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Items: 1 to 50 of 118

1.

Automated High-Throughput Capillary Circular Dichroism and Intrinsic Fluorescence Spectroscopy for Rapid Determination of Protein Structure.

Moore-Kelly C, Welsh J, Rodger A, Dafforn TR, Thomas ORT.

Anal Chem. 2019 Oct 17. doi: 10.1021/acs.analchem.9b03259. [Epub ahead of print]

PMID:
31584804
2.

Multifunctional graphene oxide-bacteriophage based porous three-dimensional micro-nanocomposites.

Passaretti P, Sun Y, Khan I, Chan K, Sabo R, White H, Dafforn TR, Oppenheimer PG.

Nanoscale. 2019 Jul 28;11(28):13318-13329. doi: 10.1039/c9nr03670a. Epub 2019 Jul 4.

PMID:
31271408
3.

SMA-PAGE: A new method to examine complexes of membrane proteins using SMALP nano-encapsulation and native gel electrophoresis.

Pollock NL, Rai M, Simon KS, Hesketh SJ, Teo ACK, Parmar M, Sridhar P, Collins R, Lee SC, Stroud ZN, Bakker SE, Muench SP, Barton CH, Hurlbut G, Roper DI, Smith CJI, Knowles TJ, Spickett CM, East JM, Postis VLG, Dafforn TR.

Biochim Biophys Acta Biomembr. 2019 Aug 1;1861(8):1437-1445. doi: 10.1016/j.bbamem.2019.05.011. Epub 2019 May 28.

PMID:
31150633
4.

Light-controlled thrombin catalysis and clot formation using a photoswitchable G-quadruplex DNA aptamer.

Ali A, Bullen GA, Cross B, Dafforn TR, Little HA, Manchester J, Peacock AFA, Tucker JHR.

Chem Commun (Camb). 2019 May 9;55(39):5627-5630. doi: 10.1039/c9cc01540j.

PMID:
31025680
5.

Analysis of SMALP co-extracted phospholipids shows distinct membrane environments for three classes of bacterial membrane protein.

Teo ACK, Lee SC, Pollock NL, Stroud Z, Hall S, Thakker A, Pitt AR, Dafforn TR, Spickett CM, Roper DI.

Sci Rep. 2019 Feb 12;9(1):1813. doi: 10.1038/s41598-018-37962-0.

6.

Linear dichroism of visible-region chromophores using M13 bacteriophage as an alignment scaffold.

Tridgett M, Moore-Kelly C, Duprey JHA, Iturbe LO, Tsang CW, Little HA, Sandhu SK, Hicks MR, Dafforn TR, Rodger A.

RSC Adv. 2018 Aug 23;8(52):29535-29543. doi: 10.1039/c8ra05475d. Epub 2018 Aug 20.

7.

A simple and convenient method for the hydrolysis of styrene-maleic anhydride copolymers to styrene-maleic acid copolymers.

Kopf AH, Koorengevel MC, van Walree CA, Dafforn TR, Killian JA.

Chem Phys Lipids. 2019 Jan;218:85-90. doi: 10.1016/j.chemphyslip.2018.11.011. Epub 2018 Dec 1.

8.

Dye Aggregate-Mediated Self-Assembly of Bacteriophage Bioconjugates.

Tridgett M, Lozano L, Passaretti P, Desai NR, Proctor TJ, Little HA, Logan RT, Arkill KP, Oppenheimer PG, Dafforn TR.

Bioconjug Chem. 2018 Nov 21;29(11):3705-3714. doi: 10.1021/acs.bioconjchem.8b00617. Epub 2018 Oct 31.

PMID:
30347978
9.

An acid-compatible co-polymer for the solubilization of membranes and proteins into lipid bilayer-containing nanoparticles.

Hall SCL, Tognoloni C, Charlton J, Bragginton ÉC, Rothnie AJ, Sridhar P, Wheatley M, Knowles TJ, Arnold T, Edler KJ, Dafforn TR.

Nanoscale. 2018 Jun 7;10(22):10609-10619. doi: 10.1039/c8nr01322e.

10.

Mutation of M13 Bacteriophage Major Coat Protein for Increased Conjugation to Exogenous Compounds.

Tridgett M, Lloyd JR, Kennefick J, Moore-Kelly C, Dafforn TR.

Bioconjug Chem. 2018 Jun 20;29(6):1872-1875. doi: 10.1021/acs.bioconjchem.8b00307. Epub 2018 Jun 1.

PMID:
29800521
11.

Purification of membrane proteins free from conventional detergents: SMA, new polymers, new opportunities and new insights.

Stroud Z, Hall SCL, Dafforn TR.

Methods. 2018 Sep 1;147:106-117. doi: 10.1016/j.ymeth.2018.03.011. Epub 2018 Mar 31. Review.

PMID:
29608964
12.

Fluorescence detected linear dichroism spectroscopy: A selective and sensitive probe for fluorophores in flow-oriented systems.

Wemyss AM, Chmel NP, Lobo DP, Sutherland JA, Dafforn TR, Rodger A.

Chirality. 2018 Mar;30(3):227-237. doi: 10.1002/chir.22795. Epub 2018 Jan 3.

PMID:
29314266
13.

Influence of Poly(styrene- co-maleic acid) Copolymer Structure on the Properties and Self-Assembly of SMALP Nanodiscs.

Hall SCL, Tognoloni C, Price GJ, Klumperman B, Edler KJ, Dafforn TR, Arnold T.

Biomacromolecules. 2018 Mar 12;19(3):761-772. doi: 10.1021/acs.biomac.7b01539. Epub 2018 Jan 16.

14.

Using a SMALP platform to determine a sub-nm single particle cryo-EM membrane protein structure.

Parmar M, Rawson S, Scarff CA, Goldman A, Dafforn TR, Muench SP, Postis VLG.

Biochim Biophys Acta Biomembr. 2018 Feb;1860(2):378-383. doi: 10.1016/j.bbamem.2017.10.005. Epub 2017 Oct 6.

15.

Characterization of a dynamic metabolon producing the defense compound dhurrin in sorghum.

Laursen T, Borch J, Knudsen C, Bavishi K, Torta F, Martens HJ, Silvestro D, Hatzakis NS, Wenk MR, Dafforn TR, Olsen CE, Motawia MS, Hamberger B, Møller BL, Bassard JE.

Science. 2016 Nov 18;354(6314):890-893.

PMID:
27856908
16.

Membrane protein extraction and purification using styrene-maleic acid (SMA) copolymer: effect of variations in polymer structure.

Morrison KA, Akram A, Mathews A, Khan ZA, Patel JH, Zhou C, Hardy DJ, Moore-Kelly C, Patel R, Odiba V, Knowles TJ, Javed MU, Chmel NP, Dafforn TR, Rothnie AJ.

Biochem J. 2016 Dec 1;473(23):4349-4360. Epub 2016 Sep 30.

PMID:
27694389
17.

Direct detection and measurement of wall shear stress using a filamentous bio-nanoparticle.

Lobo DP, Wemyss AM, Smith DJ, Straube A, Betteridge KB, Salmon AH, Foster RR, Elhegni HE, Satchell SC, Little HA, Pacheco-Gómez R, Simmons MJ, Hicks MR, Bates DO, Rodger A, Dafforn TR, Arkill KP.

Nano Res. 2015 Oct;8(10):3307-3315.

18.

Membrane protein insertion and assembly by the bacterial holo-translocon SecYEG-SecDF-YajC-YidC.

Komar J, Alvira S, Schulze RJ, Martin R, Lycklama A Nijeholt JA, Lee SC, Dafforn TR, Deckers-Hebestreit G, Berger I, Schaffitzel C, Collinson I.

Biochem J. 2016 Oct 1;473(19):3341-54. doi: 10.1042/BCJ20160545. Epub 2016 Jul 19.

19.

A method for detergent-free isolation of membrane proteins in their local lipid environment.

Lee SC, Knowles TJ, Postis VL, Jamshad M, Parslow RA, Lin YP, Goldman A, Sridhar P, Overduin M, Muench SP, Dafforn TR.

Nat Protoc. 2016 Jul;11(7):1149-62. doi: 10.1038/nprot.2016.070. Epub 2016 Jun 2.

20.

GPCR-styrene maleic acid lipid particles (GPCR-SMALPs): their nature and potential.

Wheatley M, Charlton J, Jamshad M, Routledge SJ, Bailey S, La-Borde PJ, Azam MT, Logan RT, Bill RM, Dafforn TR, Poyner DR.

Biochem Soc Trans. 2016 Apr 15;44(2):619-23. doi: 10.1042/BST20150284. Review.

PMID:
27068979
21.

Encapsulated membrane proteins: A simplified system for molecular simulation.

Lee SC, Khalid S, Pollock NL, Knowles TJ, Edler K, Rothnie AJ, R T Thomas O, Dafforn TR.

Biochim Biophys Acta. 2016 Oct;1858(10):2549-2557. doi: 10.1016/j.bbamem.2016.02.039. Epub 2016 Mar 3. Review.

22.

Polymerase Chain Reaction on a Viral Nanoparticle.

Carr-Smith J, Pacheco-Gómez R, Little HA, Hicks MR, Sandhu S, Steinke N, Smith DJ, Rodger A, Goodchild SA, Lukaszewski RA, Tucker JH, Dafforn TR.

ACS Synth Biol. 2015 Dec 18;4(12):1316-25. doi: 10.1021/acssynbio.5b00034. Epub 2015 Jul 1.

23.

Structural analysis of a nanoparticle containing a lipid bilayer used for detergent-free extraction of membrane proteins.

Jamshad M, Grimard V, Idini I, Knowles TJ, Dowle MR, Schofield N, Sridhar P, Lin YP, Finka R, Wheatley M, Thomas OR, Palmer RE, Overduin M, Govaerts C, Ruysschaert JM, Edler KJ, Dafforn TR.

Nano Res. 2015 Mar;8(3):774-789. doi: 10.1007/s12274-014-0560-6. Epub 2014 Oct 23.

24.

G-protein coupled receptor solubilization and purification for biophysical analysis and functional studies, in the total absence of detergent.

Jamshad M, Charlton J, Lin YP, Routledge SJ, Bawa Z, Knowles TJ, Overduin M, Dekker N, Dafforn TR, Bill RM, Poyner DR, Wheatley M.

Biosci Rep. 2015 Apr 16;35(2). pii: e00188. doi: 10.1042/BSR20140171.

25.

Detergent-free isolation, characterization, and functional reconstitution of a tetrameric K+ channel: the power of native nanodiscs.

Dörr JM, Koorengevel MC, Schäfer M, Prokofyev AV, Scheidelaar S, van der Cruijsen EA, Dafforn TR, Baldus M, Killian JA.

Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):18607-12. doi: 10.1073/pnas.1416205112. Epub 2014 Dec 15.

26.

The use of SMALPs as a novel membrane protein scaffold for structure study by negative stain electron microscopy.

Postis V, Rawson S, Mitchell JK, Lee SC, Parslow RA, Dafforn TR, Baldwin SA, Muench SP.

Biochim Biophys Acta. 2015 Feb;1848(2):496-501. doi: 10.1016/j.bbamem.2014.10.018. Epub 2014 Oct 23.

27.

α-1-antitrypsin variants and the proteinase/antiproteinase imbalance in chronic obstructive pulmonary disease.

Sinden NJ, Baker MJ, Smith DJ, Kreft JU, Dafforn TR, Stockley RA.

Am J Physiol Lung Cell Mol Physiol. 2015 Jan 15;308(2):L179-90.

28.

Identification and characterization of trimethylamine N-oxide (TMAO) demethylase and TMAO permease in Methylocella silvestris BL2.

Zhu Y, Jameson E, Parslow RA, Lidbury I, Fu T, Dafforn TR, Schäfer H, Chen Y.

Environ Microbiol. 2014 Oct;16(10):3318-30. doi: 10.1111/1462-2920.12585. Epub 2014 Sep 17.

PMID:
25088783
29.

Surfactant-free purification of membrane protein complexes from bacteria: application to the staphylococcal penicillin-binding protein complex PBP2/PBP2a.

Paulin S, Jamshad M, Dafforn TR, Garcia-Lara J, Foster SJ, Galley NF, Roper DI, Rosado H, Taylor PW.

Nanotechnology. 2014 Jul 18;25(28):285101. doi: 10.1088/0957-4484/25/28/285101. Epub 2014 Jun 27.

PMID:
24972373
30.

Detergent-free purification of ABC (ATP-binding-cassette) transporters.

Gulati S, Jamshad M, Knowles TJ, Morrison KA, Downing R, Cant N, Collins R, Koenderink JB, Ford RC, Overduin M, Kerr ID, Dafforn TR, Rothnie AJ.

Biochem J. 2014 Jul 15;461(2):269-78. doi: 10.1042/BJ20131477.

PMID:
24758594
31.

De novo design of Ln(III) coiled coils for imaging applications.

Berwick MR, Lewis DJ, Jones AW, Parslow RA, Dafforn TR, Cooper HJ, Wilkie J, Pikramenou Z, Britton MM, Peacock AF.

J Am Chem Soc. 2014 Jan 29;136(4):1166-9. doi: 10.1021/ja408741h. Epub 2014 Jan 16.

32.

Kinetic study of the thermal denaturation of a hyperthermostable extracellular α-amylase from Pyrococcus furiosus.

Brown I, Dafforn TR, Fryer PJ, Cox PW.

Biochim Biophys Acta. 2013 Dec;1834(12):2600-5. doi: 10.1016/j.bbapap.2013.09.008. Epub 2013 Sep 21.

33.

Production, purification and characterization of recombinant, full-length human claudin-1.

Bonander N, Jamshad M, Oberthür D, Clare M, Barwell J, Hu K, Farquhar MJ, Stamataki Z, Harris HJ, Dierks K, Dafforn TR, Betzel C, McKeating JA, Bill RM.

PLoS One. 2013 May 21;8(5):e64517. doi: 10.1371/journal.pone.0064517. Print 2013.

34.

The pH sensitivity of murine heat shock protein 47 (HSP47) binding to collagen is affected by mutations in the breach histidine cluster.

Abdul-Wahab MF, Homma T, Wright M, Olerenshaw D, Dafforn TR, Nagata K, Miller AD.

J Biol Chem. 2013 Feb 8;288(6):4452-61. doi: 10.1074/jbc.M112.409029. Epub 2012 Dec 4.

35.

Tetramerization of ZapA is required for FtsZ bundling.

Pacheco-Gómez R, Cheng X, Hicks MR, Smith CJ, Roper DI, Addinall S, Rodger A, Dafforn TR.

Biochem J. 2013 Feb 1;449(3):795-802. doi: 10.1042/BJ20120140.

PMID:
23098212
36.

Rapid injection linear dichroism for studying the kinetics of biological processes.

Hicks MR, Rodger A, Lin YP, Jones NC, Hoffmann SV, Dafforn TR.

Anal Chem. 2012 Aug 7;84(15):6561-6. doi: 10.1021/ac300842h. Epub 2012 Jul 18.

PMID:
22746248
37.

The mechanics of FtsZ fibers.

Turner DJ, Portman I, Dafforn TR, Rodger A, Roper DI, Smith CJ, Turner MS.

Biophys J. 2012 Feb 22;102(4):731-8. doi: 10.1016/j.bpj.2012.01.015. Epub 2012 Feb 21.

38.

A novel model and molecular therapy for Z alpha-1 antitrypsin deficiency.

McNab GL, Dafforn TR, Wood A, Sapey E, Stockley RA.

Mamm Genome. 2012 Apr;23(3-4):241-9. doi: 10.1007/s00335-011-9370-2. Epub 2011 Nov 11.

PMID:
22076419
39.

Detection of pathogenic bacteria using a homogeneous immunoassay based on shear alignment of virus particles and linear dichroism.

Pacheco-Gómez R, Kraemer J, Stokoe S, England HJ, Penn CW, Stanley E, Rodger A, Ward J, Hicks MR, Dafforn TR.

Anal Chem. 2012 Jan 3;84(1):91-7. doi: 10.1021/ac201544h. Epub 2011 Dec 12.

PMID:
22017566
40.

High-resolution, three-dimensional modeling of human leukocyte antigen class I structure and surface electrostatic potential reveals the molecular basis for alloantibody binding epitopes.

Kosmoliaptsis V, Dafforn TR, Chaudhry AN, Halsall DJ, Bradley JA, Taylor CJ.

Hum Immunol. 2011 Nov;72(11):1049-59. doi: 10.1016/j.humimm.2011.07.303. Epub 2011 Jul 28.

PMID:
21840357
41.

The pH dependence of polymerization and bundling by the essential bacterial cytoskeletal protein FtsZ.

Pacheco-Gómez R, Roper DI, Dafforn TR, Rodger A.

PLoS One. 2011;6(6):e19369. doi: 10.1371/journal.pone.0019369. Epub 2011 Jun 28.

42.

Surfactant-free purification of membrane proteins with intact native membrane environment.

Jamshad M, Lin YP, Knowles TJ, Parslow RA, Harris C, Wheatley M, Poyner DR, Bill RM, Thomas OR, Overduin M, Dafforn TR.

Biochem Soc Trans. 2011 Jun;39(3):813-8. doi: 10.1042/BST0390813. Review.

PMID:
21599653
43.

Nbr1 is a novel inhibitor of ligand-mediated receptor tyrosine kinase degradation.

Mardakheh FK, Auciello G, Dafforn TR, Rappoport JZ, Heath JK.

Mol Cell Biol. 2010 Dec;30(24):5672-85. doi: 10.1128/MCB.00878-10. Epub 2010 Oct 11.

44.

DNA compaction by the higher-order assembly of PRH/Hex homeodomain protein oligomers.

Soufi A, Sawasdichai A, Shukla A, Noy P, Dafforn T, Smith C, Jayaraman PS, Gaston K.

Nucleic Acids Res. 2010 Nov;38(21):7513-25. doi: 10.1093/nar/gkq659. Epub 2010 Jul 31.

45.

The synergistic action of melittin and phospholipase A2 with lipid membranes: development of linear dichroism for membrane-insertion kinetics.

Damianoglou A, Rodger A, Pridmore C, Dafforn TR, Mosely JA, Sanderson JM, Hicks MR.

Protein Pept Lett. 2010 Nov;17(11):1351-62.

PMID:
20673225
46.

Synchrotron radiation linear dichroism spectroscopy of the antibiotic peptide gramicidin in lipid membranes.

Hicks MR, Dafforn TR, Damianoglou A, Wormell P, Rodger A, Hoffmann SV.

Analyst. 2009 Aug;134(8):1623-8. doi: 10.1039/b902523e. Epub 2009 May 19.

PMID:
20448930
47.

Assembly pathway of a designed alpha-helical protein fiber.

Bromley EH, Channon KJ, King PJ, Mahmoud ZN, Banwell EF, Butler MF, Crump MP, Dafforn TR, Hicks MR, Hirst JD, Rodger A, Woolfson DN.

Biophys J. 2010 Apr 21;98(8):1668-76. doi: 10.1016/j.bpj.2009.12.4309.

48.

Characterizing the assembly of the Sup35 yeast prion fragment, GNNQQNY: structural changes accompany a fiber-to-crystal switch.

Marshall KE, Hicks MR, Williams TL, Hoffmann SV, Rodger A, Dafforn TR, Serpell LC.

Biophys J. 2010 Jan 20;98(2):330-8. doi: 10.1016/j.bpj.2009.10.020.

49.

Golgi protein FAPP2 tubulates membranes.

Cao X, Coskun U, Rössle M, Buschhorn SB, Grzybek M, Dafforn TR, Lenoir M, Overduin M, Simons K.

Proc Natl Acad Sci U S A. 2009 Dec 15;106(50):21121-5. doi: 10.1073/pnas.0911789106. Epub 2009 Nov 25.

50.

Predicting HLA class I alloantigen immunogenicity from the number and physiochemical properties of amino acid polymorphisms.

Kosmoliaptsis V, Chaudhry AN, Sharples LD, Halsall DJ, Dafforn TR, Bradley JA, Taylor CJ.

Transplantation. 2009 Sep 27;88(6):791-8. doi: 10.1097/TP.0b013e3181b4a9ff.

PMID:
19920778

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