitis and obesity.

Menon D, Innes A, Oakley AJ, Dahlstrom JE, Jensen LM, Brüstle A, Tummala P, Rooke M, Casarotto MG, Baell JB, Nguyen N, Xie Y, Cuellar M, Strasser J, Dahlin JL, Walters MA, Burgio G, O'Neill LAJ, Board PG.

Sci Rep. 2017 Dec 19;7(1):17832. doi: 10.1038/s41598-017-17861-6.

11.

79-Year-Old Woman With Jaundice and Anemia.

Tsang M, Dahlin JL, Sundsted KK.

Mayo Clin Proc. 2018 Mar;93(3):381-385. doi: 10.1016/j.mayocp.2017.03.025. Epub 2017 Dec 16. No abstract available.

PMID:
29258683
12.

Assay interference and off-target liabilities of reported histone acetyltransferase inhibitors.

Dahlin JL, Nelson KM, Strasser JM, Barsyte-Lovejoy D, Szewczyk MM, Organ S, Cuellar M, Singh G, Shrimp JH, Nguyen N, Meier JL, Arrowsmith CH, Brown PJ, Baell JB, Walters MA.

Nat Commun. 2017 Nov 15;8(1):1527. doi: 10.1038/s41467-017-01657-3.

13.

Assay Interference by Aggregation.

Auld DS, Inglese J, Dahlin JL.

In: Sittampalam GS, Coussens NP, Brimacombe K, Grossman A, Arkin M, Auld D, Austin C, Baell J, Bejcek B, Caaveiro JMM, Chung TDY, Dahlin JL, Devanaryan V, Foley TL, Glicksman M, Hall MD, Haas JV, Inglese J, Iversen PW, Kahl SD, Kales SC, Lal-Nag M, Li Z, McGee J, McManus O, Riss T, Trask OJ Jr., Weidner JR, Wildey MJ, Xia M, Xu X, editors. Assay Guidance Manual [Internet]. Bethesda (MD): Eli Lilly & Company and the National Center for Advancing Translational Sciences; 2004-. No abstract available.
2017 Jul 26.

14.

74-Year-old female with new monoclonal protein on serum immunofixation electrophoresis.

Cenaj O, Dahlin JL, Buencamino DM, Laubach JP, Jarolim P.

Clin Biochem. 2018 Jan;51:97-100. doi: 10.1016/j.clinbiochem.2017.05.013. Epub 2017 May 24. No abstract available.

PMID:
28551333
15.

Curcumin May (Not) Defy Science.

Nelson KM, Dahlin JL, Bisson J, Graham J, Pauli GF, Walters MA.

ACS Med Chem Lett. 2017 May 11;8(5):467-470. doi: 10.1021/acsmedchemlett.7b00139. eCollection 2017 May 11. No abstract available.

16.

The Essential Medicinal Chemistry of Curcumin.

Nelson KM, Dahlin JL, Bisson J, Graham J, Pauli GF, Walters MA.

J Med Chem. 2017 Mar 9;60(5):1620-1637. doi: 10.1021/acs.jmedchem.6b00975. Epub 2017 Jan 11. Review.

17.

Assay Interference by Chemical Reactivity.

Dahlin JL, Baell J, Walters MA.

In: Sittampalam GS, Coussens NP, Brimacombe K, Grossman A, Arkin M, Auld D, Austin C, Baell J, Bejcek B, Caaveiro JMM, Chung TDY, Dahlin JL, Devanaryan V, Foley TL, Glicksman M, Hall MD, Haas JV, Inglese J, Iversen PW, Kahl SD, Kales SC, Lal-Nag M, Li Z, McGee J, McManus O, Riss T, Trask OJ Jr., Weidner JR, Wildey MJ, Xia M, Xu X, editors. Assay Guidance Manual [Internet]. Bethesda (MD): Eli Lilly & Company and the National Center for Advancing Translational Sciences; 2004-.
2015 Sep 18.

18.

How to Triage PAINS-Full Research.

Dahlin JL, Walters MA.

Assay Drug Dev Technol. 2016 Apr;14(3):168-74. doi: 10.1089/adt.2015.674. Epub 2015 Oct 23.

19.

Corrigendum: The promise and peril of chemical probes.

Arrowsmith CH, Audia JE, Austin C, Baell J, Bennett J, Blagg J, Bountra C, Brennan PE, Brown PJ, Bunnage ME, Buser-Doepner C, Campbell RM, Carter AJ, Cohen P, Copeland RA, Cravatt B, Dahlin JL, Dhanak D, Edwards AM, Frederiksen M, Frye SV, Gray N, Grimshaw CE, Hepworth D, Howe T, Huber KV, Jin J, Knapp S, Kotz JD, Kruger RG, Lowe D, Mader MM, Marsden B, Mueller-Fahrnow A, Müller S, O'Hagan RC, Overington JP, Owen DR, Rosenberg SH, Ross R, Roth B, Schapira M, Schreiber SL, Shoichet B, Sundström M, Superti-Furga G, Taunton J, Toledo-Sherman L, Walpole C, Walters MA, Willson TM, Workman P, Young RN, Zuercher WJ.

Nat Chem Biol. 2015 Nov;11(11):887. doi: 10.1038/nchembio1115-887c. No abstract available.

PMID:
26485080
20.

Post-HTS case report and structural alert: Promiscuous 4-aroyl-1,5-disubstituted-3-hydroxy-2H-pyrrol-2-one actives verified by ALARM NMR.

Dahlin JL, Nissink JWM, Francis S, Strasser JM, John K, Zhang Z, Walters MA.

Bioorg Med Chem Lett. 2015 Nov 1;25(21):4740-4752. doi: 10.1016/j.bmcl.2015.08.020. Epub 2015 Aug 10.

21.

The promise and peril of chemical probes.

Arrowsmith CH, Audia JE, Austin C, Baell J, Bennett J, Blagg J, Bountra C, Brennan PE, Brown PJ, Bunnage ME, Buser-Doepner C, Campbell RM, Carter AJ, Cohen P, Copeland RA, Cravatt B, Dahlin JL, Dhanak D, Edwards AM, Frederiksen M, Frye SV, Gray N, Grimshaw CE, Hepworth D, Howe T, Huber KV, Jin J, Knapp S, Kotz JD, Kruger RG, Lowe D, Mader MM, Marsden B, Mueller-Fahrnow A, Müller S, O'Hagan RC, Overington JP, Owen DR, Rosenberg SH, Roth B, Ross R, Schapira M, Schreiber SL, Shoichet B, Sundström M, Superti-Furga G, Taunton J, Toledo-Sherman L, Walpole C, Walters MA, Willson TM, Workman P, Young RN, Zuercher WJ.

Nat Chem Biol. 2015 Aug;11(8):536-41. doi: 10.1038/nchembio.1867. No abstract available. Erratum in: Nat Chem Biol. 2015 Nov;11(11):887. Nat Chem Biol. 2015 Aug;11(8):541. Roth, Brian [Corrected to Roth, Bryan] and Frederiksen, Mathias [Added].

22.

Mitigating risk in academic preclinical drug discovery.

Dahlin JL, Inglese J, Walters MA.

Nat Rev Drug Discov. 2015 Apr;14(4):279-94. doi: 10.1038/nrd4578. Review.

23.

PAINS in the assay: chemical mechanisms of assay interference and promiscuous enzymatic inhibition observed during a sulfhydryl-scavenging HTS.

Dahlin JL, Nissink JW, Strasser JM, Francis S, Higgins L, Zhou H, Zhang Z, Walters MA.

J Med Chem. 2015 Mar 12;58(5):2091-113. doi: 10.1021/jm5019093. Epub 2015 Feb 21.

24.

Histone-modifying enzymes, histone modifications and histone chaperones in nucleosome assembly: Lessons learned from Rtt109 histone acetyltransferases.

Dahlin JL, Chen X, Walters MA, Zhang Z.

Crit Rev Biochem Mol Biol. 2015 Jan-Feb;50(1):31-53. doi: 10.3109/10409238.2014.978975. Epub 2014 Nov 3. Review.

25.

The essential roles of chemistry in high-throughput screening triage.

Dahlin JL, Walters MA.

Future Med Chem. 2014 Jul;6(11):1265-90. doi: 10.4155/fmc.14.60. Review.

26.

Pneumocystis jirovecii Rtt109, a novel drug target for Pneumocystis pneumonia in immunosuppressed humans.

Dahlin JL, Kottom T, Han J, Zhou H, Walters MA, Zhang Z, Limper AH.

Antimicrob Agents Chemother. 2014 Jul;58(7):3650-9. doi: 10.1128/AAC.02637-14. Epub 2014 Apr 14.

27.

A cell-free fluorometric high-throughput screen for inhibitors of Rtt109-catalyzed histone acetylation.

Dahlin JL, Sinville R, Solberg J, Zhou H, Han J, Francis S, Strasser JM, John K, Hook DJ, Walters MA, Zhang Z.

PLoS One. 2013 Nov 18;8(11):e78877. doi: 10.1371/journal.pone.0078877. eCollection 2013.

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