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Items: 37


Therapeutic Potential of Wnt and Notch Signaling and Epigenetic Regulation in Mammalian Sensory Hair Cell Regeneration.

Samarajeewa A, Jacques BE, Dabdoub A.

Mol Ther. 2019 May 8;27(5):904-911. doi: 10.1016/j.ymthe.2019.03.017. Epub 2019 Mar 30. Review.


Delivery of therapeutics to the inner ear: The challenge of the blood-labyrinth barrier.

Nyberg S, Abbott NJ, Shi X, Steyger PS, Dabdoub A.

Sci Transl Med. 2019 Mar 6;11(482). pii: eaao0935. doi: 10.1126/scitranslmed.aao0935. Review.


The microRNA-183/96/182 Cluster is Essential for Stereociliary Bundle Formation and Function of Cochlear Sensory Hair Cells.

Geng R, Furness DN, Muraleedharan CK, Zhang J, Dabdoub A, Lin V, Xu S.

Sci Rep. 2018 Dec 21;8(1):18022. doi: 10.1038/s41598-018-36894-z.


In vitro Methods to Cultivate Spiral Ganglion Cells, and Purification of Cellular Subtypes for Induced Neuronal Reprogramming.

Meas SJ, Nishimura K, Scheibinger M, Dabdoub A.

Front Neurosci. 2018 Nov 13;12:822. doi: 10.3389/fnins.2018.00822. eCollection 2018.


Transcriptional response to Wnt activation regulates the regenerative capacity of the mammalian cochlea.

Samarajeewa A, Lenz DR, Xie L, Chiang H, Kirchner R, Mulvaney JF, Edge ASB, Dabdoub A.

Development. 2018 Nov 27;145(23). pii: dev166579. doi: 10.1242/dev.166579.


Reprogramming Glia Into Neurons in the Peripheral Auditory System as a Solution for Sensorineural Hearing Loss: Lessons From the Central Nervous System.

Meas SJ, Zhang CL, Dabdoub A.

Front Mol Neurosci. 2018 Mar 14;11:77. doi: 10.3389/fnmol.2018.00077. eCollection 2018. Review.


Direct Reprogramming of Spiral Ganglion Non-neuronal Cells into Neurons: Toward Ameliorating Sensorineural Hearing Loss by Gene Therapy.

Noda T, Meas SJ, Nogami J, Amemiya Y, Uchi R, Ohkawa Y, Nishimura K, Dabdoub A.

Front Cell Dev Biol. 2018 Feb 14;6:16. doi: 10.3389/fcell.2018.00016. eCollection 2018.


Modifier variant of METTL13 suppresses human GAB1-associated profound deafness.

Yousaf R, Ahmed ZM, Giese AP, Morell RJ, Lagziel A, Dabdoub A, Wilcox ER, Riazuddin S, Friedman TB, Riazuddin S.

J Clin Invest. 2018 Apr 2;128(4):1509-1522. doi: 10.1172/JCI97350. Epub 2018 Mar 12.


Cochlear Implants Meet Regenerative Biology: State of the Science and Future Research Directions.

Dabdoub A, Nishimura K.

Otol Neurotol. 2017 Sep;38(8):e232-e236. doi: 10.1097/MAO.0000000000001407. Review.


Introduction to the 14th International Symposium on Cochlear Implants and other Implantable Auditory Technologies, Toronto, Canada, May 11 to 14, 2016.

Nedzelski JM, Chen JM, Lin VYW, Dabdoub A.

Otol Neurotol. 2017 Sep;38(8):e214. doi: 10.1097/MAO.0000000000001508. No abstract available.


Dynamic Expression of Sox2, Gata3, and Prox1 during Primary Auditory Neuron Development in the Mammalian Cochlea.

Nishimura K, Noda T, Dabdoub A.

PLoS One. 2017 Jan 24;12(1):e0170568. doi: 10.1371/journal.pone.0170568. eCollection 2017.


Kremen1 regulates mechanosensory hair cell development in the mammalian cochlea and the zebrafish lateral line.

Mulvaney JF, Thompkins C, Noda T, Nishimura K, Sun WW, Lin SY, Coffin A, Dabdoub A.

Sci Rep. 2016 Aug 23;6:31668. doi: 10.1038/srep31668.


Comprehensive Expression of Wnt Signaling Pathway Genes during Development and Maturation of the Mouse Cochlea.

Geng R, Noda T, Mulvaney JF, Lin VY, Edge AS, Dabdoub A.

PLoS One. 2016 Feb 9;11(2):e0148339. doi: 10.1371/journal.pone.0148339. eCollection 2016.


Molecular cloning and functional characterisation of chicken Atonal homologue 1: a comparison with human Atoh1.

Mulvaney JF, Amemiya Y, Freeman SD, Ladher RK, Dabdoub A.

Biol Cell. 2015 Feb;107(2):41-60. doi: 10.1111/boc.201400078. Epub 2015 Jan 13.


Long-term time lapse imaging of mouse cochlear explants.

Mulvaney JF, Dabdoub A.

J Vis Exp. 2014 Nov 2;(93):e52101. doi: 10.3791/52101.


Generation of induced neurons by direct reprogramming in the mammalian cochlea.

Nishimura K, Weichert RM, Liu W, Davis RL, Dabdoub A.

Neuroscience. 2014 Sep 5;275:125-35. doi: 10.1016/j.neuroscience.2014.05.067. Epub 2014 Jun 11.


β-Catenin is required for hair-cell differentiation in the cochlea.

Shi F, Hu L, Jacques BE, Mulvaney JF, Dabdoub A, Edge AS.

J Neurosci. 2014 May 7;34(19):6470-9. doi: 10.1523/JNEUROSCI.4305-13.2014.


The role of Wnt/β-catenin signaling in proliferation and regeneration of the developing basilar papilla and lateral line.

Jacques BE, Montgomery WH 4th, Uribe PM, Yatteau A, Asuncion JD, Resendiz G, Matsui JI, Dabdoub A.

Dev Neurobiol. 2014 Apr;74(4):438-56. doi: 10.1002/dneu.22134. Epub 2013 Nov 15.


Secreted factor R-Spondin 2 is involved in refinement of patterning of the mammalian cochlea.

Mulvaney JF, Yatteau A, Sun WW, Jacques B, Takubo K, Suda T, Yamada W, Dabdoub A.

Dev Dyn. 2013 Feb;242(2):179-88. doi: 10.1002/dvdy.23908.


A dual function for canonical Wnt/β-catenin signaling in the developing mammalian cochlea.

Jacques BE, Puligilla C, Weichert RM, Ferrer-Vaquer A, Hadjantonakis AK, Kelley MW, Dabdoub A.

Development. 2012 Dec 1;139(23):4395-404. doi: 10.1242/dev.080358.


The Wnt receptor Ryk plays a role in mammalian planar cell polarity signaling.

Macheda ML, Sun WW, Kugathasan K, Hogan BM, Bower NI, Halford MM, Zhang YF, Jacques BE, Lieschke GJ, Dabdoub A, Stacker SA.

J Biol Chem. 2012 Aug 24;287(35):29312-23. doi: 10.1074/jbc.M112.362681. Epub 2012 Jul 6.


Fgf signaling regulates development and transdifferentiation of hair cells and supporting cells in the basilar papilla.

Jacques BE, Dabdoub A, Kelley MW.

Hear Res. 2012 Jul;289(1-2):27-39. doi: 10.1016/j.heares.2012.04.018. Epub 2012 May 2.


Atoh1, an essential transcription factor in neurogenesis and intestinal and inner ear development: function, regulation, and context dependency.

Mulvaney J, Dabdoub A.

J Assoc Res Otolaryngol. 2012 Jun;13(3):281-93. doi: 10.1007/s10162-012-0317-4. Epub 2012 Feb 28. Review.


Sox2 induces neuronal formation in the developing mammalian cochlea.

Puligilla C, Dabdoub A, Brenowitz SD, Kelley MW.

J Neurosci. 2010 Jan 13;30(2):714-22. doi: 10.1523/JNEUROSCI.3852-09.2010.


Evidence-based medicine among Jordanian family physicians: awareness, attitude, and knowledge.

Barghouti F, Halaseh L, Said T, Mousa AH, Dabdoub A.

Can Fam Physician. 2009 Jul;55(7):e6-13.


Wnt activity guides facial branchiomotor neuron migration, and involves the PCP pathway and JNK and ROCK kinases.

Vivancos V, Chen P, Spassky N, Qian D, Dabdoub A, Kelley M, Studer M, Guthrie S.

Neural Dev. 2009 Feb 11;4:7. doi: 10.1186/1749-8104-4-7.


Sox2 signaling in prosensory domain specification and subsequent hair cell differentiation in the developing cochlea.

Dabdoub A, Puligilla C, Jones JM, Fritzsch B, Cheah KS, Pevny LH, Kelley MW.

Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18396-401. doi: 10.1073/pnas.0808175105. Epub 2008 Nov 14.


Disruption of fibroblast growth factor receptor 3 signaling results in defects in cellular differentiation, neuronal patterning, and hearing impairment.

Puligilla C, Feng F, Ishikawa K, Bertuzzi S, Dabdoub A, Griffith AJ, Fritzsch B, Kelley MW.

Dev Dyn. 2007 Jul;236(7):1905-17.


Myosin VI and VIIa distribution among inner ear epithelia in diverse fishes.

Coffin AB, Dabdoub A, Kelley MW, Popper AN.

Hear Res. 2007 Feb;224(1-2):15-26. Epub 2007 Jan 3.


Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair.

Xu Q, Wang Y, Dabdoub A, Smallwood PM, Williams J, Woods C, Kelley MW, Jiang L, Tasman W, Zhang K, Nathans J.

Cell. 2004 Mar 19;116(6):883-95.


Wnt signaling mediates reorientation of outer hair cell stereociliary bundles in the mammalian cochlea.

Dabdoub A, Donohue MJ, Brennan A, Wolf V, Montcouquiol M, Sassoon DA, Hseih JC, Rubin JS, Salinas PC, Kelley MW.

Development. 2003 Jun;130(11):2375-84.


Immunocytochemical localization of opsin, visual arrestin, myosin III, and calmodulin in Limulus lateral eye retinular cells and ventral photoreceptors.

Battelle BA, Dabdoub A, Malone MA, Andrews AW, Cacciatore C, Calman BG, Smith WC, Payne R.

J Comp Neurol. 2001 Jun 25;435(2):211-25.


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