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Items: 23

1.

Structure-Activity Relationships, Pharmacokinetics, and Pharmacodynamics of the Kir6.2/SUR1-Specific Channel Opener VU0071063.

Kharade SV, Sanchez-Andres JV, Fulton MG, Shelton EL, Blobaum AL, Engers DW, Hofmann CS, Dadi PK, Lantier L, Jacobson DA, Lindsley CW, Denton JS.

J Pharmacol Exp Ther. 2019 Sep;370(3):350-359. doi: 10.1124/jpet.119.257204. Epub 2019 Jun 14.

PMID:
31201216
2.

Glucose-mediated inhibition of calcium-activated potassium channels limits α-cell calcium influx and glucagon secretion.

Dickerson MT, Dadi PK, Altman MK, Verlage KR, Thorson AS, Jordan KL, Vierra NC, Amarnath G, Jacobson DA.

Am J Physiol Endocrinol Metab. 2019 Apr 1;316(4):E646-E659. doi: 10.1152/ajpendo.00342.2018. Epub 2019 Jan 29.

PMID:
30694690
3.

Neurog3-Independent Methylation Is the Earliest Detectable Mark Distinguishing Pancreatic Progenitor Identity.

Liu J, Banerjee A, Herring CA, Attalla J, Hu R, Xu Y, Shao Q, Simmons AJ, Dadi PK, Wang S, Jacobson DA, Liu B, Hodges E, Lau KS, Gu G.

Dev Cell. 2019 Jan 7;48(1):49-63.e7. doi: 10.1016/j.devcel.2018.11.048.

PMID:
30620902
4.

Cystic fibrosis-related diabetes is caused by islet loss and inflammation.

Hart NJ, Aramandla R, Poffenberger G, Fayolle C, Thames AH, Bautista A, Spigelman AF, Babon JAB, DeNicola ME, Dadi PK, Bush WS, Balamurugan AN, Brissova M, Dai C, Prasad N, Bottino R, Jacobson DA, Drumm ML, Kent SC, MacDonald PE, Powers AC.

JCI Insight. 2018 Apr 19;3(8). pii: 98240. doi: 10.1172/jci.insight.98240. eCollection 2018 Apr 19.

5.

Synaptotagmin 4 Regulates Pancreatic β Cell Maturation by Modulating the Ca2+ Sensitivity of Insulin Secretion Vesicles.

Huang C, Walker EM, Dadi PK, Hu R, Xu Y, Zhang W, Sanavia T, Mun J, Liu J, Nair GG, Tan HYA, Wang S, Magnuson MA, Stoeckert CJ Jr, Hebrok M, Gannon M, Han W, Stein R, Jacobson DA, Gu G.

Dev Cell. 2018 May 7;45(3):347-361.e5. doi: 10.1016/j.devcel.2018.03.013. Epub 2018 Apr 12.

6.

TALK-1 reduces delta-cell endoplasmic reticulum and cytoplasmic calcium levels limiting somatostatin secretion.

Vierra NC, Dickerson MT, Jordan KL, Dadi PK, Katdare KA, Altman MK, Milian SC, Jacobson DA.

Mol Metab. 2018 Mar;9:84-97. doi: 10.1016/j.molmet.2018.01.016. Epub 2018 Jan 31.

7.

Cytokine-mediated changes in K+ channel activity promotes an adaptive Ca2+ response that sustains β-cell insulin secretion during inflammation.

Dickerson MT, Bogart AM, Altman MK, Milian SC, Jordan KL, Dadi PK, Jacobson DA.

Sci Rep. 2018 Jan 18;8(1):1158. doi: 10.1038/s41598-018-19600-x.

8.

TALK-1 channels control β cell endoplasmic reticulum Ca2+ homeostasis.

Vierra NC, Dadi PK, Milian SC, Dickerson MT, Jordan KL, Gilon P, Jacobson DA.

Sci Signal. 2017 Sep 19;10(497). pii: eaan2883. doi: 10.1126/scisignal.aan2883.

9.

Chronic β-Cell Depolarization Impairs β-Cell Identity by Disrupting a Network of Ca2+-Regulated Genes.

Stancill JS, Cartailler JP, Clayton HW, O'Connor JT, Dickerson MT, Dadi PK, Osipovich AB, Jacobson DA, Magnuson MA.

Diabetes. 2017 Aug;66(8):2175-2187. doi: 10.2337/db16-1355. Epub 2017 May 26.

10.

Osteopontin activates the diabetes-associated potassium channel TALK-1 in pancreatic β-cells.

Dickerson MT, Vierra NC, Milian SC, Dadi PK, Jacobson DA.

PLoS One. 2017 Apr 12;12(4):e0175069. doi: 10.1371/journal.pone.0175069. eCollection 2017.

11.

β-arrestin-2 is an essential regulator of pancreatic β-cell function under physiological and pathophysiological conditions.

Zhu L, Almaça J, Dadi PK, Hong H, Sakamoto W, Rossi M, Lee RJ, Vierra NC, Lu H, Cui Y, McMillin SM, Perry NA, Gurevich VV, Lee A, Kuo B, Leapman RD, Matschinsky FM, Doliba NM, Urs NM, Caron MG, Jacobson DA, Caicedo A, Wess J.

Nat Commun. 2017 Feb 1;8:14295. doi: 10.1038/ncomms14295.

12.

Selective Small Molecule Activators of TREK-2 Channels Stimulate Dorsal Root Ganglion c-Fiber Nociceptor Two-Pore-Domain Potassium Channel Currents and Limit Calcium Influx.

Dadi PK, Vierra NC, Days E, Dickerson MT, Vinson PN, Weaver CD, Jacobson DA.

ACS Chem Neurosci. 2017 Mar 15;8(3):558-568. doi: 10.1021/acschemneuro.6b00301. Epub 2016 Nov 23.

13.

Activation of FoxM1 Revitalizes the Replicative Potential of Aged β-Cells in Male Mice and Enhances Insulin Secretion.

Golson ML, Dunn JC, Maulis MF, Dadi PK, Osipovich AB, Magnuson MA, Jacobson DA, Gannon M.

Diabetes. 2015 Nov;64(11):3829-38. doi: 10.2337/db15-0465. Epub 2015 Aug 6.

14.

Type 2 Diabetes-Associated K+ Channel TALK-1 Modulates β-Cell Electrical Excitability, Second-Phase Insulin Secretion, and Glucose Homeostasis.

Vierra NC, Dadi PK, Jeong I, Dickerson M, Powell DR, Jacobson DA.

Diabetes. 2015 Nov;64(11):3818-28. doi: 10.2337/db15-0280. Epub 2015 Aug 3.

15.

TASK-1 Potassium Channels Limit Pancreatic α-Cell Calcium Influx and Glucagon Secretion.

Dadi PK, Luo B, Vierra NC, Jacobson DA.

Mol Endocrinol. 2015 May;29(5):777-87. doi: 10.1210/me.2014-1321. Epub 2015 Apr 7.

16.

Pancreatic β-cell-specific ablation of TASK-1 channels augments glucose-stimulated calcium entry and insulin secretion, improving glucose tolerance.

Dadi PK, Vierra NC, Jacobson DA.

Endocrinology. 2014 Oct;155(10):3757-68. doi: 10.1210/en.2013-2051. Epub 2014 Jun 16.

17.

Direct activation of β-cell KATP channels with a novel xanthine derivative.

Raphemot R, Swale DR, Dadi PK, Jacobson DA, Cooper P, Wojtovich AP, Banerjee S, Nichols CG, Denton JS.

Mol Pharmacol. 2014 Jun;85(6):858-65. doi: 10.1124/mol.114.091884. Epub 2014 Mar 19.

18.

Inhibition of pancreatic β-cell Ca2+/calmodulin-dependent protein kinase II reduces glucose-stimulated calcium influx and insulin secretion, impairing glucose tolerance.

Dadi PK, Vierra NC, Ustione A, Piston DW, Colbran RJ, Jacobson DA.

J Biol Chem. 2014 May 2;289(18):12435-45. doi: 10.1074/jbc.M114.562587. Epub 2014 Mar 13.

19.

Multiple functional polymorphisms in the G6PC2 gene contribute to the association with higher fasting plasma glucose levels.

Baerenwald DA, Bonnefond A, Bouatia-Naji N, Flemming BP, Umunakwe OC, Oeser JK, Pound LD, Conley NL, Cauchi S, Lobbens S, Eury E, Balkau B, Lantieri O; MAGIC Investigators, Dadi PK, Jacobson DA, Froguel P, O'Brien RM.

Diabetologia. 2013 Jun;56(6):1306-16. doi: 10.1007/s00125-013-2875-3. Epub 2013 Mar 19.

20.

G6PC2: a negative regulator of basal glucose-stimulated insulin secretion.

Pound LD, Oeser JK, O'Brien TP, Wang Y, Faulman CJ, Dadi PK, Jacobson DA, Hutton JC, McGuinness OP, Shiota M, O'Brien RM.

Diabetes. 2013 May;62(5):1547-56. doi: 10.2337/db12-1067. Epub 2012 Dec 28.

21.

The physiological effects of deleting the mouse SLC30A8 gene encoding zinc transporter-8 are influenced by gender and genetic background.

Pound LD, Sarkar SA, Ustione A, Dadi PK, Shadoan MK, Lee CE, Walters JA, Shiota M, McGuinness OP, Jacobson DA, Piston DW, Hutton JC, Powell DR, O'Brien RM.

PLoS One. 2012;7(7):e40972. doi: 10.1371/journal.pone.0040972. Epub 2012 Jul 19.

22.

Dietary bioflavonoids inhibit Escherichia coli ATP synthase in a differential manner.

Chinnam N, Dadi PK, Sabri SA, Ahmad M, Kabir MA, Ahmad Z.

Int J Biol Macromol. 2010 Jun;46(5):478-86. doi: 10.1016/j.ijbiomac.2010.03.009. Epub 2010 Mar 25.

23.

Inhibition of ATPase activity of Escherichia coli ATP synthase by polyphenols.

Dadi PK, Ahmad M, Ahmad Z.

Int J Biol Macromol. 2009 Jul 1;45(1):72-9. doi: 10.1016/j.ijbiomac.2009.04.004. Epub 2009 Apr 16.

PMID:
19375450

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