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Circulating uromodulin inhibits systemic oxidative stress by inactivating the TRPM2 channel.

LaFavers KA, Macedo E, Garimella PS, Lima C, Khan S, Myslinski J, McClintick J, Witzmann FA, Winfree S, Phillips CL, Hato T, Dagher PC, Wu XR, El-Achkar TM, Micanovic R.

Sci Transl Med. 2019 Oct 2;11(512). pii: eaaw3639. doi: 10.1126/scitranslmed.aaw3639.


Automatic segmentation of intravital fluorescence microscopy images by K-means clustering of FLIM phasors.

Zhang Y, Hato T, Dagher PC, Nichols EL, Smith CJ, Dunn KW, Howard SS.

Opt Lett. 2019 Aug 15;44(16):3928-3931. doi: 10.1364/OL.44.003928.


Bacterial sepsis triggers an antiviral response that causes translation shutdown.

Hato T, Maier B, Syed F, Myslinski J, Zollman A, Plotkin Z, Eadon MT, Dagher PC.

J Clin Invest. 2019 Jan 2;129(1):296-309. doi: 10.1172/JCI123284. Epub 2018 Dec 3.


Quantitative Large-Scale Three-Dimensional Imaging of Human Kidney Biopsies: A Bridge to Precision Medicine in Kidney Disease.

Winfree S, Dagher PC, Dunn KW, Eadon MT, Ferkowicz M, Barwinska D, Kelly KJ, Sutton TA, El-Achkar TM.

Nephron. 2018;140(2):134-139. doi: 10.1159/000490006. Epub 2018 Jun 5. Review.


Kidney Imaging: Intravital Microscopy.

Hato T, Winfree S, Dagher PC.

Methods Mol Biol. 2018;1763:129-136. doi: 10.1007/978-1-4939-7762-8_12.


In Vivo siRNA Delivery and Rebound of Renal LRP2 in Mice.

Eadon MT, Cheng YH, Hato T, Benson EA, Ipe J, Collins KS, De Luca T, El-Achkar TM, Bacallao RL, Skaar TC, Dagher PC.

J Drug Deliv. 2017;2017:4070793. doi: 10.1155/2017/4070793. Epub 2017 Dec 20.


Endothelial STAT3 Modulates Protective Mechanisms in a Mouse Ischemia-Reperfusion Model of Acute Kidney Injury.

Dube S, Matam T, Yen J, Mang HE, Dagher PC, Hato T, Sutton TA.

J Immunol Res. 2017;2017:4609502. doi: 10.1155/2017/4609502. Epub 2017 Oct 17.


Tamm-Horsfall Protein Regulates Mononuclear Phagocytes in the Kidney.

Micanovic R, Khan S, Janosevic D, Lee ME, Hato T, Srour EF, Winfree S, Ghosh J, Tong Y, Rice SE, Dagher PC, Wu XR, El-Achkar TM.

J Am Soc Nephrol. 2018 Mar;29(3):841-856. doi: 10.1681/ASN.2017040409. Epub 2017 Nov 27.


Endotoxin Preconditioning Reprograms S1 Tubules and Macrophages to Protect the Kidney.

Hato T, Zollman A, Plotkin Z, El-Achkar TM, Maier BF, Pay SL, Dube S, Cabral P, Yoshimoto M, McClintick J, Dagher PC.

J Am Soc Nephrol. 2018 Jan;29(1):104-117. doi: 10.1681/ASN.2017060624. Epub 2017 Oct 10.


Large-scale 3-dimensional quantitative imaging of tissues: state-of-the-art and translational implications.

Winfree S, Ferkowicz MJ, Dagher PC, Kelly KJ, Eadon MT, Sutton TA, Markel TA, Yoder MC, Dunn KW, El-Achkar TM.

Transl Res. 2017 Nov;189:1-12. doi: 10.1016/j.trsl.2017.07.006. Epub 2017 Jul 22. Review.


Intravital imaging of the kidney.

Hato T, Winfree S, Dagher PC.

Methods. 2017 Sep 1;128:33-39. doi: 10.1016/j.ymeth.2017.03.024. Epub 2017 Apr 12.


Genetic Variants Contributing to Colistin Cytotoxicity: Identification of TGIF1 and HOXD10 Using a Population Genomics Approach.

Eadon MT, Hause RJ, Stark AL, Cheng YH, Wheeler HE, Burgess KS, Benson EA, Cunningham PN, Bacallao RL, Dagher PC, Skaar TC, Dolan ME.

Int J Mol Sci. 2017 Mar 18;18(3). pii: E661. doi: 10.3390/ijms18030661.


Two-Photon Intravital Fluorescence Lifetime Imaging of the Kidney Reveals Cell-Type Specific Metabolic Signatures.

Hato T, Winfree S, Day R, Sandoval RM, Molitoris BA, Yoder MC, Wiggins RC, Zheng Y, Dunn KW, Dagher PC.

J Am Soc Nephrol. 2017 Aug;28(8):2420-2430. doi: 10.1681/ASN.2016101153. Epub 2017 Mar 1.


Inhibition of Toll-Like Receptor 4 Signaling Mitigates Microvascular Loss but Not Fibrosis in a Model of Ischemic Acute Kidney Injury.

Dagher PC, Hato T, Mang HE, Plotkin Z, Richardson QV, Massad M, Mai E, Kuehl SE, Graham P, Kumar R, Sutton TA.

Int J Mol Sci. 2016 Apr 29;17(5). pii: E647. doi: 10.3390/ijms17050647.


Novel application of complementary imaging techniques to examine in vivo glucose metabolism in the kidney.

Hato T, Friedman AN, Mang H, Plotkin Z, Dube S, Hutchins GD, Territo PR, McCarthy BP, Riley AA, Pichumani K, Malloy CR, Harris RA, Dagher PC, Sutton TA.

Am J Physiol Renal Physiol. 2016 Apr 15;310(8):F717-F725. doi: 10.1152/ajprenal.00535.2015. Epub 2016 Jan 13.


A two-week regimen of high-dose integrase inhibitors does not cause nephrotoxicity in mice.

Eadon MT, Zhang H, Skaar TC, Hato T, Dagher PC, Gupta SK, Desta Z.

Antivir Chem Chemother. 2015 Apr;24(2):72-6. doi: 10.1177/2040206615595318. Epub 2015 Jul 30.


Tubular cross talk in acute kidney injury: a story of sense and sensibility.

El-Achkar TM, Dagher PC.

Am J Physiol Renal Physiol. 2015 Jun 15;308(12):F1317-23. doi: 10.1152/ajprenal.00030.2015. Epub 2015 Apr 15. Review.


Ferroxitosis: a cell death from modulation of oxidative phosphorylation and PKM2-dependent glycolysis in melanoma.

Lakhter AJ, Hamilton J, Dagher PC, Mukkamala S, Hato T, Dong XC, Mayo LD, Harris RA, Shekhar A, Ivan M, Brustovetsky N, Naidu SR.

Oncotarget. 2014 Dec 30;5(24):12694-703.


Tamm-Horsfall Protein Regulates Granulopoiesis and Systemic Neutrophil Homeostasis.

Micanovic R, Chitteti BR, Dagher PC, Srour EF, Khan S, Hato T, Lyle A, Tong Y, Wu XR, El-Achkar TM.

J Am Soc Nephrol. 2015 Sep;26(9):2172-82. doi: 10.1681/ASN.2014070664. Epub 2015 Jan 2.


The caspase 3 sensor Phiphilux G2D2 is activated non-specifically in S1 renal proximal tubules.

Hato T, Sandoval R, Dagher PC.

Intravital. 2015;4(2). pii: e1067352. Epub 2015 Aug 28.


How the Innate Immune System Senses Trouble and Causes Trouble.

Hato T, Dagher PC.

Clin J Am Soc Nephrol. 2015 Aug 7;10(8):1459-69. doi: 10.2215/CJN.04680514. Epub 2014 Nov 20. Review.


The macrophage mediates the renoprotective effects of endotoxin preconditioning.

Hato T, Winfree S, Kalakeche R, Dube S, Kumar R, Yoshimoto M, Plotkin Z, Dagher PC.

J Am Soc Nephrol. 2015 Jun;26(6):1347-62. doi: 10.1681/ASN.2014060561. Epub 2014 Nov 14.


Sisters in arms: myeloid and tubular epithelial cells shape renal innate immunity.

Hato T, El-Achkar TM, Dagher PC.

Am J Physiol Renal Physiol. 2013 May 15;304(10):F1243-51. doi: 10.1152/ajprenal.00101.2013. Epub 2013 Mar 20. Review.


p53 is renoprotective after ischemic kidney injury by reducing inflammation.

Sutton TA, Hato T, Mai E, Yoshimoto M, Kuehl S, Anderson M, Mang H, Plotkin Z, Chan RJ, Dagher PC.

J Am Soc Nephrol. 2013 Jan;24(1):113-24. doi: 10.1681/ASN.2012050469. Epub 2012 Dec 6.


The p53 inhibitor pifithrin-α can stimulate fibrosis in a rat model of ischemic acute kidney injury.

Dagher PC, Mai EM, Hato T, Lee SY, Anderson MD, Karozos SC, Mang HE, Knipe NL, Plotkin Z, Sutton TA.

Am J Physiol Renal Physiol. 2012 Jan 15;302(2):F284-91. doi: 10.1152/ajprenal.00317.2011. Epub 2011 Nov 2.


Endotoxin uptake by S1 proximal tubular segment causes oxidative stress in the downstream S2 segment.

Kalakeche R, Hato T, Rhodes G, Dunn KW, El-Achkar TM, Plotkin Z, Sandoval RM, Dagher PC.

J Am Soc Nephrol. 2011 Aug;22(8):1505-16. doi: 10.1681/ASN.2011020203. Epub 2011 Jul 22.


Fueling the fire in acute kidney injury: endothelial cells collect their Toll.

Sutton TA, Dagher PC.

Kidney Int. 2011 Feb;79(3):267-9. doi: 10.1038/ki.2010.456.


Tamm-Horsfall protein-deficient thick ascending limbs promote injury to neighboring S3 segments in an MIP-2-dependent mechanism.

El-Achkar TM, McCracken R, Rauchman M, Heitmeier MR, Al-Aly Z, Dagher PC, Wu XR.

Am J Physiol Renal Physiol. 2011 Apr;300(4):F999-1007. doi: 10.1152/ajprenal.00621.2010. Epub 2011 Jan 12.


siRNA targeted to p53 attenuates ischemic and cisplatin-induced acute kidney injury.

Molitoris BA, Dagher PC, Sandoval RM, Campos SB, Ashush H, Fridman E, Brafman A, Faerman A, Atkinson SJ, Thompson JD, Kalinski H, Skaliter R, Erlich S, Feinstein E.

J Am Soc Nephrol. 2009 Aug;20(8):1754-64. doi: 10.1681/ASN.2008111204. Epub 2009 May 21.


Pathways of renal injury in systemic gram-negative sepsis.

El-Achkar TM, Hosein M, Dagher PC.

Eur J Clin Invest. 2008 Oct;38 Suppl 2:39-44. doi: 10.1111/j.1365-2362.2008.02007.x. Review.


p53 regulates renal expression of HIF-1{alpha} and pVHL under physiological conditions and after ischemia-reperfusion injury.

Sutton TA, Wilkinson J, Mang HE, Knipe NL, Plotkin Z, Hosein M, Zak K, Wittenborn J, Dagher PC.

Am J Physiol Renal Physiol. 2008 Dec;295(6):F1666-77. doi: 10.1152/ajprenal.90304.2008. Epub 2008 Sep 24.


Tamm-Horsfall protein protects the kidney from ischemic injury by decreasing inflammation and altering TLR4 expression.

El-Achkar TM, Wu XR, Rauchman M, McCracken R, Kiefer S, Dagher PC.

Am J Physiol Renal Physiol. 2008 Aug;295(2):F534-44. doi: 10.1152/ajprenal.00083.2008. Epub 2008 May 21.


An expanding role of Toll-like receptors in sepsis-induced acute kidney injury.

Dagher PC, Basile DP.

Am J Physiol Renal Physiol. 2008 May;294(5):F1048-9. doi: 10.1152/ajprenal.00125.2008. Epub 2008 Mar 19. No abstract available.


Sepsis induces an increase in thick ascending limb Cox-2 that is TLR4 dependent.

El-Achkar TM, Plotkin Z, Marcic B, Dagher PC.

Am J Physiol Renal Physiol. 2007 Oct;293(4):F1187-96. Epub 2007 Jul 18.


Renal Toll-like receptors: recent advances and implications for disease.

El-Achkar TM, Dagher PC.

Nat Clin Pract Nephrol. 2006 Oct;2(10):568-81. Review.


Up-regulation of AMP-activated kinase by dysfunctional cystic fibrosis transmembrane conductance regulator in cystic fibrosis airway epithelial cells mitigates excessive inflammation.

Hallows KR, Fitch AC, Richardson CA, Reynolds PR, Clancy JP, Dagher PC, Witters LA, Kolls JK, Pilewski JM.

J Biol Chem. 2006 Feb 17;281(7):4231-41. Epub 2005 Dec 18.


Sepsis induces changes in the expression and distribution of Toll-like receptor 4 in the rat kidney.

El-Achkar TM, Huang X, Plotkin Z, Sandoval RM, Rhodes GJ, Dagher PC.

Am J Physiol Renal Physiol. 2006 May;290(5):F1034-43. Epub 2005 Dec 6.


Minocycline reduces renal microvascular leakage in a rat model of ischemic renal injury.

Sutton TA, Kelly KJ, Mang HE, Plotkin Z, Sandoval RM, Dagher PC.

Am J Physiol Renal Physiol. 2005 Jan;288(1):F91-7. Epub 2004 Sep 7.


Apoptosis in ischemic renal injury: roles of GTP depletion and p53.

Dagher PC.

Kidney Int. 2004 Aug;66(2):506-9. Review.


Minocycline inhibits apoptosis and inflammation in a rat model of ischemic renal injury.

Kelly KJ, Sutton TA, Weathered N, Ray N, Caldwell EJ, Plotkin Z, Dagher PC.

Am J Physiol Renal Physiol. 2004 Oct;287(4):F760-6. Epub 2004 Jun 1.


Newly developed techniques to study and diagnose acute renal failure.

Dagher PC, Herget-Rosenthal S, Ruehm SG, Jo SK, Star RA, Agarwal R, Molitoris BA.

J Am Soc Nephrol. 2003 Aug;14(8):2188-98. Review.


A novel method to determine specificity and sensitivity of the TUNEL reaction in the quantitation of apoptosis.

Kelly KJ, Sandoval RM, Dunn KW, Molitoris BA, Dagher PC.

Am J Physiol Cell Physiol. 2003 May;284(5):C1309-18. Epub 2002 Dec 21.


Rho GTPases show differential sensitivity to nucleotide triphosphate depletion in a model of ischemic cell injury.

Hallett MA, Dagher PC, Atkinson SJ.

Am J Physiol Cell Physiol. 2003 Jul;285(1):C129-38. Epub 2003 Mar 5.


P53 mediates the apoptotic response to GTP depletion after renal ischemia-reperfusion: protective role of a p53 inhibitor.

Kelly KJ, Plotkin Z, Vulgamott SL, Dagher PC.

J Am Soc Nephrol. 2003 Jan;14(1):128-38. Erratum in: J Am Soc Nephrol. 2003 Mar;14(3):823-4.


Functional studies of the kidney of living animals using multicolor two-photon microscopy.

Dunn KW, Sandoval RM, Kelly KJ, Dagher PC, Tanner GA, Atkinson SJ, Bacallao RL, Molitoris BA.

Am J Physiol Cell Physiol. 2002 Sep;283(3):C905-16.


Guanine nucleosides and Jurkat cell death: roles of ATP depletion and accumulation of deoxyribonucleotides.

Batiuk TD, Schnizlein-Bick C, Plotkin Z, Dagher PC.

Am J Physiol Cell Physiol. 2001 Dec;281(6):C1776-84.


Modulation of chloride secretion in the rat ileum by intracellular bicarbonate.

Dagher PC, Chawla H, Michael J, Egnor RW, Charney AN.

Comp Biochem Physiol A Physiol. 1997 May;117(1):89-97.


Short-chain fatty acids inhibit cAMP-mediated chloride secretion in rat colon.

Dagher PC, Egnor RW, Taglietta-Kohlbrecher A, Charney AN.

Am J Physiol. 1996 Dec;271(6 Pt 1):C1853-60.


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