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Items: 14

1.

Engineering Pak1 Allosteric Switches.

Dagliyan O, Karginov AV, Yagishita S, Gale ME, Wang H, DerMardirossian C, Wells CM, Dokholyan NV, Kasai H, Hahn KM.

ACS Synth Biol. 2017 Jul 21;6(7):1257-1262. doi: 10.1021/acssynbio.6b00359. Epub 2017 Apr 6.

PMID:
28365983
2.

Engineering extrinsic disorder to control protein activity in living cells.

Dagliyan O, Tarnawski M, Chu PH, Shirvanyants D, Schlichting I, Dokholyan NV, Hahn KM.

Science. 2016 Dec 16;354(6318):1441-1444.

3.

FRET binding antenna reports spatiotemporal dynamics of GDI-Cdc42 GTPase interactions.

Hodgson L, Spiering D, Sabouri-Ghomi M, Dagliyan O, DerMardirossian C, Danuser G, Hahn KM.

Nat Chem Biol. 2016 Oct;12(10):802-809. doi: 10.1038/nchembio.2145. Epub 2016 Aug 8.

4.

Gain-of-Function Mutation W493R in the Epithelial Sodium Channel Allosterically Reconfigures Intersubunit Coupling.

Shobair M, Dagliyan O, Kota P, Dang YL, He H, Stutts MJ, Dokholyan NV.

J Biol Chem. 2016 Feb 19;291(8):3682-92. doi: 10.1074/jbc.M115.678052. Epub 2015 Dec 14.

5.

Engineered kinase activation reveals unique morphodynamic phenotypes and associated trafficking for Src family isoforms.

Chu PH, Tsygankov D, Berginski ME, Dagliyan O, Gomez SM, Elston TC, Karginov AV, Hahn KM.

Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):12420-5. doi: 10.1073/pnas.1404487111. Epub 2014 Aug 12.

6.

Intrinsic disorder mediates cooperative signal transduction in STIM1.

Furukawa Y, Teraguchi S, Ikegami T, Dagliyan O, Jin L, Hall D, Dokholyan NV, Namba K, Akira S, Kurosaki T, Baba Y, Standley DM.

J Mol Biol. 2014 May 15;426(10):2082-97. doi: 10.1016/j.jmb.2014.03.006. Epub 2014 Mar 17.

7.

Computational approaches to understanding protein aggregation in neurodegeneration.

Redler RL, Shirvanyants D, Dagliyan O, Ding F, Kim DN, Kota P, Proctor EA, Ramachandran S, Tandon A, Dokholyan NV.

J Mol Cell Biol. 2014 Apr;6(2):104-15. doi: 10.1093/jmcb/mju007. Epub 2014 Mar 11. Review.

8.

Identification of novel integrin binding partners for calcium and integrin binding protein 1 (CIB1): structural and thermodynamic basis of CIB1 promiscuity.

Freeman TC Jr, Black JL, Bray HG, Dagliyan O, Wu YI, Tripathy A, Dokholyan NV, Leisner TM, Parise LV.

Biochemistry. 2013 Oct 8;52(40):7082-90. doi: 10.1021/bi400678y. Epub 2013 Sep 25.

9.

Knowledge-based design of a biosensor to quantify localized ERK activation in living cells.

Kummer L, Hsu CW, Dagliyan O, MacNevin C, Kaufholz M, Zimmermann B, Dokholyan NV, Hahn KM, Plückthun A.

Chem Biol. 2013 Jun 20;20(6):847-56. doi: 10.1016/j.chembiol.2013.04.016.

10.

Rational design of a ligand-controlled protein conformational switch.

Dagliyan O, Shirvanyants D, Karginov AV, Ding F, Fee L, Chandrasekaran SN, Freisinger CM, Smolen GA, Huttenlocher A, Hahn KM, Dokholyan NV.

Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):6800-4. doi: 10.1073/pnas.1218319110. Epub 2013 Apr 8.

11.

Structure based discovery of small molecules to regulate the activity of human insulin degrading enzyme.

Çakir B, Dağliyan O, Dağyildiz E, Bariş İ, Kavakli IH, Kizilel S, Türkay M.

PLoS One. 2012;7(2):e31787. doi: 10.1371/journal.pone.0031787. Epub 2012 Feb 15.

12.

Structural and dynamic determinants of protein-peptide recognition.

Dagliyan O, Proctor EA, D'Auria KM, Ding F, Dokholyan NV.

Structure. 2011 Dec 7;19(12):1837-45. doi: 10.1016/j.str.2011.09.014.

13.

Optimization based tumor classification from microarray gene expression data.

Dagliyan O, Uney-Yuksektepe F, Kavakli IH, Turkay M.

PLoS One. 2011 Feb 4;6(2):e14579. doi: 10.1371/journal.pone.0014579.

14.

Classification of cytochrome P450 inhibitors with respect to binding free energy and pIC50 using common molecular descriptors.

Dagliyan O, Kavakli IH, Turkay M.

J Chem Inf Model. 2009 Oct;49(10):2403-11. doi: 10.1021/ci900247t.

PMID:
19777996

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