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Items: 48


Linear ubiquitin assembly complex regulates lung epithelial driven responses during influenza infection.

Brazee PL, Morales-Nebreda L, Magnani ND, Garcia JG, Misharin AV, Ridge KM, Budinger GRS, Iwai K, Dada LA, Sznajder JI.

J Clin Invest. 2019 Nov 12. pii: 128368. doi: 10.1172/JCI128368. [Epub ahead of print]


Influenza A Virus Infection Induces Muscle Wasting via IL-6 Regulation of the E3 Ubiquitin Ligase Atrogin-1.

Radigan KA, Nicholson TT, Welch LC, Chi M, Amarelle L, Angulo M, Shigemura M, Shigemura A, Runyan CE, Morales-Nebreda L, Perlman H, Ceco E, Lecuona E, Dada LA, Misharin AV, Mutlu GM, Sznajder JI, Budinger GRS.

J Immunol. 2019 Jan 15;202(2):484-493. doi: 10.4049/jimmunol.1701433. Epub 2018 Dec 7.


Ubiquitin-proteasome signaling in lung injury.

Magnani ND, Dada LA, Sznajder JI.

Transl Res. 2018 Aug;198:29-39. doi: 10.1016/j.trsl.2018.04.003. Epub 2018 Apr 23. Review.


Splice Wars: The Role of MLCK Isoforms in Ventilation-induced Lung Injury.

Brazee PL, Dada LA.

Am J Respir Cell Mol Biol. 2018 May;58(5):549-550. doi: 10.1165/rcmb.2017-0385ED. No abstract available.


HIF and HOIL-1L-mediated PKCζ degradation stabilizes plasma membrane Na,K-ATPase to protect against hypoxia-induced lung injury.

Magnani ND, Dada LA, Queisser MA, Brazee PL, Welch LC, Anekalla KR, Zhou G, Vagin O, Misharin AV, Budinger GRS, Iwai K, Ciechanover AJ, Sznajder JI.

Proc Natl Acad Sci U S A. 2017 Nov 21;114(47):E10178-E10186. doi: 10.1073/pnas.1713563114. Epub 2017 Nov 6.


Downregulation of PKCζ/Pard3/Pard6b is responsible for lung adenocarcinoma cell EMT and invasion.

Zhou Q, Dai J, Chen T, Dada LA, Zhang X, Zhang W, DeCamp MM, Winn RA, Sznajder JI, Zhou G.

Cell Signal. 2017 Oct;38:49-59. doi: 10.1016/j.cellsig.2017.06.016. Epub 2017 Jun 24.


FXYD5 Is an Essential Mediator of the Inflammatory Response during Lung Injury.

Brazee PL, Soni PN, Tokhtaeva E, Magnani N, Yemelyanov A, Perlman HR, Ridge KM, Sznajder JI, Vagin O, Dada LA.

Front Immunol. 2017 Jun 1;8:623. doi: 10.3389/fimmu.2017.00623. eCollection 2017.



Habeck M, Tokhtaeva E, Nadav Y, Ben Zeev E, Ferris SP, Kaufman RJ, Bab-Dinitz E, Kaplan JH, Dada LA, Farfel Z, Tal DM, Katz A, Sachs G, Vagin O, Karlish SJ.

J Biol Chem. 2016 Oct 28;291(44):23159-23174. Epub 2016 Sep 13.


The O-glycosylated ectodomain of FXYD5 impairs adhesion by disrupting cell-cell trans-dimerization of Na,K-ATPase β1 subunits.

Tokhtaeva E, Sun H, Deiss-Yehiely N, Wen Y, Soni PN, Gabrielli NM, Marcus EA, Ridge KM, Sachs G, Vazquez-Levin M, Sznajder JI, Vagin O, Dada LA.

J Cell Sci. 2016 Jun 15;129(12):2394-406. doi: 10.1242/jcs.186148. Epub 2016 May 3.


FXYD5 Protein Has a Pro-inflammatory Role in Epithelial Cells.

Lubarski-Gotliv I, Asher C, Dada LA, Garty H.

J Biol Chem. 2016 May 20;291(21):11072-82. doi: 10.1074/jbc.M115.699041. Epub 2016 Mar 22.


Role of Linear Ubiquitination in Health and Disease.

Brazee P, Dada LA, Sznajder JI.

Am J Respir Cell Mol Biol. 2016 Jun;54(6):761-8. doi: 10.1165/rcmb.2016-0014TR. Review.


High CO2 Leads to Na,K-ATPase Endocytosis via c-Jun Amino-Terminal Kinase-Induced LMO7b Phosphorylation.

Dada LA, Trejo Bittar HE, Welch LC, Vagin O, Deiss-Yehiely N, Kelly AM, Baker MR, Capri J, Cohn W, Whitelegge JP, Vadász I, Gruenbaum Y, Sznajder JI.

Mol Cell Biol. 2015 Dec;35(23):3962-73. doi: 10.1128/MCB.00813-15. Epub 2015 Sep 14.


High CO2 levels cause skeletal muscle atrophy via AMP-activated kinase (AMPK), FoxO3a protein, and muscle-specific Ring finger protein 1 (MuRF1).

Jaitovich A, Angulo M, Lecuona E, Dada LA, Welch LC, Cheng Y, Gusarova G, Ceco E, Liu C, Shigemura M, Barreiro E, Patterson C, Nader GA, Sznajder JI.

J Biol Chem. 2015 Apr 3;290(14):9183-94. doi: 10.1074/jbc.M114.625715. Epub 2015 Feb 17.


Septin dynamics are essential for exocytosis.

Tokhtaeva E, Capri J, Marcus EA, Whitelegge JP, Khuzakhmetova V, Bukharaeva E, Deiss-Yehiely N, Dada LA, Sachs G, Fernandez-Salas E, Vagin O.

J Biol Chem. 2015 Feb 27;290(9):5280-97. doi: 10.1074/jbc.M114.616201. Epub 2015 Jan 9.


Intratracheal administration of influenza virus is superior to intranasal administration as a model of acute lung injury.

Morales-Nebreda L, Chi M, Lecuona E, Chandel NS, Dada LA, Ridge K, Soberanes S, Nigdelioglu R, Sznajder JI, Mutlu GM, Budinger GR, Radigan KA.

J Virol Methods. 2014 Dec;209:116-20. doi: 10.1016/j.jviromet.2014.09.004. Epub 2014 Sep 17.


HOIL-1L functions as the PKCζ ubiquitin ligase to promote lung tumor growth.

Queisser MA, Dada LA, Deiss-Yehiely N, Angulo M, Zhou G, Kouri FM, Knab LM, Liu J, Stegh AH, DeCamp MM, Budinger GR, Chandel NS, Ciechanover A, Iwai K, Sznajder JI.

Am J Respir Crit Care Med. 2014 Sep 15;190(6):688-98. doi: 10.1164/rccm.201403-0463OC.


Evolutionary conserved role of c-Jun-N-terminal kinase in CO2-induced epithelial dysfunction.

Vadász I, Dada LA, Briva A, Helenius IT, Sharabi K, Welch LC, Kelly AM, Grzesik BA, Budinger GR, Liu J, Seeger W, Beitel GJ, Gruenbaum Y, Sznajder JI.

PLoS One. 2012;7(10):e46696. doi: 10.1371/journal.pone.0046696. Epub 2012 Oct 8.


Lord of the RING: ubiquitination and directed degradation of skeletal muscle in acute lung injury.

Vadász I, Dada LA, Maltais F.

Am J Respir Crit Care Med. 2012 Apr 15;185(8):795-6. doi: 10.1164/rccm.201202-0225ED. No abstract available.


Identification of the amino acid region involved in the intercellular interaction between the β1 subunits of Na+/K+ -ATPase.

Tokhtaeva E, Sachs G, Sun H, Dada LA, Sznajder JI, Vagin O.

J Cell Sci. 2012 Mar 15;125(Pt 6):1605-16. doi: 10.1242/jcs.100149. Epub 2012 Feb 10.


The Na-K-ATPase α₁β₁ heterodimer as a cell adhesion molecule in epithelia.

Vagin O, Dada LA, Tokhtaeva E, Sachs G.

Am J Physiol Cell Physiol. 2012 May 1;302(9):C1271-81. doi: 10.1152/ajpcell.00456.2011. Epub 2012 Jan 25. Review.


Hypoxia leads to Na,K-ATPase downregulation via Ca(2+) release-activated Ca(2+) channels and AMPK activation.

Gusarova GA, Trejo HE, Dada LA, Briva A, Welch LC, Hamanaka RB, Mutlu GM, Chandel NS, Prakriya M, Sznajder JI.

Mol Cell Biol. 2011 Sep;31(17):3546-56. doi: 10.1128/MCB.05114-11. Epub 2011 Jul 5.


Mitochondrial Ca²+ and ROS take center stage to orchestrate TNF-α-mediated inflammatory responses.

Dada LA, Sznajder JI.

J Clin Invest. 2011 May;121(5):1683-5. doi: 10.1172/JCI57748. Epub 2011 Apr 25.


Extracellular signal-regulated kinase (ERK) participates in the hypercapnia-induced Na,K-ATPase downregulation.

Welch LC, Lecuona E, Briva A, Trejo HE, Dada LA, Sznajder JI.

FEBS Lett. 2010 Sep 24;584(18):3985-9. doi: 10.1016/j.febslet.2010.08.002. Epub 2010 Aug 6.


E3 ubiquitin ligase Mule ubiquitinates Miz1 and is required for TNFalpha-induced JNK activation.

Yang Y, Do H, Tian X, Zhang C, Liu X, Dada LA, Sznajder JI, Liu J.

Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13444-9. doi: 10.1073/pnas.0913690107. Epub 2010 Jul 12.


Insulin regulates alveolar epithelial function by inducing Na+/K+-ATPase translocation to the plasma membrane in a process mediated by the action of Akt.

Comellas AP, Kelly AM, Trejo HE, Briva A, Lee J, Sznajder JI, Dada LA.

J Cell Sci. 2010 Apr 15;123(Pt 8):1343-51. doi: 10.1242/jcs.066464. Epub 2010 Mar 23.


Role of ubiquitination in Na,K-ATPase regulation during lung injury.

Helenius IT, Dada LA, Sznajder JI.

Proc Am Thorac Soc. 2010 Feb;7(1):65-70. doi: 10.1513/pats.200907-082JS. Review.


Hypoxia-induced alveolar epithelial-mesenchymal transition requires mitochondrial ROS and hypoxia-inducible factor 1.

Zhou G, Dada LA, Wu M, Kelly A, Trejo H, Zhou Q, Varga J, Sznajder JI.

Am J Physiol Lung Cell Mol Physiol. 2009 Dec;297(6):L1120-30. doi: 10.1152/ajplung.00007.2009. Epub 2009 Oct 2.


Alpha1-AMP-activated protein kinase regulates hypoxia-induced Na,K-ATPase endocytosis via direct phosphorylation of protein kinase C zeta.

Gusarova GA, Dada LA, Kelly AM, Brodie C, Witters LA, Chandel NS, Sznajder JI.

Mol Cell Biol. 2009 Jul;29(13):3455-64. doi: 10.1128/MCB.00054-09. Epub 2009 Apr 20.


Endothelin-1 impairs alveolar epithelial function via endothelial ETB receptor.

Comellas AP, Briva A, Dada LA, Butti ML, Trejo HE, Yshii C, Azzam ZS, Litvan J, Chen J, Lecuona E, Pesce LM, Yanagisawa M, Sznajder JI.

Am J Respir Crit Care Med. 2009 Jan 15;179(2):113-22. doi: 10.1164/rccm.200804-540OC. Epub 2008 Oct 23.


Regulation of alveolar epithelial function by hypoxia.

Zhou G, Dada LA, Sznajder JI.

Eur Respir J. 2008 May;31(5):1107-13. doi: 10.1183/09031936.00155507. Review.


Hypoxic inhibition of alveolar fluid reabsorption.

Dada LA, Sznajder JI.

Adv Exp Med Biol. 2007;618:159-68. Review.


AMP-activated protein kinase regulates CO2-induced alveolar epithelial dysfunction in rats and human cells by promoting Na,K-ATPase endocytosis.

Vadász I, Dada LA, Briva A, Trejo HE, Welch LC, Chen J, Tóth PT, Lecuona E, Witters LA, Schumacker PT, Chandel NS, Seeger W, Sznajder JI.

J Clin Invest. 2008 Feb;118(2):752-62. doi: 10.1172/JCI29723.


Hypoxia-mediated Na-K-ATPase degradation requires von Hippel Lindau protein.

Zhou G, Dada LA, Chandel NS, Iwai K, Lecuona E, Ciechanover A, Sznajder JI.

FASEB J. 2008 May;22(5):1335-42. Epub 2007 Dec 11.


High CO2 levels impair alveolar epithelial function independently of pH.

Briva A, Vadász I, Lecuona E, Welch LC, Chen J, Dada LA, Trejo HE, Dumasius V, Azzam ZS, Myrianthefs PM, Batlle D, Gruenbaum Y, Sznajder JI.

PLoS One. 2007 Nov 28;2(11):e1238.


Role of the small GTPase RhoA in the hypoxia-induced decrease of plasma membrane Na,K-ATPase in A549 cells.

Dada LA, Novoa E, Lecuona E, Sun H, Sznajder JI.

J Cell Sci. 2007 Jul 1;120(Pt 13):2214-22. Epub 2007 Jun 5.


Phosphorylation and ubiquitination are necessary for Na,K-ATPase endocytosis during hypoxia.

Dada LA, Welch LC, Zhou G, Ben-Saadon R, Ciechanover A, Sznajder JI.

Cell Signal. 2007 Sep;19(9):1893-8. Epub 2007 May 5.


Na,K-ATPase alpha1-subunit dephosphorylation by protein phosphatase 2A is necessary for its recruitment to the plasma membrane.

Lecuona E, Dada LA, Sun H, Butti ML, Zhou G, Chew TL, Sznajder JI.

FASEB J. 2006 Dec;20(14):2618-20. Epub 2006 Oct 25.


Hypoxia-mediated degradation of Na,K-ATPase via mitochondrial reactive oxygen species and the ubiquitin-conjugating system.

Comellas AP, Dada LA, Lecuona E, Pesce LM, Chandel NS, Quesada N, Budinger GR, Strous GJ, Ciechanover A, Sznajder JI.

Circ Res. 2006 May 26;98(10):1314-22. Epub 2006 Apr 13.


Norepinephrine increases alveolar fluid reabsorption and Na,K-ATPase activity.

Azzam ZS, Adir Y, Crespo A, Comellas A, Lecuona E, Dada LA, Krivoy N, Rutschman DH, Sznajder JI, Ridge KM.

Am J Respir Crit Care Med. 2004 Oct 1;170(7):730-6. Epub 2004 Jul 15.


Mechanisms of pulmonary edema clearance during acute hypoxemic respiratory failure: role of the Na,K-ATPase.

Dada LA, Sznajder JI.

Crit Care Med. 2003 Apr;31(4 Suppl):S248-52. Review.


Hypoxia-induced endocytosis of Na,K-ATPase in alveolar epithelial cells is mediated by mitochondrial reactive oxygen species and PKC-zeta.

Dada LA, Chandel NS, Ridge KM, Pedemonte C, Bertorello AM, Sznajder JI.

J Clin Invest. 2003 Apr;111(7):1057-64.


Effects of L-arginine in rat adrenal cells: involvement of nitric oxide synthase.

Cymeryng CB, Dada LA, Colonna C, Mendez CF, Podestá EJ.

Endocrinology. 1999 Jul;140(7):2962-7.


Effect of nitric oxide on rat adrenal zona fasciculata steroidogenesis.

Cymeryng CB, Dada LA, Podestá EJ.

J Endocrinol. 1998 Aug;158(2):197-203.


Involvement of arachidonic acid and the lipoxygenase pathway in mediating luteinizing hormone-induced testosterone synthesis in rat Leydig cells.

Mele PG, Dada LA, Paz C, Neuman I, Cymeryng CB, Mendez CF, Finkielstein CV, Cornejo Maciel F, Podestá EJ.

Endocr Res. 1997 Feb-May;23(1-2):15-26.


Site of action of proteinases in the activation of steroidogenesis in rat adrenal gland.

Mele PG, Dada LA, Paz C, Cymeryng CB, Cornejo Maciel MF, Neuman MI, Finkielstein CV, Mendez CF, Podestá EJ.

Biochim Biophys Acta. 1996 Feb 29;1310(3):260-8.


Purification of a novel 43-kDa protein (p43) intermediary in the activation of steroidogenesis from rat adrenal gland.

Paz C, Dada LA, Cornejo Maciel MF, Mele PG, Cymeryng CB, Neuman I, Mendez CF, Finkielstein CV, Solano AR, Park M, et al.

Eur J Biochem. 1994 Sep 1;224(2):709-16.


The cytosol as site of phosphorylation of the cyclic AMP-dependent protein kinase in adrenal steroidogenesis.

Dada LA, Paz C, Mele P, Solano AR, Cornejo Maciel F, Podesta EJ.

J Steroid Biochem Mol Biol. 1991 Dec;39(6):889-96.


Leukotrienes as common intermediates in the cyclic AMP dependent and independent pathways in adrenal steroidogenesis.

Solano AR, Dada LA, Luz Sardañons M, Sánchez ML, Podestá EJ.

J Steroid Biochem. 1987;27(4-6):745-51.


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