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Items: 1 to 50 of 116

1.

Lipidoid-siRNA Nanoparticle-Mediated IL-1β Gene Silencing for Systemic Arthritis Therapy in a Mouse Model.

Song P, Yang C, Thomsen JS, Dagnæs-Hansen F, Jakobsen M, Brüel A, Deleuran B, Kjems J.

Mol Ther. 2019 Aug 7;27(8):1424-1435. doi: 10.1016/j.ymthe.2019.05.002. Epub 2019 May 15.

PMID:
31153827
2.

Targeted lipid nanoparticle delivery of calcitriol to human monocyte-derived macrophages in vitro and in vivo: investigation of the anti-inflammatory effects of calcitriol.

Rafique A, Etzerodt A, Graversen JH, Moestrup SK, Dagnæs-Hansen F, Møller HJ.

Int J Nanomedicine. 2019 Apr 23;14:2829-2846. doi: 10.2147/IJN.S192113. eCollection 2019.

3.

cAIMP administration in humanized mice induces a chimerization-level-dependent STING response.

Andersen AHF, Olesen R, Jønsson KL, Højen JF, Krapp C, Mack K, Thomsen MK, Østergaard L, Tolstrup M, Dagnaes-Hansen F, Jakobsen MR, Denton PW.

Immunology. 2019 Jun;157(2):163-172. doi: 10.1111/imm.13061. Epub 2019 May 6.

PMID:
30919991
4.

In Vivo Editing of the Adult Mouse Liver Using CRISPR/Cas9 and Hydrodynamic Tail Vein Injection.

Niola F, Dagnæs-Hansen F, Frödin M.

Methods Mol Biol. 2019;1961:329-341. doi: 10.1007/978-1-4939-9170-9_20.

PMID:
30912055
5.

Synchronous delivery of hydroxyapatite and connective tissue growth factor derived osteoinductive peptide enhanced osteogenesis.

Xu R, Zhang Z, Toftdal MS, Møller AC, Dagnaes-Hansen F, Dong M, Thomsen JS, Brüel A, Chen M.

J Control Release. 2019 May 10;301:129-139. doi: 10.1016/j.jconrel.2019.02.037. Epub 2019 Mar 14.

PMID:
30880079
6.

A new class of recombinant human albumin with multiple surface thiols exhibits stable conjugation and enhanced FcRn binding and blood circulation.

Schelde KK, Nicholls K, Dagnæs-Hansen F, Bunting K, Rawsthorne H, Andersen B, Finnis CJA, Williamson M, Cameron J, Howard KA.

J Biol Chem. 2019 Mar 8;294(10):3735-3743. doi: 10.1074/jbc.RA118.005870. Epub 2019 Jan 2.

PMID:
30602565
7.

Up-Regulated FGFR1 Expression as a Mediator of Intrinsic TKI Resistance in EGFR-Mutated NSCLC.

Gammelgaard KR, Vad-Nielsen J, Clement MS, Weiss S, Daugaard TF, Dagnæs-Hansen F, Meldgaard P, Sorensen BS, Nielsen AL.

Transl Oncol. 2019 Mar;12(3):432-440. doi: 10.1016/j.tranon.2018.11.017. Epub 2018 Dec 16.

8.

Non-covalent hitchhiking on endogenous carriers as a protraction mechanism for antiviral macromolecular prodrugs.

Frich CK, Krüger F, Walther R, Domar C, Andersen AHF, Tvilum A, Dagnæs-Hansen F, Denton PW, Tolstrup M, Paludan SR, Münch J, Zelikin AN.

J Control Release. 2019 Jan 28;294:298-310. doi: 10.1016/j.jconrel.2018.12.016. Epub 2018 Dec 12.

PMID:
30552954
9.

Improved Lentiviral Gene Delivery to Mouse Liver by Hydrodynamic Vector Injection through Tail Vein.

Dalsgaard T, Cecchi CR, Askou AL, Bak RO, Andersen PO, Hougaard D, Jensen TG, Dagnæs-Hansen F, Mikkelsen JG, Corydon TJ, Aagaard L.

Mol Ther Nucleic Acids. 2018 Sep 7;12:672-683. doi: 10.1016/j.omtn.2018.07.005. Epub 2018 Aug 6.

10.

Cellular recycling-driven in vivo half-life extension using recombinant albumin fusions tuned for neonatal Fc receptor (FcRn) engagement.

Larsen MT, Rawsthorne H, Schelde KK, Dagnæs-Hansen F, Cameron J, Howard KA.

J Control Release. 2018 Oct 10;287:132-141. doi: 10.1016/j.jconrel.2018.07.023. Epub 2018 Aug 29.

PMID:
30016735
11.

Theranostic Niosomes for Efficient siRNA/MicroRNA Delivery and Activatable Near-Infrared Fluorescent Tracking of Stem Cells.

Yang C, Gao S, Song P, Dagnæs-Hansen F, Jakobsen M, Kjems J.

ACS Appl Mater Interfaces. 2018 Jun 13;10(23):19494-19503. doi: 10.1021/acsami.8b05513. Epub 2018 May 29.

PMID:
29767944
12.

Fibrogenic and angiogenic commitments of human induced pluripotent stem cells derived mesenchymal stem cells in connective tissue growth factor-delivering scaffold in an immune-deficient mice model.

Xu R, Dagnaes-Hansen F, Wogensen L, Axelsen SM, Seliktar D, Chen M.

J Biomed Mater Res B Appl Biomater. 2018 Aug;106(6):2266-2274. doi: 10.1002/jbm.b.34030. Epub 2017 Oct 31.

PMID:
29087024
13.

CRISPR/Cas9 Engineering of Adult Mouse Liver Demonstrates That the Dnajb1-Prkaca Gene Fusion Is Sufficient to Induce Tumors Resembling Fibrolamellar Hepatocellular Carcinoma.

Engelholm LH, Riaz A, Serra D, Dagnæs-Hansen F, Johansen JV, Santoni-Rugiu E, Hansen SH, Niola F, Frödin M.

Gastroenterology. 2017 Dec;153(6):1662-1673.e10. doi: 10.1053/j.gastro.2017.09.008. Epub 2017 Sep 18.

14.

A genetically inducible porcine model of intestinal cancer.

Callesen MM, Árnadóttir SS, Lyskjaer I, Ørntoft MW, Høyer S, Dagnaes-Hansen F, Liu Y, Li R, Callesen H, Rasmussen MH, Berthelsen MF, Thomsen MK, Schweiger PJ, Jensen KB, Laurberg S, Ørntoft TF, Elverløv-Jakobsen JE, Andersen CL.

Mol Oncol. 2017 Nov;11(11):1616-1629. doi: 10.1002/1878-0261.12136. Epub 2017 Oct 10.

15.

Analysis of Factor D Isoforms in Malpuech-Michels-Mingarelli-Carnevale Patients Highlights the Role of MASP-3 as a Maturase in the Alternative Pathway of Complement.

Pihl R, Jensen L, Hansen AG, Thøgersen IB, Andres S, Dagnæs-Hansen F, Oexle K, Enghild JJ, Thiel S.

J Immunol. 2017 Aug 9. pii: ji1700518. doi: 10.4049/jimmunol.1700518. [Epub ahead of print]

PMID:
28794230
16.

Psoriasiform skin disease in transgenic pigs with high-copy ectopic expression of human integrins α2 and β1.

Staunstrup NH, Stenderup K, Mortensen S, Primo MN, Rosada C, Steiniche T, Liu Y, Li R, Schmidt M, Purup S, Dagnæs-Hansen F, Schrøder LD, Svensson L, Petersen TK, Callesen H, Bolund L, Mikkelsen JG.

Dis Model Mech. 2017 Jul 1;10(7):869-880. doi: 10.1242/dmm.028662.

17.

Pancreas specific expression of oncogenes in a porcine model.

Berthelsen MF, Callesen MM, Østergaard TS, Liu Y, Li R, Callesen H, Dagnæs-Hansen F, Hamilton-Dutoit S, Jakobsen JE, Thomsen MK.

Transgenic Res. 2017 Oct;26(5):603-612. doi: 10.1007/s11248-017-0031-4. Epub 2017 Jun 29.

PMID:
28664456
18.

Fatty Acid-Modified Gapmer Antisense Oligonucleotide and Serum Albumin Constructs for Pharmacokinetic Modulation.

Hvam ML, Cai Y, Dagnæs-Hansen F, Nielsen JS, Wengel J, Kjems J, Howard KA.

Mol Ther. 2017 Jul 5;25(7):1710-1717. doi: 10.1016/j.ymthe.2017.05.009. Epub 2017 Jun 20.

19.

Clonal outbreaks of [ Pasteurella] pneumotropica biovar Heyl in two mouse colonies.

Adhikary S, Bisgaard M, Dagnæs-Hansen F, Christensen H.

Lab Anim. 2017 Dec;51(6):613-621. doi: 10.1177/0023677217698503. Epub 2017 Mar 30.

PMID:
28358244
20.

Impact of PEG Chain Length on the Physical Properties and Bioactivity of PEGylated Chitosan/siRNA Nanoparticles in Vitro and in Vivo.

Yang C, Gao S, Dagnæs-Hansen F, Jakobsen M, Kjems J.

ACS Appl Mater Interfaces. 2017 Apr 12;9(14):12203-12216. doi: 10.1021/acsami.6b16556. Epub 2017 Apr 3.

PMID:
28332829
21.

Endogenous Natural Complement Inhibitor Regulates Cardiac Development.

Mortensen SA, Skov LL, Kjaer-Sorensen K, Hansen AG, Hansen S, Dagnæs-Hansen F, Jensenius JC, Oxvig C, Thiel S, Degn SE.

J Immunol. 2017 Apr 15;198(8):3118-3126. doi: 10.4049/jimmunol.1601958. Epub 2017 Mar 3.

22.

Cholinergic PET imaging in infections and inflammation using 11C-donepezil and 18F-FEOBV.

Jørgensen NP, Alstrup AK, Mortensen FV, Knudsen K, Jakobsen S, Madsen LB, Bender D, Breining P, Petersen MS, Schleimann MH, Dagnæs-Hansen F, Gormsen LC, Borghammer P.

Eur J Nucl Med Mol Imaging. 2017 Mar;44(3):449-458. doi: 10.1007/s00259-016-3555-6. Epub 2016 Oct 26.

PMID:
27785538
23.

Lack of immunological DNA sensing in hepatocytes facilitates hepatitis B virus infection.

Thomsen MK, Nandakumar R, Stadler D, Malo A, Valls RM, Wang F, Reinert LS, Dagnaes-Hansen F, Hollensen AK, Mikkelsen JG, Protzer U, Paludan SR.

Hepatology. 2016 Sep;64(3):746-59. doi: 10.1002/hep.28685. Epub 2016 Jul 26.

PMID:
27312012
24.

An albumin-mediated cholesterol design-based strategy for tuning siRNA pharmacokinetics and gene silencing.

Bienk K, Hvam ML, Pakula MM, Dagnæs-Hansen F, Wengel J, Malle BM, Kragh-Hansen U, Cameron J, Bukrinski JT, Howard KA.

J Control Release. 2016 Jun 28;232:143-51. doi: 10.1016/j.jconrel.2016.04.013. Epub 2016 Apr 12.

PMID:
27084489
25.

Rifampicin-containing combinations are superior to combinations of vancomycin, linezolid and daptomycin against Staphylococcus aureus biofilm infection in vivo and in vitro.

Jørgensen NP, Skovdal SM, Meyer RL, Dagnæs-Hansen F, Fuursted K, Petersen E.

Pathog Dis. 2016 Jun;74(4):ftw019. doi: 10.1093/femspd/ftw019. Epub 2016 Apr 1.

PMID:
27036412
26.

Cell therapy centered on IL-1Ra is neuroprotective in experimental stroke.

Clausen BH, Lambertsen KL, Dagnæs-Hansen F, Babcock AA, von Linstow CU, Meldgaard M, Kristensen BW, Deierborg T, Finsen B.

Acta Neuropathol. 2016 May;131(5):775-91. doi: 10.1007/s00401-016-1541-5. Epub 2016 Feb 9.

27.

Treatment of Clostridium difficile infection in mice with vancomycin alone is as effective as treatment with vancomycin and metronidazole in combination.

Erikstrup LT, Aarup M, Hagemann-Madsen R, Dagnaes-Hansen F, Kristensen B, Olsen KE, Fuursted K.

BMJ Open Gastroenterol. 2015 Nov 2;2(1):e000038. doi: 10.1136/bmjgast-2015-000038. eCollection 2015.

28.

Robust Lentiviral Gene Delivery But Limited Transduction Capacity of Commonly Used Adeno-Associated Viral Serotypes in Xenotransplanted Human Skin.

Jakobsen M, Askou AL, Stenderup K, Rosada C, Dagnæs-Hansen F, Jensen TG, Corydon TJ, Mikkelsen JG, Aagaard L.

Hum Gene Ther Methods. 2015 Aug;26(4):123-33. doi: 10.1089/hgtb.2014.135.

29.

Restoration of Haemoglobin Level Using Hydrodynamic Gene Therapy with Erythropoietin Does Not Alleviate the Disease Progression in an Anaemic Mouse Model for TGFβ1-Induced Chronic Kidney Disease.

Pedersen L, Wogensen L, Marcussen N, Cecchi CR, Dalsgaard T, Dagnæs-Hansen F.

PLoS One. 2015 Jun 5;10(6):e0128367. doi: 10.1371/journal.pone.0128367. eCollection 2015.

30.

A tissue-engineered therapeutic device inhibits tumor growth in vitro and in vivo.

Sun M, Wang M, Chen M, Dagnaes-Hansen F, Le DQ, Baatrup A, Horsman MR, Kjems J, Bünger CE.

Acta Biomater. 2015 May;18:21-9. doi: 10.1016/j.actbio.2015.02.004. Epub 2015 Feb 14.

PMID:
25686557
31.

A modified chronic infection model for testing treatment of Staphylococcus aureus biofilms on implants.

Jørgensen NP, Meyer RL, Dagnæs-Hansen F, Fuursted K, Petersen E.

PLoS One. 2014 Oct 3;9(10):e103688. doi: 10.1371/journal.pone.0103688. eCollection 2014. Erratum in: PLoS One. 2015;10(3):e0118124. Meyer, Rikke [corrected to Meyer, Rikke L].

32.

Cellular disposal of miR23b by RAB27-dependent exosome release is linked to acquisition of metastatic properties.

Ostenfeld MS, Jeppesen DK, Laurberg JR, Boysen AT, Bramsen JB, Primdal-Bengtson B, Hendrix A, Lamy P, Dagnaes-Hansen F, Rasmussen MH, Bui KH, Fristrup N, Christensen EI, Nordentoft I, Morth JP, Jensen JB, Pedersen JS, Beck M, Theodorescu D, Borre M, Howard KA, Dyrskjøt L, Ørntoft TF.

Cancer Res. 2014 Oct 15;74(20):5758-71. doi: 10.1158/0008-5472.CAN-13-3512. Epub 2014 Sep 26.

33.

Macrophage-mediated nanoparticle delivery to the periodontal lesions in established murine model via Pg-LPS induction.

Ma Z, Dagnaes-Hansen F, Løvschall H, Song W, Nielsen GK, Yang C, Wang Q, Kjems J, Gao S.

J Oral Pathol Med. 2015 Aug;44(7):538-42. doi: 10.1111/jop.12269. Epub 2014 Sep 25.

PMID:
25258036
34.

Megalin-mediated specific uptake of chitosan/siRNA nanoparticles in mouse kidney proximal tubule epithelial cells enables AQP1 gene silencing.

Gao S, Hein S, Dagnæs-Hansen F, Weyer K, Yang C, Nielsen R, Christensen EI, Fenton RA, Kjems J.

Theranostics. 2014 Aug 13;4(10):1039-51. doi: 10.7150/thno.7866. eCollection 2014.

35.

Functional screening identifies miRNAs influencing apoptosis and proliferation in colorectal cancer.

Christensen LL, Holm A, Rantala J, Kallioniemi O, Rasmussen MH, Ostenfeld MS, Dagnaes-Hansen F, Øster B, Schepeler T, Tobiasen H, Thorsen K, Sieber OM, Gibbs P, Lamy P, Hansen TF, Jakobsen A, Riising EM, Helin K, Lubinski J, Hagemann-Madsen R, Laurberg S, Ørntoft TF, Andersen CL.

PLoS One. 2014 Jun 3;9(6):e96767. doi: 10.1371/journal.pone.0096767. eCollection 2014.

36.

Induction of atherosclerosis in mice and hamsters without germline genetic engineering.

Bjørklund MM, Hollensen AK, Hagensen MK, Dagnaes-Hansen F, Christoffersen C, Mikkelsen JG, Bentzon JF.

Circ Res. 2014 May 23;114(11):1684-9. doi: 10.1161/CIRCRESAHA.114.302937. Epub 2014 Mar 27.

PMID:
24677271
37.

A novel homologous model for gene therapy of dwarfism by non-viral transfer of the mouse growth hormone gene into immunocompetent dwarf mice.

Cecchi CR, Higuti E, Oliveira NA, Lima ER, Jakobsen M, Dagnaes-Hansen F, Gissel H, Aagaard L, Jensen TG, Jorge AA, Bartolini P, Peroni CN.

Curr Gene Ther. 2014 Feb;14(1):44-51.

PMID:
24559069
38.

The inflammatory response in blood and in remote organs following acute kidney injury.

Brøchner AC, Dagnaes-Hansen F, Højberg-Holm J, Toft P.

APMIS. 2014 May;122(5):399-404. doi: 10.1111/apm.12157. Epub 2013 Sep 6.

PMID:
24033773
39.

A simple method for deriving functional MSCs and applied for osteogenesis in 3D scaffolds.

Zou L, Luo Y, Chen M, Wang G, Ding M, Petersen CC, Kang R, Dagnaes-Hansen F, Zeng Y, Lv N, Ma Q, Le DQ, Besenbacher F, Bolund L, Jensen TG, Kjems J, Pu WT, Bünger C.

Sci Rep. 2013;3:2243. doi: 10.1038/srep02243.

40.

Directing HER4 mRNA expression towards the CYT2 isoform by antisense oligonucleotide decreases growth of breast cancer cells in vitro and in vivo.

Nielsen TO, Sorensen S, Dagnæs-Hansen F, Kjems J, Sorensen BS.

Br J Cancer. 2013 Jun 11;108(11):2291-8. doi: 10.1038/bjc.2013.247. Epub 2013 May 21.

41.

Optimized siRNA-PEG conjugates for extended blood circulation and reduced urine excretion in mice.

Iversen F, Yang C, Dagnæs-Hansen F, Schaffert DH, Kjems J, Gao S.

Theranostics. 2013;3(3):201-9. doi: 10.7150/thno.5743. Epub 2013 Feb 25.

42.

Protection and Systemic Translocation of siRNA Following Oral Administration of Chitosan/siRNA Nanoparticles.

Ballarín-González B, Dagnaes-Hansen F, Fenton RA, Gao S, Hein S, Dong M, Kjems J, Howard KA.

Mol Ther Nucleic Acids. 2013 Mar 5;2:e76. doi: 10.1038/mtna.2013.2.

43.

Mitochondria and the lectin pathway of complement.

Brinkmann CR, Jensen L, Dagnæs-Hansen F, Holm IE, Endo Y, Fujita T, Thiel S, Jensenius JC, Degn SE.

J Biol Chem. 2013 Mar 22;288(12):8016-27. doi: 10.1074/jbc.M112.430249. Epub 2013 Feb 1.

44.

Diabetes-induced changes in mannan-binding lectin levels and complement activation in a mouse model of type 1 diabetes.

Ostergaard JA, Bjerre M, Dagnaes-Hansen F, Hansen TK, Thiel S, Flyvbjerg A.

Scand J Immunol. 2013 Mar;77(3):187-94. doi: 10.1111/sji.12027.

45.

Bone formation and resorption are both increased in experimental autoimmune arthritis.

Keller KK, Thomsen JS, Stengaard-Pedersen K, Dagnæs-Hansen F, Nyengaard JR, Hauge EM.

PLoS One. 2012;7(12):e53034. doi: 10.1371/journal.pone.0053034. Epub 2012 Dec 27.

46.

Spatial distribution of transgenic protein after gene electrotransfer to porcine muscle.

Spanggaard I, Corydon T, Hojman P, Gissel H, Dagnaes-Hansen F, Jensen TG, Gehl J.

Hum Gene Ther Methods. 2012 Dec;23(6):387-92. doi: 10.1089/hgtb.2012.173. Epub 2013 Jan 11.

PMID:
23157397
47.

Generation of minipigs with targeted transgene insertion by recombinase-mediated cassette exchange (RMCE) and somatic cell nuclear transfer (SCNT).

Jakobsen JE, Johansen MG, Schmidt M, Dagnæs-Hansen F, Dam K, Gunnarsson A, Liu Y, Kragh PM, Li R, Holm IE, Callesen H, Mikkelsen JG, Nielsen AL, Jørgensen AL.

Transgenic Res. 2013 Aug;22(4):709-23. doi: 10.1007/s11248-012-9671-6. Epub 2012 Oct 31.

48.

Reduction of choroidal neovascularization in mice by adeno-associated virus-delivered anti-vascular endothelial growth factor short hairpin RNA.

Askou AL, Pournaras JA, Pihlmann M, Svalgaard JD, Arsenijevic Y, Kostic C, Bek T, Dagnaes-Hansen F, Mikkelsen JG, Jensen TG, Corydon TJ.

J Gene Med. 2012 Nov;14(11):632-41. doi: 10.1002/jgm.2678.

PMID:
23080553
49.

Peritoneal macrophages mediated delivery of chitosan/siRNA nanoparticle to the lesion site in a murine radiation-induced fibrosis model.

Nawroth I, Alsner J, Deleuran BW, Dagnaes-Hansen F, Yang C, Horsman MR, Overgaard J, Howard KA, Kjems J, Gao S.

Acta Oncol. 2013 Nov;52(8):1730-8. doi: 10.3109/0284186X.2012.726373. Epub 2012 Oct 1.

PMID:
23020526
50.

SKG arthritis as a model for evaluating therapies in rheumatoid arthritis with special focus on bone changes.

Keller KK, Lindgaard LM, Wogensen L, Dagnæs-Hansen F, Thomsen JS, Sakaguchi S, Stengaard-Pedersen K, Hauge EM.

Rheumatol Int. 2013 May;33(5):1127-33. doi: 10.1007/s00296-012-2500-7. Epub 2012 Sep 5.

PMID:
22948540

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