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Items: 8


Fraction Unbound for Liver Microsome and Hepatocyte Incubations for All Major Species Can Be Approximated Using a Single-Species Surrogate.

Barr JT, Lade JM, Tran TB, Dahal UP.

Drug Metab Dispos. 2019 Apr;47(4):419-423. doi: 10.1124/dmd.118.085936. Epub 2019 Feb 7.


The Role of Protein-Protein and Protein-Membrane Interactions on P450 Function.

Scott EE, Wolf CR, Otyepka M, Humphreys SC, Reed JR, Henderson CJ, McLaughlin LA, Paloncýová M, Navrátilová V, Berka K, Anzenbacher P, Dahal UP, Barnaba C, Brozik JA, Jones JP, Estrada DF, Laurence JS, Park JW, Backes WL.

Drug Metab Dispos. 2016 Apr;44(4):576-90. doi: 10.1124/dmd.115.068569. Epub 2016 Feb 5. Review.


A tag-free collisionally induced fragmentation approach to detect drug-adducted proteins by mass spectrometry.

Ballard TE, Dahal UP, Bessire AJ, Schneider RP, Geoghegan KF, Vaz AD.

Rapid Commun Mass Spectrom. 2015 Nov 30;29(22):2175-83. doi: 10.1002/rcm.7375.


Chemical and computational methods for the characterization of covalent reactive groups for the prospective design of irreversible inhibitors.

Flanagan ME, Abramite JA, Anderson DP, Aulabaugh A, Dahal UP, Gilbert AM, Li C, Montgomery J, Oppenheimer SR, Ryder T, Schuff BP, Uccello DP, Walker GS, Wu Y, Brown MF, Chen JM, Hayward MM, Noe MC, Obach RS, Philippe L, Shanmugasundaram V, Shapiro MJ, Starr J, Stroh J, Che Y.

J Med Chem. 2014 Dec 11;57(23):10072-9. doi: 10.1021/jm501412a. Epub 2014 Nov 26.


Benchmarking in vitro covalent binding burden as a tool to assess potential toxicity caused by nonspecific covalent binding of covalent drugs.

Dahal UP, Obach RS, Gilbert AM.

Chem Res Toxicol. 2013 Nov 18;26(11):1739-45. doi: 10.1021/tx400301q. Epub 2013 Oct 28.


Comparative study of the affinity and metabolism of type I and type II binding quinoline carboxamide analogues by cytochrome P450 3A4.

Dahal UP, Joswig-Jones C, Jones JP.

J Med Chem. 2012 Jan 12;55(1):280-90. doi: 10.1021/jm201207h. Epub 2011 Dec 1.


Small molecule quantification by liquid chromatography-mass spectrometry for metabolites of drugs and drug candidates.

Dahal UP, Jones JP, Davis JA, Rock DA.

Drug Metab Dispos. 2011 Dec;39(12):2355-60. doi: 10.1124/dmd.111.040865. Epub 2011 Sep 21.


The kinetic mechanism for cytochrome P450 metabolism of type II binding compounds: evidence supporting direct reduction.

Pearson J, Dahal UP, Rock D, Peng CC, Schenk JO, Joswig-Jones C, Jones JP.

Arch Biochem Biophys. 2011 Jul;511(1-2):69-79. doi: 10.1016/ Epub 2011 Apr 21.

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